• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2011.11a
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• pp.478-481
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• 2011

This study is intended to evaluate and optimize the characteristics of smoke spreading and the appropriateness of evacuation time extended by operation of smoke control system during fire within the underground space of the building structured in compliance with the smoke control system performance criteria from the local fire safety standard, which has been currently applied to the buildings in Korea. Using the heat release per unit weight of the combustibles, a numerical analysis both in case of smoke control system in operation and the system not in operation was carried out at the several different shopping malls. From the viewpoint of securing the evacuation time, the results were compared in an attempt to assess the appropriateness of the fire safety criteria.

• Proceedings of the SAREK Conference
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• 2008.11a
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• pp.103-106
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• 2008

This study is intended to evaluate the characteristics of smoke spreading and the appropriateness of evacuation time extended by operation of smoke control system during fire within the underground space of the building structured in compliance with the smoke control system performance criteria from the local fire safety standard, which has been currently applied to the buildings in Korea. Using the heat release per unit weight of the combustibles, a numerical analysis both in case of smoke control system in operation and the system not in operation was carried out at the several different shopping malls. From the viewpoint of securing the evacuation time, the results were compared in an attempt to assess the appropriateness of the fire safety criteria.

• Journal of The Korean Society of Agricultural Engineers
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• v.61 no.2
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• pp.51-61
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• 2019

In this study, interest in rural life of good natural environment rather than busy life is increasing as human life is extended by scientific and medical technology and society has improved. The reckless development of rural villages has caused social problems as the natural environment has been damaged, failing to function as a pleasant home. To address these problems, the government has implemented a rural village development project, but if the site is selected incorrectly, the residents may not be recruited, or applicants may lose their status, or the portion of the infrastructure building fee may increase. In order to prepare objective and clear assessment methods for the target site not to cause such problems, a layering analysis method (AHP: Analytic Method) was used to identify the current status of the rural village formation project, draw assessment items, and determine the importance of each item.

• Archives of Obesity and Metabolism
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• v.1 no.2
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• pp.83-88
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• 2022

Obesity increases the risk of developing metabolic diseases such as hypertension, type 2 diabetes, hyperlipidemia, and cardiovascular diseases, as well as some cancers. To prevent the occurrence of these diseases and death, it is essential to manage obesity. Though there are several treatments for obesity, lifestyle interventions, such as diet and exercise, and drug therapy are most widely used in clinical practice. Among the anti-obesity drugs available, the weight loss effect of naltrexone/bupropion has been well-proven. We present a case study in which naltrexone/bupropion, a glucagon-like peptide-1 agonist, and a sodium-glucose transporter 2 inhibitor showed significant weight loss and improved metabolic parameters. Additionally, the management of type 2 diabetes and hypertension, which are common diseases in patients with obesity, was also included.

• The Journal of the Korea Contents Association
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• v.17 no.10
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• pp.503-517
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• 2017

After a few recent documentary films had commercial success, factors for their success are getting attention. This paper explores the factors of the financial success of two documentary films. "My Love, Don't Cross That River" gained extended popularity with its universal message, and "Two Doors" conveyed a poweful political message. This paper conducted a case study by inteviewing production directors and distribution managers. Analysis was based on the three categories suggested by Litman and Kohl(1989): creative sphere, distribution-scheduling release pattern, and marketing efforts. Findings present the common factors of the two movies' success in the following areas: persons and events showing a powerful reality, a message with new and fresh insight, artistic quality, distribution strategy with timely scheduling, release time (period), public relations, and advertising.. In addition, "My Love, Don't Cross That River" was helped by a sufficient budget for scheduling/releasing and advertising. Its wide-release stratergy worked as well. "Two Doors" was aided by the government support for release and by the special factor called 'Participating viewer'. By examining the factors of documentary films' commercial success, this study has an implication for the popularization of documentary movies by indicating how to strategically apply relevant factors.

• The Journal of Advanced Prosthodontics
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• v.3 no.3
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• pp.145-151
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• 2011

PURPOSE. This study was performed to investigate the ability of recombinant human-bone morphogenic protein-2 immobilized on a heparin-grafted bone substrate to enhance the osteoblastic functions. MATERIALS AND METHODS. The Bio-$Oss^{(R)}$, not coated with any material, was used as a control group. In rhBMP-2-Bio-$Oss^{(R)}$ group, rhBMP-2 was coated with Bio-$Oss^{(R)}$ using only deep and dry methods (50 ng/mL, 24 h). In heparinized rhBMP-2-Bio-$Oss^{(R)}$ group, dopamine was anchored to the surface of Bio-$Oss^{(R)}$, and coated with heparin. rhBMP-2 was immobilized onto the heparinized- Bio-$Oss^{(R)}$ surface. The release kinetics of the rhBMP-2-Bio-$Oss^{(R)}$ and heparinized rhBMP-2-Bio-$Oss^{(R)}$ were analyzed using an enzyme-linked immunosorbent assay. The biological activities of the MG63 cells on the three groups were investigated via cytotoxicity assay, cell proliferation assay, alkaline phosphatase (ALP) measurement, and calcium deposition determination. Statistical comparisons were carried out by one-way ANOVA test. Differences were considered statistically significant at $^*$P<.05 and $^{**}$P<.001. RESULTS. The heparinized rhBMP-2-Bio-$Oss^{(R)}$ showed more sustained release compared to the rhBMP-2-Bio-$Oss^{(R)}$ over an extended time. In the measurement of the ALP activity, the heparinized group showed a significantly higher ALP activity when compared with the non-heparinized groups (P<.05). The MG63 cells cultivated in the group with rhBMP-2 showed increased calcium deposition, and the MG63 cells from the heparinized group increased more than those that were cultivated in the non-heparinized groups. CONCLUSION. Heparin increased the rhBMP-2 release amount and made sustained release possible, and heparinized Bio-$Oss^{(R)}$ with rhBMP-2 successfully improved the osteoblastic functions.

• The Korean Journal of Urological Oncology
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• 제15권3호
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• pp.178-186
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• 2017

Purpose: Poloxamer 407 (P407) thermo-sensitive hydrogel formulations were developed to enhance the retention time in the urinary bladder after intravesical instillation. Materials and Methods: P407 hydrogels (P407Gels) containing 0.2 w/w% fluorescein isothiocyanate dextran (FD, MW 4 kDa) as a fluorescent probe were prepared by the cold method with different concentrations of the polymer (20, 25, and 30 w/w%). The gel-forming capacities were characterized in terms of gelation temperature (G-Temp), gelation time (G-Time), and gel duration (G-Dur). Homogenous dispersion of the probe throughout the hydrogel was observed by using fluorescence microscopy. The in vitro bladder simulation model was established to evaluate the retention and drug release properties. P407Gels in the solution state were administered to nude mice via urinary instillation, and the in vivo retention behavior of P407Gels was visualized by using an in vivo imaging system (IVIS). Results: P407Gels showed a thermo-reversible phase transition at $4^{\circ}C$ (refrigerated; sol) and $37^{\circ}C$ (body temperature; gel). The G-Temp, G-Time, and G-Dur of FD-free P407Gels were approximately $10^{\circ}C-20^{\circ}C$, 12-30 seconds, and 12-35 hours, respectively, and were not altered by the addition of FD. Fluorescence imaging showed that FD was spread homogenously in the gelled P407 solution. In a bladder simulation model, even after repeated periodic filling-emptying cycles, the hydrogel formulation displayed excellent retention with continuous release of the probe over 8 hours. The FD release from P407Gels and the erosion of the gel, both of which followed zero-order kinetics, had a linear relationship ($r^2=0.988$). IVIS demonstrated that the intravesical retention time of P407Gels was over 4 hours, which was longer than that of the FD solution (<1 hour), even though periodic urination occurred in the mice. Conclusions: FD release from P407Gels was erosion-controlled. P407Gels represent a promising system to enhance intravesical retention with extended drug delivery.

• Journal of Hospice and Palliative Care
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• v.20 no.2
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• pp.131-135
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• 2017

Purpose: Oral naloxone is combined with oxycodone to alleviate or prevent opioid-induced constipation in cancer pain patients. However, there is still concern that oral naloxone may precipitate opioid withdrawal symptoms in patients on opioids. We retrospectively investigated clinical characteristics of cancer patients who experienced opioid withdrawal symptoms. Methods: We reviewed medical records of all patients who were prescribed with oral oxycodone/naloxone at a tertiary cancer center from January 1, 2012 through December 31, 2016. Eligible patients were screened based on demographics, opioid and naloxone dosages, clinical manifestation and pain intensity. Results: Among a total of 1,641 patients, 10 patients were selected. Seven patients were male, and the average age was 68.1 years. The median dose of naloxone that induced withdrawal symptoms was 20 mg. Most common withdrawal symptom was shivering (seven patients) followed by cold sweating (five), and muscle twitching (five). Other symptoms included restlessness, fever, dizziness, and yawning. Pain was exacerbated from the median intensity of numeric rating scale (NRS) 3 to NRS 6. Conclusion: Opioid withdrawal symptoms may occur when switching to oral oxycodone/naloxone for cancer patients who have been treated with other strong opioids. A prospective, multicenter study on this issue should be conducted in future.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.38 no.5
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• pp.298-303
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• 2005

This study described the reproductive behavior and the morphological development of the larvae and juvenile of the hedgehog seahorse (Hippocampus spinosissimus). Larvae released from male seahorse were reared for 30 days in the laboratory. At the birth, the small flap-like mouth and anus of the yolk-sac larvae were open, and the yolk was completely absorbed within 1 day. The size of newborn larvae ranged 7.01-13.19mm (mean $9.26\pm1.9mm$, n=9) in TL (total length). The larvae had 15-16 pectoral fin rays and 19 dorsal fin rays, but 4 anal fin rays were not completely developed. The larval size ranged 13.38-14.38 mm (mean $13.96\pm0.3mm$, n=6) in TL at 1 day after release, and they had 17 pectoral fin rays, 20 dorsal fin rays and 4 anal fin rays when the larvae reached the juvenile stage. Juvenile size ranged 14.98-16.42mm (mean $15.84\pm0.5mm$, n=5) in TL at 3 days after release, and 1, 4, 6, 8 trunk spines extended quickly. Terminal part of the coronet became a four-forked wedge shape concurrently. Juvenile became 23.25mm (n=l) in TL after 15 days and all 11 trunk rings was connected completely. After 20 days, the juveniles were 24.66-28.65mm (mean $27.26\pm1.6mm$, n=5) in TL, and many melanophores appeared in integument. In the eye lenses, 5-6 lusters were formed. After 30 days, the juveniles were 26.78-28.26 mm (mean $27.36\pm0mm$, n=4)in TL and 8-9 lusters appeared on the eye lenses. Coronet terminal part developed to a five-forked crown-shape completely.

• Environmental and Resource Economics Review
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• v.17 no.2
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• pp.287-311
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• 2008

This paper is designed to examine how the global timber market impacted by climate change would affect global warming through the carbon flux of forests. For this purpose, we integrated the modified TSM 2000 and the extended TCM in order to simulate the projection of net carbon release of forests from 1995 to 2085. On the basis of the simulation results under normal demand growth scenario, we identified that the global timber market impacted by climate change ameliorates the atmospheric carbon about 3.60% of carbon dioxide concentration in 1990 over 90 years. This implies that the global timber market impacted by climate change has a negative feedback effect on global warming over 90 years. For sensitivity analysis, we performed these simulation procedure under high demand growth scenario and very high demand growth scenario.