• Title/Summary/Keyword: extended release

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A non-inferiority study evaluating a new extended-release preparation of tilmicosin injected subcutaneously vs. ceftiofur administered intramammary, as dry-cow therapy in Holstein Friesian cows

  • Ortega, Esteban;Alfonseca-Silva, Edgar;Posadas, Eduardo;Tapia, Graciela;Sumano, Hector
    • Journal of Veterinary Science
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    • v.21 no.6
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    • pp.87.1-87.11
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    • 2020
  • Background: A new, extended long-acting tilmicosin (TLAe) preparation was tested against intramammary ceftiofur (CEF) using a non-inferiority trial model during dry-cow therapy (DCT) in a farm with high bovine population density and deficient hygiene application. Objectives: To evaluate the possibility that TLAe administered parenterally can achieve non-inferiority status compared to CEF administered intramammary for DCT. Methods: Cows were randomly assigned to TLAe (20 mg/kg subcutaneous; n = 53) or CEF (CEF-HCl, 125 mg/quarter; n = 38 cows) treatment groups. California mastitis testing, colony-forming unit assessment (CFU/mL), and number of cases positive for Staphylococcus aureus were quantified before DCT and 7 d after calving. A complete cure was defined as no bacteria isolated; partial cure when CFU/mL ranged from 150 to 700, and cure-failure when CFU/mL was above 700. Results: TLAe and CEF had overall cure rates of 57% and 53% (p > 0.05) and S. aureus cure rates of 77.7% and 25%, respectively (p < 0.05). The pathogens detected at DCT and 7 days after calving were S. aureus (62.71% and 35.55%), Staphylococcus spp. (22.03% and 35.55%), Streptococcus uberis (10.16% and 13.33%), and Escherichia coli (5.08% and 15.55%). Non-inferiority and binary logistic regression analyses revealed a lack of difference in overall efficacies of TLAe and CEF. Apart from S. aureus, S. uberis was the predominant pathogen found in both groups. Conclusions: This study is the first successful report of parenteral DCT showing comparable efficacy as CEF, the gold-standard. The extended long-term pharmacokinetic activity of TLAe explains these results.

Modal analysis of cracked cantilever composite beams

  • Kisa, Murat;Arif Gurel, M.
    • Structural Engineering and Mechanics
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    • v.20 no.2
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    • pp.143-160
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    • 2005
  • Modal analysis of cracked cantilever composite beams, made of graphite-fibre reinforced polyamide, is studied. By using the finite element and component mode synthesis methods, a numeric model applicable to investigate the vibration of cracked composite beams is developed. In this new approach, from the crack section, the composite beam separated into two parts coupled by a flexibility matrix taking into account the interaction forces. These forces are derived from the fracture mechanics theory as the inverse of the compliance matrix calculated with the proper stress intensity factors and strain energy release rate expressions. Numerical results are obtained for modal analysis of composite beams with a transverse non-propagating open crack, addressing the effects of the location and depth of the crack, and the volume fraction and orientation of the fibre on the natural frequencies and mode shapes. By means of modal data, the position and dimension of the defect can be found. The results of the study confirmed that presented method is suitable for the vibration analysis of cracked cantilever composite beams. Present technique can be easily extended to composite plates and shells.

Combustion Characteristics of Common Rail System by Using a Heavy Duty Transparent Engine (Common Rail을 이용한 대형 디젤 가시화엔진에서의 연소특성)

  • Kim, Y.M.;Lee, J.H.;Kim, S.H.;Lee, W.G.;Hong, C.H.;Choi, B.C.
    • Proceedings of the KSME Conference
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    • 2001.06d
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    • pp.896-902
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    • 2001
  • To meet strict emission regulation while improving engine performances, common rail injection system which is suitable for electronic control, and capable of controlling injection quantity, timing, rate and pressure individually as well as realizing high pressure has been developed. At present study, a 8L DI diesel engine was converted to a single-cylinder experimental engine allowing optical access through an extended piston and a prototype of common rail injector in progress was applied to the engine. The combustion characteristics of the engine were analysed by using direct images and characteristics of the injector were analysed. We can not say that the results are always the same to general common rail injection system but that they are just characteristics of specific prototype injector.

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Status of Conducting the Field Trip in the Middle and High School Science (중등학교 과학과 야외활동의 실태 및 개선 방안)

  • Hong, Jeong-Soo;Chang, Nam-Kee
    • Journal of The Korean Association For Science Education
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    • v.17 no.1
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    • pp.85-92
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    • 1997
  • The field is a good learning environment that offers many opportunities. Status of conducting field trip in the middle and high school was investigated As a result, there was few teachers who disagree that a course in science should include learning in the field. Yet, on practical side, teachers who used to conduct the field trip over once a year in science class appeared to be about 23% only. Most of schools conducting field trips hadn't well-planned program for instructional activities. Many of teachers appealed that they should not get release time for conducting an extended field experiences, and that they could not obtained good information in relation to the contents, the methods and strategies of field activities. It says that a good field trip needs administrative and financial surport, many informations, and the teacher's exertion.

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Characteristization of Spray Combustion and Turbulent Flame Structures in a Typical Diesel Engine Condition (디젤 엔진 운전 조건에서 분무 연소 과정과 난류 화염 구조 특성에 대한 해석)

  • Lee, Young-J.;Huh, Kang-Y.
    • Journal of the Korean Society of Combustion
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    • v.14 no.3
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    • pp.29-36
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    • 2009
  • Simulation is performed to analyze the characteristics of turbulent spray combustion in a diesel engine condition. An extended Conditional Moment Closure (CMC) model is employed to resolve coupling between chemistry and turbulence. Relevant time and length scales and dimensionless numbers are estimated at the tip and the mid spray region during spray development and combustion. The liquid volume fractions are small enough to support validity of droplets assumed as point sources in two-phase flow. The mean scalar dissipation rates (SDR) are lower than the extinction limit to show flame stability throughout the combustion period. The Kolmogorov scales remain relatively constant, while the integral scales increase with decay of turbulence. The chemical time scale decreases abruptly to a small value as ignition occurs with subsequent heat release. The Da and Ka show opposite trends due to variation in the chemical time scale. More work is in progress to identify the spray combustion regimes.

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Fuel Injection System on Combustion and Exhaust Emissions Characteristics in Compression Ignition Engines (압축착화 엔진에서 디젤-가솔린 Dual Fuel이 연소 및 배기 특성에 미치는 영향)

  • Kwon, Seok-Joo;Cha, June-Pyo;Sung, Ki-An;Park, Sung-Wook
    • Journal of the Korean Society of Combustion
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    • v.16 no.1
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    • pp.52-57
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    • 2011
  • The present study describes the characteristics of combustion and exhaust emissions in compression ignition engines using diesel-gasoline dual fuel. For investigating combustion characteristics, diesel fuel was injected directly in a single-cylinder compression ignition engine with a common-rail injection system and gasoline fuel was injected into a premixed chamber installed in an intake port. In order to investigate exhaust emission characteristics, exhaust gas was measured by emission analyzer and smoke meter. The experimental results showed that cases of diesel-gasoline dual fuel combustion exhibited extended ignition delay and reduced peak combustion pressure compared to those of directly injected diesel fuel cases. Furthermore, premixed gasoline-air mixture reduced NOx emissions due to low peak of rate of heat release(ROHR).

Extension of a High Resolution Lagrangian Method to Consider the Real Gas Effect

  • Mazaheri K
    • 한국전산유체공학회:학술대회논문집
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    • 2003.10a
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    • pp.48-49
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    • 2003
  • In the present research a high order Gudonov-type method has been used for the simulation of very high pressure flow fields, as well as the capturing of strong shocks, which usually occur in explosion of high explosives. The treatment strong shocks and the flow field behind the shocks needs a very high resolution scheme. To resolve accurately the shock and the release waves behind the shock the piece­wise parabolic method (PPM) of Colella [1] was utilized in this research. A major problem which encountered in very high pressure problems is the equation of state which differs completely form the ideal-gas equation of state (EOS). Here, the original PPM is extended for real gas effect consideration.

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Extended Linear Vulnerability Discovery Process

  • Joh, HyunChul
    • Journal of Multimedia Information System
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    • v.4 no.2
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    • pp.57-64
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    • 2017
  • Numerous software vulnerabilities have been found in the popular operating systems. And recently, robust linear behaviors in software vulnerability discovery process have been noticeably observed among the many popular systems having multi-versions released. Software users need to estimate how much their software systems are risk enough so that they need to take an action before it is too late. Security vulnerabilities are discovered throughout the life of a software system by both the developers, and normal end-users. So far there have been several vulnerability discovery models are proposed to describe the vulnerability discovery pattern for determining readiness for patch release, optimal resource allocations or evaluating the risk of vulnerability exploitation. Here, we apply a linear vulnerability discovery model into Windows operating systems to see the linear discovery trends currently observed often. The applicability of the observation form the paper show that linear discovery model fits very well with aggregate version rather than each version.

LIVELOCK-THIN LOCKING PROTOCOL FOR TRANSACTION SCHEDULING IN DISTRIBUTED DATA NETWORK MANAGEMENT (분산망 거래관리를 위한 기아현상 극소화 잠금규약)

  • 이혜경;김응모
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.24 no.12A
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    • pp.1891-1898
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    • 1999
  • Traditional syntax-oriented serializability notions are considered to be not enough to handle in particular various types of transaction in terms of duration of execution. To deal with this situation, altruistic locking has attempted to reduce delay effect associated with lock release moment by use of the idea of donation. An improved form of altruism has also been deployed in extended altruistic locking in a way that scope of data to be early released is enlarged to include even data initially not intended to be donated. In this paper, we first of all investigated limitations inherent in both altruistic schemes from the perspective of alleviating starvation occasions for transactions in particular of short-lived nature. The idea of two-way donation locking(2DL) has then been experimented to see the effect of more than single donation in distributed database systems. Simulation experiments shows that 2DL outperforms the conventional two-phase locking in terms of the degree of oncurrency and average transaction waiting time.

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A Genetic Algorithm for Dynamic Job Shop Scheduling (동적 Job Shop 일정계획을 위한 유전 알고리즘)

  • 박병주;최형림;김현수;이상완
    • Journal of the Korean Operations Research and Management Science Society
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    • v.27 no.2
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    • pp.97-109
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    • 2002
  • Manufacturing environments in the real world are subject to many sources of change and uncertainty, such as new job releases, job cancellations, a chance in the processing time or start time of some operation. Thus, the realistic scheduling method should Properly reflect these dynamic environment. Based on the release times of jobs, JSSP (Job Shoe Scheduling Problem) can be classified as static and dynamic scheduling problem. In this research, we mainly consider the dynamic JSSP with continually arriving jobs. The goal of this research is to develop an efficient scheduling method based on GA (Genetic Algorithm) to address dynamic JSSP. we designed scheduling method based on SGA (Sing1e Genetic Algorithm) and PGA (Parallel Genetic Algorithm) The scheduling method based on GA is extended to address dynamic JSSP. Then, This algorithms are tested for scheduling and rescheduling in dynamic JSSP. The results is compared with dispatching rule. In comparison to dispatching rule, the GA approach produces better scheduling performance.