• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.189-195
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• 2016

Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cancer subtype with a maximum propensity for regional spread. Our objective was to study if p53 expression might have any correlation with aggressive patterns of invasion within oral tongue cancers as well as with the histologically identified degree of oral tongue dysplasia. p53 immunoexpression was studied using immunohistochemistry in early staged OTSCCs (n=155), oral tongue dysplasias, (n=29) and oral tongue normal specimens (n=10) and evaluated for correlations with histological and clinicopathological parameters. Our study (n=194) showed a pattern of p53 expression increasing with different grades of tongue dysplasia to different grades of invasive OTSCC (p=0.000). Among the OTSCC tumours, positive p53 expression was seen in 43.2% (67/155) and a higher p53 labelling index was significantly associated with increased Bryne's grade of the tumour invasive front (p=0.039) and increased tumour depth (p=0.018). Among the OTSCC patients with tobacco habits, (n=91), a higher p53 labelling index was significantly associated with increased risk of local recurrence (p=0.025) and with lymphovascular space involvement (p=0.014). Evaluation of p53 through varying degrees of dysplasia to oral tongue cancer indicates that p53 expression is linked to aggressive features of oral tongue cancers and tongue precancers entailing a closer monitoring in positive cases. Among the OTSCCs, p53 expression is associated with tumour aggressiveness correlating with increased grading of invasive tumour front and tumour depth.

• 한국의류학회지
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• 제37권3호
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• pp.371-385
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• 2013

This study considers types of expression and examines aesthetic characteristics through analyzing designs (such as the Coca-Cola contour bottle as fashion) which has actively progressed in the collaboration of fashion designers and fashion brands. The conclusions of this study are as follows. The types of fashion expression on the Coca-Cola contour bottle are a presentation of diverse fashion images through a digital print expression that allow people-friendly images to be three-dimensional (or by adding a formative element) and the use of accessories or clothes. The symbolism characteristic were first indicated for the aesthetic characteristics on the Coca-Cola contour bottle. Symbolism is indicated through the identification of an implicit meaning towards a specific object. The symbolism of fashion was highlighted by designing the Coca-Cola's contour bottle with a typical material and pattern pursued by fashion designers and fashion brands. Second, the characteristic of playfulness was presented to expresses the instinctive desire in human nature for pleasure. The expression of visual playfulness is emphasized through the combination of item and image or by changing and re-analyzing a form through refuting stereotypes. Third, the characteristic of femininity was shown to express beauty in external image or a woman's delicate and soft inner propensity. Femininity was created by presenting a sensual femininity that recognized the voluminous curve silhouette of the Coca-Cola bottle such as a sexy female body or through the combination of a women's inner beauty with the sensory image of the object.

• 디자인학연구
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• 제11권1호
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• pp.209-218
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• 1998

뉴 미디어를 비롯한 신문지상과 TV에서 날마다 쏟아있고 있는 정보의 확산은 점차로 소비자의 의식을 새로운 가치관으로 이끌어가고 있으며 또 소비적 성향을 그 제품이 주는 실용성이나 경제성이라는 가치보다는 감성적 욕구로서의 기호 가치로서 제품의 가치를 인식하게 하고 있다. 가치관과 의식의 변화는 디자인에 많은 변화를 초래했는데 그 변화를 살펴보면 획일적이고 일방적이었던 모던 시대의 디자인에서 다의적이고 다중 적으로, 상품 소비에서 기호 소비 또는 이미지 소비로 물건의 외면 성, 현시성에 대립되는‘상품의 내면화’를 추구하게 되었으며, 유행 위주의 대중 소비에서 개성 중심의 개인 소비 성향으로서 변화이다. 이것은 기호 소비자의‘디자인 의미 해독’범위가 다양해지고 있음을 의미한다. 기호는 담론(discourse)을 옮기는 커뮤니케이션의 형태이며 담론은 의미 생성자와 의미소비자간의 커뮤니케이션에 관한 것을 말한다. 이 논문에서는 담론으로서의 기호 표현을 살펴보는 첫 단계로 광고의 기호 표현을 통해 직접적 표현의 경우, 은유적 표현의 경우로 나누어 생각해 보았다. 그리고 그 중 포스트모던의 성향을 표현하기에 적합하다고 판단되는 은유적 기호 표현에 대해서 좀더 깊이 있게 분석해 보고자하였다.

• 한국가구학회지
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• 제25권4호
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• pp.338-344
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• 2014

Modern furniture design is advancing by putting value on individual sensitivity. Accordingly, this study will focus on optical art, which can give various changes in people's sensitivity. Optical art was actively applied in various fields of image, photograph, fashion, textile, accessory and interior from the 1950s till the 1960s. Optical art realized by Victor Vasarely (1908~) opened a new trend in art by accurately realizing concise and precise expressions. This study analyzed the impact of pattern expression on sensitivity in optical art and suggested a method, which can spatiotemporally maximize the emotional change by combining optical art with the form of furniture. Modern furniture design is changing toward the direction of fitting to the propensity and emotional taste of an individual. Accordingly, this study analyzed the emotional expression felt in the furniture modeling works featured by concise, straight and standardized rectangular shape. Based on the result of analysis, this study would like to suggest a method to utilize optical pattern as a means for emotional design, with which people are able to perform various emotional expressions while keeping the function and form of furniture.

• 복식
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• 제52권8호
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• pp.73-85
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• 2002

Decadence is a phenomenon that people express fear from their inside, so unsound aspects appear in the social culture when the existing society is about to be collapsed. This study covered the cultural and aesthetic meaning and the role of decadence by examining the concept and phenomenon of it and analyzing the real case of expression appeared in the modern fashion. Characteristics of decadent phenomenon were divided into sexual corruption, ideality, cynicism and extreme technique, and decadent expression appeared in the fashion images was examined based on the divided phenomenon. Main results are as fellows. People bring the incidents that animals go through into relief, sticking to animal instinct when the society is on the decline. At that time, sexual decadence becomes remarkable, so voyeurism by exposure in their dress is deepen, revealing abnormal sexual propensity with bisexual tendency and sexual perversion. The real facts and appearance of people are revealed by transforming and distorting bodies for the fear of humans inside suppressed in the fin-de-siecle mood. The sense of alienation and helplessness of people anxious about the future is developed to cynicism expressing the uncertain emotion in their dress, and the formative methods of dismantlement. destruction and abrasion appear to form sickly images in the gloomy and cold mood. The intention of affirmative decadence is realized by mixing heterogeneous styles and producing new things. Extreme decorative technique and gorgeousness are even mysterious and show the highest refinement.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제27권2호
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• pp.110-122
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• 2005

Adenoid cystic carcinoma (ACC) of salivary glands has a protracted clinical course with perineural invasion, delayed onset of hematogenous metastasis, and poor responses to classical cytotoxic chemotherapic agents. Most deaths from salivary ACC are caused by lung metastases that are resistant to conventional therapy. Therefore, knowledge of cellular properties and tumor-host interactions that influence the dissemination of metastatic cells is important for the design of more effective therapy of salivary cancer. I determined in vitro expression of epidermal growth factor receptor (EGFR) and its downstream effectors and vascular endothelial growth factor receptor (VEGFR)-2 on a human salivary ACC cell line (ACC2). I also evaluated the expression of EGF and VEGF signaling molecules and metastasis-related proteins on human salivary ACC cells orthotopically growing in nude mice. In Western blot and immunohistochemical analyses, EGFR and VEGFR-2 were presented and phosphorylated in ACC2 cells. In human parotid cancer xenografts in nude mice, EGF and VEGF signaling molecules, IL-8, and MMP-9 were expressed at markedly higher levels than in normal parotid tissues. Moreover, tumor-associated endothelial cells of this orthotopic parotid tumor expressed phosphorylated VEGFR-2 and phosphorylated Akt, which is a cell-survival protein. These data show that those biomarkers can be molecular targets for therapy of salivary ACC, which has a propensity for delayed lung metastasis.

• 패션비즈니스
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• 제13권3호
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• pp.99-108
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• 2009

The purpose of this study is to analyze the middle-aged British women's apparel purchase behavior. The results of this study can be used to present the tendency of Korean middle-aged women's apparel purchase behavior when they become the old-aged by comparing and analyzing the British women's purchase behavior. We found that they prefer to choose and purchase their clothes by their own decision-making and search for actively the new brands for old age. Strong willingness was showed that their level of consumption amounts for clothing would be the same level between middle-aged and old-aged. It was also presented that they like to see a old-aged fashion model for fashion advertisement rather than a younger one and prefer to use the expression of 'mature' rather than a stereotypical expression such as a silver, gray and gold. The segmentation of fashion market by age can not be simply standardized. We expect that the propensity for clothing purchase behavior pattern of middle-aged women will not be changed and keep the same tendency by the time of their old-aged. We expect that this research results can be used as a basic material for another study and setting up the product developments and marketing strategies.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2007년도 춘계학술대회 논문집
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• pp.242-247
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• 2007

As individual's experiences become more diverse and abundant, demands for design are becoming stronger and the propensity to consume is becoming more diverse. In such an age of pluralization, while hotels displaying distinct design characteristics are spreading rapidly like a trend studies regarding expressive characteristics of such design are still insufficient so the accurate understanding and analysis of hotel guest room designs is needed. To this end, this study analyzes and studies the characteristics and trends of design expressions, surveying domestic cases using hotel guest rooms, which have begun to diversify through the rise of design hotels in Korea, as subjects.

• 한국의류산업학회지
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• 제11권6호
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• pp.867-877
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• 2009

These days, the fantastic in opposition to classic beauty becomes a genre of creative body expression. The purpose of this study was to analyze the expressive characteristics of body types and meanings in recent fantastic fashion illustration. The method of this study was to analyze recent documentaries, fashion books, internet web site and so forth. The results were as follows: In literatures, pictures and movies, the category of the fantastic body's expressive types were classified as dominant mutant based on SF, multi body or fragment body by disruption, heterogeneous compound based on myth, personified humanoid and non substance in supernatural boundary. The dominant mutant based on SF was expressed image morphing, composition of machine image with body and modern metamorphosis of classic SF body. It means propensity to post-feminism and reservation of meaning analysis based on human unconsciousness. The multi body or fragment body by disruption in fashion illustration was expressed distorted composition of same body pictures, replacement of different bodies, deconstruction and partial omission of body and composition of meaning or non meaning images. It means permanence of self and basic narcissism. The heterogeneous compound based on myth was expressed general composition or optical illusion of various and aggressive animal motive. It means reinterpretation of original myth, metaphor of basic femme fatale, pursuit of permanence and sign of primitive mind in unconsciousness. The personified humanoid was expressed real human body description of mannequin or ball joint doll and anthropomorphism of robot image. It means representative satisfaction and nostalgia of childhood. The non substance in supernatural boundary was expressed grotesque description of ghost, zombie, vampire, angel, fairy, using of symbolic red, black color and non body. It means human's basic desire about immortality and taboo. Through the result of these study, the expression of fantastic body in fashion illustration will expend expressive method and we will understand human and cultural codes of today.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9355-9360
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• 2014

Background: Oral squamous cell carcinoma (OSCC) remains as one of the most difficult malignancies to control because of its high propensity for local invasion and cervical lymph node dissemination. In this study, we evaluate the efficacy of our novel pH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting HER2 expression profile in OSCC model in rat. Results: DOX-MTX- nanoparticle complexes caused significant decrease in mRNA level of HER2 compared to untreated cancers (p<0.05) and this finding was more pronounced with the IV mode (p<0.000). Surprisingly, HER2 mRNA was not affected in DOX treated as compared to the control group (p>0.05). On the other hand, in the DOX-MTX NP treated group, fewer tumors characterized with advanced stage and decreased HER2 paralleled improved clinical outcome (P<0.05). Moreover, the effectiveness of the oral route in the group treated with nanodrug accounted for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Furthermore, there was no significant difference in mRNA level of HER2 (p>0.05). Conclusions: Influence of HER2 gene expression is a new feature and mechanism of action observed only in dual action DOX-MTX-NPs treated groups. Down-regulation of HER2 mRNA as a promising marker and prognosticator of OSCC adds to the cytotoxic benefits of DOX in its new formulation. Both oral and IV application of this nanodrug could be used, with no preferences in term of their safety or toxicity. As HER2 is expressed abundantly by a wide spectrum of tumors, i DOX-MTX NPs may be useful for a wide-spectrum of lesions. However, molecular mechanisms underlying HER2 down regulation induced by DOX-MTX NPs remain to be addressed.