• Clinical and Experimental Reproductive Medicine
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• v.24 no.2
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• pp.225-232
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• 1997

폐색성 혹은 비폐색성 무정자증에서 부정소 정자채취법 등이 부적절하다고 여겨질때는 정소 조직을 일부 절제하여 그 조직으로부터 정자를 직접 채취하게 되는데 일반적으로 이렇게 정소로부터 추출한 정소정자는 운동성이 전혀 없거나 매우 약한 운동성을 보이는 경우가 많다. 본 연구의 목적은 이러한 정소정자를 Vero cell과 공배양을 시킴으로써 운동성을 획득시키거나 향상시키고 이를 수정시키는 시기까지 지속시킴으로써 정소정자추출술 (TESE)을 시행하는 환자나 의료진들에게 보다 편안하고 융통성있는 시간대를 부여하고, 아울러 정자직접주입술 (ICSI)을 보다 용이하게 하여 성공적인 수정률과 임신율을 얻음에 있다. 또한 ICSI를 시행한 후, 운동성이 향상된 잉여의 정소정자를 냉동보존함으로써 차후에 TESE을 다시 시행치않고도 시험관 아기 시술을 시도할 수 있는 부가적인 잇점도 있다고 할 수 있다. 대상환자군은 정관폐색증(n=11) 혹은 비정관폐색증(n=2)을 보이는 13명의 무정자증의 남성불임환자였으며 난자회수예정일 3일전에 TESE를 시행하여 정소정자를 얻은 후 이를 정자직접주입술이 시행되는 당일까지 Vero cell과 공배양을 실시하였다. Vero cell과의 공배양에 의하여 운동성이 있는 정소정자의 수는 공배양전과 비교하여 평균 3.3배가 증가하였으며, 특히 공배양전에 운동성이 있는 정소정자의 수가 50,000/ml이하의 미약한 운동성만을 보였던 경우 (n=5)에는 공배양 후에 운동성이 있는 정소정자 수의 평균증가율이 7.7배였다. 공배양전 정자운동성이 전혀 없었던 2례의 비정관폐색증환자중 3일간의 공배양을 통하여 1례에서 운동성을 획득한 정소정자를 얻을 수 있었으며 (14,300/ml), 정자직접주입술을 통하여 성공적인 수정 및 임신에 도달할 수 있었다. Vero cell과 공배양을 하고 ICSI했던 결과, 평균 수정률은 75.0% 이었으며 임신율은 61.5%였다.

• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.4
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• pp.467-474
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• 2018

The purpose of this study is related to automatic hull-form design for ships operating at two speeds. Research was conducted using a series 60 ($C_B=0.6$) ship as a target, which has the most basic ship hull-form. Hull-form development was pursued from the viewpoint of improving resistance performance. In particular, automatic hull-form design for a ship was performed to improve wave resistance, which is closely related to hull-forms. For this purpose, we developed automatic hull-form design software for ships by combining an optimization technique, resistance prediction technique and hull-form modification technique, appling the software developed to a target ship. A sequential quadratic programming method was used for optimization, and a potential-based panel method was used to predict resistance performance. A Gaussian-type modification function was developed and applied to change the ship hull-form. The software developed was used to design a target ship operating at two different speeds, and the performance of the resulting optimized hull was compared with the results of the original hull. In order to verify the validity of the program developed, experimental results obtained in model tests were compared with calculated values by numerical analysis.

• Structural Engineering and Mechanics
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• v.50 no.5
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• pp.589-603
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• 2014

Expressions for determining the value of the impact force as reported in the literature and incorporated into code provisions are essentially quasi-static forces for emulating deflection. Quasi-static forces are not to be confused with contact force which is generated in the vicinity of the point of contact between the impactor and target, and contact force is responsible for damage featuring perforation and denting. The distinction between the two types of forces in the context of impact actions is not widely understood and few guidelines have been developed for their estimation. The value of the contact force can be many times higher than that of the quasi-static force and lasts for a matter of a few milli-seconds whereas the deflection of the target can evolve over a much longer time span. The stiffer the impactor the shorter the period of time to deliver the impulsive action onto the target and consequently the higher the peak value of the contact force. This phenomenon is not taken into account by any contemporary codified method of modelling impact actions which are mostly based on the considerations of momentum and energy principles. Computer software such as LS-DYNA has the capability of predicting contact force but the dynamic stiffness parameters of the impactor material which is required for input into the program has not been documented for debris materials. The alternative, direct, approach for an accurate evaluation of the damage potential of an impact scenario is by physical experimentation. However, it can be difficult to extrapolate observations from laboratory testings to behaviour in real scenarios when the underlying principles have not been established. Contact force is also difficult to measure. Thus, the amount of useful information that can be retrieved from isolated impact experiments to guide design and to quantify risk is very limited. In this paper, practical methods for estimating the amount of contact force that can be generated by the impact of a fallen debris object are introduced along with the governing principles. An experimental-calibration procedure forming part of the assessment procedure has also been verified.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.31 no.1
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• pp.22-31
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• 2018

Objectives : In this study, we investigated whether Astragali Radix Pharmacocupuncture (ARP) has an effective on the full thickness defect wound healing process of mouse. Methods : A total of 50 mice (ICR mouse, 7 week-old male) were divided into control group and ARP group. A single full thickness skin defect was made on the dorsal side of the each mouse using an 8mm diameter biopsy punch. Control group were treated with 0.2㎖ saline and ARP group were treat with 0.2ml ARP at 8 points around the wound every three days total 4 times during the experimental period. The change in wound size, contraction rate, healing rate, and epithelization rate was measured by digital images taken on days 3, 6, 9, and 13, and evaluated using a digital image analysis program. Tissues were collected for histological analysis, RT-PCR, and Western blot on days 3, 6, 9, and 15. Results : The results are as follows. ARP group accelerated the rate of wound contraction, wound healing and epithelization compared to the control group. ARP group showed the decrease of inflammatory cells in early inflammatory phase compared to the control group. ARP group upregulated PECAM-1 mRNA and protein expression compared to the control group. ARP group inhibited the scar width and area compared to the control group. Conclusions: ARP showed positive effects on wound healing through the inhibition of inflammatory reaction and increase of PECAM-1 expression related to the wound healing process.

• Journal of the Korea Convergence Society
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• v.12 no.5
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• pp.327-335
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• 2021

The aim of this study is to examine the effectiveness of group art therapy on the depression and job satisfaction of local government officials. The study was conducted from March 2017 to March 2018 and the participants of this study were twenty public officials in North Chung-Chung Province. They randomly placed in two different group : 10 in experimental group, 10 in control group. To measure the effects of group art therapy, K-BDI and Job Satisfaction Scale were used a week before and a week after the intervention of group art therapy program. Data was analyzed using paired t-test with SPSS Statistics 23.0. The result was as follows : First, there was significant change to alleviate Depression. Second, there was significant change to increase job satisfaction. This study provides empirical evidence of effectiveness of group art therapy. The findings in this study are not only helping public officials' individual mental health but also enhancing productivity of local government and the quality of service to local residents in Chung-Chung province area.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.5
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• pp.32-39
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• 2021

Recently, necessities of steel form for reinforced concrete beam and girder have been emphasized in building structures for the reduction of the construction period and the labor cost. SY Beam was developed for the these purposes and is roll-formed using thin steel plate. On this research, we tried to evaluate and verify the performance and behavior of SY Beam under construction loading stage as like pouring in situ concrete. For the standard shape of SY beam, structural modelling with various steel thicknesses has carried out using MIDAS GEN program. From results of modelling, the width and height of SY Beam were determined 600mm and 400mm respectively. For 3 SY Beams, the loading experiment was performed to measure vertical and horizontal displacement under stacking sand, concrete block, and bundle of rebar. As a result, the vertical deflection showed a tendency to decrease as the thickness increased. In the horizontal displacement, the trend according to the thickness was not clearly observed. From the evaluation on the loading experiment, it is considered that the SY Beam can secure both workability and structural safety. In particular, the SY Beam(1.2mm) hardly generates horizontal displacement, so it has excellent load-bearing capacity. So, we judged that the SY Beam with 1.2mm steel plate has excellent performance and consider to be immediately commercially available.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.8
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• pp.139-148
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• 2019

Fostering science-gifted individuals are very important for the future of the nation, and it is especially important to cultivate information-gifted individuals in the age of the fourth industry. There is no standardized curriculum for each gifted education center of the University. Therefore, in this study, we analyzed how effective the curriculum developed on the basis of computing thinking is to affect the characteristics of the information-gifted individuals. The curriculum developed on the components of computing thinking was applied to the information-gifted students of K University. In order to verify the effectiveness of the curriculum, we developed a creative personality test and an intrinsic motivation test, and conducted tests before and after the training. We compared pre-post test results by t-test with R program. The creative personality test consisted of 36 items with 6 factors: risk-taking, self - acceptance, curiosity, humor, dominance, and autonomy. The intrinsic motivation test consisted of 20 items with 5 items: curiosity and interest oriented tendency, challenging learning task preference orientation, independent judgment dependency propensity, independent mastery propensity, and internal criterion propensity. The effect of the curriculum on the creative personality of the experimental group was significant (0.009, 0.05). The significance level of the intrinsic motivation was 0.056 and was not significant at the 0.05 level of significance.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.233-236
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• 2014

The purpose of this study is for the students who are naturally diverse in personality and behavior in the alternative school to examine the effect of the computer subject achievement and how to increase the student's interest in learning by means of the implementation of Howard Gardener, the Multiple-Intelligence Hypothesis. To verify this study, two groups of sophomore students from an Alternative High School located in Hwasung : The Experimental group consisted of 20 students who would participate in the Computer Science program by learning or applying new skills, based on the Multiple Intelligence Hypothesis. The Comparison Group consisted of 19 students who would follow the standardized Computer Science teaching and lesson plan. During five weeks, the multiple-Intelligence effect was executed in the search groups comparing the differences of the pre-test and pro-test. Pro-test showed following results: Firstly, the experiment search group showed a higher significant improvement in the subject achievement, compared to the comparison group. Secondly, the experiment search group showed a much higher increase in the interest of learning, compared to the comparison group. Thirdly, the experiment search group did not show any differences of the social development compared to the comparison group.

• The Korean Journal of Psychodrama
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• v.21 no.2
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• pp.1-12
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• 2018

The purpose of this study was to investigate the effects of psychodrama on self - esteem, well - being, anxiety and depression among domestic violence victims who entered the shelter. This study is a similar experimental study of a single group pre-and post-design. Data were collected from 7 participants, pre - post - questionnaire surveys conducted ten times psychodrama, during the period from January 4 to February 26, 2015. Data were analyzed using frequency, percentage, Pearson correlation coefficient and Wilcoxon 's sign rank test using SPSS 22.0 program. As a result, the participants' self-esteem was negatively correlated with anxiety(r=-.866, p =.012), depression(r=-.824, p =.023). There was no statistically significant difference in self-esteem, well-being, and anxiety, depression between before and after the psychodrama, but there was an increase in post-score of self-esteem and well-being, and the post-score of anxiety and depression decreased. In order to improve the self-esteem and well-being and to reduce anxiety and depression in women victimized by domestic violence, long-term support programs are needed for the application of leisure and psychological support programs and continuous participation in psychodrama.

• Clinical and Experimental Pediatrics
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• v.63 no.11
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• pp.438-446
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• 2020

Background: Most developmental screening tools in Korea are adopted from foreign tests. To ensure efficient screening of infants and children in Korea, a nationwide screening tool with high reliability and validity is needed. Purpose: This study aimed to independently develop, standardize, and validate the Korean Developmental Screening Test for Infants and Children (K-DST) for screening infants and children for neurodevelopmental disorders in Korea. Methods: The standardization and validation conducted in 2012-2014 of 3,284 subjects (4-71 months of age) resulted in the first edition of the K-DST. The restandardization and revalidation performed in 2015-2016 of 3.06 million attendees of the National Health Screening Program for Infants and Children resulted in the revised K-DST. We analyzed inter-item consistency and test-retest reliability for the reliability analysis. Regarding the validation of K-DST, we examined the construct validity, sensitivity and specificity, receiver operating characteristic curve analysis, and a criterion-related validity analysis. Results: We ultimately selected 8 questions in 6 developmental domains. For most age groups and each domain, internal consistency was 0.73-0.93 and test-retest reliability was 0.77-0.88. The revised K-DST had high discriminatory ability with a sensitivity of 0.833 and specificity of 0.979. The test supported construct validity by distinguishing between normal and neurodevelopmentally delayed groups. The language and cognition domain of the revised K-DST was highly correlated with the K-Bayley Scales of Infant Development-II's Mental Age Quotient (r=0.766, 0.739), while the gross and fine motor domains were highly correlated with Motor Age Quotient (r=0.695, 0.668), respectively. The Verbal Intelligence Quotient of Korean Wechsler Preschool and Primary Scales of Intelligence was highly correlated with the K-DST cognition and language domains (r=0.701, 0.770), as was the performance intelligence quotient with the fine motor domain (r=0.700). Conclusion: The K-DST is reliable and valid, suggesting its good potential as an effective screening tool for infants and children with neurodevelopmental disorders in Korea.