• 대한약침학회지
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• 제9권3호통권21호
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• pp.147-154
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• 2006

Objectives : The focus of the analysis was laid on changes in research pertaining to pharmacopuncture in regards to time progression. Methods : Type analysis was done on pharmacopuncture related papers published in the Journal of Korean Institute of Pharmacopuncture from the inaugural issue to June 2006 issue. 196 papers are analyzed to the sort of type. Results : For type analysis of the type of studies, experiment papers outnumbered other types with 94 cases, followed by 67 for clinical trials, and 35 for literary studies. Type analysis on the type of illnesses listed in the Methods section, 31 papers concentrated on arthritis or HIVD of spine, 6 for Pharmacopuncture response in human, 5 for anti-cancer and immune disorders, etc. Conclusion : Since its inaugural issue in 1997 to August 2006 issue ranging 10 years, type analysis revealed that the number of journals pertaining to pharmacopuncture has risen steadily over the years and nearly half of papers published recently are dealing with pharmacopuncture. Pharmacopuncture is a treatment method based on the unique theory of Korean traditional medicine. Its superior efficacy is proven through numerous research works, and effort and academical approach on pharmacopuncture are expected to receive positive evaluation.

• 동의신경정신과학회지
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• 제23권3호
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• pp.63-76
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• 2012

Objectives : The aim of this study was to investigate the value and efficacy of BDI, STAI, STAXI, ISI, and SCL-90-R in correlation with depression, anxiety, and insomnia patients. Methods : A total of 39 patients, who were diagnosed with depression, anxiety, and insomnia were evaluated using BDI, STAI, STAXI, ISI, and SCL-90-R. They were then statistically analyzed. Results : 1. BDI scores of depression patients were significantly different from other patients. 2. BDI scores of depression patients had strong positive correlation with STAI-S, and STAI-T scores. 3. STAI-S scores of anxiety patients had positive correlation with BDI, and ISI scores. 4. SCL-90-R depression subscale scores of depression patients had strong positive correlation with somatization, obsessive compulsive, interpersonal sensitivity, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism, global severity index, and positive symptom total subscale scores. 5. SCL-90-R anxiety subscale scores of anxiety patients had strong positive correlation with somatization, obsessive compulsive, depression, phobic anxiety, and global severity index subscale scores. Phobic anxiety subscale scores had strong positive correlation with anxiety, global severity index, and positive symptom total subscale scores. Conclusions : The result findings are expected to serve as a useful resource in future stress-related depression, anxiety, and insomnia case reports and clinical research in oriental neuropsychiatry.

• Journal of Nutrition and Health
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• 제33권7호
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• pp.745-754
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• 2000

Effects of oral taurine supplementation (6g/day)for 2-4 weeks on activities of red blood cell(RBC)total superoxide dismutase (SOD) and plasma glutathione peroxidase(GSH-Px) and the level of malondialdehyde(MDA) were evaluated in healthy female adults (23.6$\pm$0.3 years old). Compared to the value for 0 week plasma GSH-Px activity of the subjects was significantly lower after 2 weeks of taurine supplementation(p<0.05) and recovered to the value similar to 0 week after 4 weeks of taurine supplementation. RBC total SOD activity tended to be decreased after 2 weeks of taurine supplmentation compared to the values for 0 week although the difference between the means of the two group was not statistically significant. Plasma MDA level was not significantly decreased by taurine supplementation most probably due to the fact that the subjects participated in the present study were healthy and their antioxidant defense system had been in the 'normal' range. Plasma MDA concentration was negatively correlated with plasma taurine concentration(r=-0.2003m p<0.05) but tended to be positively correlated with plasma cholesterol concentration(r=0.2465, p=0.0645) as expected Plasma GSH-Px activity was positively associated with the percentage of 22:0 (r=0.2892, p<0.05) or 20:4w6(r=0.2939, p<0.05). On the other hand plasma MDA concentration was positively correlated with the percentage of 20:5w3 in plasma total lipids(r=0.2635 p<0.05) and negatively correlated with $\Delta$5 desaturation index of w6 fatty acids(20:3w6⇒20:4w6) in plamsa total lipids(r=-0.2714, p<0.05) as well as in phospholipids(r=-0.2864, p<0.05). From these results protective effect of taurine supplementation against lipid peroxidation and antioxidant defense system in humans appears to be minimal when the subjects are in a relatively healthy state. Further studies concerning the antioxidant efficacy of taurine should be conducted in human subjects under various disease states related to oxidative stress such as diabetes and artheroxclerosis.

• Nutrition Research and Practice
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• 제11권3호
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• pp.223-231
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• 2017

BACKGROUND/OBJECTIVES: Soy isoflavones are expected to improve menopausal symptoms and osteoporosis in women. However, their efficacy is still inconclusive, and there was limited data for postmenopausal women in South Korea. We examined the effects of soy isoflavones on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women. SUBJECTS/METHODS: A randomized, double-blind study design was used. Eighty-seven participants who had undergone natural menopause were randomly administered either 70 mg/day isoflavones (n = 43) or placebo (n = 41) for 12 weeks. We assessed the Kupperman index for climacteric symptoms and the menopause-specific quality of life (MENQOL) questionnaire for quality of the life. Biomarkers of bone metabolism were also measured in serum bone-specific alkaline phosphatase (BALP), osteocalcin (OC), N- and C-terminal cross-linking telopeptides of type Ι collagen (NTx, CTx), and urine-deoxypyridinolin (u-DPD). RESULTS: Scores of the Kupperman index were decreased in both the isoflavones group ($-7.0{\pm}15.8$, P = 0.0074) and placebo group ($-6.3{\pm}14.6$, P = 0.0064) during the intervention, but no significant difference was noted between the groups. Regarding the bone formation markers, the level of serum BALP increased by $6.3{\pm}4.1%$ (P = 0.004) and OC increased by $9.3{\pm}6.2%$ (P < 0.001), meanwhile those of the placebo were not changed. For the bone resorption markers, NTx, CTx, and u-DPD were not significantly different in either group. MENQOL was significant decreased in the isoflavone group ($-0.6{\pm}0.5$) and placebo group ($-0.6{\pm}0.4$), with a significant difference between groups (P = 0.0228). CONCLUSIONS: Our study suggests that 70 mg isoflavones supplement has beneficial effects on bone formation markers; however, it showed no benefit compared to the placebo on climacteric symptoms or quality of life.

• 한국콘텐츠학회논문지
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• 제10권7호
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• pp.159-168
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• 2010

90년대 이후부터 스토리보드의 디지털화가 꾸준히 연구되어 오면서 많은 종류의 스토리보드 소프트웨어들이 탄생하게 되었다. 그러나 이러한 소프트웨어들이 기존의 방식에 비해 효율적으로 어떠한 차이점이 있는지에 대한 구체적인 데이터가 부족하여 85명의 실험대상자에게 사용빈도수에 따른 스토리보드 소프트웨어 5개를 선정하여 사용성을 분석해 본 결과 크게 2가지의 결과를 도출해 낼 수 있었다. 첫째로는 선정된 5개의 소프트웨어 모두 상호작용 표현기능이 누락되어 있어 이것의 개발방향을 제시 할 수 있었으며. 둘째로는 스토리보드 소프트웨어로 얻을 수 있는 가장 중요한 효과는 콘텐츠의 디지털화가 아닌 콘텐츠의 실시간 플레이를 통해 얻을 수 있는 정보 전달력에 있다는 것을 실험을 통해 알 수 있었다. 본 연구를 통하여 얻은 결과는 소프트웨어의 개발자에게 새로운 모델을 제시 할 수 있으며 사용자에게는 스토리보드 소프트웨어를 통해 얻을 수 있는 효과를 이해하는 데에 도움이 될 수 있기를 기대한다.

• 한국콘텐츠학회논문지
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• 제14권11호
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• pp.930-943
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• 2014

현대사회에서 박물관은 기존의 전통적인 역할을 넘어, 지역사회와의 소통 및 교육의 공간으로서의 사회적 역할에 대한 중요성이 강조되고 있다. 박물관의 다양한 기능 중에서도 특히 사회적 약자 지원과 관련하여 "교육적 기능"이 교육 참가자 및 사회에 미치는 영향은 매우 크다. 사회적 약자를 대상으로 한 박물관 교육은 역사와 문화를 체험하는 기회를 제공함과 동시에 개인의 삶 그리고 지역사회 일원으로서의 역할에 대한 자존감을 함양하고, 나아가 긍정적인 사회 기반 구축에 기여하는 효과가 기대된다. 이러한 프로그램의 성과와 효과분석은 지속적인 평가와 개선 및 실천을 전제로 논의가 계속 되어야 하겠지만, 새로운 프로그램을 시작하고 개선 발전 시켜야 하는 초기 단계에서의 평가 또한 중요하다. 이를 위해 본 연구에서는 현재 신설, 운영되고 있는 노숙자를 대상으로 한 박물관 교육 프로그램을 질적 평가 방법을 통해 그 성과와 효과를 살펴보고자 하였다. 본 연구를 통해 박물관을 활용한 사회적 약자 지원 교육 프로그램의 평가 모델을 제시하였다. 또한 개발된 평가 모델을 실제 적용하여 프로그램을 평가하고, 그 성과를 측정 하였다.

• Investigative Magnetic Resonance Imaging
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• 제15권2호
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• pp.91-101
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• 2011

관류 자기공명영상은 크게 외인성과 내인성 조영제를 사용하는 방법으로 나눌 수 있고, 외인성 조영제를 사용하는 방법으로는 DSC 와 DCE 방법이 있으며, 내인성 조영제를 사용하는 방법으로는 ASL 이 있다. 이들 관류 자기공명영상 방법들은 환자의 상태와 나타내고자 하는 영상인자에 따라 선별적으로 최적화되어 사용되어야 한다. 그 예로 급성 뇌졸중 환자의 경우 매우 빠른 영상획득이 최우선적인 인자이므로 DSC 가 주로 이용되고 있고, 뇌종양 환자의 경우 여러 물리적 인자를 고려한 DSC 혹은 DCE 스캔이 필요하다. 또한 소아나 가임여성 및 신장병질환이 있는 경우는 ASL 을 이용되고 있다. 관류 자기공명영상 기술은 방사성 물질을 전혀 사용하지 않아 약물효과의 평가와 기타 치료 효과를 이해하는데 많은 응용이 있을 것으로 생각된다.

• 한국의료질향상학회지
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• 제2권1호
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• pp.86-109
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• 1995

Clinical trials of drugs on humans is the final and most important stage in evaluating the safety and efficacy of the drugs. Good Clinical Practice(GCP) standards were announced in 1987 to protect testees' rights as well as to ensure validity of the clinical trial results, but its implementation has been delayed until now. The purpose of this study is to evaluate the preparedness of the designated institutions to abide by GCP standards during clinical trials, and thereby to determine GCP implementability at the institutions. Survey on the status of clinical trials was conducted for the designated 83 clinical trial hospitals. Response rate was 95.2%. Donabedian's quality assessment model was applied as the basic framework for the study. And the relative - weights for the evaluation items were determined by expert's evaluation. Among the designated 83 hospitals, 39 conducted clinical trials to obtain drug manufacturing approval from 1990 to 1994. Only 19 institutions are found to be able to meet the requirements of KGCP. Structure variables - manpower, organization, and facility -, which are the basic elements for GCP, are evaluated as unsatisfied in many hospitals. Institutions which established IRB accounted for 41 or 51.9%, but those who have a protocol evaluation guideline, or Adverse Drug Reaction(ADR) reporting system were only 12 and 21 institutions, respectively. Also, the institutions providing educational programs on conducting clinical trials are few - 20. The study results indicates that the level of conducting KGCP is unsatisfactory. However, more institutions are expected to be able to meet the standards soon because GCP standards does not require so much regulation on facilities, but stress importance on research methodology and human right. At present as the institutions for clinical trials are primarily training hospitals with residency programs, such efforts as education will accelerate the implementability of GCP in Korea. Institutions must build the appropriate infrastructure and government must prepare to strongly enforce KGCP before it can successfully take place.

• Asian-Australasian Journal of Animal Sciences
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• 제21권10호
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• pp.1506-1515
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• 2008

Two feeding trials were conducted to assess the relative bioavailability (RBV) of methionine hydroxy analogue calcium salt (MHA-Ca) in comparison to DL-methionine (DL-Met). Male Ross 308 (1-38 days) and Cobb 500 chickens (1-42 days) were used in studies 1 and 2, respectively. Experimental diets based on wheat and soybean meal or sorghum and soybean meal were fed during three phases. In both experiments graded levels of DL-Met and MHA-Ca were supplemented to Met+Cys deficient basal diets. Additionally, in experiment 1, increasing levels of a DL-Met preparation diluted with corn starch to 65% purity (DL-Met65) were supplemented. Birds were kept in floor pens and feed and water were available ad libitum. Body weights and feed consumption were recorded at the beginning and end of the experimental periods and weight gain and feed efficacy were computed subsequently. At the end of the experiments, a number of birds were slaughtered for carcass evaluation (dressing percentage, breast meat yield). Dose response data were analysed by both ANOVA and nonlinear common plateau asymptotic regression. In both experiments birds responded significantly to increasing levels of either methionine source. However, RBV of MHA-Ca compared to DL-Met was markedly (in many cases significantly) below 84%, the value which would have been expected from MHA-Ca's chemical characteristics. Excluding some extremely low RBV figures of trial 2, RBV of MHA-Ca averaged to about 63% in relation to DL-Met. In addition, supplementation of DL-Met65 allowed confirmation of nonlinear common plateau asymptotic regression to be suitable to determine RBV.

• 한국콘텐츠학회논문지
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• 제16권11호
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• pp.11-19
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• 2016

생체인식기술 발달과 그 활용범위가 점차 확장하는 상황에서 이에 대해 사용자 입장에 중심을 둔 사용의도에 대한 연구는 매우 미미한 실정이다. 본 연구는 생체인식기술 종류에 따라 사용자가 인식하는 자기 효능감, 신뢰성, 보안성, 안전성, 편의성에 대해 살펴보고 각 인증수단에 대한 인식 차이가 향후 해당 생체인식기술 사용의도와 어떤 관련이 있는지 알아보고자 하였다. 인지된 자기 효능감, 신뢰성, 보안성, 안전성, 편의성을 독립변수로, 사용의도를 종속변수로 하여 각 생체인증 수단별로 종속변수에 미치는 독립변인 효과를 분석한 결과 지문인식의 경우 인지된 신뢰성과 편의성이 향후 지속사용의도에 유의미한 영향을 주고, 홍채인식은 인지된 편의성이, 정맥인식의 경우 인지된 신뢰성이 각 생체인식수단 사용의도에 가장 큰 영향을 주는 요인으로 나타났다. 이와 같은 연구결과는 향후 다양한 분야에서 생체인식 기술을 도입하는 과정에 사용자 인식이 고려된 적용 방향을 제시할 수 있을 것이다.