• Nutrition Research and Practice
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• 제8권3호
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• pp.292-296
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• 2014

BACKGROUND/OBJECTIVES: This study was conducted to assess the potential of St. John's Wort (Hypericum perforatum) to prevent obesity and abnormalities in lipid metabolism induced by ovariectomy in a rat model without stimulatory activity on uterus. MATERIALS/METHODS: Ovariectomized (OVX) rats were treated for 6 weeks with 70% ethanol extracts of Hypericum perforatum [HPEs: whole plant (WHPE) and flower and leaves (FLHPE)], ${\beta}$-estradiol-3-benzoate at a dose of $50{\mu}g/kg/day$ (E2) or vehicle (distilled water). RESULTS: As expected, OVX increased body weight gain and adiposity and showed higher food efficacy ratio. OVX also increased the serum cholesterol as well as insulin resistance, while reducing uterus weight and uterine epithelial proliferation rate. HPEs (WHPE and FLHPE) showed estrogen-like effect on body weight gain, adipose tissue weight and food efficacy ratio in OVX rats. HPEs prevented hypercholesterolemia induced by OVX more effectively than E2. E2 increased uterus weight and epithelial proliferation rate in OVX rats, while HPEs maintained them at the level of the sham-operated animals. CONCLUSIONS: Our finding demonstrates that HPEs can be considered as an effective agent to prevent OVX-induced obesity without stimulatory activity on uterus.

• 한국콘텐츠학회논문지
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• 제13권11호
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• pp.1046-1057
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• 2013

본 연구의 목적은 일개 대학 간호과 3학년 학생 145명을 대상으로 학습유형별 시뮬레이션 교육 전 후 자기효능감, 문제해결능력, 임상수행능력 차이를 파악하여 학습유형별 시뮬레이션 교육을 제공하기 위한 기초자료를 마련하고자 실시하였다. 본 연구는 시뮬레이션교육 후 학습유형별로 효과를 검증하기 위한 단일군 전후설계 실험연구이다. 본 연구 결과 간호학생의 학습유형은 적응자가 가장 많았으며, 시뮬레이션 교육 후 문제해결능력(F=5.015, p=.02)과 임상수행능력(F=3.288, p=.02)은 유의한 차이를 나타냈으며, 문제해결능력은 융합자와 분사자가 적응자보다, 임상수행능력은 융합자가 적응자보다 유의하게 높게 나타나 학습유형별 시뮬레이션 교육의 효과에 차이가 있음을 확인하였다. 그러나 자기효능감은 통계적으로 유의한 차이를 나타나지 않았다. 이상의 연구결과를 바탕으로 학습유형별로 시뮬레이션교육을 제공할 수 있을 것으로 기대된다.

• Archives of Plastic Surgery
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• 제41권4호
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• pp.355-361
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• 2014

Background A blow-out fracture is one of the most common facial injuries in midface trauma. Orbital wall reconstruction is extremely important because it can cause various functional and aesthetic sequelae. Although many materials are available, there are no uniformly accepted guidelines regarding material selection for orbital wall reconstruction. Methods From January 2007 to August 2012, a total of 78 patients with blow-out fractures were analyzed. 36 patients received absorbable mesh plates, and 42 patients received titanium-dynamic mesh plates. Both groups were retrospectively evaluated for therapeutic efficacy and safety according to the incidence of three different complications: enophthalmos, extraocular movement impairment, and diplopia. Results For all groups (inferior wall fracture group, medial wall fractrue group, and combined inferomedial wall fracture group), there were improvements in the incidence of each complication regardless of implant types. Moreover, a significant improvement of enophthalmos occurred for both types of implants in group 1 (inferior wall fracture group). However, we found no statistically significant differences of efficacy or complication rate in every groups between both implant types. Conclusions Both types of implants showed good results without significant differences in long-term follow up, even though we expected the higher recurrent enophthalmos rate in patients with absorbable plate. In conclusion, both types seem to be equally effective and safe for orbital wall reconstruction. In particular, both implant types significantly improve the incidence of enophthalmos in cases of inferior orbital wall fractures.

• 동의신경정신과학회지
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• 제21권3호
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• pp.29-44
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• 2010

Objectives : The purpose of this research is to examine the efficacy of Gamisoyosan on anxiety of generalized anxiety disorder according to dosage form. Methods : In this randomized, double blinded, placebo-controlled study, we planned to give Gamisoyosan simple extract mixture or Gamisoyosan compound extract or controlled medication for major symptoms of generalized anxiety disorder. As preparatory research, Hamilton rating Scale for Anxiety(HAM-A) was measured as the 1st evaluative instrument, and Korean State-Trait Anxiety Inventory(STAI-K), Penn State Worry Questionnaire(PSWQ) Korean Beck's Depression Inventory (BDI-K), Symptom Checklist-90-Revised(SCL-90R), WHO Quality of Life Abbreviated(WHOQOL-BREF) and Heart Rate Variability(HRV) were also measured as the 2nd evaluative instrument at the before treatment. Results : Demographic characteristics showed that there are Clinical characteristics-vital signs are within the normal range. The characteristics of disease-chief complaint, pattern Identification and etiological factor of the highest frequency number were worry, heart deficiency with timidity(心膽虛怯), family matters. The average period of disease in subjects is 6.31years. The results of Chest PA, EKG and clinicopathologic examination are within the reference range. The Scores of HAM-A, STAI-K, PSWQ were measured above the cutoff point. There are significant positive correlations among HAM-A, STAI-K, BDI-K and among HAM-A, STAI-K, PSWQ. There are no significant correlations between PSWQ and BDI-K. Conclusions : We considered that selection of subjects in this research is appropriately accomplished And this methodology is expected to be applied to the subsequent research. And also, we hope to make up for this study through various study and discussion.

• 한국동물위생학회지
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• 제40권3호
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• pp.177-185
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• 2017

In this study, we evaluated the efficacy of a commercial vaccine stress-relieving agent (Anti VS-2 injection) to reduce the adverse effects of foot-and-mouth disease (FMD) vaccination site in 120 pigs on two tested pig farms. The results showed that incidence of pig with abnormal meat, size of abnormal meat and weight of discarded abnormal meat are significantly decreased in Anti VS-2 injection-supplemented FMD vaccinated pig groups (n=60) compared to the non-supplemented FMD vaccinated pig groups (n=60) (P<0.05). And the average economic loss by discard of abnormal meat were estimated 99,382 won or 21,514 won in the non-supplemented FMD vaccinated groups or in the Anti VS-2 injection-supplemented FMD vaccinated groups, respectively, showing that the cost saving effect was 78% (77,869 won). In conclusion, it is expected to reduce the incidence and severity of abnormal meat in the FMD vaccinated pigs and to contribute not only to the reduced economic loss of pig farmers but also to the promotion of food hygiene when the Anti VS-2 injection is mixed with FMD vaccine.

• Clinical and Experimental Reproductive Medicine
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• 제43권4호
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• pp.215-220
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• 2016

Objective: To evaluate the efficacy and safety of dienogest treatment in patients who had received dienogest for 12 months or more to treat endometriosis. Methods: We analyzed the clinical data of 188 women with endometriosis who had been treated with 2 mg of dienogest once a day for 12 months or more at a single institute. We evaluated changes in endometriosis-associated pain and endometrioma size, recurrence rate, and adverse events following dienogest administration. Bone mineral density (BMD) was measured in patients who were prescribed dienogest for more than 18 months. Results: Pain was significantly reduced at 12 months after dienogest medication. In those treated with dienogest due to recurrent endometrioma, the size of the endometrioma was significantly decreased at the 12-month and 18-month follow-ups. We found only one case of sonographic recurrence during dienogest administration among those who were treated postoperatively to prevent recurrence (1 of 114, 0.9%). The most common adverse drug reaction was uterine bleeding (3.2%), and other adverse events were generally tolerable and associated with low discontinuation rates (5.2%). Among the 50 patients in whom BMD was measured, 10 patients (20%) had a Z-score below the expected range for age. Conclusion: The administration of dienogest for a year or more seems to be highly effective in preventing recurrence after surgery, reducing endometriosis-associated pain, and decreasing the size of recurrent endometrioma, with a favorable safety and tolerability profile. However, BMD should be checked in patients on long-term medication due to possible bone loss in some women.

• 디지털융복합연구
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• 제18권1호
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• pp.333-342
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• 2020

본 연구는 이직의도 철회 경험이 있는 상담원이 이직의도 철회시 어떠한 요인들이 중요한 역할을 했는지 알아보기 위해 모 통신사 고객센터 상담원을 대상으로 3개월에 걸쳐 인터뷰 설문조사 연구를 실시하였다. 연구결과 업무이동, 동기부여, 자기효능감, 정서조절이 상담원 이직의도 철회에 주요 영향 요인으로 나타났으며, 상사지원, 동료지원은 이직 의도 철회에 영향을 미치지 못하는 것으로 나타났다. 그중, 정서조절과 업무이동은 이직의도 철회에 있어 다른 요인보다 많은 영향을 미치는 것으로 나타났다. 본 연구의 결과는 기업에서 중요성이 점점 커지고 있는 고객센터 부서의 상담원 이직률을 낮춰 조직의 안정화를 극대화하고, 또한 고객센터 상담원의 이직의도 철회에 관련된 연구에 이론적 기반을 제공할 수 있을 것으로 생각된다.

• 정보교육학회논문지
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• 제14권3호
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• pp.385-393
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• 2010

초등 정보교육은 2000년의 정보통신기술 교육운영지침이 근간을 이루고 있다. 2005년 이후 개정을 통해 활용중심의 교육에서 정보과학 중심으로 교육의 초점이 바뀌었음에도 불구하고 교과의 방향에 대한 인식이 명확하지 않은 실정이다. 대학생들을 대상으로는 교육용 프로그래밍 도구 활용에 대한 효과 검증이 진행되었으나 초등학생들을 대상으로는 연구가 진행되지 않았다. 이에 본 연구는 초등학생들의 정보과학에 대한 인식을 검증하고자, 12차시에 걸쳐 정보과학 내용인 언플러그드 학습, 스크래치, 로봇 프로그래밍을 교육하였다. 교육 후, 실험집단 31명, 통제집단 45명을 대상으로 정보과학에 대한 인식 비교 결과, 실험집단이 통제집단에 비해 정보과학에 대한 태도, 정보과학 교육에 대한 흥미 및 만족도, 자신감 그리고 정보과학 교육의 가치 변인 모두에서 유의미하게 높음을 알 수 있었다. 이상을 토대로 할 때, 활용 중심의 정보 교육보다는 사고력 향상 중심의 교육을 통해 정보과학 교육의 기본 가치를 높일 필요가 있을 것으로 보인다.

• Journal of Preventive Medicine and Public Health
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• 제40권4호
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• pp.291-296
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• 2007

Objectives : To explore the information sources and knowledge on infant vaccinations of pro-vaccination community members and anti-vaccination community members on the internet. Methods : An online survey of 245 parents from three pro-vaccination communities and 92 parents from one anti-vaccination community was conducted from June 7 to June 23, 2006. Results : Parents from pro-vaccination communities usually gained the information regarding vaccination efficacy and risk mainly from healthcare providers (49.8%) and mass media (47.7%). Pro-vaccination community members considered healthcare providers as the most credible sources of information on vaccination, whereas the anti-vaccination community members usually gained their information regarding vaccine efficiency and risk from Internet child-care cafes and online vaccination communities. Parents of the anti-vaccination community considered the internet as the most credible information source (77.6% for efficacy, 94.8% for risk). In addition, the major reason why anti-vaccination community members didn't vaccinate and, will not vaccinate, was concern about possible side effects of the vaccine. The knowledge level on infant vaccination, education and economic status was higher in the anti-vaccination community. Conclusions : On-line communities concerned with vaccination are getting popular. The influence of anti-vaccination parents on the Internet is expected to be high. The government and healthcare providers need to increase their efforts to improve the credibility of information about vaccination. Our findings suggest that online communication regarding vaccinations needs to be considered as a means to increase vaccination rates.

• Journal of Korean Neurosurgical Society
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• 제37권5호
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• pp.325-328
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• 2005

Objective: Stereotactic thalamic procedure is well known to be a effective treatment for disabling upper limb tremor of essential tremor. However, the effect of this procedure for head tremor, which is midline symptom of that disease entity, has not been sufficiently established. The authors discuss the result of stereotactic thalamic operations for head tremor of their patients who suffered from essential tremor. Methods: We evaluated 4 patients of essential tremor who had head tremor combined with both upper limb tremor. One patient underwent unilateral ventralis intermedius thalamotomy, two patients had unilateral Vim deep brain stimulation(DBS) and one patient had unilateral Vim thalamotomy and contralateral DBS. Postoperative results of tremor were evaluated using our proposed scale. Results: Contralateral upper limb tremors to surgical side were markedly resolved in all patients but there was no meaningful effect for head tremor in 3 patients who underwent unilateral thalamic surgery. In a patient having simultaneously unilateral thalamotomy and contralateral DBS, remarkable improvement of head tremor was observed. Conclusion: Although it is difficult to evaluate the efficacy of thalamic surgery for axial symptom of essential tremor with a few cases, simultaneous unilateral thalamotomy and contralateral DBS would be expected to induce favorable outcomes for head tremor with significant economical advantages.