• 제목/요약/키워드: expected efficacy

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Foodborne Pathogen Reduction을 위한 항균제의 새로운 Delivery System인 Aerosolization

  • O, Se-Uk;Gang, Dong-Hyeon
    • Bulletin of Food Technology
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    • v.18 no.1
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    • pp.91-98
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    • 2005
  • Aims: As a preliminary experiment on new sanitizer delivery tools, the efficacy of aerosolizedsanitizer on foodborne pathogens was investigated in larger model chamber system.Methods: Peroxyacetic acid and hydrogen peroxide were aerosolized in a model system againstartificially inoculated target microorganisms on laboratory media. Cultures of 4 different foodborne pathogens were inoculated and affixed onto 3 different heights (bottom, wall, and ceiling), and 3different orientations (face-down, vertical, and face-down) inside a commercial semi-trailer cabinet(14.6 x 2.6 x 2.8 m). Sanitizer was aerosolized into 2 m droplet size fog and treated for 1 h atambient temperature.Results: Populations of Bacillus cereus, Listeria innocua, Staphylococcus aureus, and Salmonellatyphimurium were reduced by an average of 3.09, 7.69, 6.93 and 8.18 log units per plate, respectively.Interestingly, L. innocua, Staph. aureus, and Salm. typhimurium showed statistically not different (P$\leq$ 0.05) reduction patterns relative to height and orientation that were never expected in a sprayingsystemConclusion and significance: Aerosolized sanitizers diffuse like gaseous sanitizers, so it has greatpotential for use in commercial applications.

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User Acceptance of the Mobile Internet Services (무선 인터넷 서비스의 사용자 수용)

  • Lee, Won-Jun;Lee, Chung-Seop;Kim, Tae-Ung;Paik, Tae-Young
    • Asia pacific journal of information systems
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    • v.14 no.2
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    • pp.61-86
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    • 2004
  • Despite their potential value, the mobile Internet services in the domestic market have not been widely accepted as industry experts have expected. To understand why, this study uses the TAM, Technology Acceptance Model, and explores the factors affecting the usage behavior of the end-users. Based on statistical analysis of survey data, we show that social influence and perceived ease of use affect perceived usefulness, and that self-efficacy and focus significantly influence perceived ease of use. Furthermore, perceived usefulness is shown to play a significant role in explaining actual usage of the mobile Internet services. However, contrary to the hypothesized relationships, service quality, focus, and innovativeness of users turn out to have little impact on the traditional endogenous TAM variables such as perceived usefulness, perceived ease of use, and actual usage behavior. Based on these results, we attempt to provide managerial implications for the domestic mobile Internet service providers and to suggest future research directions in this domain of research.

Nuclear Cardiology in Acute Coronary Syndrome (급성관상동맹증후군에서 심장핵의학의 이용)

  • Paeng, Jin-Chul;Lee, Dong-Soo
    • Nuclear Medicine and Molecular Imaging
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    • v.43 no.3
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    • pp.215-221
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    • 2009
  • Nuclear myocardial perfusion imaging is very effective in the evaluation of patients with suspicious acute coronary syndrome (ACS), for adequate diagnosis and treatment. There have been many clinical evidences to support the efficacy and cost-effectiveness. In addition, many authoritative guidelines support the utility of myocardial perfusion imaging in ACS with an appropriate diagnostic protocol. However, with the development of other cardiac imaging modalities, the choice of modality for the diagnosis of suspicious ACS now depends on the availability of each modality in each institute. Newly developed imaging technologies, especially including molecular imaging, are expected to have great potential not only for diagnosis but also for primary, secondary, and tertiary prevention of ACS.

Clinical Application of $^{18}F-FDG$ PET in Neuroblastoma (신경모세포종에서 $^{18}F-FDG$ PET의 임상 이용)

  • Paeng, Jin-Chul
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.sup1
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    • pp.134-136
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    • 2008
  • Neuroblastoma is the most common extracranial solid tumor in children. In diagnostic assessment of neuroblastoma, $^{18}F-FDG$ PET has been reported to have high diagnostic performance, especially, very high sensitivity in staging, restaging, and assessment of therapeutic efficacy. In comparison with conventional diagnostic imaging modalities including a, bone scan, and MIBG scan, $^{18}F-FDG$ PET showed better diagnostic performance. According to clinical research data hitherto, $^{18}F-FDG$ PET is expected to be an effective diagnostic tool in the management of neuroblastoma.

Clinical Application of $^{18}F-FDG$ PET in Alzheimer's Disease (알쯔하이머병(Alzheimer's disease)에서 FDG PET의 임상이용)

  • Ryu, Young-Hoon
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.sup1
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    • pp.166-171
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    • 2008
  • PET of the cerebral metabolic rate of glucose is increasingly used to support the clinical diagnosis in the examination of patients with suspected major neurodegenerative disorders, such as Alzheimer's disease. $^{18}F-FDG$ PET has been reported to have high diagnostic performance, especially, very high sensitivity in the diagnosis and clinical assessment of therapeutic efficacy. According to clinical research data hitherto, $^{18}F-FDG$ PET is expected to be an effective diagnostic tool in early and differential diagnosis of Alzheimer's disease. Since 2004, Medicare covers $^{18}F-FDG$ PET scans for the differential diagnosis of fronto-temporal dementia (FTD) and Alzheimer's disease (AD) under specific requirements; or, its use in a CMS approved practical clinical trial focused on the utility of $^{18}F-FDG$ PET in the diagnosis or treatment of dementing neurodegenerative diseases.

Progress in Transgenic Cloned Pig for Xenotransplantation

  • Park, Kwang-Wook
    • Proceedings of the Korean Society of Embryo Transfer Conference
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    • 2003.10a
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    • pp.9-19
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    • 2003
  • Pig organ is thought to be the most suitable nonhuman organ for xenotransplanstation. However, one of the major constraints to using pig organs for xenotransplantation is human natural antibody-mediated hyperacute rejection (HAR). Elimination of a(1,3) galactosyltransferase (GGTA1) from the pig is expected to be a solution to the problem of hyperacute rejection. ry1any efforts have made characterization of GGTA1 in structure and function. improvement in the technique of DNA transfection of somatic cells and advancement of the pig NT, a specific modification has been made to one copy of the GGTA1 gene by Missouri group in 2002. To date because homozygousity of the genetic modification has been achieved in this gene, the role of gala(1,3) gal specific natural antibody in HAR and the efficacy of xenotransplantation in a nonhuman primate model will be addressed. If other genes are found to be involved in rejection of pig donors by primates, the technology will be available to modify those genes so that rejection can be overcome.

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On an Equal Mean Quadratic Classification Rule With Unknown Prior Probabilities

  • Kim, Hea-Jung;Inada, Koichi
    • Journal of Korean Society for Quality Management
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    • v.23 no.3
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    • pp.126-139
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    • 1995
  • We describe a formal approach to the construction of optimal classification rule for the two-group normal classification with equal population mean problem. Based on the utility function of Bernardo, we suggest a balanced design for the classification and construct the optimal rule under the balanced design condition. The rule is characterized by a constrained minimization of total risk of misclassification, the constraint of which is constructed by the process of equation between expected utilities of the two group conditional densities. The efficacy of the suggested rule is examined through numerical studies. This indicates that, in case little is known about the relative population sizes, dramatic gains in accuracy of classification result can be achieved.

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Output Feedback Control and Its Application to a Flexible Spacecraft

  • Sung, Yoon-Gyeoung;Joo, Hae-Ho
    • International Journal of Precision Engineering and Manufacturing
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    • v.1 no.2
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    • pp.105-114
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    • 2000
  • An output feedback control (OFC) is presented for a linear stochastic system with known disturbance and applied to a flexible spacecraft for the reduction of residual vibration while allowing the natural deflection during operation. By converting the tracking problem into regulator problem, the OFC minimizes the expected value of a guadratic objective function composing of error stats which always remain on the intersection of sliding hypersurfaces. For the numerical evaluation with a flexible spacecraft, a large slewing maneuver strategy is devised with a tracking model for nominal trajectory and start-cost-stop strategy for economical maneuver in conjunction with the input shaping technique. The performance and efficacy of the proposed control scheme are illustrated with the comparison of different maneuver strategies.

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A Study on Preferences for Ginseng in Korean III. The ginseng user's viewpoint (한국인의 인삼기호도 조사연구 제 3보. 인삼취급 전문인 중심)

  • 성현순;전병선
    • Journal of Ginseng Research
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    • v.13 no.1
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    • pp.136-141
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    • 1989
  • The purpose of this survey was to understand the attitudes, consumption patterns and preferences of domestic consumers relating to ginseng products in general. This study involved 1,305 people (420 agents, 742 ginseng farmer, 143 staff of Korea Tobacco and Ginseng Co.). The results obtained are summerized as follows. 1, Preferences for ginseng were very high for the majority of the respondents. 2. Most (80%) of the respondents had experience in taking ginseng. They expected ginseng to have efficacy as remidy for the hang-over syndrome, gastronil troubles and high blood pressure, in that order. 3. The patron of ginseng were, for the most part, men in the prime of manhood and old age. The favored products and the preferences regarding the organic condition of the ginseng products differed by sex and age. 4 To sum up the results of this study, we conclude that moderate priced ginseng products, not only easy to use and carry but also attractive to age and sex, should be developed without losing the efficacious components and characteristics.

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Antibody productivity of HBsAg containing both preS2 and S regions expressed in Chinese hamster ovary cells (Chinese hamster ovary세포에서 발현된 pres2 및 S부위 함유 HBsAg의 항체유발능)

  • 정성균;박정민;이상봉;박동우;김동연;김기호;김홍진
    • YAKHAK HOEJI
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    • v.45 no.6
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    • pp.708-714
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    • 2001
  • Many studies have provided evidences that hepatitis B surface antigen (HBsAg) including preS region could be an ideal candidate for a new hepatitis B virus (HBV) vaccine with higher efficacy. We established CHO cell lines, IY-CHO-2 and IY-CHO-11 expressing high levels of HBsAg containing preS2 and S protein by stable transfection method. These cell lines expressed the correct size (about 1 kb in length) of HBsAg mRNA as expected. The purified protein from the culture supernatants of the clones showed the same sizes as those expressed in native hepatitis B virus (24 kDa, 27 kDa, 34 kDa and 36 kDa). Antibody productivity of CHO-derived HBsAg protein at lower dose challenge was higher than the protein containing S region alone expressed in yeast system. These results indicate that CHO-derived HBsAg protein containing preS2 and S region can be effectively used for a better immune response as a HBV vaccine.

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