• 한국융합학회논문지
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• 제13권4호
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• pp.573-582
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• 2022

부작용을 줄인 사물탕을 개발하고자 오미자를 사용한 변형 사물탕을 난소를 절제한 랫드에 경구투여하고 여성갱년기 기능성 효능의 평가지표 변화를 측정하였다. 체중 증가, 자궁과 질의 상대 장기중량, 혈중 지질관련 지표, 혈중 estradiol 의 변화에서 대조군과 비교하여 변형 사물탕이 통계적으로 유의한 개선효과는 나타나지 않았다. 그러나 자궁 조직내 단백질 변화에서 estrogen receptor alpha 와 beta 의 발현이 증가하는 경향성이 관찰되었고 estrogen receptor 신호전달에 관여하는 것으로 알려진 ERK와 AKT에서 활성화에 기여하는 인산화 ERK의 발현량이 유의한 증가를 나타내었고 인산화 AKT의 발현량은 유의하진 않지만 증가하는 경향성을 나타내었다. 난소절제로 유도한 여성갱년기 모델에서 시험물질 변형 사물탕을 비교적 적은 용량 투여했음에도 이러한 결과를 나타내는 것은 시험물질인 변형 사물탕에 estrogen receptor를 활성화시키는 능력이 있는 것으로 판단된다. 추후 위장장애가 적으면서 사물탕의 효능을 나타내고자 할 때 유용한 천연물 배합으로 이용이 가능할 것으로 본다.

• 대한화장품학회지
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• 제48권2호
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• pp.113-121
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• 2022

본 연구에서는 발효 과정을 거친 구기자(Lycium chinense) 추출물을 이용하여 항염증 및 항노화 관련 기능성 화장품 소재로서의 활용가치를 검증하고자 nitric oxide (NO) 및 항노화 관련 인자들의 억제 효능을 분석하였다. 물과 70% 에탄올을 용매로 구기자를 추출, 발효, 농축, 동결건조하여 시료를 제조한 다음, MTT assay, NO inhibition activity assay, western blot assay, UPLC 분석을 진행하였다. MTT assay를 통해 세포독성을 측정한 다음, 500 ㎍/mL의 농도를 세포실험에 적용하여 진행하였다. NO 억제 효능의 분석 결과, 발효 구기자 열수 추출물(FLW), 발효 구기자 70% 에탄올 추출물(FLE) 각각 47.96%, 56.71%의 우수한 NO 억제 효능을 나타내었다. Western blot을 통해 주름 관련 단백질인 MMP-1, TRPV-1의 발현양상을 측정한 결과, FLW, FLE 모두 MMP-1, TRPV-1에 대한 발현 억제 효능을 나타내었다. 따라서 발효 구기자 추출물은 항염증 및 항노화 관련 기능성 화장품 소재로서의 높은 활용 가치가 있을 것으로 판단된다.

• Journal of applied mathematics & informatics
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• 제32권1_2호
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• pp.171-184
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• 2014

A higher order iterative method to compute the Moore-Penrose inverses of arbitrary matrices using only the Penrose equation (ii) is developed by extending the iterative method described in [1]. Convergence properties as well as the error estimates of the method are studied. The efficacy of the method is demonstrated by working out four numerical examples, two involving a full rank matrix and an ill-conditioned Hilbert matrix, whereas, the other two involving randomly generated full rank and rank deficient matrices. The performance measures are the number of iterations and CPU time in seconds used by the method. It is observed that the number of iterations always decreases as expected and the CPU time first decreases gradually and then increases with the increase of the order of the method for all examples considered.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2005년도 춘계 학술발표회 논문집
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• pp.489-496
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• 2005

In this paper, the feasibility of the high-performance damping device vibration suppression of stay cables has been investigated. The proposed damping system consists of a linear viscous damper and a scissor-jack-type toggle linkage. Since the mechanism of the scissor-jack-type toggle linkage amplifies the relative displacement of the linear viscous damper, it is expected that the capacity of the viscous damper used in the scissor-jack-damper energy dissipation system can be reduced without the loss of the control performance. Numerical simulation results demonstrate the efficacy of the damping system employing the scissor-jack-type toggle linkage. Therefore, the proposed damping system could be considered as one of the promising candidates for suppressing vibration of stay cable.

• 보건의료산업학회지
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• 제11권2호
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• pp.129-142
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• 2017

Objectives : The purpose of this study was to identify the main variables of difference in high school students' oral health promotion behaviors among adolescents and to improve their academic and oral health promotion behaviors. Methods : The research subjects consisted of 311 high school students in Jeonju. Results : The adequacy of the hypothetical model accounted for 46.9 % of the oral health promotion behavior. The Redundancy of all variables showed the value of the positive values, indicating that the Goodness of fit was greater than the optimum value of the model, and the model of the PLS was a desirable model. The effects of perceived benefits, self efficacy, and social support on oral health promotion behaviors were found to be higher in oral health promotion behaviors. Conclusions : This study is expected to have a significant impact on the perception of the oral health promotion for adolescents in the future and will contribute to the expansion and generalization of Pender's oral health promotion model.

• 대한의용생체공학회:의공학회지
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• 제30권1호
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• pp.1-9
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• 2009

Many types of small animal imaging modalities, like micro-CT, micro-PET, and micro-SPECT, have been recently developed worldwide. Small animal imaging systems are now recognized as indispensable tools to validate efficacy and safety of new drugs or new therapeutic methods using the animal disease models. With increasing demands for small animal imaging in biomedical research, multimodal small animal imaging systems, like micro-PET/CT or micro PET/MRI, are now also being developed. Small animal imaging with spatial resolution and sensitivity comparable to human imaging is quite challenging since laboratory small animals are much smaller than human beings. Research activities in Korea on small animal imaging systems are reviewed in this paper. In the field of micro-CT and micro-PET, many world-class technologies have been developed successfully in Korea. It is expected that the developed animal imaging system technologies can be used in the development of clinical imaging systems in Korea in the near future.

• 동의신경정신과학회지
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• 제20권3호
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• pp.283-295
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• 2009

Objectives : Parkinson's disease is a chronic neuron-degenerative disease. The medication of dopamine, one of the most common treatment for the disease, has effects of improving the symptom, but when taken for a long term, the medicine brings about side-effects such as the phenomenon of medicinal efficacy disappearance and dyskinesia. In addition, it doesn't have any effects in slowing down or stopping the development of Parkinson's disease. Methods : Accordingly, this study aims to investigate the clinical cases to stop or improve the development of Parkinson's disease by carrying out an independent treatment with Oriental medicine and a combined treatment with Western and Oriental medicines respectively for over 6 months. Results and Conclusions : The results of the study is expected to be an important precedent for the treatment of neuron-degenerative diseases of cranial nerve including Parkinson's disease in the future.

• 조명전기설비학회논문지
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• 제13권2호
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• pp.39-45
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• 1999

약계자 영역에서 토크는 자속에 직접적으로 영향을 받는다. 이 영역에서는 자속준위는 회전자 속도에 대하여 반비례로 감소시킨다. 자속이 감소함에 따라 자화인덕턴스는 증가하게 된다. 자회인덕턴스는 전류를 제어하기 위한 접압을 제한한다. 본 노문에서는 약계자 영역에서 q-축전압을 측정함으로써 자화인덕턴스의 변화를 계산하며, 이에 따라 기준 자화전류를 재조정한다. 컴퓨터 시뮬레이션 실험결과를 통하여 제안한 방법을 입증한다. 본 연구에서 제안한 알고리즘은 방적기계등의 적용분야의 가변속 구동시스템에 활용이 기대된다.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.9-19
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• 2003

Pig organ is thought to be the most suitable nonhuman organ for xenotransplanstation. However, one of the major constraints to using pig organs for xenotransplantation is human natural antibody-mediated hyperacute rejection (HAR). Elimination of a(1,3) galactosyltransferase (GGTA1) from the pig is expected to be a solution to the problem of hyperacute rejection. Many efforts have made characterization of GGTA1 in structure and function, improvement in the technique of DNA transfection of somatic cells and advancement of the pig NT, a specific modification has been made to one copy of the GGTAl gene by Missouri group in 2002 To date because homozygousity of the genetic modification has been achieved in this gene, the role of gala(1,3) gal specific natural antibody in HAR and the efficacy of xenotransplantation in a nonhuman primate model will be addressed. Of other genes are found to be involved in rejection of pig donors by primates, the technology will be available to modify those genes so that rejection can be overcome.

• Journal of Preventive Medicine and Public Health
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• 제15권1호
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• pp.161-166
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• 1982

Cyanide poisoning is expected to be antagonized by the administration of oxygen, when it is administered in combination with the conventional cyanide antidote, sodium thiosulfate. However, the antidotal efficacy and its exact mechanism of oxygen in cyanide poisoning is still a controversial one. To test the effect of oxygen on the antidotal action of thiosulfate in cyanide poisoning, author designed this study on the dose-mortality patterns for potassium cyanide in mice. Potency ratios derived from $LD_{50}$ values were compared in groups of mice treated with sodium thiosulfate alone and sodium thiosulfate with oxygen. These results indicated that oxygen enhances the antidotal effect of sodium thiosulfate, effectively. This fact demonstrates that oxygen is of importance in the treatment of cyanide poisoning.