• 운동영양학회지
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• 제24권3호
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• pp.32-38
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• 2020

[Purpose] Sarcopenia is considered one of the major causes of disability in the elderly population and is highly associated with aging. Exercise is an essential strategy for improving muscle health while aging and involves multiple metabolic and transcriptional adaptations. Although the beneficial effects of exercise modalities on skeletal muscle structure and function in aging are well recognized, the exact cellular and molecular mechanisms underlying the influence of exercise have not been fully elucidated. [Methods] We summarize the biochemical pathways involved in the progression and pathogenesis of sarcopenia and describe the beneficial effects of exercise training on the relevant signaling pathways associated with sarcopenia. [Results] This study briefly introduces current knowledge on the signaling pathways involved in the development of sarcopenia, effects of aerobic exercise on mitochondria-related parameters and mitochondrial function, and role of resistance exercise in the regulation of muscle protein synthesis against sarcopenia. [Conclusion] This review suggested that the beneficial effects of exercise are still under-explored, and accelerated research will help develop better modalities for the prevention, management, and treatment of sarcopenia.

• The Journal of Korean Physical Therapy
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• 제19권2호
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• pp.21-31
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• 2007

Purpose: This study investigated effect of skating exercise on balance ability improvement in cerebral palsy. Methods: Total five subject with cerebral palsy were recruited from school for disability childen in Daegu, and the skating exercise was conducted 3times at a week during 8 weeks the skating exercise. Balance test was measured using Balance System with overall index, anterior/posterior index, medial/lateral index of balance ability. Results: There was significant difference between 4 and 8weeks training session in the overall index(p<0.05). There was no significant difference between 4 and 8weeks training session in the anterior/posterior index(p<0.05). There was significant difference between 4 and 8weeks training session in the medial/lateral index(p<0.05). There was significant difference between 4 and 8weeks training session in the anterior/posterior index and medial/lateral index(p<0.05). Conclusion: This study showed that skating exercise was effect on balance ability improvement in cerebral palsy. The future study needs more detailed research and comparison about effect of skating exercise on balance ability improvement in cerebral palsy.

• 운동영양학회지
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• 제13권2호
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• pp.131-140
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• 2009

The aim of this study was to investigate the expression of PPAR-α, -β/δ, -γ, PGC-1α, GLUT-4 and p-AMPK-α₂ protein in the skeletal muscle of diabetic induced-rats by endurance training combined with rosiglitazone. The expression of PPAR-α, -β/δ, -γ, PGC-1α, GLUT-4 and p-AMPK-α₂ protein in red and white gastrocnemius by western blotting. The body weight was higher in diabetic induced-rats compared to the normal rats and after the treatment of exercise combined with rosiglitazone was significantly reduced in the all group. The levels of blood glucose was higher in diabetic induced-rats compared to the normal rats and after the treatment of exercise combined with rosiglitazone was significantly reduced in the all group. The expression of PPAR-α, -γ, PGC-1α in skeletal muscle of diabetic induced-rats were increased all groups and increased significantly in the group with exercise combined with rosiglitazone. The expression of GLUT-4 and p-AMPK-α₂ protein in the skeletal muscle of diabetic induced-rats were increased all groups and increased significantly in the group with exercise combined with rosiglitazoneI. These results suggest that exercise training and rosiglitazone may act as complementary therapies for the treatment of insulin rasistance.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.1648-1652
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• 2004

An advanced training machine designed for elderly people is proposed. The training machine allows users to have a safe and effective training through exercise close to ordinal motion appears in daily life such as standing up/down motion. The activation level of user's muscle is real timely monitored during the exercise and the training load is adjusted based on the body information. The training load is exerted and continuously controlled by actuation of an air cylinder.

• The Journal of Korean Physical Therapy
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• 제22권6호
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• pp.65-70
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• 2010

Purpose: Exercise has been shown to be a simple and economical therapeutic modality that may be considered as an effective aid for diabetic mellitus. For example, exercise training increases insulin sensitivity in type 2 diabetes. But we found no reported of how exercise affect type 1 diabetes. This study investigated the impact of aerobic and graduated treadmill exercise regimens on body weight, glucose and insulin concentrations, lipid profiles, and oxidative stress indicators in rats with streptozotocin (STZ) induced diabetes. Glycosylated hemoglobin ($HbA_{1c}$) was determined as an indicator of glucose control during exercise. Methods: In our study, a total of 40 rats were used. Three groups of 10 rats each were given STZ to induce diabetes. The remaining 10 rats became the normal group. After 28 days we determined biochemical parameters such as glucose, glycosylated hemoglobin ($HbA_{1c}$), insulin concentration, serum total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL). Superoxide dismutase (SOD) and catalase activities were also measured. Results: Concentrations of blood glucose and $HbA_{1c}$ in the moderated exercise groups were significantly decreased after 28 days compared with the control group (p<0.05). There was a significant reduction in serum TC and TG in the experimental groups. The activity of SOD increased significantly by 17.70% and 48.25% respectively. Conclusion: These results indicate that physical training and exercise training affects body weight, fasting blood glucose, $HbA_{1c}$, insulin, lipid profiles, and antioxidant status in rats with streptozotocin-induced diabetes. We suggest that graduated treadmill exercise may have therapeutic, preventative, and protective effects against diabetes mellitusby improving glycemic control, oxidant defenses, and lipid metabolism.

• 융합보안논문지
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• 제22권1호
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• pp.135-140
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• 2022

본 연구는 스마트 디바이스와 기술을 활용한 운동 사례와 이슈를 분석하고 기존의 실버세대와 달리 높은 활동력과 경제력을 지닌 액티브시니어의 웰니스 라이프에 적합한 향후 스마트 운동 환경의 발전 방향을 제시하고자 하였다. 피트니스 산업에서도 필요한 운동도구나 서비스, 디지털 콘텐츠 등을 정기적으로 받아보거나 이용하는 구독경제가 확장되고 있는 추세이며, 하드웨어 판매와 콘텐츠 구독을 기반으로 한 비즈니스 모델이 계속 등장하고 있다. 액티브시니어에게 건강관리를 위한 통합적인 운동 서비스를 제공하는 플랫폼으로서의 가치경쟁력을 갖추기 위해서는 피트니스센터 뿐만 아니라 홈트레이닝 운동기구, 피트니스 관련 애플리케이션, 스마트 웨어러블 디바이스 시장 등이 유기적으로 연결되어 확장된 토털 플랫폼으로서의 모습을 이루어야 할 것이다. 개인별 건강상태에 알맞은 운동프로그램을 제안 받고 선택하여 운동 전, 후, 운동 중 웨어러블 디바이스를 통해 지속적인 모니터링과 피드백에 따른 운동프로그램에 실시간 변화를 주는 디지털 헬스케어 기능 연동이 스마트 피트니스 모델의 차별적 요소이다.

• 대한의생명과학회지
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• 제4권2호
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• pp.87-101
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• 1998

장기간 체중부하운동이 흰쥐의 심근에 미치는 효과를 규명하기 위하여 생후 3개월, 10개월 및 20개월된 흰쥐를 5개월간 운동시킨 후 각각의 비운동군과 비교하여 심근의 조직학적ㆍ세포학적 변화를 관찰하고, 심근세포내 미세구조적 변화를 입체해석학적으로 비교 분석하였다. 운동 15개월군부터 노화색소의 양이 현저히 증가되었고 사립체의 변성, 공포화 현상 그리고 간질조직의 증식이 뚜렷하였으며, 25개월군에서는 윤반분리, 근원섬유의 소실 및 과수축대 출현빈도가 증가되었다. Glucose-6-phosphatase의 활성도는 15개월 운동군에서 감소하여 25개월 운동군에서는 활성도가 거의 나타나지 않았다. 입체해석학적 결과에서도 장기간 체중부하운동으로 인해 15개월, 25개월군에서 모두 사립체와 근원섬유의 체적밀도는 감소되었고, 간질조직의 체적밀도는 증가되었다. 본 연구의 결과로 볼 때 장기간 체중부하운동은 3개월군에 있어서 심장에 미치는 역효과가 없으나 10개월군과 20개월군에서는 심근기능강화에 역효과를 초래 할 우려가 큰 것으로 판단된다.

• 생명과학회지
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• 제18권6호
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• pp.796-803
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• 2008

알츠하이머 질환은 신경퇴행성질환으로 노령인구에서 뿐만 아니라 $30{\sim}60$세 사이에서도 상염색체성우성형으로 발생하여 사회문제로 대두되고 있으며 발병기전도 명확하게 규명되지 않은 상태이다. 따라서 이 연구에서는 hAPP695sw 돌연변이를 neuron-specific enolase (NSE) 유전자의 프로모터 조절 하에 연결시킨 융합 유전자(pNSE/APP695sw fusion gene)를 과 발현시킨 알츠하이머 질환 모델생쥐를 대상으로 16주간 지구성 운동에 따른 알츠하이머 질환 모델생쥐의 인지능력의 변화와 주병변인 $A{\beta}-42$ 단백질과 함께 GLUT-1, BDNF, HSP-70 단백질의 발현량을 분석하였다. 그 결과 지구성 운동은 APPsw 알츠하이머 질환 모델생쥐의 인지능력을 개선시키는데 긍정적인 영향을 미친 것으로 나타났으며 이러한 인지능력의 개선은 알츠하이머 질환의 주 병변인 뇌의 $A{\beta}-42$ 감소뿐만 아니라 BDNF, GLUT-1과 HSP-70 단백질의 발현 증가와 관련이 있음을 확인하였다. 따라서 지구성 운동은 약물 처치 이외에 알츠하이머 질환을 예방하거나 지연시킬 수 있는 전략적인 방법으로 활용할 수 있음을 알 수 있다.

• 대한통합의학회지
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• 제6권3호
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• pp.103-112
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• 2018

Purpose : The purpose of this study was to determined the effects of resistance and aerobic exercise on gait ability, physical fitness and body compositions in older women. Method : The subjects were 24 older women who were randomly divided into two groups (resistance exercise, n=12, and aerobic exercise, n=12). They 65~80 years old. The subjects done the Gym-ball, Togu, and senior dance exercise three times per week-for 70 minutes each time for 16 weeks. Body compositions, physical fitness, and gait ability were measured in this study. Result : There were significantly improved the walk performance after exercise training for 16 weeks. In particular, it was more effective on resistance exercise training in older women. There were significant differences in muscle endurance, flexibility, balance, body weight, percent of body fat, and body mass index (BMI) after the exercise program. Conclusion : It was more effective improved on muscle endurance, flexibility, and balance performance after resistance exercise program than an aerobic exercise program in older women.

• The Journal of Korean Physical Therapy
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• 제22권1호
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• pp.53-60
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• 2010

Purpose: The purpose of our study was to evaluate the effects of an exercise program on activities of daily living (ADL), balance and cognition in elderly individuals with Alzheimer’s disease and vascular dementia. Methods: Thirty-two patients with mild to moderate cognitive impairment were assigned to one of two groups: an exercise group (n=16) and a control group (n=16). The exercise group carried on regular exercise for 60 minutes a day, 4-5 times per week for 8 weeks. The exercise group participated in an exercise program (treadmill training and physical training). ADL, balance and cognitive function were evaluated before and at the end of the program using the Korean modified Bathel Index (K-MBI), the Functional independence measure (FIM), the Berg balance scale (BBS), the Balance performance monitor (BPM), and the Mini mental state examination (MMSE) in both groups. Results: There were significant exercise-induced improvements in ADL and Balance from pre to post tests; but not in MMSE. Conclusion: Exercise programs can improve ADL and balance in elderly with Alzheimer’s disease and vascular dementia.