• 한국응급구조학회지
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• 제4권1호
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• pp.35-46
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• 2000

The results of analyzing the cognition of CPR by college students who major in public health or not order to enhance the educational efficiency of first aid ability and its expansion are as follows. 1. In case of students majoring in public health, the students who have the knowledge of term 'CPR' are 95.3% of total 300 students and 62.6% of the students who don't major in public health know it. In the item test of examining the degree of theoretical knowledge of CPR, the cases who know all 12 items are 5.2% and 1.6% respectively in cases who major in public health and don't major in it and it is judged that the extension of educational opportunity for them should be urgent. 2. The students who have experienced the practice of CPR are 20.6% in case who major in public health and 7.4% in other case. Therefore it seems to desirable that indirect field experience should be obtained by strengthening practice centered education. 3. The order of practice to examine the CPR ability is asked and the students who show very good remark are just 21~22% in both cases and they conducted very ineffective CPR and it is examined that they did first aid which may a serious damage to patients. Then the cases who recovered pulse and respiration after CPR were very low as 28.8% in the students who major in public health and 35.7% in others. It is therefore considered that the exact education of conducting the maintenance of respiratory trace, artificial respiration and CPR is necessary. 4. The cases who had the education of CPR were 51% in the students who major in public health and 39.4% in others, who had little opportunities to have CPR and 92.5~93.2% in both groups fee the necessity of continuous education and it is very encouraging to extend the education of CPR. 5. The education of CPR is mainly done at school (70.3~79.4%) and from teachers (52.7~55.4%) and 71.2% of the students majoring in public health responded that it is good for them to have education of CPR at school and lecture by first-aider and 58.9% of others did it. The cases who ask for lecture by the Professors of Dept. of First-Aid are 11.8 in students majoring in public health and 13.1% in others and it is judged that lecture by them having the theoretical foundation and first-aider with practical ability will be desirable. 6. On teaching methods, 57.5% of the cases majoring in public health and 63.3% of others ask for practice and 20% of both groups need theory centered teaching. 7. On lecture fee, 83% of the cases majoring in public health and 83.3% of others consider it should be free and 8~11.8% who are to pay for 10,000 won and it is judged that it should be opened and operated as liberal arts by college in the dimension of lifelong education. 8. On the objects of education, 83% of cases majoring in public health and 66.6% of others consider it should be conducted in people of all ages and both sexes and it is known that everyone recognizes the necessity of popularizing the education of first-aid.

• Journal of Gastric Cancer
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• 제2권2호
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• pp.85-90
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• 2002

Purpose: Perforated gastric cancer (PGC) is rare and occurs in $1\∼4\%$ of all gastric cancers. Possible dissemination of tumor cells at the time of perforation of the gastric carcinoma has been a matter of concern. The intraoperative determination of what kind of operation should be done and how extensive the lymphnode dissection should be still remains controversial. The purpose of this study is to evaluate the factors influencing the survival and to determine the optimal treatment for PGC. Materials and Methods: A total of 42 patients were operated on for a perforated gastric carcinoma at Soonchunhyang University Chunan Hospital from 1983 to 2000. the age and the sexes of the patients, the location of perforation, the diameter of perforation, the histologic type of the tumor, the depth of wall invasion, the absence or presence of lymph node metastasis / distant metastasis, the stage of disease, the type of operation, and the outcomes were examined. Statistically significant differences were analyzed by using Fisher's exact test. Results: The stage distributions according to the UICC classification were 1 case of stage I, 6 cases of stage II, 17 cases of stage III, and 11 cases of stage IV. An emergency gastrectomy was done in 26 patients ($61.9\%$), with a 5-yr survival rate of $44\%$. The survival of patients was significantly influenced by the depth of wall invasion, the lymphnode metastasis, distant metastasis, the stage of disease, and the type of operation. Conclusions: an emergency gastrectomy is the treatment of choice for most patients with resectable PGC. Choosing more a optimistic surgical approach for potentially curative cases of PGC should be one way to increase the patient's survival rate.

• Clinical and Experimental Pediatrics
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• 제52권1호
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• pp.105-110
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• 2009

목적 : 신생 백서의 저산소 허혈 뇌손상에 있어서의 erythropietin (Epo) 투여의 손상 예방 효과와 보호 기전에 철 대사가 관여하는지를 조사하고자 하였다. 방 법 : 신생 백서를 암수 구별 없이 생후 7일째에 편측 온목동맥 결찰 후 산소 농도 8%인 환경에 2시간 노출시켜 저산소 허혈을 유도하였으며 저산소 노출 직후 Epo 5,000 u/kg를 복강내 투여하였다. 이들은 저산소 허혈 유도 전 투여한 생리식염수, 철, deferoxamine 등에 따라 Epo군, Iron+Epo군, Def+Epo군, Iron+ Def+Epo군, 대조군으로 나누어 저산소 허혈 유도 후 7일에 뇌손상 정도를 비교하였다. 결 과 : Epo 투여시 뇌손상의 빈도와 정도는 대조군에 비해 감소하였다. 뇌손상의 빈도와 손상 점수로 뇌손상 정도를 비교한 결과 철 투여는 Epo의 뇌손상 예방 효과를 감소시키지 않았다. Deferoxamine 투여는 Epo 단독 투여군에 비해 뇌손상의 빈도와 정도가 경감하였으나 통계적 유의성은 없었다. 결 론 : Epo는 저산소 허혈 뇌손상에 있어 뇌손상 보호 효과를 보인다. 철 투여는 뇌손상을 악화시키지 않았으나 deferoxamine 동시 투여는 Epo 단독 투여에 비해 뇌손상의 빈도와 손상 점수가 감소하여 뇌손상 보호 효과에 철 대사가 관여할 가능성을 제시하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6451-6455
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• 2015

Background: Primary bone neoplasms are rare, contributing only 0.2% of the global burden of all human malignancies. Osteosarcoma (OS) and chondrosarcoma (CS) are the most common malignancies of bone. The giant cell tumor of bone (GCTb) is a benign tumor with behavior characterized by osteolytic bone destruction. The OS, CS and GCTb affect both sexes, all races and generally have incidence peaks regarding the age of the patient which vary according to the tumor type. We analyzed the incidences of OS, CS and GCTb and their relations with gender and age in patients treated in the National Rehabilitation Institute (INR, for its acronym in Spanish) over a period of nine years. Materials and Methods: In the study period, clinic pathological data for 384 patients were obtained with clinical, radiological and histopathological diagnosis for OS, GCTb and CS. Data analysis was performed using the chi-square and Fisher's exact tests. Results: From 2006 to 2014 were recorded 384 cases of bone malignancies in the database of INR. The GCTb had the highest incidence (53.1%), followed by OS (31.3%) and finally the CS (15.6%). The overall average age was $33.6{\pm}15.8$ years and the overall frequency of gender had a ratio of 1/1.03 male/female. The states with the highest incidence were Distrito Federal and Estado de Mexico with 29.2% and 25.3% respectively. Malignant neoplasms of bone assessed in the course of nine years show three significant increases in 2008, 2011 and 2014 (p=0.14). We found association between sex and tumor type (p=0.03), GCTb and CS predominated in females (54.9% and 56.6% respectively), while for the OS males were most affected (59.1%). Age was different in relation with tumor type (p=0.0001), average age was $24.3{\pm}11.2$ years for OS, $34.5{\pm}13$ years for GCTb and $49.2{\pm}18.5$ years for CS. Furthermore, associations of tumor type with topographic location of the primary tumor (P=0.0001) were found. Conclusions: In this study we can see that incidence of musculoskeletal tumor in our population is continuously increasing and in nine years an approximately 200% increase of musculoskeletal tumor cases was observed.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7523-7527
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• 2015

Background: Pediatric acute lymphoblastic leukemia (pALL) patients at King Abdulaziz Medical City represent a pure Saudi Arabian population. ETV6-RUNX1 positive pALL patients have good prognosis as compared to ETV6-RUNX1 negative counterparts. Therefore, frequencies of these two patient groups have a huge consideration in treatment strategies of pALL in a given population. Different geographical locations have been reported to have different frequencies of ETV6-RUNX1 ranging from 10% in Southeast Asia to 30% in Australia. Aim: Therefore, the objective of this study was to establish the ETV6-RUNX1 status of Saudi Arabian pALL patients and its association with clinical parameters and early remission. Materials and Methods: Clinical parameters and ETV6-RUNX1 status (using FISH technique) of pALL patients attending the Pediatric Oncology Clinic, King Abdulaziz Medical City, Riyadh from 2006 to 2011 were studied. Comparisons between ETV6-RUNX1 positive and negative groups were accomplished using chi-square test or Fisher's exact test. All statistical analyses were performed using SAS version 9.2 (SAS Institute, Inc., Cary, NC). Results: Out of 54 patients, 33 were male and 21 were females (ratio 1.57:1). B- and T-cell lineages were found in 47 (87%) and 7 (13%) patients respectively. Only 5 (9.3%) patients were ETV6-RUNX1 positive while 49(80.7%) were ETV6-RUNX1 negative. All ETV6-RUNX1 patients (100%) were of B-cell lineage and 80% (4/5) were in the 3-7 year age group. None of the ETV6-RUNX11 patients had ${\geq}5%$ blasts (no remission) at day 14 as compared with 9% in the ETV6-RUNX1 negative group (Figure 1). Conclusions: Frequency of ETV6-RUNX1 positive patients (less than 10%) in our pALL patients is much lower than reported for most European countries, North America, Australia and Japan while it is in accordance with ETV6-RUNX1 frequencies from Egypt (11.6%), Pakistan (10%), Spain (2%) and India (5-7%). This shows ethnic differences in genetics of pALL as well as higher frequencies of ETV6-RUNX1 positive pALL mostly in more industrialized countries, probably due to some industrial pollutants or westernized lifestyle.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7639-7644
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• 2014

Background: Results from previous studies concerning the association of ERCC4 rs1800067 polymorphism with risk of cancer were inconsistent. To explore the exact relation with susceptibility, we conducted the present meta-analysis. Materials and Methods: Literature of electronic databases including PubMed, Web of Science, EMBASE, Wanfang and Chinese National Knowledge Infrastructure (CNKI) were systematically searched. ORs and their 95%CIs were used to assess the strength of associations between ERCC4 polymorphism and cancer risk. Results: There was no significant association between ERCC4 rs1800067 AA or AG genotypes and overall risk of cancer (AA vs. GG: OR=0.998, 95%CI=0.670-1.486, P=0.992; AG vs. GG: OR=0.970, 95%CI=0.888-1.061, P=0.508). A dominant genetic model also did not demonstrate significant association of (AA+AG) genotype carriers with altered risk of overall cancer (OR=0.985, 95%CI=0.909-1.068, P=0.719). In addition, no significant association was observed between A allele of ERCC4 rs1800067 A/G polymorphism and altered cancer risk compared with G allele (OR=0.952, 95%CI=0.851-1.063, P=0.381). Subgroup analysis suggested that AA genotype carriers were significantly associated with decreased risk of glioma compared with wild-type GG genotype individuals (OR=0.523, 95%CI=0.275-0.993, P=0.048). For subgroup of lung cancer, A allele of ERCC4 rs1800067 A/G polymorphism was significantly associated with decreased risk of lung cancer compared with G allele (OR=0.806, 95%CI=0.697-0.931, P=0.003). Conclusions: This meta-analysis indicated that ERCC4 rs1800067 A/G polymorphism might not be associated with risk of overall cancer. However, individuals with the AA genotype were associated with significantly reduced risk of glioma compared with wild-type GG genotype; The A allele was associated with significantly reduced risk of lung cancer compared with G allele. Future large-scale studies performed in multiple populations are warranted to confirm our results.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6261-6265
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• 2013

Background: Recent studies have suggested that expression of the RAS protein activator like-1 gene (RASAL1) is decreased in gastric carcinoma tissues and cell lines, indicated a role in tumorigenesis and development of gastric cancer. Reduced expression of RASAL1 could result in aberrant increase of activity of RAS signaling pathways in cancer cells. However, the exact mechanism which induces down-regulation of the RASAL1 gene remains unclear. This study aimed to determine the methylation status and regulation of RASAL1 in gastric cancer. Materials and Methods: Using the methylation-specific polymerase chain reaction (MSP), the methylation status of CpG islands in the RASAL1 promoter in gastric cancers and paired adjacent non-cancerous tissues from 40 patients was assessed and its clinicopathological significance was analyzed. The methylation status of RASAL1 in gastric cancer lines MKN-28, SGC-790l, BGC-823, as well as in normal gastric epithelial cell line GES-l was also determined after treatment with a DNA methyltransferase inhibitor, 5-aza-2'-doexycytidine (5-Aza-CdR). RAS activity (GAS-GTP) was assessed through a pull-down method, while protein levels of ERK1/2, a downstream molecule of RAS signaling pathways, were determined by Western blotting. Results: The frequencies of RASAL1 promoter methylation in gastric cancer and paired adjacent non-cancerous tissues were 70% (28/40) and 30% (12/40) respectively (P<0.05). There were significantly correlations between RASAL1 promoter methylation with tumor differentiation, tumor size, invasive depth and lymph node metastasis in patients with gastric cancer (all P<0.05), but no correlation was found for age or gender. Promoter hypermethylation of the RASAL1 gene was detected in MKN-28, SGC-790l and BGC-823 cancer cells, but not in the normal gastric epithelial cell line GES-1. Elevated expression of the RASAL1 protein, a decreased RAS-GTP and p-ERK1/2 protein were detected in three gastric cancer cell lines after treatment with 5-Aza-CdR. Conclusions: Aberrant hypermethylation of the RASAL1 gene promoter frequently occurs in gastric cancer tissues and cells. In addition, the demethylating agent 5-Aza-CdR can reverse the hypermethylation of RASAL1 gene and up-regulate the expression of RASAL1 significantly in gastric cancer cells in vivo. Our study suggests that RASAL1 promoter methylation may have a certain relationship with the reduced RASAL1 expression in gastric cancer.

• 전자공학회논문지CI
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• 제39권2호
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• pp.35-44
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• 2002

카메라의 이동과 회전은 영상 프레임 전체에 영향을 미치는 전역 움직임(global motion)을 유발한다. 이러한 전역 움직임을 포함하는 영상을 부호화하는 경우, 변화성분 검출(change detection) 기법을 사용하여 정확한 오브젝트를 분할하는 것은 실제적으로는 불가능하며 큰 움직임 벡터로 인해 높은 압축률을 얻기 어렵다. 이러한 문제는 전역 움직임이 보상된 영상 시퀀스를 사용함으로써 해결할 수 있다. 전역 움직임 보상을 위한 기존의 카메라 움직임 추정 방법들은 계산량이 많다는 문제점을 가지고 있다. 따라서, 본 논문에서는 간단한 선 형식으로 구성되는 전역 움직임 추정 알고리즘을 제안한다 제안 알고리즘은 영상 프레임 내의 대칭점(symmetric points)의 움직임 정보를 이용하여 패닝(panning)과 틸팅(tilting), 줌잉(zooming)에 대한 전역 움직임 파라미터를 산출한다. 전역 움직임 계산에는 카메라 회전에 대해 깊이(depth)에 독립적인 원경만이 사용되며, 영상 내에서 원경을 구분하기 위한 판별식도 논문에 제시된다. 또한, MPEG 시험 영상을 사용한 실험 결과도 나타내었다. 본 논문에서 제안한 기법의 실시간 수행 능력은 많은 영상처리 분야의 전처리 단계에서 사용될 수 있다.

• 한국지진공학회논문집
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• 제14권1호
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• pp.25-34
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• 2010

비선형 이력거동을 가지는 교량 구조계에 지진하중이 작용하였을 때 파괴확률을 추정할 수 있는 기법을 제시하였다. 교량 구조계는 지진하중이 작용할 때 이중선형 이력거동을 보이는 단자유도 진동계로서 모델링하였다. 교량의 파괴는 상단의 변위 응답이 지진 지속시간 동안 정해진 한계 상태 값을 최초로 넘어설 때 발생하는 것으로 정의하였다. 지진하중에 대한 비선형 구조계의 최초통과확률을 추정하기 위하여, 단위시간 동안 한계상태를 넘어서는 빈도수를 계산하는 crossing theory를 적용하였다. 단위시간 동안의 한계상태 초과 빈도수 추정을 위하여 필요한, 비선형 구조계의 응답과 응답의 미분값 간의 결합확률밀도함수를 추정하기 위한 기법으로서, Non-Gaussian closure 기법을 제시하였다. 다양한 지반운동 특성을 가지는 다수의 인공지진 가속도 시간이력을 생성하여 교량의 동적 특성에 따른 파괴확률을 추정하였다. 제시된 기법을 사용한 결과 얻어진 파괴확률 값을 crude Monte-Carlo 시뮬레이션을 통하여 얻어진 정해 및 기존의 방법을 적용하여 얻어진 파괴확률 값과 비교함으로써 제시된 파괴확률 추정 기법의 정확성과 효율성을 검증하였다.

• 대한임상독성학회지
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• 제14권1호
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• pp.37-46
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• 2016

Purpose: This study was designed to determine the factors hindering psychiatric intervention for suicide attempters in the emergency room (ER). Methods: Participants were 299 patients aged 18 years or older admitted to the ER for suicidal drug overdose between July 2012 and June 2014. Patients were divided into two groups according to whether they had received psychiatric treatment in the ER. Medical histories and follow-up treatments were determined by examining patients' medical records and through phone surveys, and were then compared using ${\chi}^2$-test and Fisher's exact test. In addition, the rate of satisfaction of the treatment group and the reasons for their dissatisfaction were also determined. Results: The treatment and non-treatment groups comprised 135 (45%) and 164 patients (55%), respectively. Factors influencing participation in psychiatric intervention were previous history of suicide attempts (p=0.004), history of psychiatric disorder (p<0.001), time of day (p=0.039), and day of the week (p=0.040) of arrival in the ER. Whether or not the patient received follow-up psychiatric treatment was not significantly relevant (p=0.300). Of the 82 patients who participated in the treatment satisfaction survey, 50.2% reported being unsatisfied, mainly because of unfriendly medical personnel (36.6%), discomfort regarding other people's perceptions (24.4%), and cursory care (14.6%). Conclusion: To raise the participation rate of psychiatric consult, cooperation with psychiatry at night and on weekends is required, and incorporation of patients without previous history of suicidal attempt or other psychiatric disorder is important. Resolution of complaints toward psychiatric consult in suicide attempt survivors is also required.