• Asian-Australasian Journal of Animal Sciences
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• 제31권2호
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• pp.180-188
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• 2018

Objective: The aim of this study was to investigate the effect of single nucleotide polymorphisms (SNPs) of the melanogenesis associated transcription factor (MITF) and dopachrome tautomerase (DCT) genes on plumage coloration in Asian native duck breeds. MITF encodes a protein for microphthalmia-associated transcription factor, which regulates the development and function of melanocytes for pigmentation of skin, hair, and eyes. Among the tyrosinase-related family genes, DCT is a pigment cell-specific gene that plays important roles in the melanin synthesis pathway and the expression of skin, feather, and retina color. Methods: Five Asian duck varieties (black Korean native, white Korean native, commercial Peking, Nageswari, and Bangladeshi Deshi white ducks) were investigated to examine the polymorphisms associated with plumage colors. Among previously identified SNPs, three synonymous SNPs and one indel of MITF and nine SNPs in exon regions of DCT were genotyped. The allele frequencies for SNPs of the black and white plumage color populations were estimated and Fisher's exact test was conducted to assess the association between the allele frequencies of these two populations. Results: Two synonymous SNPs (c.114T>G and c.147T>C) and a 14-bp indel (GCTGCAAAC AGATG) in intron 7 of MITF were significantly associated with the black- and white-colored breeds (p<0.001). One non-synonymous SNP [c.938A>G (p.His313Arg)] in DCT, was highly significantly associated (p<0.001) and a synonymous SNP (c.753A>G) was significantly associated (p<0.05) with black and white color plumage in the studied duck populations. Conclusion: The results of this study provide a basis for further investigations of the associations between polymorphisms and plumage color phenotypes in Asian duck breeds.

• The Korean Journal of Pain
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• 제21권1호
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• pp.57-61
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• 2008

Background: Shoulder joint injection is currently performed under fluoroscopic or computed tomography scan guidance. We performed this study to determine if an ultrasound guided shoulder joint injection through rotator cuff interval would have clinical usefulness. Methods: A total of 17 volunteers [12 women, 5 men; mean age 28 yr (23-32 yr)] received shoulder joint injection under multilinear ultrasound (5-10 MHz). Volunteers were positioned supinely on a table with their arm in a neutral position. The anterior shoulder region of the patient was sterilized using povidone iodine. A 24 gauge needle was introduced and directly visualized in real time as it passed obliquely from the skin surface to the inferior space of the biceps tendon. If there was little or no resistance to the injection, a contrast media (omnipaque) was injected and checked fluoroscopically. Results: Ultrasound guided shoulder joint injection through rotator cuff interval was successful in all cases. The average time taken for the procedure was $27.5{\pm}16.5sec$. The vertical distance from skin to the inferior space of the biceps tendon was $1.6{\pm}0.4cm$ and the distance of needle from the skin to the inferior space of biceps tendon was $2.8{\pm}0.6cm$. The procedure was well tolerated by all volunteers. Conclusions: Ultrasound guided shoulder joint injection through rotator cuff interval is an effective, rapid, and easy-to-perform injection technique. Ultrasound guided injection enables exact needle placement and avoids the use of both ionizing radiation and iodinated contrast material.

• 정보관리학회지
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• 제34권4호
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• pp.293-320
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• 2017

본 연구는 지역방송국들의 기록관리 현황을 분석하고 개선방안을 모색하는 것을 목적으로 한다. 이를 위해 분석의 기준점이 되어 줄 KBS서울총국을 비롯하여 KBS 지역방송국 1곳, MBC 지역방송국 1곳, 지역민방 2곳을 방문하여 담당자와의 면담을 통한 현황 조사를 실시하였다. 분석 결과, 대부분의 지역방송국은 디지털로 생산되어 송출된 방송영상물은 방송국 내 서버를 통해 비교적 체계적으로 보관하고 있는 것으로 나타났다. 그러나 이들은 과거에 생산된 아날로그 자료에 대한 디지털화 작업을 실시하지 않고, 보유 기록물의 수량조차 정확하게 파악하지 못하고 있었다. 게다가 보존설비나 검색장비가 낙후되어 기록물에 대한 기본적인 보존과 이용에 있어서 어려움이 많은 것으로 나타났다. 본 연구에서는 이러한 결과를 바탕으로 방송국 자체 기록관리 규정 마련, 목록 작성을 통한 보유 기록물 수량 파악, 아날로그 기록에 대한 디지털화 작업 실시, PD들에 대한 메타데이터 교육 등의 개선방안을 제안하였다.

• 대한한방소아과학회지
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• 제29권3호
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• pp.54-64
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• 2015

Objectives : This study was to investigate the anti-oxidative and anti-inflammatory effect of Lonicera japonica water extracts (LE) on Ulcerative Colitis Induced by DSS (Dextran Sulfate Sodium) in Mice. Methods : Colitis was induced by DSS in Balb/c mice. The sample group was divided into three. The mice in control group were not inflammation-induced. The pathological group was composed of untreated colitis elicited mice. The experimental group was administered Lonicera japonica water extracts (LE) after colitis elicitation. The effects on ulcerative colitis were evaluated the anti-oxidant effect, inhibition of COX-2 mRNA expression, the morphological change of colonic mucosa, decrease effect of HSP 70 and COX-2 in mucosa. Results : The SOD ability of LE was dose-dependently increased and the LPS-induced COX-2 mRNA expression of LE was dose-dependently decreased. LE showed the protective effects on DSS-induced experimental colitis. LE inhibited shortening of colon length, the hemorrhagic erosion in colonic mucosa. LE also showed the decrease effect for HSP70 and COX-2 in mucosa. Conclusions : The current results demonstrate the clinical utility of LE in traditional medicine and indicate the possible treatments for ulcerative colitis from natural products. Further investigations for exact mechanisms will be needed.

• Clinical and Experimental Pediatrics
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• 제59권11호
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• pp.440-445
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• 2016

Purpose: This study aimed to identify prognostic factors of neurological outcomes, including developmental delay, cerebral palsy and epilepsy in late-preterm and term infants with perinatal asphyxia. Methods: All late-preterm and term infants with perinatal asphyxia or hypoxic-ischemic insults who admitted the neonatal intensive care unit of Inje University Sanggye Paik Hospital between 2006 and 2014 and were followed up for at least 2 years were included in this retrospective study. Abnormal neurological outcomes were defined as cerebral palsy, developmental delay and epilepsy. Results: Of the 114 infants with perinatal asphyxia, 31 were lost to follow-up. Of the remaining 83 infants, 10 died, 56 had normal outcomes, and 17 had abnormal outcomes: 14 epilepsy (82.4%), 13 cerebral palsy (76.5%), 16 developmental delay (94.1%). Abnormal outcomes were significantly more frequent in infants with later onset seizure, clinical seizure, poor electroencephalography (EEG) background activity, lower Apgar score at 1 and 5 minutes and abnormal brain imaging (P<0.05). Infants with and without epilepsy showed significant differences in EEG background activity, clinical and electrographic seizures on EEG, Apgar score at 5 minutes and brain imaging findings. Conclusion: We should apply with long-term video EEG or amplitude integrated EEG in order to detect and management subtle clinical or electrographic seizures in neonates with perinatal asphyxia. Also, long-term, prospective studies with large number of patients are needed to evaluate more exact prognostic factors in neonates with perinatal asphyxia.

• Clinical and Experimental Pediatrics
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• 제60권5호
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• pp.145-150
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• 2017

Purpose: The gut microbiota can influence several diseases through immune modulation; however, the exact role of microbes such as Clostridium difficile and the relationship between microbiota colonization and allergic diseases are not well known. This study aimed to determine the relationship between C. difficile colonization and/or infection (CDCI) during infancy and allergic diseases during early childhood. Methods: Infants 1-12 months of age presenting changes in bowel habits for more than 2 weeks were enrolled in this study. After dividing them into 2 groups according to the presence and absence of C. difficile, the risk of allergic disease development during childhood was identified and compared. Results: Sixty-five patients were included in this study; 22 (33.8%) were diagnosed with CDCI. No significant differences were observed in baseline characteristics between the C. difficile-positive and-negative groups except for antibiotic exposure (22.7% vs. 60.5%, P=0.004). Compared to the C. difficile-negative group, the risk of developing at least one allergic disease was higher in the C. difficile-positive group after adjusting other variables (adjusted odds ratios, 5.61; 95% confidence interval, 1.52-20.74; P=0.007). Furthermore, food allergies were more prevalent in the C. difficile-positive group (P=0.03). Conclusion: CDCI during infancy were associated with a higher risk of developing allergic diseases during early childhood. These results suggest that CDCI during infancy might reflect the reduced diversity of the intestinal microbiota, which is associated with an increased risk of allergic sensitization. To identify the underlying mechanism, further investigation and a larger cohort study will be needed.

• Journal of Korean Neurosurgical Society
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• 제53권3호
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• pp.161-166
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• 2013

Objective : Neuroendoscopy is applied to various intracranial pathologic conditions. But this technique needs informations for the anatomy, critically. Neuronavigation makes the operation more safe, exact and lesser invasive procedures. But classical neuronavigation systems with rigid pinning fixations were difficult to apply to pediatric populations because of their thin and immature skull. Electromagnetic neuronavigation has used in the very young patients because it does not need rigid pinning fixations. The usefulness of electromagnetic neuronavigation is described through our experiences of neuroendoscopy for pediatric groups and reviews for several literatures. Methods : Between January 2007 and July 2011, nine pediatric patients were managed with endoscopic surgery using electromagnetic neuronavigation (AxiEM, Medtronics, USA). The patients were 4.0 years of mean age (4 months-12 years) and consisted of 8 boys and 1 girl. Totally, 11 endoscopic procedures were performed. The cases involving surgical outcomes were reviewed. Results : The goal of surgery was achieved successfully at the time of surgery, as confirmed by postoperative imaging. In 2 patients, each patient underwent re-operations due to the aggravation of the previous lesion. And one had transient mild third nerve palsy due to intraoperative manipulation and the others had no surgery related complication. Conclusion : By using electromagnetic neuronavigation, neuroendoscopy was found to be a safe and effective technique. In conclusion, electromagnetic neuronavigation is a useful adjunct to neuroendoscopy in very young pediatric patients and an alternative to classical optical neuronavigation.

• Journal of Korean Neurosurgical Society
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• 제58권2호
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• pp.112-118
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• 2015

Objective : Thoracic ossification of the ligamentum flavum (OLF) is a relatively rare disease. Because of ambiguous clinical symptom, it is difficult for early diagnosis of OLF and subsequent treatment can be delayed or missed. Therefore, the purpose of this study is to comprehensively assess the prevalence and distribution of thoracic OLF by magnetic resonance imaging (MRI) and coexisting spinal disease in Korean patients with back pain or leg pain. Methods : The sample included 2134 Korean patients who underwent MRI evaluation for back pain. The prevalence and distribution of thoracic OLF were assessed using lumbar MRI with whole spine sagittal images. Additionally, we examined the presence of coexisting lumbar and cervical diseases. The presence of thoracic OLF as well as clinical parameters such as age, sex, and surgery were retrospectively reviewed. Results : The prevalence of thoracic OLF in total patients was 16.9% (360/2134). The prevalence tended to increase with aging and was higher in women than in men. The lower thoracic segment of T10-11 was the most frequently affected segment. Of the 360 patients with OLF, 31.9% had coexisting herniated thoracic discs at the same level. Approximately 74% of the patients with OLF had coexisting lumbar and cervical disease. Nine (2.5%) of 360 OLF patients underwent surgery for thoracic lesion. Conclusion : The prevalenceof thoracic OLF was relatively higher than those of previous reports. And coexisting lumbar and cervical disease were very frequent. Therefore, we should check coexisting spinal diseases and the exact diagnostic localization of ossification besides lumbar disease.

• 대한공간정보학회지
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• 제10권2호
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• pp.19-27
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• 2002

본 논문은 시설물 관리에서 시스템분석과 업무분석으로 인터넷기반 시설물 관리 시스템을 개발하고 AHP모델을 시스템에 도입하여 원활한 시설물관리기법을 제시하는데 있다. 기존의 공간분석과 연산은 정확성의 기준이 불분명하며 단순한 수준의 출력만을 하기 때문에, 의사결정을 위한 지리적자료에 대한 정확한 분석을 위해서는 통계적인 분석이 필요하였으며, 관리자위주의 시스템은 사용자의 욕구를 충족시키지 못하였다. 그리고, 인터넷 GIS 기반의 분석적 요구 사항을 충족시켜줄 수 있는 일련의 공간통계분석기법들을 GIS로 공간분석기능으로 구조화시키기 위해서는 기존의 일반통계 모듈과 인터넷 GIS의 통합 또는 인터페이스의 구성이 필요하다. 따라서, 본 연구에서는 시설물의 장기적인 유지관리에 있어서 인터넷 GIS 기술도입의 필요성을 제시하고 의사 결정에서 AHP모델의 적용가능성을 제시하였다.

• 정보관리학회지
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• 제34권1호
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• pp.31-50
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• 2017

본 연구에서는 2001년 개발을 시작으로 학교도서관의 자료 관리를 해결하고, 자료의 공동 활용을 위한 데이터 구축을 지원해 온 DLS의 근본적인 문제점을 조사하고, 이를 해결할 수 있는 개선방안을 모색하고자 한다. 연구방법으로 DLS 전문위원 9명을 대상으로 자료선정, 자료등록, 대출반납, 장서점검, 통계, 이용자검색의 6가지 영역에서 DLS의 사용현황과 문제점을 조사하고 이를 해결할 개선방안을 제안하였다. 자료선정 측면에서는 수서시스템 도입 및 온라인 희망도서 구입신청 기능 추가가 필요하다. 자료등록 측면에서는 데이터 품질 관리 향상과 검색기능 향상을 위한 색인어의 체계적 입력 및 어휘통제가 필요하다. 대출반납 측면에서는 대출속도 향상이, 장서점검 측면에서는 폐기자료의 복원 기능이, 통계 측면에서는 정확한 통계자료 생성이 필요하다. 이용자검색에서는 검색속도 향상 및 이용자 인터페이스 기능 향상이 필요하다. 본 연구는 앞으로 DLS 시스템 개선에 많은 기여를 할 것이며 이에 따라 DLS 이용도 향상될 것이다.