• 제목/요약/키워드: evolution process

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단백질 기능 향상을 위한 방향적 진화 (Directed Evolution in Protein Functionality Improvement)

  • 강환구;김학성
    • KSBB Journal
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    • 제16권2호
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    • pp.107-114
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    • 2001
  • The dynamic evolution process has resulted in the myriad shapes, functions, and systems evident in every living organism. For centuries, people have been harnessing the power of evolution to produce new varieties of plants and animals, such as producing tomatoes from berries and Chihuahuas from wolves. Now scientists are using it to produce better molecules, ranging from drugs to industrial chemicals, and doing it in days or weeks rather than eons. The ingenious process, which creates genetic diversity and selects those with desired features in the laboratory, is called directed evolution or test tube evolution. In this paper, concepts of directed molecular evolution and some examples will be discussed.

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직/간접 압출공정에 의해 제조된 AZ31Mg 합금의 미세조직 및 집합조직 변화 분석 (Analysis of microstructure and texture evolution in AZ31Mg alloy fabricated by direct/indirect extrusion process)

  • 김대하;유봉선;박성수;윤덕재;최시훈
    • 한국소성가공학회:학술대회논문집
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    • 한국소성가공학회 2008년도 추계학술대회 논문집
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    • pp.38-41
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    • 2008
  • To investigate the evolution of microstructure and texture in AZ31 Mg alloy, direct/indirect extrusion process was carried out at $300^{\circ}C$ with various extrusion speeds. The distribution of grain size depends on extrusion method and extrusion speed. More homogeneous grain site can be obtained at higher extrusion speed of indirect extrusion process. Extrusion speed does not affect significantly texture evolution during extrusion process regardless of extrusion method. ODF section is more useful to understand texture evolution during extrusion process compared with pole figure.

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공진화 분석기반 기술 인텔리전스 : 반도체 패키지공정 사례 (Technology Intelligence based on the Co-evolution Analysis : Semiconductor Package Process Case)

  • 이병준;신준석
    • 기술혁신연구
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    • 제28권4호
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    • pp.63-93
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    • 2020
  • 본 연구는 반도체 제품과 설비기술을 대상으로 제품-공정기술 공진화를 교차영향분석(cross impact analysis)을 통해 구체화하고, 공진화 관계를 기술 인텔리전스의 대표적 도구 중 하나인 기술레이더에 통합하는 방법을 제시한다. 교차영향분석을 통해 공정기술 발전과 제품특성 개선이 반복되는 공진화 경로와 축이 되는 세부기술들을 파악했다. 또한 공진화 관계를 기술레이더의 기술가치평가 프로세스에 반영해 가치평가와 연구개발 포트폴리오의 신뢰성을 제고했다. 학술적 측면에서 기술간 공진화를 세부기술 단위에서 구체화했으며, 기술 공진화 이론과 기술 인텔리전스의 접점을 제시했다는 의미가 있다. 실무적 측면에서는 반도체 관통전극-하이브리드 패키지 제품과 주요 후공정 기술간 공진화 및 기술레이더 분석 실례를 제시하고, 이를 통해 기술간 공진화 관계를 기존 기술전략 및 기획도구에 반영해 기업의 미래준비역량과 전략기획의 신뢰성을 제고하는 방법을 구체화했다는 점에서 가치가 있다.

미세조직 변화를 고려한 열간 단조 공정에서의 유한요소해석 (Computer Simulation of Microstructure Evolution during Hot Forging of Waspaloy)

  • 강경필;이경훈;이승욱
    • 한국소성가공학회:학술대회논문집
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    • 한국소성가공학회 2007년도 추계학술대회 논문집
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    • pp.53-56
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    • 2007
  • Computer simulation of microstructure evolution during hot forging process is of great interest in recent years. Recrystallization model and grain growth model which use a phenomenological approach were summarized. For the waspaloy, upsetting process and cogging process were simulated using $DEFORM^{TM}$ and the change in grain size were investigated in each deformation procedure.

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차분진화 알고리듬을 이용한 전역최적화 (Global Optimization Using Differential Evolution Algorithm)

  • 정재준;이태희
    • 대한기계학회논문집A
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    • 제27권11호
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    • pp.1809-1814
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    • 2003
  • Differential evolution (DE) algorithm is presented and applied to global optimization in this research. DE suggested initially fur the solution to Chebychev polynomial fitting problem is similar to genetic algorithm(GA) including crossover, mutation and selection process. However, differential evolution algorithm is simpler than GA because it uses a vector concept in populating process. And DE turns out to be converged faster than CA, since it employs the difference information as pseudo-sensitivity In this paper, a trial vector and its control parameters of DE are examined and unconstrained optimization problems of highly nonlinear multimodal functions are demonstrated. To illustrate the efficiency of DE, convergence rates and robustness of global optimization algorithms are compared with those of simple GA.

A Semantic Aspect-Based Vector Space Model to Identify the Event Evolution Relationship within Topics

  • Xi, Yaoyi;Li, Bicheng;Liu, Yang
    • Journal of Computing Science and Engineering
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    • 제9권2호
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    • pp.73-82
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    • 2015
  • Understanding how the topic evolves is an important and challenging task. A topic usually consists of multiple related events, and the accurate identification of event evolution relationship plays an important role in topic evolution analysis. Existing research has used the traditional vector space model to represent the event, which cannot be used to accurately compute the semantic similarity between events. This has led to poor performance in identifying event evolution relationship. This paper suggests constructing a semantic aspect-based vector space model to represent the event: First, use hierarchical Dirichlet process to mine the semantic aspects. Then, construct a semantic aspect-based vector space model according to these aspects. Finally, represent each event as a point and measure the semantic relatedness between events in the space. According to our evaluation experiments, the performance of our proposed technique is promising and significantly outperforms the baseline methods.

창발적 기계설계를 위한 컴퓨터기반 프레임워크 (Framework for Innovative Mechanical Design Using Simulated Emergent Evolution)

  • 이인호;차주헌;김재정
    • 대한기계학회논문집A
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    • 제26권4호
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    • pp.701-710
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    • 2002
  • The framework, described in this paper, involves artificial evolutionary systems that re -produce aimed solutions through a simulated Darwinian evolution process. Through this process the framework designs structures of machines innovatively and emergently especially in the stages of conceptual and basic design. Since the framework simulates the evolution of nature, it inevitably involves processes that converse the natural evolution to the artificial evolution. For the conversion, based on several methods as the building block modeling, Artificial Life, evolutionary computation and the law of natural selection, we propose a series of processes that consists of modeling, evaluation, selection, evolution etc. We have demonstrated the implementation of the framework with the design of multi-step gear systems.

유한요소법에 의한 열간성형공정에서 강의 미세조직변화 예측 (Prediction of Microstructural Evolution in Hot Forging of Steel by the Finite Element Method)

  • 장용순;고대철;김병민
    • 한국정밀공학회지
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    • 제15권7호
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    • pp.129-138
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    • 1998
  • The objective of this study is to demonstrate the ability of a computer simulation of microstructural evolution in hot forging of C-Mn steels. The development of microstructure is strongly dependent on process variables and metallurgical factors that affect time history of thermodynamical variables such as temperature, strain. and strain rate during deformation. Then finite element method is applied for the prediction of microstructural evolution, and it should be coupled with heat transfer analysis to consider the change of thermodynamical properties during forming process. In this study, Yada's recrystallization model and rigid-thermoviscoplastic finite element method are employed in order to analyze microstructural evolution during hot forging process. To show the validity and effectiveness of the proposed method, experiments are accomplished and the results of experiments are compared with those of simulations.

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Change Antecedents, Explicit Reactions and Consequences for Revolution and Evolution: A Case Study of Commercial Banks in Pakistan

  • SHAFIQ, Madiha;SAEED, Bilal Bin
    • The Journal of Asian Finance, Economics and Business
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    • 제9권5호
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    • pp.119-133
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    • 2022
  • The purpose of this study is to examine how change recipients react to change (affective commitment to change) and how change leads to positive consequences (job satisfaction) in Revolution and Evolution, taking into account the change content (perceived change impact), change context (change climate), and change process (participation in the change process). The present study uses a deductive approach with an exploratory research design. Data was collected from 254 employees of the head offices of three major banks, who have gone through Revolution, and 354 employees of the head offices, three banks who have gone through Evolution in the last five years. The hypothesized model is tested and analyzed through structural equation modeling using SmartPLS. The findings revealed that, in the case of Revolution, the presence of the favorable context and process might revert the negative perception of the change and lead towards explicit positive reactions (affective commitment to change) and change consequences (job satisfaction). In the case of Evolution, the change can be more effectively implemented using favorable context and process by achieving explicit positive reactions (affective commitment to change) and change consequences (job satisfaction).

A NON-MARKOVIAN EVOLUTION MODEL OF HIV POPULATION WITH BUNCHING BEHAVIOUR

  • Sridharan, V.;Jayshree, P.R.
    • Journal of applied mathematics & informatics
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    • 제5권3호
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    • pp.785-796
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    • 1998
  • In this paper we propose a model of HIv population through method of phases with non-Markovian evolution of immi-gration. The analysis leads to an explicit differnetial equations for the generating functions of the total population size. The detection process of antibodies (against the antigen of virus) is analysed and an explicit expression for the correlation functions are provided. A measure of bunching is also introduced for some particular choice of parameters.