• Interdisciplinary Bio Central
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• v.1 no.1
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• pp.2.1-2.3
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• 2009

There is evidence that cholesterol in the brain plays an important role in the neurotransmitter release. A decrease of the cholesterol level severely hampers the activity of the membrane fusion machinery, thereby inhibiting the release. Meanwhile, the results from several clinical studies suggest that a low cholesterol level is linked to the dysfunction of some brain activities. Because the neurotransmitter release underlies the basic brain function, the combined results lead to a testable hypothesis that the cholesterol-lowering drugs may inhibit the neurotransmitter release at the synapse. Such inhibition of the release could result in impaired brain function for a limited group of people. A molecular basis for the hypothesis is discussed.

• Molecules and Cells
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• v.37 no.2
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• pp.89-94
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• 2014

Fission and fusion of mitochondrial tubules are the main processes determining mitochondrial shape and size in cells. As more evidence is found for the involvement of mitochondrial morphology in human pathology, it is important to elucidate the mechanisms of mitochondrial fission and fusion. Mitochondrial morphology is highly sensitive to changing environmental conditions, indicating the involvement of cellular signaling pathways. In addition, the well-established structural connection between the endoplasmic reticulum (ER) and mitochondria has recently been found to play a role in mitochondrial fission. This minireview describes the latest advancements in understanding the regulatory mechanisms controlling mitochondrial morphology, as well as the ER-mediated structural maintenance of mitochondria, with a specific emphasis on mitochondrial fission.

• Journal of fish pathology
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• v.13 no.2
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• pp.147-151
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• 2000

Deformed vertebrae by cold shock in Rhynchocypris oxycephalus were discovered. Deformity was externally noticed in the caudal penducle region of R. oxycephalus. Radiographic and histologic investigation confirmed the deformity. Especially, histological investigations provided the fact that extensive fusion between neighbouring vertebrae is caused by removal of endogeneous mineralized tissue. Deformed vertebrae appeared suggesting the direct evidence of vertebral fusion had arisen internally by cold shock in this species.

• Journal of Cadastre & Land InformatiX
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• v.51 no.1
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• pp.111-124
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• 2021

Recently, Interest in the restoration and 3D reconstruction of cultural properties due to the fire of Notre Dame Cathedral on April 15, 2019 has been focused once again after the 2008 Sungnyemun fire incident in South Korea. In particular, research to restore and reconstruct the actual measurement of cultural properties using LiDAR(Light Detection and ranging) and conventional surveying, which were previously used, using various 3D reconstruction technologies, is being actively conducted. This study acquires data using unmanned aerial imagery of UAV(Unmanned Aerial Vehicle), which has recently established itself as a core technology in the era of the 4th industrial revolution, and the existing CRP(Closed Range Photogrammetry) and terrestrial LiDAR scanning for the Recumbent Buddha of Unju Temple. Then, the 3D reconstruction was performed with three fusion models based on SfM(Structure-from-Motion), and the reproducibility and accuracy of the models were compared and analyzed. In addition, using the best fusion model among the three models, the relationship with the Polar Star(Polaris) was confirmed based on the real world coordinates of the Recumbent Buddha, which contains the astronomical history of Buddhism in the early 11th century Goryeo Dynasty. Through this study, not only the simple external 3D reconstruction of cultural properties, but also the method of reconstructing the historical evidence according to the type and shape of the cultural properties was sought by confirming the historical evidence of the cultural properties in terms of spatial information.

• Journal of Korean Neurosurgical Society
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• v.48 no.5
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• pp.455-460
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• 2010

We reviewed 9 cases of pyogenic spondylodiscitis following percutaneous endoscopic lumbar discectomy (PELD). Microbiologic cultures revealed 6 causative organisms. Five patients were managed conservatively and four were treated surgically. The mean follow-up period was 20.6 months and the average length of hospitalization was 24 days. Radiological evidence of spinal fusion was noted and infection was resolved in all patients. Although PELD is a safe and effective procedure, the possibility of pyogenic spondylodiscitis should always be considered.

• Journal of Korean Neurosurgical Society
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• v.51 no.6
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• pp.343-349
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• 2012

Objective : Pedicle-based dynamic stabilization systems, in which semi-rigid rods or cords are used to restrict or control spinal segmental motion, aim to reduce or eliminate the drawbacks associated with rigid fusion. In this study, we analyzed the two-year clinical outcomes of patients treated with the NFlex (Synthes Spine, Inc.), a pedicle-based dynamic stabilization system. Methods : Five sites participated in a retrospective study of 72 consecutive patients who underwent NFlex stabilization. Of these 72 patients, 65 were available for 2-year follow-up. Patients were included based on the presence of degenerative disc disease (29 patients), degenerative spondylolisthesis (16 patients), lumbar stenosis (9 patients), adjacent segment degeneration (6 patients), and degenerative lumbar scoliosis (5 patients). The clinical outcome measures at each assessment were Visual Analogue Scale (VAS) to measure back pain, and Oswestry Disability Index (ODI) to measure functional status. Radiographic assessments included evidence of instrumentation failure or screw loosening. Results : Sixty-five patients (26 men and 39 women) with a mean age of 54.5 years were included. Mean follow-up was 25.6 months. The mean VAS score improved from 8.1 preoperatively to 3.8 postoperatively, representing a 53% improvement, and the ODI score from 44.5 to 21.8, representing a 51% improvement. Improvements in pain and disability scores were statistically significant. Three implant-related complications were observed. Conclusion : Posterior pedicle-based dynamic stabilization using the NFlex system seems effective in improving pain and functional scores, with sustained clinical improvement after two years. With appropriate patient selection, it may be considered an effective alternative to rigid fusion.

• Journal of the Korean Society for information Management
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• v.25 no.2
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• pp.49-68
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• 2008

In many information retrieval experiments, the data fusion techniques have been used to achieve higher effectiveness in comparison to the single evidence-based retrieval. However, there had not been many image retrieval studies using the data fusion techniques especially in combining retrieval results based on multiple retrieval methods. In this paper, we describe how the image retrieval effectiveness can be improved by combining two sets of the retrieval results using the Sobel operator-based edge detection and the Self Organizing Map(SOM) algorithms. We used the clip art images from a commercial collection to develop a test data set. The main advantage of using this type of the data set was the clear cut relevance judgment, which did not require any human intervention.

• Journal of the Korean Institute of Intelligent Systems
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• v.26 no.3
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• pp.233-238
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• 2016

In this paper, we propose the algorithms of processing the uncertainty data using data fusion for the next generation intrusion detection. In the next generation intrusion detection, a lot of data are collected by many of network sensors to discover knowledge from generating information in cyber space. It is necessary the data fusion process to extract knowledge from collected sensors data. In this paper, we have proposed method to represent the uncertainty data, by classifying where is a confidence interval in interval of uncertainty data through feature analysis of different data using inference method with Dempster-Shafer Evidence Theory. In this paper, we have implemented a detection experiment that is classified by the confidence interval using IRIS plant Data Set for anomaly detection of uncertainty data. As a result, we found that it is possible to classify data by confidence interval.

• Journal of the Korean earth science society
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• v.42 no.6
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• pp.605-622
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• 2021

Seasonal forecasting has numerous socioeconomic benefits because it can be used for disaster mitigation. Therefore, it is necessary to diagnose and improve the seasonal forecast model. Moreover, the model performance is partly related to the ocean model. This study evaluated the hindcast performance in the upper ocean of the Global Seasonal Forecasting System version 5-Global Couple Configuration 2 (GloSea5-GC2) using a multivariable integrated evaluation method. The normalized potential temperature, salinity, zonal and meridional currents, and sea surface height anomalies were evaluated. Model performance was affected by the target month and was found to be better in the Pacific than in the Atlantic. An increase in lead time led to a decrease in overall model performance, along with decreases in interannual variability, pattern similarity, and root mean square vector deviation. Improving the performance for ocean currents is a more critical than enhancing the performance for other evaluated variables. The tropical Pacific showed the best accuracy in the surface layer, but a spring predictability barrier was present. At the depth of 301 m, the north Pacific and tropical Atlantic exhibited the best and worst accuracies, respectively. These findings provide fundamental evidence for the ocean forecasting performance of GloSea5.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.11
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• pp.2945-2965
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• 2023

The laser inertial measurement unit is a precision device widely used in rocket navigation system and other equipment, and its quality is directly related to navigation accuracy. In the quality evaluation of laser inertial measurement unit, there is inevitably uncertainty in the index input information. First, the input numerical information is in interval form. Second, the index input grade and the quality evaluation result grade are given according to different national standards. So, it is a key step to transform the interval information input by the index into the data form consistent with the evaluation result grade. In the case of uncertain input, this paper puts forward a method based on probability distribution to solve the problem of asymmetry between the reference grade given by the index and the evaluation result grade when evaluating the quality of laser inertial measurement unit. By mapping the numerical relationship between the designated reference level and the evaluation reference level of the index information under different distributions, the index evidence symmetrical with the evaluation reference level is given. After the uncertain input information is transformed into evidence of interval degree distribution by this method, the information fusion of interval degree distribution evidence is carried out by interval evidential reasoning algorithm, and the evaluation result is obtained by projection covariance matrix adaptive evolution strategy optimization. Taking a five-meter redundant laser inertial measurement unit as an example, the applicability and effectiveness of this method are verified.