• Journal of Pharmaceutical Investigation
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• 제32권2호
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• pp.73-80
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• 2002

Cefuroxime axetil is a cephalosporin antibiotic having a high activity against a wide spectrum of Grampositive and Gram-negative microorganisms. It is a cephalosporin antibiotic which exist as 2 diastereoisomers: diastereoisomer A and B. It shows polymorphism of three forms: a crystalline form having a melting point of about $180^{\circ}C$, a substantially amorphous form having a high melting point of about $135^{\circ}C$ and a substantially amorphous form having a low melting point of about 70^{\circ}C$. The crystalline form of cefuroxime axetil is slightly soluble in water because diastereoisomer A has lower solubility than B in water. Substantially amorphous form of which there are no difference in solubility between diastereoisomer A and B has better solubility than crystalline form, but it forms a thicker gel than crystalline form upon contact with an aqueous medium. Based on this reason, cefuroxime axetil is not readily absorbable in the gastrointestinal tract, rendering its bioavailability on oral administration very low. The object of this study was to develop an improved non-crystalline cefuroxime axetil composition having a high physicochemical stability and bioavailability. A non-crystalline cefuroxime axetil solid dispersant showing no peak on a Differential Scanning Calorimetry (DSC) scan is prepared by dissolving cefuroxime axetil and a surfactant in an organic solvent; suspending a water-insoluble inorganic carrier in the resulting solution; and spray drying the resulting suspension to remove the organic solvent, said solid dispersant having an enhanced dissolution and stability of cefuroxime axetil and being useful for the preparation of a pharmaceutical composition for oral administration. Tablet was formulated with this cefuroxime axetil solid dispersant, disintegrants and other ingredients. It disintegrated and dissolved easily and dynamically in dissolution medium, so showed a good dissolution profile.

• 한국건축시공학회지
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• 제18권6호
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• pp.577-584
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• 2018

본 논문은 합성수지 거푸집 성능평가를 위해 길이 변화율, 충격시험, 소음테스트를 실시하였다. 또한 현장 적용을 통해 합성수지 거푸집 시공성에 대해 검토하였다. 실험결과, 가열 길이 변화 시험, 충격시험은 KS기준치를 모두 만족하는 것으로 나타났다. 소음 테스트의 경우 유로폼이 평균 106dB(A)을 나타냈으며, 합성수지 거푸집은 평균 100.4dB(A)을 나타났다. 음압레벨의 경우, 합성수지 거푸집이 유로폼보다 고주파영역에서 낮게 나타나 시공시 소음 피로도가 적고 주변민원은 감소할 것으로 판단된다. 마지막으로 현장적용결과, 콘크리트 타설 중 거푸집 휨 현상이나 배부름 현상은 발생하지 않았다. 또한 콘크리트 표면 마감도가 합성수지 거푸집이 유로폼면 보다 더 우수한 것으로 나타났다.

• 대한의용생체공학회:의공학회지
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• 제31권6호
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• pp.434-437
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• 2010

For approval of medical devices manufactured or imported, submission of technical documents as well as the application form is required. The manufacturer (or importer) should properly identify the raw materials the applied product is made of and the manufacturing processes the product undergoes before it is shipped in the application form. In the technical documents, scientific data to evaluate the efficacy, safety, and quality of the applied product that has been described in the application form should be provided. Therefore, identifying the raw materials that were used for the parts of the applied product and describing the physical and chemical characteristics of the raw materials are quite important and essential in ensuring the efficacy, safety, and quality of the applied product. To describe the physical and chemical characteristics of the raw materials correctively, the applicant is required to have broad knowledge in the scientific fields such as chemical, polymer, metal, and ceramic science and engineering. But most of the applicant are not experts in these fields, so that the description in the application form often includes wrong and improper descriptions. Thus, we developed a guideline which explains the raw materials for medical devices, show the their examples. The purpose of this description guideline is to help the applicant properly completing the "Raw materials or constituents and their volumes" part in the application form.

• 대한가정학회지
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• 제30권2호
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• pp.21-34
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• 1992

The purpose of this study was to investigate (1) the effect of a masculine-feminine image in women's blouse·skirt on the perception of the wearer's occupational characteristics and suitability of the clothing for certain occupations, and (2) the effect of perceiver's sex, sex-role attitudes, and occupation on the perception formed by the function of clothing cues. The research design of the study consisted of 2(skirt color) × 2(blose color) × 3(masculine-feminine blouse forms) factorial desing of a blouse·skirt set. The experimental materials developed for this study were a set of stimuli and 2 response scales. The stimuli consisted of 12 drawings of woman's clothing made by systematic manipulations of 2 independent variabels (color and form) in drawings of blouse-skirt. The dependent variables were the perceptions of the wearer's occupational characteristics and suitability of the masculine or feminine clothing for certain occupations. Occupational characteristics were measured with a 7-point semantic differential scale composed of 21 bipolar adjectives. Perception of occupational suitability was assessed with 12 items of 5-point Likert type questions. In addition, the Bem Sex-role Inventory was used to assess perceiver's sex-role attitudes. The subjects consisted of 393 men and 389 women, whose occupations were classified as professionals, secondary school teachers, and white-collar workers. The data were analyzed by factor analysis, MANOVA, ANOVA, Mean and S.D. Three factors emerged to account for the perception of occupational characteristics. These factors were given the titles of (1) activity, (2) potency, and (3) evaluation factors. The activity factor was the largest, including 9 adjectives and accounting for 33.3% of the variance in blouse-skirt. On the blouse-skirt set, the form of the blouse had an effect on activity and evaluation for both sexes, while the color of the skirt had an effect on evaluation for both sexes as well as on potency for men. Strong effect of color and form on blouse·skirt were seen in perception of occupational suitability for the occupations of attorney(masculine) and secretary(feminine). On suitability for secondary school teaching occupations, the effects of color and form of blouse·skirt differed by sex of the subjects. Male subjects determined suitability by the color of the blouse, while female subjects determinied suitability on the basis of the form of the blouse. Perceiver's sex-role attitude and occupation partially influenced the perception of the wearer's occupational characteristics and suitability of the clothing for certain occupations.

• 한국농공학회지
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• 제18권1호
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• pp.4021-4037
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• 1976

This paper describes the actual experiments of the error propagation and studies of analytical photogrammetry using the simulation method in which we can find the causes of the errors. These studies and the results give the valuable data which are very effective for systematically controlling the errors in aerial triangulation. The main contents in my paper are as follows: 1. Dose the scale errors in the successive models in the form of normal distribution appear when the observation errors propagate in the form of normal distribution\ulcorner 2. In what form does this scale error propagation in the actual model appear\ulcorner 3. When the causes of the scale error propagation are found, is the evaluation standard determined normally\ulcorner 4. What degree of influence is there form the constant errors\ulcorner I have done several experiments using the simulation method technique to solve the complicated error propgation of aerial triangulation which is the effective means to research the relations between cause and effect. In this paper, the studies have concentrated on the following points of simulation experiments. (1) The first part descries how we can produce the soft program of the simulation experiment. (2) The second part is the method propagating the errors in the simulation models and the kinds of errors. (3) The final part is the most important; that is the analyzing and evaluation of control during actual work. From the above-mentioned points, it is said that these studies are a very important development in the field of controlling and managing aerial photogrammetry and especially in the case of error propagation, we can clearly find the causes of the errors and steps and parts of errors generated when we use these techniques.

• 복식문화연구
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• 제12권1호
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• pp.121-135
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• 2004

The purpose of this study is to analyze the image evaluation and the preference of tailored jacket according to the body type and the degree of satisfaction with their body of middle-aged women. The subjects used for this study were three hundred and twenty three middle-aged women ranging from 35 to 50 years old. We measured their bodies and asked them report to the questionnaire. The results are as follows. 1) Middle-aged women were classified into four typical types of body. The type 1 was tall and thin and had a front view silhouette with the form of a letter X. The type 2 was the tallest and the medium of fatness and had a front view silhouette with the form of a letter H that the lower part of the body is short. The type 3 was the medium of height and width and had a front view silhouette with the form of a letter A that the upper part of the body is short compared with their height. The type 4 were the shortest and the fattest and had a front view silhouette with the form of a letter Y that the lower and upper parts of the body is the longest. 2) Middle-aged women roughly tended not to be satisfied with part of their body. The results showed that a neck was the most satisfied body part and the weight was the least satisfied as well as overall leg shape among all 13 body parts. 3) The type 1 had the highest the degree of satisfaction on their face size, upper arm girth, waist, hip girth, weight and body shape, etc., excepting hip shape among 4 body types.

• 약학회지
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• 제16권3호
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• pp.113-120
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• 1972

The last decade of this centry is now the accepted birth date of that sub-discipline of pharmacy that is now called 'biopharmceutics'. Wagner defines biopharmaceutics 'as the study of the influence of fomulation on the therapeutic activity of a drug product.' More specifically, he states that biopharmaceutics encompasses the study of the relationship between the nature and intensity of the biological effects observed in animals or man and the following factors: 1. The nature of the form of the drug (ester, salt, complex, etc). 2. The physical state, particle size, and surface area. 3. Presence or absence of adjuvants with the drug. 4. The type of dosage form in which the drug is administered. 5. The pharmaceutical process (es) used to make the dosage form. The philosophy inherent in this definition has revolutionized our thinking with respect to product development, quality control, and to the practice of pharmacy itself. Althoughthe the emphasis herein will be on quality control, the interrelationship between this and the other areas of pharmacy will be evident. The principles of quality control dictate that a wide variety of techniques be used to evaluate the quality of a dosage form. Since quality must be built into a dosage form, the pharmaceutical scientist begins the process at the research stage, continues it during the production stage, and ends it by applying the tests and procedures established by parmacopeial commissions. These stages are usually separate and distinct and, because of this, product quality has become synonymous with compliance with pharmacopeial specifications.

• 복식
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• 제55권5호
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• pp.55-64
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• 2005

The concern with three-dimensional measurement has been growing in recent years. And over the last few years, several studies have been made on three-dimensional measurement. Some of the studies using a three-dimensional measurement have focused on type of form of human body and evaluation of fitness. But there has been no study about applications of three-dimensional measurement system for shape analysis. So, the purpose of this study was to investigate about application of three-dimensional mea-surement system lot shape analysis. The instrument and tools for three-dimensional measurement was Whole Body 3D scanner(model name: Exyma-WBS2H). Analysis program used in experiment is Rapid Form 2004 PPI (INUS technology, Int, Korea). The following results were obtained; 1. The point data using three-dimensional measurement system built 3D model. 2. The three-dimensional data were used to analyze length and curvature of shape. 3. The shape using three-dimensional measurement system could be used in variety field.

• 디지털산업정보학회논문지
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• 제10권4호
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• pp.37-51
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• 2014

In this study, we propose a scheme for providing the consumer of Korea and China with more effective information about the safety of the food to understand easily. Among these countries and consumers, we proposed the graphical displays to help you understand the factors disturbing to think of pesticide residues in common. In the form of a one-dimensional graphical display, whether to provide a safety-related information in the form of conventional foods character, as compared to the graph representation of the larger amounts of information than a two-dimensional character which easily measures the effect of promoting the understanding of the most appropriate information, were reviewed. As a result, in the case of Korea, text and graphs utilizing the standards of pesticide residues than the information provided in a one-dimensional form'Text + Graphics Display'to take advantage of the information provided with the relevant safety standards form the three was found that easy to show. On the other hand, Chinese, between the character and graph form with the advantage that the information providing service type information using the graphic display shown in one dimension could not see the difference between the evaluation and understanding.

• 말소리와 음성과학
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• 제1권4호
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• pp.47-59
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• 2009

The purpose of this paper is to propose an automatic evaluation technique for the prosodic aspect of an English sentence uttered by Korean speakers learning English. The underlying hypothesis is that the consistency of the manual prosody scoring is reflected in an imaginary space of prosody evaluation model constructed out of the three physical properties of the prosody considered in this paper, namely: the fundamental frequency (F0) contour, the intensity contour, and the segmental durations. The evaluation proceeds first by building a prosody evaluation model for the sentence. For the creation of the model, utterances from native speakers of English and Korean learners for the target sentence are manually scored by either native teachers of English or Korean phoneticians in terms of their prosody. Multiple native utterances from the manual scoring are selected as the "model" native utterances against which all the other Korean learners' utterances as well as the model utterances themselves can be semi-automatically evaluated by comparison in terms of the three prosodic aspects [7]. Each learner utterance, when compared to the multiple model native utterances, produces multiple coordinates in a three-dimensional space of prosody evaluation, each axis of which corresponds to the three prosodic aspects. The 3D coordinates from all the comparisons form a prosody evaluation model for the particular sentence and the associated manual scores can display regions of particular scores. The model can then be used as a predictive model against which other Korean utterances of the target sentence can be evaluated. The model from a Korean phonetician appears to support the hypothesis.