• 제목/요약/키워드: evaluation analysis

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LC-QTOF-MS를 이용한 발기부전치료제 유사물질의 fragmentation pathway 분석 (Identification and evaluation of fragmentation pathways of PDE-5 inhibitor analogues using LC-QTOF-MS)

  • 도정아;노은영;윤순병;박형준;조수열;박성관;윤창용
    • 분석과학
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    • 제28권4호
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    • pp.278-287
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    • 2015
  • Phosphodiesterase type 5 inhibitors (PDE-5 inhibitors) are used in the treatment of erectile dysfunction. In recent years, a number of reports have been conducted on dietary supplements contaminated with PDE-5 analogues. In this study, 58 analogues of PDE-5 inhibitors were sorted into five groups: tadalafil, sildenafil, hongdenafil, vardenafil, and other analogues. These analogues were then evaluated using a liquid chromatography-quadrupole-time of flight mass spectrometry (LC-QTOF-MS) electrospray ionization mass method. Each compound has a unique fragmentation ion, which can be easily analyzed qualitatively. The fragmentation pathways of the analogues were elucidated based on the QTOF-MS and MS/MS data. Common ions were confirmed for each group by analyzing the structural characteristics and fragmentation pathways. Specifically, common ions were observed at m/z 169.08 and 135.04 (tadalafil analogues), m/z 311.15 and 283.12 (sildenafil analogues and hongdenafil analogues), and m/z 312.16 and 151.09 (vardenafil analogues). The advantage of this method is that the structure of unknown components can be determined by interpreting the product ions. Hence, the developed method can be used for the identification of unknown compounds. Fragmentation pathways may also aid in the detection and identification of PDE-5 inhibitor analogues.

정부출연연구기관 기관평가시스템 유효성 분석 모형: 유효성 분석을 위한 새로운 접근방법 (A New Model for Effectiveness Analysis of Government- supported R&D Institutes Evaluation System)

  • 이민형
    • 기술혁신연구
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    • 제13권3호
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    • pp.175-196
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    • 2005
  • This Paper examines analytic studies of the evaluation system used for evaluating government-supported R&D Institutes (GSRIs), and designs a new model for analyzing the evaluation system's effectiveness. The analytic models in existing studies use the meta evaluation and balanced scorecard (BSC) models. However, theses studies focused on the structure and elements of the evaluation system for examples, the appropriateness of the elements within the evaluation system and the balance of the evaluation index. Accordingly, the effectiveness of the GSRI evaluation system, that is, the evaluation's influence on GSRI performance improvement was not analyzed. This study uses the institution theory and contingency theory perspectives as related to government organization management to develop an analytical model of GSRI evaluation system effectiveness. The new model proposes an analytical approach for improving the effectiveness of the GSRI evaluation system in an institutionalized environment.

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제품에 대한 사용자의 가치의식에 따른 디자인 평가의 유형에 관한 연구 (A Study on User's Value Consciousness toward Products and Patterns of Design Evaluation)

  • 송창호;최명식
    • 디자인학연구
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    • 제19권5호
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    • pp.255-268
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    • 2006
  • 본 연구에서는 '제품에 대한 사용자의 심리적 가치의식이 디자인 평가에 어떠한 작용을 하는가'에 문제의식을 제기하여 14가지의 제품 샘플을 대상으로 평가를 실시하였다. 이에 따른 주요내용은 '제품평가의 단계별 사고', '제품에 대한 가치의식', '조형이미지 생성과 디자인 평가' 등 크게 3가지 영역을 주요 골자로 하여 분석을 실시하였다. 결론 도출을 위해 먼저 4개의 연구가설을 설정하였고, 이를 검증하기 위하여 '종결적 조사'의 일환으로 사례연구를 실시하였다. 표본은 데이터의 정확성을 높이기 위하여 제품디자인을 전공으로 하는 20대 대학생 120명을 대상으로 선정하였다. 수집된 데이터는 '단순집계'에 의하여 전체적인 흐름을 파악하였고, 이를 토대로 3개의 평가항목에 대한 구체적인 분석을 실시하였다. 분석방법은 '요인분석(factor analysis)', '클러스터분석(duster analysis)' 등 '다변량분석(multivariate analysis)'에 의한 '정량적 분석'에 중점을 두었다. 본 연구의 실증분석은 유의수준 p<.05에서 검증하였고, 통계처리는 'SPSSWIN 12.0' 프로그램을 사용하였다. 그 결과 '제품에 대한 사용자의 가치의식에 따른 디자인 평가의 유형'에 관해 4가지 결론을 얻었다.

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시스템 엔지니어링 프로세스를 적용한 사전/사후분석 방안 (A Scheme of the defence project analysis and evaluation using a systems engineering process)

  • 민성기;권용수;이임수
    • 시스템엔지니어링워크숍
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    • 통권1호
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    • pp.32-39
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    • 2003
  • This work describes a study of analysis and evaluation activities applied systems engineering approach. It is presented technique of derivation and management requirement. A scheme of the defence project analysis and evaluation using a systems engineering process is described.

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불확실성하에서 북태평양 미드웨이 시험어장의 경제성 평가 : 다랑어연승 어장을 중심으로 (The Economic Evaluation of Experimental Fishing Grounds in the North Pacific Midway Ocean Under Uncertainty : Focusing on Tuna Longline Fishing Grounds)

  • 문성주;진상대;안영수;김영승;황선재
    • 수산경영론집
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    • 제40권1호
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    • pp.153-172
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    • 2009
  • Developing foreign fishing ground executed in various uncertainty such as fishing price, oil price, exchange rate. But traditional economic evaluation method, CVP(Cost-Volume-Profit) analysis doesn't consider uncertainty of foreign fishing ground. So we need new approach about economic evaluation that can take into account uncertainty. This study focus on the economic evaluation about experimental survey of tuna fishing grounds in the north pacific ocean by sensitive analysis and simulation. The results of the economic evaluation can be summarized as follows. First, when we take it for granted that the other uncertainty factors except for each fishing price, oil price, and exchange rate are constant. CVP gross sales has positive relation to the increasing rate of oil price, exchange rate(W/$) and negative relation to the increasing rate of fishing price and exchange rate(W/${\yen}$). Second, when we are supposing that fishing price, oil price, and exchange rate are followed. the probability of less than CVP gross sales is A ship(48.87%), B ship(49.64%), C ship(50.55%). Consequently, the economic evaluation by sensitive analysis and simulation is more useful tool than CVP(Cost-Volume-Profit) analysis under uncertainty.

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여자 중·고등학생의 개인주의-집단주의에 따른 교복태도와 교복선택기준 (Attitude toward Uniform and Evaluation Criteria toward Uniform according to Individualism-collectivism of Middle and High School Girls)

  • 박은희
    • 한국의상디자인학회지
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    • 제17권3호
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    • pp.45-60
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    • 2015
  • The purpose of this study is to classify individualism-collectivism into groups and analyze the difference of attitude toward uniform and evaluation criteria toward uniform. Questionnaires are being administered to 369 middle and high school girls in Deagu province. The Frequency, factor analysis, reliability analysis, cluster analysis, correlation analysis, ANOVA, Duncan-test, and t-test are used for data analysis. Individualism-collectivism factors are found to be other focus, individuality focus, competition consciousness, love of family, and self-esteem. Attitude toward uniform are categorized into fashion pursuit, symbol of role, conformity, color, and neatness. Evaluation criteria toward uniform is categorized into 7 factors: practicality, care, promotion, aesthetics, service, brand focus, and regulation focus. Individualism-collectivism are classify into three groups such as high individualism-collectivism, low individuality, and high individuality. Individualism-collectivism shows a significant correlation with the sub-variable attitude toward uniform and evaluation criteria toward uniform. The groups show a significant difference in the attitude toward uniform and evaluation criteria toward uniform. There is a significant difference among individualism-collectivism, attitude toward uniform, and evaluation criteria toward uniform by the middle and high school girls.

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AHP 기법을 활용한 소프트웨어 제안평가요인의 상대적 중요도에 관한 연구 : 발주자와 수주자 비교를 중심으로 (A Priority Analysis on Influential Factors for Software Bid Evaluation in Public Sectors based on Analytic Hierarchy Process(AHP))

  • 김홍진;조동혁;안태호
    • 한국IT서비스학회지
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    • 제16권1호
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    • pp.41-53
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    • 2017
  • Recently, due to the economic recession and increase of ITO (IT Outsourcing), bidding in software industry has been recognized as more competitive and the importance of software bid evaluation for corporate selection is being increased. This study aims to analyze and prioritize influential factors in the software bid evaluation criteria which is adopted as the main evaluation model of national software businesses by Ministry of Science. The priority was developed by AHP (Analytic Hierarchy Process) through pair-wise comparison. For the analysis, this study developed analysis model for AHP and conducted survey of experts who have work experience for more than 10 years in the IT industry. As the result of analysis, weighted factors in the evaluation criteria were deduced and differences of priority factors between purchaser and bidder were investigated. The analysis showed differences of view point in the bidding process. With these results, this study suggests how to write a proposal strategically and effectively in perspective of the purchaser. It is expected that priority factors will be adopted in strategic proposals in both bidder and purchaser. For purchaser, the priority will be adopted to select reliable bidder. So, we expect that the priority factors will be used to get more values for both bidder and purchaser in their business atmosphere.

반잠수식 시추선의 Shale Shaker Room 폭발 사고에 대한 위험도 기반 사고한계상태 평가 (Risk Based Accidental Limit State Evaluation on Explosion Accident at Shale Shaker Room of Semi-Submersible Drilling Rig)

  • 유승재;김한별;박진후;원선일;최병기
    • 대한조선학회 특별논문집
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    • 대한조선학회 2015년도 특별논문집
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    • pp.69-73
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    • 2015
  • An evaluation of the accidental limit state (ALS) for design of a semi-submersible drilling rig is one of the essential design requirements as well as ultimate limit state (ULS) and fatigue limit state (FLS). This paper describes the ALS evaluation on the explosion accident at shale shaker room of semi-submersible drilling rig. There are three steps for the ALS evaluation such as structural analysis at concept design, risk based safety design and structural analysis at detailed design. For the ALS evaluation at concept design, conceptual explosion overpressure from the Rule guided by the classification society was used in the structural analysis that was carried out using LS-DYNA. To set up the design accidental load (DAL), explosion analysis was carried out using FLACS taking safety barriers into consideration. Then, the structural analysis was carried out applying DAL for the ALS evaluation at detailed design. Through the ALS evaluation on the explosion at shale shaker room, the importance of the risk based safety design was described.

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e-Learning 만족도 평가 (Evaluation of e-Learning Satisfaction)

  • 이동후;황승국
    • 한국지능시스템학회:학술대회논문집
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    • 한국퍼지및지능시스템학회 2005년도 추계학술대회 학술발표 논문집 제15권 제2호
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    • pp.345-348
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    • 2005
  • In this paper, we suggested an evaluation model for satisfaction of e-Learning. This model was composed decision of evaluation criteria, analysis of consciousness structure for evaluation factors using the Fuzzy Structural Modeling method, decision of weights for evaluation factors considering intersectional dependence relations and evaluation of satisfaction of e-Learning. The case study of this model was done for comparative analysis between teachers and students of e-Learning in high school.

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