• 정보보호학회논문지
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• 제26권6호
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• pp.1551-1560
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• 2016

스마트 헬스케어 기술의 발전과 웨어러블 디바이스의 증가로 인해 최근 WBN을 활용한 원격지 건강정보 모니터링 시스템이 제시되고 있다. 그러나 네트워크를 통해 전송되는 환자 개인의 건강기록에 대한 보호가 필요하며, 허가되지 않은 정보의 수집으로 인한 환자의 개인 식별정보나 건강기록이 노출되지 않도록 환자의 프라이버시도 반드시 보호되어야 한다. 이를 위해 Yang 등은 암호기술의 키 격리 기법을 적용한 원격 건강정보 모니터링 시스템의 익명 인증기법을 제안하였다. 그러나 이들의 기법은 키 격리 기법을 잘못 구성하여 다른 사용자의 개인키 위조 가능성 문제를 가지고 있으며, 헬스케어 서비스 제공자에게 사용자의 식별정보가 그대로 노출되어 익명성을 보장하지 못한다. 이에 본 논문은 Yang 등의 기법의 보안상의 문제점을 지적하고, 이를 개선한 건강정보 모니터링 시스템의 익명인증 기법을 제안한다.

• Tuberculosis and Respiratory Diseases
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• 제50권2호
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• pp.182-195
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• 2001

연구배경 : IPF에 의한 유병률과 사망률은 점차 증가하는 추세이나 좋은 치료는 없는 상태이다. 폐 섬유화 과정에서 TGF-${\beta}_1$, TNF-$\alpha$, ET-1, IFN-$\gamma$등의 사이토카인이 중요한 역할을 함이 알려져 있다. 본 실험은 파라콰트를 기관지 내로 주입하여 섬유화가 유발되는 과정의 백서의 폐 조직 내에서 ET-1과 TGF-${\beta}_1$의 발현을 살펴보고, 또한 비선택적 ET-1 receptor blocker인 Bosentan이 폐 섬유화의 치료에 효과가 있는지를 보고자 하였다. 방 법 : 웅성 7-8 주령의 백서 120 마리를 세 그룹으로 나누고 제 1그룹은 대조군으로 하여 기관지 내로 생리 식염수를 투여하였고, 제2그룹은 파라콰트를 투여하였으며, 제3그룹은 첫날 파라콰트를 투여한 후 매일 gastric gavage 방법으로 보센탄을 투여하였다. 파라콰트 혹은 생리식염수를 투여한 지 1, 3, 5, 7, 10, 14일째 각각 세 그룹의 일정 수를 희생하여 폐의 병리조직을 보고 면역세포화학염색으로 ET-1과 TGF-${\beta}_1$의 발현 율을 조사하여 분석하였다. 폐 섬유화의 정도는 H&E 염색과 Masson trichrome 염색을 하여 컴퓨터 영상분석을 시행하였고, 면역세포화학염색은 염색정도에 따라 반정량화하여 분석하였다. 결 과 : 파라콰트를 투여한 군이 대조군에 비해 콜라겐의 침착이 실험 3일째부터 현저히 증가하였고, ET-1과 TGF-${\beta}_1$의 발현이 주로 실험 초기에 증가하였다. 그러나 보센탄을 투여한 경우 콜라겐이 침착된 양에는 유의한 변화가 없었고 파라콰트군과 비교해서 ET-1과 TGF-${\beta}_1$의 발현에 뚜렷한 변화는 없었다. 결 론: 파라콰트를 투여한 경우 폐 섬유화가 증가하였다. 그리고 ET-1과 TGF-${\beta}_1$의 발현이 증가하였다. 그러나 ET-1 에 대한 receptor blocker인 보센탄이 폐 섬유화를 막지는 못하였다. 파라콰트에 의한 폐 섬유화에 ET-1이 연관성이 있으나 그 역할에 대해서는 추후 더 연구가 필요할 것으로 사료된다.

• 대한두경부종양학회지
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• 제15권2호
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• pp.217-221
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• 1999

Background and Objectives: Subacute necrotizing lymphadenitis or Kikuchi's disease has now become recognized in many parts of the world as a well-defined clinicopathologic entity. It typically affects cervical lymph nodes of young women, and subsides spontaneously within a few months without recurrences. The purpose of this study is to report the clinicopathologic finding, radiologic finding and many laboratory tests to elaborate the criteria that are useful in distinguishing this entity from inflammatory disease, granulomatous disease, lymphoma, malignant disease. Material and Methods: Authors evaluated 22 patients, who were diagnosed as subacute necrotizing lymphadenitis on excisional biopsy or fine needle aspiration cytology with retrospective chart review. Results: The patient population consisted of 21 women and 1 men. The mean age was 25 years old(range 17 to 42 years). All patient had palpable neck mass and associated fever, headache, weight loss, otalgia, diarrhea, night sweating. and associated disorder is dermatitis, hepatitis B, SLE, Hashimoto's thyroiditis, albinism et al. The multiple bilateral involvement of cervical lymph node was 20 cases(91%) and multiple unilateral 18 cases(82%), multiple bilateral 2 cases(9%). Solitary involvement was 2 cases(9%), mean size of involved lymph node was 2.0cm. In laboratory tests, leukopenia 17 cases(72%), elevated ESR 12 cases(54%), elevated GOT, GPT 3 cases(13%). In CT finding, lymph nodes enhanced in homogeneous fashion, and there was no evidence of central necrosis. Conclusion: Subacute necrotizing lymphadenitis, Kikuchi's disease may be easily confused clinically, pathologically, radiologically with malignant lymphoma, inflammatory disease, granulomatous disease. We should consider open biopsy of lymph node in the patient which had unilateral multiple cervical lymph node and in laboratory tests, were leukopenia, elevated ESR, especially in young women. otherwise, result of fine needle aspiration biopsy is nonspecific, excisional biopsy is recommended in order to differentiate other disease.

• 성인간호학회지
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• 제12권3호
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• pp.477-489
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• 2000

The purpose of study was to assess how hospital nurses practice their health promoting lifestyle and to identify affecting factors. The subjects were 286 nurses working at three general hospitals in Kwang-ju. The data were collected by questionnaire from September 1st. to September 10th, 1999. The instruments for this study were the Health Promoting Lifestyle Profile developed by Walker et al., perceived health status scale developed by Ware et al., self-efficacy scale developed by Sherer et al., and social support scale developed by Cohen et al.. The data were analyzed with mean, standard deviation, t-test, ANOVA, Pearson's Correlation Coefficient and Stepwise Multiple Regression. The results of this study were as follows: 1. The mean score of health promoting lifestyle was 2.36. Interpersonal support showed the highest score(2.67) and health responsibility (1.92) showed the lowest score. The mean score of perceived health status was 3.07, self-efficacy was 2.62, and social support was 2.91. 2. The relationship between general characteristics of subjects and health promoting lifestyle showed significant differences according to duty cycle(t=4.15, p=.042), disease experience (t=5.18, p=.023), monthly income(F=3.13, p=.025), exercise frequency(F=9.12, p=.000), stress reliefe method(F=5.98, p=.000), job satisfaction(t=11.44, p=.000), and perceived fatigue(F=6.13, p=.002). 3. Health promoting lifestyle showed significant positive correlations with perceived health status (r=.2190, p=.0002), self-efficacy (r=.5137, p=.0001) and social support (r=.5181, p=.0001). 4. The combination of social support(27.1%), exercise frequency(10.4%), self-efficacy(8.8%), job satisfaction, perceived health status, perceived fatigue and explained 53.5% of the variance of health promoting lifestyle. Therefore, this study suggests that a replicate study is needed until more affecting factors other than health promoting lifestyle.

• Journal of Oral Medicine and Pain
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• 제8권1호
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• pp.69-76
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• 1983

Background variables in 203 patients with TMJ pain dysfunction showing no bony change, ranging from 11 to 76 of age, were studied by use of the modified form of self-administered questionnaires deviced by Carlsson et al intended to give a review of the patient's history. All the patients were identified in the Dept. of Oral Diagnosis and Oral Diagnosis and Oral Medicine, Seoul National University Hospital, during the period from Feb. 1983 to Nov. 1983. The questions concerning general somatic and psychic health, educational and social condition were dealt with in this article. The obtained results were as follows : 1. The main symptoms reported by 203 patients were difficulties in opening the mouth wide(74.4%), clicking of TMJ(70.9%), chewing difficulties(69.0%), and pain on movement of mandible(57.6%) 2. The most fequently reported medical symptoms or histories were stomach disease (21.2%), insominia(15.3%), ENT disease(13.8%) and skin disease (12.8%) 3. Seventy-eight percent of the patients denied having had a nervous or psychic disorders while 4% were currently under treatment for such disorders. 4. Eleven percent of 203 patients with TMJ dysfunction thought their family situation was distressing(8.4%) or very troublesome(3.4%).

• 종양간호연구
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• 제2권1호
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• pp.5-16
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• 2002

Purpose: This study was to develop a stress-adaptation model for family caregivers of cancer patients that could provide the basis of planning nursing intervention. Method: A hypothetical model was developed using the family adaptation model proposed by Haley et al. (1987). In the literature, the stressor was identified as patient's characteristics, caregiver's characteristics, duration of illness, and family life events. It affected stress appraisal, family resources, family coping and finally caregiver's adaptation. In this model, 18 paths were constructed. Data were collected from 241 caregivers, whose family members were in treatment between June and August 2000, at 3 university hospitals and were analyzed by SPSS and LISREL programs. Results: 1) The overall fitness indices of the hypothetical model were x 2=267.78 (P= .0), GFI= .92, AGFI= .87, NFI= .93, NNFI= .93, PNFI= .64, PGFI= .55, and RMR= .43. Ten of the eighteen paths proved to be significant. 2) To improve the model fitness, the hypothetical model was modified considering modification indices and the paths proved not significant. Final model excluded 3 paths demonstrated to be improved by x2=161.96 (P= .00), GFI= .95, AGFI= .91, NFI= .96, NNFI= .96, and RMR= .23. Twelve of fifteen paths proved to be significant. 3) Stress appraisal was influenced by disease related characteristics and duration of illness and was explained 22% of the variance. Family resources were influenced by stress appraisal and was explained 57% of variance. Family coping was influenced by disease related characteristics, caregiver's characteristics, duration of illness, family life event, and stress appraisal and was explained 57% of variance. Family caregiver adaptation was influenced by disease related characteristics, caregiver's characteristics, stress appraisal, and family coping and was explained 31% of variance. Twelve of fifteen paths were significant. Conclusion: Based on this study, to help family caregivers to adapt, individual intervention is necessary with consideration of disease related and caregiver's characteristics and duration of illness. The intervention should include efforts to raise the family resources and to identify positively the stress they encounter, and there is a need to establish an adaptation model that considers emotional aspects of family caregivers. Since there is a difference in emotional status depending on the disease stage, a study needs to be done to analyze the differences among the disease stages (diagnosis, treatment, recurrence, and terminal stages).

• 보건교육건강증진학회지
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• 제35권5호
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• pp.69-78
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• 2018

Objectives: This study is aimed to analyze service user's benefit and perceived-outcomes of visiting healthcare. Methods: Using a questionnaire survey we analyzed the subjective service quality and satisfaction of survey respondents. The sampling was designed with socioeconomic characteristics(age, sex, user group et al.), and each respondent (N=1,000) was presented with double-bounded dichotomous choice questions. To measure the value of visiting healthcare, we employed a contingent valuation method. Results: The respondents were satisfied with service and quality on visiting healthcare. And the acceptance-to-pay of respondent's benefit was 50,458 won for each visit and in totality, service user's benefit was 185.9 billion won. Conclusions: It is necessary to invest in visiting healthcare in public health centers.

• 생약학회지
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• 제41권3호
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• pp.190-195
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• 2010

Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as Parkinson's disease, Alzheimer's disease, epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. NNMBS098, a composition comprising the water insoluble of the 70% EtOH extract of Zingiberis Rhizoma, showed the potent neuroprotective effects on glutamateinduced neurotoxicity by induced the expression of heme oxygenase (HO)-1 and increased HO activity in the mouse hippocampal HT22 cells. Furthermore, NNMBS098 caused the nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2) in mouse hippocampal HT22 cells. In addition, we found that treatment with c-Jun N-terminal kinase (JNK) inhibitor (SP600125) reduced NNMBS098-induced HO-1 expression and NNMBS098 also increased JNK phosphorylation. Therefore, these results suggest that NNMBS098 increases cellular resistance to glutamate-induced oxidative injury in mouse hippocampal HT22 cells, presumably through JNK pathway-Nrf2-dependent HO-1 expression.

• 한국균학회지
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• 제23권3호통권74호
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• pp.257-265
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• 1995

잔디의 마름병을 일으키는 Rhizoctonia spp.의 형태적 특징과 병원성을 조사하였다. R. cerealis Van der Hoeven, R. oryzae Ryker et Gooch 및 R. solani $K{\ddot{u}hn}$이 형태 및 배양적 특성에 따라 동정되었다. R. solani의 균주들은 균사융합군 및 배양형이 1(1A), 2-2(IIIB) 및 2-2(IV)로 나누어졌다. R. cerealis, R. oryzae 및 R. solani는 bentgrass와 한국들잔디에 잎집썩음과 잎마름증상을 나타냈다. 접종실험결과 R. cerealis와 R. oryzae 균주들은 한국들잔디보다는 bentgrass에서 병을 심하게 유발시켰다. R. solani AG 1(1A) 균주들은 bentgrass에 대해서 강한 병원성을 나타냈으나 한국들잔디에는 병원성이 중정도이였고 AG 2-2(IIIB) 균주들의 병원성은 들잔디에 중정도, bentgrass에는 약하였다. 들잔디에서 분리한 AG 2-2(IV)는 들잔디에는 중정도, bentgrass에는 약한 병원성을 나타냈다.

• 농약과학회지
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• 제16권3호
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• pp.209-216
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• 2012

계혈등으로부터 6종의 항균활성물질을 분리 정제하여 화학구조를 결정하였다. 계혈등 시료를 음건하여 80% aq. MeOH로 추출하고 감압 농축한 후 n-hexane, EtOAc, n-BuOH, 그리고 $H_2O$ 층으로 분획하였다. 각 분획을 이용하여 벼 도열별, 벼 잎집무늬마름병, 토마토 잿빛곰팡이병, 토마토 역병, 밀 붉은녹병, 보리 흰가루병 등 6가지 식물병에 대하여 식물병 방제효과를 검정한 결과, EtOAc 층이 가장 강한 활성을 보였으며, 벼 도열병, 토마토 잿빛 곰팡이병, 토마토 역병 및 보리 흰가루병에 대하여 80% 이상의 활성을 보였다. EtOAc층을 대상으로 silica gel chromatography 및 preparative TLC, HPLC 등을 이용하여 6종의 화합물을 분리, 정제하고 $^1H$-NMR, $^{13}C$-NMR, ESI-MS/MS, HMQC, $^1H-^1H$ COSY의 기기분석을 통해 ethanone, hydroxytyrosol, epicatechin, procyanidin B-2, dimethoxy daizein과 formononetin 으로 구조를 동정하였다. Epicatechin을 제외한 나머지 화합물들은 계혈등에서 처음으로 분리되었다. 분리한 물질들의 in vitro 및 in vivo 항균활성에 대한 연구를 진행하고 있다.