• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.113-114
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• 2013

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging is a powerful technique for producing chemical images of small biomolecules (ex. metabolites, lipids, peptides) "as received" because of its high molecular specificity, high surface sensitivity, and submicron spatial resolution. In addition, matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) imaging is an essential technique for producing chemical images of large biomolecules (ex. genes and proteins). For this talk, we will show that label-free mass imaging technique can be a platform technology for biomedical studies such as early detection/diagnostics, accurate histologic diagnosis, prediction of clinical outcome, stem cell therapy, biosensors, nanomedicine and drug screening [1-7].

• Journal of Educational Research in Mathematics
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• v.10 no.1
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• pp.73-84
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• 2000

This study, after careful consideration on Piaget's structuralism, showed the relationship between Bourbaki's matrix structure of mathematics and Piaget's structure of mathematical thinking. This, studying the basic characters that structure of knowledge should have, pointed out that 'transformation' and to it, too. Also it revealed that group structure is a 'development' are essential typical one which has very important characters not only of mathematical structure but also general structure, and discussed the problem that learners construct the group structure as a mathematical concept.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.482-482
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• 2000

The essential requirements of neural network for human skill transfer are fast convergence, high storage capacity, and strong noise immunity. Bidirectional associative memory(BAM) suffering from low storage capacity and abundance of spurious memories is rarely used for skill transfer application though it has fast and wide association characteristics for visual data. This paper suggests generalization of classical BAM structure and new learning algorithm which uses supervised learning to guarantee perfect recall starting with correlation matrix. The generalization is validated to accelerate convergence speed, to increase storage capacity, to lessen spurious memories, to enhance noise immunity, and to enable multiple association using simulation work.

• Journal of Korea Spatial Information System Society
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• v.11 no.1
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• pp.105-114
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• 2009

Recently, location-based services which provides k nearest POIs, e.g., gas stations, restaurants and banks, are essential such applications as telematics, ITS(Intelligent Transport Systems) and kiosk. For this, the Voronoi Diagram k-NN(Nearest Neighbor) search algorithm has been proposed. It retrieves k-NNs by using a file storing pre-computed network distances of POIs in Voronoi diagram. However, this algorithm causes the cost problem when expanding a Voronoi diagram. Therefore, in this paper, we propose an algorithm which generates a matrix of the shortest distance between border points of a Voronoi diagram. The shortest distance is measured each border point to all of the rest border points of a Voronoi Diagram. To retrieve desired k nearest POIs, we also propose a k-NN search algorithm using the matrix of the shortest distance. The proposed algorithms can m inim ize the cost of expanding the Voronoi diagram by accessing the pre-computed matrix of the shortest distances between border points. In addition, we show that the proposed algorithm has better performance in terms of retrieval time, compared with existing works.

• Journal of Nutrition and Health
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• v.51 no.5
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• pp.379-385
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• 2018

Purpose: Zinc (Zn) is an essential trace element for bone mineralization and osteoblast function. We examined the effects of Zn deficiency on osteoblast differentiation and mineralization in MC3T3-E1 cells. Methods: Osteoblastic MC3T3-E1 cells were cultured at concentration of 1 to $15{\mu}M$ $ZnCl_2$ (Zn- or Zn+) for 5, 15 and 25 days up to the calcification period. Extracellular matrix mineralization was detected by staining Ca and P deposits using Alizarin Red and von Kossa stain respectively, and alkaline phosphatase (ALP) activity was detected by ALP staining and colorimetric method. Results: Extracellular matrix mineralization was decreased in Zn deficiency over 5, 15, and 25 days. Similarly, staining of ALP activity as the sign of an osteoblast differentiation, was also decreased by Zn deficiency over the same period. Interestingly, the gene expression of bone-related markers (ALP, PTHR; parathyroid hormone receptor, OPN; osteopontin, OC; osteocalcin and COLI; collagen type I), and bone-specific transcription factor Runx2 were downregulated by Zn deficiency for 5 or 15 days, however, this was restored at 25 days. Conclusion: Our data suggests that Zn deficiency inhibits osteoblast differentiation by retarding bone marker gene expression and also inhibits bone mineralization by decreasing Ca/P deposition as well as ALP activity.

• Journal of Embryo Transfer
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• v.26 no.4
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• pp.287-296
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• 2011

Mammalian fertilization is a complex cascade process consisting of sperm migration through the female reproductive tract, physiological changes to sperm such as sperm capacitation and acrosome reaction, and sperm-egg interaction in the oviduct in vivo. On the other hand, in vitro fertilization (IVF) is a process by which egg cells are fertilized by sperm outside the body: in vitro. IVF has been used for a variety of purposes in reproductive biotechnology for human and animals. The discovery of sperm capacitation in 1951 promoted the development of IVF technology. In the initial stage of IVF, sperm capacitation in preincubation medium was shown to be essential to fuse with eggs. Besides, sperms should detour some of the in vivo regulations for IVF. This review introduces a general mammalian fertilization process, including sperm capacitation, removal of cumulus matrix, acrosome reaction, and sperm-egg fusion and focuses on the roles of key biochemical molecules, signal mechanisms, and genes involved during IVF and novel results of sperm-oocyte interaction elucidated in various gene-knockout mice models.

• Korean Institute of Interior Design Journal
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• v.14 no.5 s.52
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• pp.133-140
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• 2005

Jacques Derrida, a leading theorist of the post-structuralism, has explicated how the material reality is subordinated to the ideality of form, by noticing the platonic concept, 'chora', which implicates the spatiality as the matrix and also by actualizing its essential meaning as the femininity. On the basis of the idea of the platonic 'chora', the Derridian deconstructive spatiality and its feminist oriented enlargement of Grosz this study is purposed to elucidate the architectural idea of Zaha Hadid that is located in the similar horizon with the deconstructionism. On the one hand it is focused on the explication of the new concept of space, which is dealt with the deconstruction of the traditional concept of space, on the other on the inference of the feminity of the originally understood spatiality. With this inference it is finally intended to reexamine the foundation of the discussion for the architectural space that must be ahead of the discussion for the difference between the masculine and the feminine space. If it is fundamentally and manifoldly executed, not only the architectural paradigm will enter into an renewed phase, but also the various ways toward the new direction of the architecture be explored.

• Proceedings of the KIEE Conference
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• 2007.11c
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• pp.183-186
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• 2007

Realistic deformation of computer simulated anatomical structures is computationally intensive. As a result, simple methodologies not based in continuum mechanics have been employed for achieving real time deformation of virtual reality. Since the graphical interpolations and simple spring models commonly used in these simulations are not based on the biomechanical properties of tissue structures, these "quick and dirty"methods typically do not accurately represent the complex deformations and force-feedback interactions that can take place during surgery. Finite Element(FE) analysis is widely regarded as the most appropriate alternative to these methods. However, because of the highly computational nature of the FE method, its direct application to real time force feedback and visualization of tissue deformation has not been practical for most simulations. If the mathematics are optimized through pre-processing to yield only the information essential to the simulation task run-time computation requirements can be drastically reduced. To apply the FEM, We examined a various in verse matrix method and a deformed material model is produced and then the graphic deformation with this model is able to force. As our simulation program is reduced by the real-time calculation and simplification because the purpose of this system is to transact in the real time.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2000.10a
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• pp.55-61
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• 2000

Tungsten heavy metal is characterized bi a high density and novel combination of strength and ductility. Among them, 90W-7Ni-3Fe is used for applications, where the high specific weight of the material plays an important role. They are used as counterweights, rotating inertia members, as well as for defense purposes(kinetic energy penetrators, etc.). Because of these applications, it is essential to detemine the dynamic characteristics of tungsten alloy. In this paper, Explicit FEM(finite element method) is employed to investigate the dynamic characteristics of tungsten heavy metal under base of stress wave propagation theory for SHPB, and the model of specimen is divided into two parts to understand the phenomenon that stress wave penetrates through each tungsten base and matrix. This simulation results were compared to experimental one and through this program the dynamic stress-strain curve of tungsten heavy metal can be obtained using quasi static stress-strain curve of pure tungsten and matrix.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.8 s.173
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• pp.92-99
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• 2005

Tungsten heavy metal is characterized by a high density and novel combination of strength and ductility. Among them, 90W-7Ni-3Fe is used for applications, where the high specific weight of the material plays an important role. They are used as counterweights, rotating inertia members, as well as fur defense purposes(kinetic energy Penetrators, etc.). Because of these applications, it is essential to detemine the dynamic characteristics of tungsten alloy. In this paper, Explicit FEM(finite element method) is employed to investigate the dynamic characteristics of tungsten heavy metal under base of stress wave propagation theory for SHPB, and the model of specimen is divided into two parts to understand the phenomenon that stress wave penetrates through each tungsten base and matrix. This simulation results were compared to experimental one and through this program, the dynamic stress-strain curve of tungsten heavy metal can be obtained using quasi static stress-strain curve of pure tungsten and matrix.