• 비파괴검사학회지
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• 제26권2호
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• pp.115-121
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• 2006

유한 요소 해석을 위해서는 형상과 경계, 하중 조건 그리고 물성을 결정하여야 한다. 그러나 살아 있는 인체에 대해서는 실험이 어렵기 때문에 정확한 형상과 물성을 얻기가 매우 어렵다. 본 논문에서는 한국인 표준체형을 가진 젊은 남성의 생체 자기 공명 영상(MRI : magnetic resonance imaging)을 이용하여 내부 장기를 38가지로 구역화 하고 이것을 이용하여 정밀 유한 요소 모델을 만들었다. 또한 인체를 이루고 있는 다양한 물질들 가운데 뼈에 대한 물성을 얻기 위한 연구를 시행하였다. 인체 뼈의 이방성을 표현할 수 있는 물성을 얻기 위해 성인 남성과 여성의 사체에서 얻은 대퇴골두 시편을 RUS(resonant ultrasound spectroscopy)를 사용하여 탄성 계수 행렬을 얻을 수 있었다.

• Geomechanics and Engineering
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• 제14권4호
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• pp.399-406
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• 2018

The influences of mineral content and porosity on ultrasonic wave velocity were assessed for ten hornfelsic rocks collected from southern and western parts of the city of Hamedan, western Iran. Selected rock samples were subjected to mineralogical, physical, and index laboratory tests. The tested rocks contain quartz, feldspar, biotite, muscovite, garnet, sillimanite, kyanite, staurolite, graphite and other fine grained cryptocrystalline matrix materials. The values of dry unit weight of the rocks were high, but the values of porosity and water absorption were low. In the rocks, the values of dry unit weight are related to the presence of dense minerals such as garnet so not affected by porosity. The statistical relationships between mineral content, porosity and ultrasonic wave velocity indicated that the porosity is the most important factor influencing ultrasonic wave velocity of the studied rocks. The values of P-wave velocity of the rocks range from moderate to very high. Empirical equations, relevant to different parameters of the rocks, were proposed to determine the rocks' essential characteristics such as primary and secondary wave velocities. Quality indexes (IQ) of the studied samples were determined based on P-wave velocities of them and their composing minerals and the samples were classified as non-fissured to moderately fissured rocks. Also, all tested samples are classified as slightly fissured rocks according to the ratio of S-wave to P-wave velocities.

• Bulletin of the Korean Chemical Society
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• 제30권8호
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• pp.1783-1792
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• 2009

Although overlapping resonances have been studied extensively in conventional resonance theories, there have not been many studies on them in multichannel quantum defect theories (MQDT). In MQDT, overlapping resonances occur between the channels instead of states, which pose far greater difficulty. Their systematic treatment was obtained for cases involving degenerate closed channels by applying our previous theory, which decouples background scattering from the resonance scattering in the MQDT formulation. The use of mathematical theory on con-diagonalization and con-similarity was essential for handling the non-Hermitian symmetric complex matrix. Overlapping resonances in rare gas spectra of Ar, Kr and Xe were analyzed using this theory and the results were compared with the ones of the previous alternative parameterizations of MQDT which make the open-open part $K^{oo}$ and closed-closed part $K^{cc}$ of reactance submatrices zero. The comparison revealed that separation of background and resonance scatterings achieved in our formulation in a systematic way was not achieved in the representation of $K^{oo}\;=\;0\;and\;K^{cc}$ = 0 when overlapping resonances are present.

• 대한토목학회논문집
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• 제7권2호
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• pp.121-130
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• 1987

본 연구에서는 다층탄성체에서 주파수에 제약없이 Rayleigh 파의 이론적 분산곡선을 결정할 수 있는 새로운 해석적 방법을 개발하였다. 이는 표면파기법에 있어 자연지반 및 포장구조의 성층구조와 동적물성을 정확히 추정하는 역산기법의 근간이 되는 것이다. 본 연구에서는 델타 매트릭스 기법을 활용하여 원래의 Thomson-Haskell 방법이 내포하고 있는 수치한계초과 및 유효수치소실로 인한 수치연산적 장애를 극복하였다. 원래의 Thomson-Haskell 방법을 토대로 한 종래의 역산기법들은 성층구조 및 주파수 크기의 제약으로 인하여 부정확한 결과를 초래하게 된다. 본 연구에서 개발한 방법은 자연지반은 물론, 특히 포장구조에 있어 보다 정확하고 효율적인 역산기법에 대한 연구에 토대가 될 것으로 판단된다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1998년도 제13차 학술회의논문집
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• pp.496-500
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• 1998

Not merely running at the designated constant speed as the classical cruise control, the adaptive cruise control (ACC) maintains safe headway distance when the front is blocked by other vehicles. One of the most essential part of ACC System is the range sensor which can measure the position and speed of all objects in front continuously, ignore all irrelevant objects, distinguish vehicles in different lanes and lock on to the closest vehicle in the same lane. In this paper, the hierarchical object recognition algorithm (HORA) is proposed to process raw scanning laser data and acquire valid distance to target vehicle. HORA contains two principal concepts. First, the concept of life quantifies the reliability of range data to filter off the spurious detection and preserve the missing target position. Second, the concept of conformation checks the mobility of each obstacle and tracks the position shift. To estimate and predict the vehicle position Kalman filter is used. Repeatedly updated covariance matrix determines the bound of valid data. The algorithm is emulated on computer and tested on-line with our ACC vehicle.

• 제어로봇시스템학회논문지
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• 제12권9호
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• pp.935-944
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• 2006

EMG pattern recognition is essential for the control of a multifunction myoelectric hand. The main goal of this study is to develop an efficient feature projection method for EMC pattern recognition. To this end, we propose a linear supervised feature projection that utilizes linear discriminant analysis (LDA). We first perform wavelet packet transform (WPT) to extract the feature vector from four channel EMC signals. For dimensionality reduction and clustering of the WPT features, the LDA incorporates class information into the learning procedure, and finds a linear matrix to maximize the class separability for the projected features. Finally, the multilayer perceptron classifies the LDA-reduced features into nine hand motions. To evaluate the performance of LDA for the WPT features, we compare LDA with three other feature projection methods. From a visualization and quantitative comparison, we show that LDA has better performance for the class separability, and the LDA-projected features improve the classification accuracy with a short processing time. We implemented a real-time pattern recognition system for a multifunction myoelectric hand. In experiment, we show that the proposed method achieves 97.2% recognition accuracy, and that all processes, including the generation of control commands for myoelectric hand, are completed within 97 msec. These results confirm that our method is applicable to real-time EMG pattern recognition far myoelectric hand control.

• The Korean Journal of Physiology and Pharmacology
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• 제19권1호
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• pp.35-42
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• 2015

In cardiovascular disorders, understanding of endothelial cell (EC) function is essential to elucidate the disease mechanism. Although the mouse model has many advantages for in vivo and in vitro research, efficient procedures for the isolation and propagation of primary mouse EC have been problematic. We describe a high yield process for isolation and in vitro culture of primary EC from mouse arteries (aorta, braches of superior mesenteric artery, and cerebral arteries from the circle of Willis). Mouse arteries were carefully dissected without damage under a light microscope, and small pieces of the vessels were transferred on/in a Matrigel matrix enriched with endothelial growth supplement. Primary cells that proliferated in Matrigel were propagated in advanced DMEM with fetal calf serum or platelet-derived serum, EC growth supplement, and heparin. To improve the purity of the cell culture, we applied shearing stress and anti-fibroblast antibody. EC were characterized by a monolayer cobble stone appearance, positive staining with acetylated low density lipoprotein labeled with 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate, RT-PCR using primers for von-Willebrand factor, and determination of the protein level endothelial nitric oxide synthase. Our simple, efficient method would facilitate in vitro functional investigations of EC from mouse vessels.

• Journal of Microbiology
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• 제41권4호
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• pp.295-299
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• 2003

Adenovirus (Ad) precursor to the terminal protein (pTP) plays an essential roles in the viral DNA replication. Ad pTP serves as a primer for the synthesis of a new DNA strand during the initiation step of replication. In addition, Ad pTP forms organized spherical replication foci on the nuclear matrix (NM) and anchors the viral genome to the NM. Here we identified the interferon inducible gene product 1-8D (Inid) as a pTP binding protein by using a two-hybrid screen of a HeLa cDNA library. Of the clones obtained in this assay, nine were identical to the Inid, a 13-kDa polypeptide that shares homology with genes 1-8U and Leu-13/9-27, most of which have little known functions. The entire open reading frame (ORF) of Inid was cloned into the tetracycline inducible expression vector in order to determine the biological functions related with adenoviral infection. When Inid was introduced to the cells along with adenoviruses, fifty to sixty percent of Ad-infected cells expressing Inid had rounded morphology, which was suggestive of apoptosis. Results from the terminal deoxynucleotidyl transferase (TdT) and DNA fragmentation assays confirmed that Inid induces apoptosis in Ad-infected or in uninfected cells. The Inid binding to pTP may target the cell for apoptotic destruction as a host defense mechanism against the viral infection.

• Molecules and Cells
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• 제38권8호
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• pp.729-733
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• 2015

C. elegans has two functional peroxidasins (PXN), PXN-1 and PXN-2. PXN-2 is essential to consolidate the extracellular matrix during development and is suggested to interact with PXN-1 antagonistically. pxn-1 is involved in neuronal development and possibly maintenance; therefore, we investigated the relationship between pxn-1 and pxn-2 in neuronal development and in aging. During neuronal development, defects caused by pxn-1 overexpression were suppressed by overexpression of both pxn-1 and pxn-2. In neuronal aging process, pxn-1 mutants showed less age-related neuronal defects, such as neuronal outgrowth, neuronal wavy processes, and enhanced short-term memory performance. In addition, pxn-2 overexpressing animals retained an intact neuronal morphology when compared with age-matched controls. Consistent with these results, overexpression of both pxn-1 and pxn-2 restored the severe neuronal defects present with pxn-1 overexpression. These results implied that there is a negative relationship between pxn-1 and pxn-2 via pxn-1 regulating pxn-2. Therefore, pxn-1 may function in neuronal development and age-related neuronal maintenance through pxn-2.

• 한국산업융합학회 논문집
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• 제23권4_2호
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• pp.683-691
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• 2020

In the era of super-aged societies, research and development (R&D) projects related to aging are very important agenda for establishing the direction of future R&D planning and technological competitiveness in the country. In order to respond promptly to this agenda, it is essential to establish a national-level convergence R&D policy. In this study, we utilized the global R&D funding project data from major nations (US, Europe, Japan), and then standardized them with the same fields. To analyze the current status of global R&D related to aging, we performed cluster analysis based on the co-occurrence matrix to explore convergence R&D areas in the US, Europe, and Japan related to aging. In addition, comparative analysis by country suggested that different points on the interdisciplinary area and the convergence of aging-related R&D by each country. These results provide fundamental understandings for the status of convergence in aging-related global R&D, the current technology trends, and establish the direction and strategy of R&D policy.