• Title/Summary/Keyword: equilibrium test

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Polymorphisms of CDH9 and CDH10 in Chromosome 5p14 Associated with Autism in the Korean Population (한국인 자폐증과 Chromosome 5p14에 존재하는 CDH9, CDH10 유전자 다형성의 연관성 연구)

  • Lee, Ae-Ri;Park, Jung-Won;Nam, Min;Bang, Hee-Jung;Yang, Jae-Won;Choi, Kyung-Sik;Kim, Su-Kang;Chung, Joo-Ho;Kwack, Kyu-Bum
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.22 no.4
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    • pp.287-293
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    • 2011
  • Objectives : The region of chromosome 5p14 is known to be associated with autism spectrum disorder (ASD). The cadherin9 (CDH9) and cadherin10 (CDH10) genes are located in the region of chromosome 5p14 and reported to be associated with ASD in the Caucasian population. We performed an association study to identify if single nucleotide polymorphisms (SNPs) located on the CDH9 and CDH10 genes are associated in the Korean population. Methods : Genomic DNA was extracted from the blood of 214 patients with ASD and 258 controls. SNPs selected from two genes were genotyped using an Illumina Golden-Gate Genotyping assay with VeraCode technology. Statistical analysis was performed using SAS and Plink software. Results : All controls and ASD patients were in Hardy-Weinberg equilibrium. In the results of logistic regression analyses for the genotype model and the chi-square test for the allele model, we found that SNPs on the CDH9 and CDH10 genes were not associated with ASD. Conclusion : Our data suggests that the CDH9 and CDH10 genes are not associated with ASD in the Korean population.

Simulation of Rough Rice Drying by Natural Air(I) (자연공기(自然空氣)에 의한 벼건조(乾燥) 시뮤레이션(I))

  • Chang, D.I.;Chung, D.S.;Pfost, H.B.;Calderwood, D.L.
    • Korean Journal of Agricultural Science
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    • v.10 no.1
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    • pp.118-128
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    • 1983
  • Simulation model of natural air grain drying was discussed and modified to predict the changes of grain moisture content and dry matter loss of rough rice drying. The modified simulation model was then validated using actual test data. A series of simulated drying tests using official weather data for 15 years from Beaumont, Texas, was taken to make minimum airflow rate and maximum bed depth of rough rice drying by natural air, under different conditions of initial moisture content of rough rice, airflow rate and harvest date.

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Design Approach for Boundary Element of Flexure-Governed RC Slender Shear Walls Based on Displacement Ductility Ratio (휨 항복형 철근콘크리트 전단벽의 경계요소설계를 위한 변위연성비 모델제시)

  • Mun, Ju-Hyun;Yang, Keun-Hyeok
    • Journal of the Korea Concrete Institute
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    • v.26 no.6
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    • pp.687-694
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    • 2014
  • This study established a displacement ductility ratio model for ductile design for the boundary element of shear walls. To determine the curvature distribution along the member length and displacement at the free end of the member, the distributions of strains and internal forces along the shear wall section depth were idealized based on the Bernoulli's principle, strain compatibility condition, and equilibrium condition of forces. The confinement effect at the boundary element, provided by transverse reinforcement, was calculated using the stress-strain relationship of confined concrete proposed by Razvi and Saatcioglu. The curvatures corresponding to the initial yielding moment and 80% of the ultimate state after the peak strength were then conversed into displacement values based on the concept of equivalent hinge length. The derived displacement ductility ratio model was simplified by the regression approach using the comprehensive analytical data obtained from the parametric study. The proposed model is in good agreement with test results, indicating that the mean and standard deviation of the ratios between predictions and experiments are 1.05 and 0.19, respectively. Overall, the proposed model is expected to be available for determining the transverse reinforcement ratio at the boundary element for a targeted displacement ductility ratio.

Prediction of Tcv for Coal Slags under Reducing Condition (환원 조건에서 석탄 슬래그의 Tcv 예측)

  • Park, Yoonkyung;Oh, Myungsook
    • Korean Chemical Engineering Research
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    • v.44 no.6
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    • pp.623-630
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    • 2006
  • The slag viscosity is an important factor determining the operation temperature of entrained flow type of gasifiers. The temperature of critical viscosity, $T_{cv}$, for 5 crystalline slags was predicted by empirical models and FactSage equilibrium calculations, and the validity of each method was tested. Two empirical models were employed: one using $T_h$ from the ash fusion test, and the other using the concentrations of 5 major components. The first model using $T_h$ over-predicted $T_{cv}$ by $20{\sim}100^{\circ}C$, while the model based on the slag composition under-predicted $T_{cv}$ by $80{\sim}120^{\circ}C$. In the equlibrium calculations, $T_{cv}$ was obtained from the liquidus temperature. When the 4-major component concentrations were used in the calculation, the predicted temperatures were higher than the observed. The liquidus temperature was very sensitive to the concentrations of minor components, and the addition of MgO and $Na_2O$ lowered the liquidus temperature. The results with 4 major and 3 minor components most closely described experimentally observed $T_{cv}$. In the case that a chromia refractory was used, it was shown that $Cr_2O_3$ concentration in the slag also needs to be included for more accurate prediction of $T_{cv}$.

The Peeling Effect on the Natural Seasoning of Pitch Pine Log (리기다소나무 조재목(造材木)의 천연건조(天然乾燥)에 미치는 박피처리(剝皮處理)의 효과(効果))

  • Lee, Phil Woo
    • Journal of Korean Society of Forest Science
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    • v.6 no.1
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    • pp.37-42
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    • 1967
  • This experiment was carried out to study the peeling effect affecting to the natural seasoning by the treatments such as complete peeling, outer bark peeling (attached inner bark) and non peeling for the logs felled in summer and winter season in the stand of about 40 years old pitch pine, located in Kwangyang College Forest, Chollanam-do, Korea. According to the results this study may be concluded as followings. 1. Although the complete peeled logs are seasoned rapidly as compared with the outer barked and non peeled logs but they are more developed seasonal checking. 2. As to the drying effects of the logs felled in summer season, the difference between complete peeled and outer barked or non peeled logs are recognized. Whereas, the difference between outer barked and non peeled logs was not recognized. 3. As to the drying effects of the test logs felled in winter season the difference between complete peeled and outer barked logs were not shown, whereas, the difference between complete peeled or outer barked, and non peeled logs was significantly recognized. Accordingly it is considered that the drying effect of outer barked logs is same with those of complete peeled logs. 4. In this experiment it is expected that the complete peeled logs of summer season felling, and complete peeled or outer barked logs of winter season felling were attained equilibrium moisture contents within four months.

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Influence of Estimation of Hydraulic Conductivity Function on Rainfall Infiltration into Unsaturated Soil Slope (투수계수함수의 추정이 불포화 토사 사면의 강우 침투거동에 미치는 영향)

  • Cho, Sung-Eun
    • Journal of the Korean Geotechnical Society
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    • v.33 no.9
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    • pp.5-22
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    • 2017
  • The procedure that combines the result of infiltration analysis into stability analysis based on the limit equilibrium method is widely used to evaluate the impact of rainfall infiltration on slope stability. Accurate prediction of rainfall infiltration is essential to the prediction of landslides caused by rainfall, requires to obtain accurate unsaturated hydraulic properties of the soil. Among the unsaturated hydraulic characteristics of the soil, the importance of the soil-water characteristic curve describing the retained water characteristics of the soil is relatively well known and the measurement by test method to obtain the SWCC is gradually increasing. However, it takes a lot of time and expenses to experimentally measure the unsaturated conductivity characteristics of the soil. Therefore, it is common practice to estimate the hydraulic conductivity function from the SWCC. Although it is widely known that the SWCC has a great influence on rainfall infiltration, studies on the effect of the hydraulic conductivity function estimated from the SWCC on rainfall infiltration are very limited. In this study, we explained how the estimation model of the hydraulic conductivity function affects rainfall infiltration and slope stability analysis. To this end, one-dimensional infiltration analysis and slope stability analysis were conducted by using the data on the SWCC of weathered granite soil widely distributed in Korea. The applicability of each estimation model is discussed through review of the analysis results.

Estimating Stability Indices from the MODIS Infrared Measurements over the Korean Peninsula (MODIS 적외 자료를 이용한 한반도 지역의 대기 안정도 지수 산출)

  • Park, Sung-Hee;Chung, Eui-Seok;Koenig, Marianne;Sohn, B.J.
    • Korean Journal of Remote Sensing
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    • v.22 no.6
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    • pp.469-483
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    • 2006
  • An algorithm was developed to estimate stability indices (SI) over the Korean peninsula using Terra Moderate Resolution Imaging Spectroradiometer (MODIS) infrared brightness temperatures (TBs). The SI is defined as the stability of the atmosphere in the hydrostatic equilibrium with respect to the vertical displacements and is used as an index for the potential severe storm development. Using atmosphere temperature and moisture profiles from Regional Data Assimilation and Prediction System (RDAPS) as initial guess data for a nonlinear physical relaxation method, K index (KI), KO Index (KO), lifted index (LI), and maximum buoyancy (MB) were estimated. A fast radiative transfer model, RTTOV-7, is utilized for reducing the computational burden related to the physical relaxation method. The estimated TBs from the radiative transfer simulation are in good agreement with observed MODIS TBs. To test usefulness for the short-term forecast of severe storms, the algorithm is applied to the rapidly developed convective storms. Compared with the SIs from the RDAPS forecasts and NASA products, the MODIS SI obtained in this research predicts the instability better over the pre-convection areas. Thus, it is expected that the nowcasting and short-term forecast can be improved by utilizing the algorithms developed in this study.

Genetic Variation of Pinus densiflora Populations in South Korea Based on ESTP Markers (ESTP 표지를 이용한 국내 소나무 집단의 유전변이)

  • Ahn, Ji Young;Hong, Kyung Nak;Lee, Jei Wan;Hong, Yong Pyo;Kang, Hoduck
    • Korean Journal of Plant Resources
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    • v.28 no.2
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    • pp.279-289
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    • 2015
  • Genetic diversity and genetic differentiation of thirteen Pinus densiflora populations in South Korea were estimated using nine ESTP (Expressed Sequence Tag Polymorphism) markers. The numbers of allele and the effective allele were 2.2 and 1.8, respectively. The percentage of polymorphic loci (P) was 98.8%. The observed and the expected heterozygosity were 0.391 and 0.402, respectively, and the eleven populations except for Ahngang and Gangneung population were under Hardy-Weinberg equilibrium state. The level of genetic differentiation (Wright’s FST = 0.057) was higher than those of isozyme or nSSR markers. We could not find out any relationship between the genetic distance and geographic distribution among populations from cluster analysis. Also, the genetic differentiation between populations was not correlated with the geographic distance (r = 0.017 and P = 0.344 from Mantel test). From the result of FST-outlier analysis to identify a locus under selection, six loci were detected at confidence interval of 99% by the frequentist’s method. However, only three loci (sams2+AluⅠ, sams2+RsaⅠ, PtNCS_p14A9+HaeⅢ) were presumed as outliers by Bayesian method. The sams2+AluⅠ and sams2+RsaⅠlocus were originated from the sams2 gene and seemed to be the loci under balancing selection.

An Analysis of the Absolute Vs. Conditional Convergency Hypothesis and the Determinants of Labor Productivity in Manufacturing Industries: The Korean Case (16개 광역시도별 제조업 부문에 대한 절대적 및 조건부 수렴가설 검증 및 생산성 결정요인 분석)

  • Park, Chuhwan;Shin, Kwang Ha
    • International Area Studies Review
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    • v.17 no.4
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    • pp.89-106
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    • 2013
  • In this paper, we analysed the absolute and conditional convergency hypothesis and the determinants of productivity in manufacturing industries from 2000 to 2009 with 16 provinces and metro-cities by using panel analysis. In terms of convergency hypothesis test, the results show that both of the convergency hypothesis, the absolute vs. conditional hypothesis, reject the null hypothesis(H0) implying the labor productivity of the 16 province and metro-cities converged to the steady state equilibrium. Also, the speed of the absolute and conditional convergency for the 16 province and metro-cities are average 4.4% and 0.73% respectively. In addition, the results of the determinants of the labor productivity in manufacturing industry show that human capital and manufacturing location coefficient affect to the value- added per capita significantly, but government expenditure per capita doesn't affect to the value- added per capita. As for the total factor productivity, government expenditure per capita and fixed capital per capita are important factors, but research and development doesn't. Hence the government has to revise the balanced regional development policy to develop regional manufacturing industries for the vulnerable regions. Also, it requires more study regarding income disparities and productivity.

Association analysis of polymorphisms of G protein-coupled receptor 54 gene exons with reproductive traits in Jiaxing Black sows

  • Wu, Fen;Zhang, Wei;Song, Qian-Qian;Li, Hai-Hong;Xu, Ming-Shu;Liu, Guo-Liang;Zhang, Jin-Zhi
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.8
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    • pp.1104-1111
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    • 2019
  • Objective: The aim of this study was to detect single nucleotide polymorphisms (SNP) of G protein-coupled receptor 54 (GPR54) gene and explore association of this candidate gene with reproductive traits in Jiaxing Black sows. Methods: Six pairs of primers of the gene were designed to amplify all exons thus sequences of which were detected by means of direct sequencing and then SNP loci were scanned. The effects of SNPs on total number of piglets born (TNB), number of piglets born alive (NBA), number of still born piglets (NSB), and litter weight at birth (LWB) of Jiaxing Black sows were analyzed. Results: Three SNP loci, including T3739C, C3878T and T6789C, were identified via comparison of sequencing and two genotypes (AB, BB) at each SNP site were observed. T3739C resulted in the change of amino acid ($Leu{\rightarrow}Pro$) in corresponding protein, and C3878T resulted in synonymous mutation ($Ile{\rightarrow}Ile$). Statistical results demonstrated that allele B was the preponderant allele at the three SNP loci and Genotype BB was the preponderant genotype. Meanwhile, Chi-Square test of these three SNPs indicated that all mutation sites fitted in Hardy-Weinberg equilibrium (p>0.05). For GPR54-T3739C locus, Jiaxing Black sows with genotype BB had 1.23 TNB and 1.28 NBA (p<0.01) that were more than those with genotype AB, respectively. Jiaxing Black sows that had the first two parities with genotype BB had additional 2.23 TNB, 2.27 NBA (p<0.01), and 1.94 LWB (p<0.05) compared to those with genotype AB, respectively. However, for other two loci, no significant difference was found between TNB, NBA, NSB, and LWB, and different genotypes of Jiaxing Black sows. Conclusion: In conclusion, the polymorphisms of GPR54-T3739C locus were significantly associated to TNB, NBA, and LWB and could be used as a potential genetic marker to improve reproductive function of Jiaxing black sows.