• The Journal of Bigdata
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• v.5 no.2
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• pp.187-199
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• 2020

The World Health Organization declared COVID-19 a pandemic on March 11. South Korea recorded 27,000 cases of the coronavirus illness, and more than 50 million coronavirus cases were confirmed all over the world. An epidemiological investigation becomes important once again due to the spread of COVID-19 infections. However, there were a number of confirmed coronavirus cases from Deagu and Gyeongbuk. Limitations of the epidemiological investigation methods were recognized. The Korea Disease Control and Prevention Agency developed the Epidemiological Investigation Support System(EISS) to utilize the smart city data hub technology and utilized the system in the epidemiological investigation. As a part of EISS, The proposed system is big-data bsed epidemiological investigation support system processing mobile network data. The established system is the epidemiological investigation support system based on big data to process mobile carriers' big data. Processing abnormal values of mobile carriers' data which was impossible with existing staff or creating hotspot regions where more than two people were in contact with an infected person were realized. As a result, our system processes outlier of mobile network data in 30 seconds, while processes hotspot around in 10 minutes. as a first time to adapt and support bigdata system into epidemiological investigation, our system proposes the practical utilizability of big-data system into epidemiological investigation.

• Pediatric Infection and Vaccine
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• v.27 no.3
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• pp.171-179
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• 2020

Purpose: In Korea, seasonal influenza is an important respiratory illness afflicting children every year. We aimed to investigate the childhood epidemiology in Jeju during the 2017-2018 and 2018-2019 seasons. Methods: Children aged <13 years, who were tested for influenza at the Jeju National University Hospital during the 2017-2018 and 2018-2019 influenza seasons, were included. Demographics and the influenza test results were retrospectively reviewed from their medical records. Results: This study included 5,219 cases of influenza-like illness (ILI) (2017-2018: n=2,279; 2018-2019: n=2,940). The mean age of the eligible children was 2.85±2.79 years, and the most common age among ILI patients in each season was 1 year group. There were 902 (17.3%, 902/5,219) confirmed influenza cases during the 2 seasons. The rate of influenza confirmed by rapid influenza diagnostic test or polymerase chain reaction among ILI patients in the 2017-2018 and 2018-2019 seasons was 10.4% (236/2,279) and 10.3% (303/2,940) for influenza A, and 9.1% (208/2,279) and 5.3% (155/2,940) for influenza B, respectively. The mean age of influenza-confirmed cases was 4.09 years and 5.05 years in the 2017-2018 and 2018-2019 seasons, respectively (P<0.05). Weekly distribution of influenza was similar to that of ILI in the clinical sentinel surveillance system in both seasons. Conclusion: The difference in the influenza epidemic trend and age-group distribution between the 2017-2018 and 2018-2019 seasons was distinct in Jeju. Steady epidemiological studies on influenza in Jeju are needed for comparison with other regions of Korea.

• KIPS Transactions on Computer and Communication Systems
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• v.10 no.6
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• pp.181-190
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• 2021

Sports activities conducted by multiple people are difficult to proceed in a situation where a widespread epidemic such as COVID-19 is spreading, and this causes a lack of physical activity in modern people. This problem can be overcome by using online exercise contents, but it is difficult to check detailed postures such as during face-to-face exercise. In this study, we present a model that detects posture and tracks movement using IT system for better non-face-to-face exercise content management. The proposed motion tracking model defines a body model with reference to motion analysis methods widely used in physical education and defines posture and movement accordingly. Using the proposed model, it is possible to recognize and analyze movements used in exercise, know the number of specific movements in the exercise program, and detect whether or not the exercise program is performed. In order to verify the validity of the proposed model, we implemented motion tracking and exercise program tracking programs using Azure Kinect DK, a markerless motion capture device. If the proposed motion tracking model is improved and the performance of the motion capture system is improved, more detailed motion analysis is possible and the number of types of motions can be increased.

• Journal of Veterinary Science
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• v.23 no.4
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• pp.55.1-55.12
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• 2022

Background: ASF was first reported in Kenya in 1910 in 1921. In China, ASF spread to 31 provinces including Henan and Jiangsu within six months after it was first reported on August 3, 2018. The epidemic almost affected the whole China, causing direct economic losses of tens of billions of yuan. Cause great loss to our pig industry. As ELISA is cheap and easy to operate, OIE regards it as the preferred serological method for ASF detection. P54 protein has good antigenicity and is an ideal antigen for detection. Objective: To identify a conservative site in the African swine fever virus (ASFV) p54 protein and perform a Cloth-enzyme-linked immunosorbent assay (ELISA) for detecting the ASFV antibody in order to reduce risks posed by using the live virus in diagnostic assays. Method: We used bioinformatics methods to predict the antigen epitope of the ASFV p54 protein in combination with the antigenic index and artificially synthesized the predicted antigen epitope peptides. Using ASFV-positive serum and specific monoclonal antibodies (mAbs), we performed indirect ELISA and blocking ELISA to verify the immunological properties of the predicted epitope polypeptide. Results: The results of our prediction revealed that the possible antigen epitope regions were A23-29, A36-45, A72-94, A114-120, A124-130, and A137-150. The indirect ELISA showed that the peptides A23-29, A36-45, A72-94, A114-120, and A137-150 have good antigenicity. Moreover, the A36-45 polypeptide can react specifically with the mAb secreted by hybridoma cells, and its binding site contains a minimum number of essential amino acids in the sequence 37DIQFINPY44. Conclusions: Our study confirmed a conservative antigenic site in the ASFV p54 protein and its amino acid sequence. A competitive ELISA method for detecting ASFV antibodies was established based on recombinant p54 and matching mAb. Moreover, testing the protein sequence alignment verified that the method can theoretically detect antibodies produced by pigs affected by nearly all ASFVs worldwide.

• Journal of the Korea Convergence Society
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• v.13 no.2
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• pp.67-75
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• 2022

The purpose of this study is to present an appropriate management plan as a supplement to the scientific evidence of the currently operated distancing system for preventing COVID-19. The currently being used mathematical models are expressed as simultaneous ordinary differential equations, there is a problem in that it is difficult to use them for the management of entry and exit of small business owners. In order to supplement this point, in this paper, a method for quantitatively expressing the risk of infection by people who gather is presented in consideration of the allowable risk given to the gathering space, the basic infection reproduction index, and the risk reduction rate due to vaccination. A simple quantitative model was developed that manages the probability of infection in a probabilistic level according to a set of visitors by considering both the degree of infection risk according to the vaccination status (non-vaccinated, primary inoculation, and complete vaccination) and the epidemic status of the virus. In a given example using the model, the risk was reduced to 55% when 20% of non-vaccinated people were converted to full vaccination. It was suggested that management in terms of quarantine can obtain a greater effect than medical treatment. Based on this, a generalized model that can be applied to various situations in consideration of the type of vaccination and the degree of occurrence of confirmed cases was also presented. This model can be used to manage the total risk of people gathered at a certain space in a real time, by calculating individual risk according to the type of vaccine, the degree of inoculation, and the lapse of time after inoculation.

• Genomics & Informatics
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• v.20 no.2
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• pp.21.1-21.14
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• 2022

The influenza A viruses have high mutation rates and cause a serious health problem worldwide. Therefore, this study focused on genome characterization of the viruses isolated from Thai patients based on the next-generation sequencing technology. The nasal swabs were collected from patients with influenza-like illness in Thailand during 2017-2018. Then, the influenza A viruses were detected by reverse transcription-quantitative polymerase chain reaction and isolated by MDCK cells. The viral genomes were amplified and sequenced by Illumina MiSeq platform. Whole genome sequences were used for characterization, phylogenetic construction, mutation analysis and nucleotide diversity of the viruses. The result revealed that 90 samples were positive for the viruses including 44 of A/H1N1 and 46 of A/H3N2. Among these, 43 samples were successfully isolated and then the viral genomes of 25 samples were completely amplified. Finally, 17 whole genomes of the viruses (A/H1N1, n=12 and A/H3N2, n=5) were successfully sequenced with an average of 232,578 mapped reads and 1,720 genome coverage per sample. Phylogenetic analysis demonstrated that the A/H1N1 viruses were distinguishable from the recommended vaccine strains. However, the A/H3N2 viruses from this study were closely related to the recommended vaccine strains. The nonsynonymous mutations were found in all genes of both viruses, especially in hemagglutinin (HA) and neuraminidase (NA) genes. The nucleotide diversity analysis revealed negative selection in the PB1, PA, HA, and NA genes of the A/H1N1 viruses. High-throughput data in this study allow for genetic characterization of circulating influenza viruses which would be crucial for preparation against pandemic and epidemic outbreaks in the future.

• Journal of Digital Convergence
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• v.19 no.5
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• pp.81-92
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• 2021

The purpose of this study is to present an approach to the "Digital Health Passport" (DHP), which will be the most important in the change of the travel industry among the sudden environmental changes brought about by COVID-19. To this end, this study reviewed a variety of empirical literature on DHP, and proposed a framework for DHP based on literature review. The framework is composed of travel intention, health information provision intention, and new technology acceptance/adoption of tourists. First, in terms of travel intention, providing information to DHP should not undermine the travel intention of the travelers. It should be possible to facilitate the travelers' enjoyment by using the information provided by the traveler. In addition, there is a need to assure that the data provided by travelers is managed in a reliable way. Second, it is necessary to understand why the travelers want to provide additional personal information (information disclosure), rather than seeing healthcare information only in terms of mandatory information provision. Finally, from the perspective of new technology, it is necessary to understand the intention of travelers to use/adopt DHP. The key implication of this work is that it proposed a DHP framework for realizing the travel bubble to predict and respond to foreign travelers' behaviors.

• Journal of the Korean Applied Science and Technology
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• v.38 no.2
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• pp.465-475
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• 2021

This study conducted an online and offline survey of 210 people from March 11 to 27, 2021 for the purpose of investigating and analyzing the current status of skin stress recognition and beauty care behavior due to wearing masks. The collected data were analyzed using SPSS 25.0 with Cronbach's α, Frequency Analysis, Chi-square test, and One way Anova. The average daily mask wearing time of more than 7 hours during the Covid-19 period was 43.8%, and skin stress recognition by wearing masks was highest among those in their 30s (M=4.27) and service workers (M=4.64), and those with acne and skin troubles (M=4.47) perceived high stress. The most important factor for home care treatment was cleansing(67.6%) and for beauty care was skin care(36.7%). Considerations factors on beauty care were 54.3% for service and customer care capabilities, and on body shape management method 45.7% for exercise. According to this study, respondents are recognizing skin stress due to the long-term use of masks, and home care treatment has been increasing as the esthetic salon has become unstable to visit due to the Covid-19 epidemic.

• Journal of Korea Entertainment Industry Association
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• v.14 no.7
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• pp.121-139
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• 2020

A variety of the approaches to the unification of the South Korea and North Korea have been implemented based on both the view of the national-centered unification and that of the reunification of the South and North Korea as a unit of nation through political, economic, military and diplomatics. A culture itself plays a significant role for people to understand one another through communicating and sharing cultural values. At this point, Korean-Wave called'Hallyu' should have various meanings and values for the reunification of South and North Korea. It has been expanded to the world beyond Asia as an icon of the culture. In this situation, North Korea is not exceptional. In other words, North Korea should be influenced by the Korean wave. Sharing a cultural value about Korean-Wave between South and North Koreans would be a way to speed up the reunification by having a common sense about the national identifications. The culture of Hallyu reflecting on the national identification could be helpful to enhance national pride and play a part for curing for the scarlet letters that they have got since the Korea was divided by two parts. The North Korean government's distorted policy to have blamed for the South Korean governing would be challenged if the Korean-wave would be epidemic in the Korean peninsular. In addition, if the North Koreans would be perceptive to the real freedom and universal value for the humanity, it would be more feasible for two Koreas to be reunified than before. In fact, it must serve as a catalyst for the reunification, two Koreas experiencing the Korean wave as a cultural value. As a result, the reunification for the people should have a meaning of the universal value as like everyone in the world can pursue for their own happiness. Through the Hallyu, That is, the change of the people's perception to the reunification will facilitate the reunification of two Koreas more than we expected.

• The Korea Journal of Herbology
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• v.33 no.4
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• pp.19-26
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• 2018

Objectives : The aim of this study was to investigate the immunopotentiating activity of combine extract that Silkworm and Cinnamomum cassia. Recently, acute epidemic diseases such as cold and viral respiratory diseases have been emerging. So, interested in immunity enhancement has been increasing, and research on natural products to promote immunity activity has been actively conducted. Methods : To confirm the immunopotentiating activity effect, Silkworm (SW), Cinnamomum cassia (CC), and SWCC combined extracts were treated 14 days at 300 mg/kg/day. The changes of glutamic oxalacetic transaminase (GOT), glutamic pyruvate transaminase (GPT) in serum were analyzed after experiment. The changes in the total spleen cell number were measured. Immune cells in spleen were analyzed using fluorescence activated cell sorter (FACS). also, analyzed the expression of cytokines in spleen. Results : Total number of cells in the spleen and FACS analysis of T lymphocytes activated in the spleen showed that the SWCC combined treated group had much higher frequency of active cells than both single groups. The ratio of CD4+CD8+, CD4+CD69+ and CD4+CD25+ T cells in spleen, SWCC is higher than other groups except Nor in CD4+, CD4+CD69+, CD4+CD25+ T cells. The results of this study suggest that SWCC can help immune function via IL-2, IL-10, IL-12, IFN-${\gamma}$ cytokine production, increased T lymphocytes and splenocyte proliferation. Conclusion : Therefore, these results suggested that the SWCC combined extracts administration increase stronger immunity enhancement than when SW and CC adminstration.