• 대한간호학회지
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• 제34권8호
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• pp.1451-1459
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• 2004

Purpose. With a sample of cognitively impaired nursing home residents and nursing staff, the following were examined 1) the proportion and nature of aggressive behavior, 2) the frequency and types of aggressive behavior, 3) the difference between the residents who demonstrate aggressive behavior and those who do not demonstrate aggressive behavior (age, mental status, functional status, and pain, length of nursing home stay), and 4) nursing staff responses to aggressive behavior by residents. Methods. A cross-sectional descriptive study design was used. Data were collected from cognitively impaired nursing home residents (N=205) and nursing staff (N=60) at two nursing homes using Ryden Aggression Scale I and II, Mini-Mental State Exam, Modified Barthel Index, Verbal Descriptor Scale, and aggressive behavior management questionnaire. Data were analyzed using descriptive statistics including t-test. Results. About $62.9\%$ residents were found to be aggressive and $38.5\%$ were both physically and verbally aggressive. Pushing, making threatening gestures, hitting, slapping, cursing/obscene/vulgar languages, making verbal threats were occurred frequently. Aggressive residents were significantly older, had more cognitive impairment, had more pain, and stayed longer in the nursing home when compared with non-aggressive residents. Considerable proportion of nursing staff responded to aggressive behaviors inadequately. Conclusion. Aggressive behavior among cognitively impaired nursing home residents is prevalent thus needs to be prevented and reduced. Along with environmental modification, educational programs for nursing staff and family caregivers need to be developed and implemented so that they can have extensive knowledge and skills to manage aggressive behaviors.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2006년도 춘계 학술발표회 논문집
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• pp.562-571
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• 2006

Mean shear wave velocity of the upper 30m $(V_s30)$ used as the current site classification criterion for determining seismic design ground motions in Korea was established based on the typical depth of site investigations in western US, in which the depth to bedrock is much deeper than that in Korea. In this study, to establish appropriate site classification system for site conditions of Korea, site investigations including in-situ seismic tests to determine shear wave velocity $(V_s)$ were carried out at total 72 sites in Korean peninsula. The mean $V_s's$ to the depths of 5m, 10m, 15m, 20m and 25m together with the $V_s30$ at the testing sites were determined, and the correlation between the mean $V_s$ to a depth shallower than 30m and the $V_s30$ was drawn and suggested for the efficient seismic site classification in Korea. The proposed correlation could be utilized for the seismic design in case of the $V_s$ profiles shallower than 30 m in depth. The correlation in this study, nevertheless, requires further modification by means of the accumulation of various site data in Korea.

• 대한토목학회논문집
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• 제31권3A호
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• pp.145-152
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• 2011

일반적으로 교량의 교대 날개벽 설계를 위한 해석은 날개벽을 4개의 구역으로 나누고 이를 1차원 캔틸레버 구조로 간략화하여 단면력을 산정하는 방법이 실무에서 관례적으로 사용되고 있다. 이러한 간편법은 수계산에 의존하던 때에 만들어진 일본 규정으로 국내 도로교설계기준에 채택되어 개정없이 계속 사용되어지고 있다. 본 연구에서는 불합리한 교대 날개벽의 단면력 산정법을 개선하기 위해서 날개벽을 단순 캔틸레버 해석이 아닌 실제에 가까운 2변 고정 판구조로 해석하여 현 도로교설계기준의 단면력과 비교 분석을 실시하였다. 또한 해외의 날개벽 단면력 산정법을 조사 분석하여 국내의 규정과 비교하였다. 본 연구에서 제시한 날개벽의 가용 매개변수 범위 내에서 유한요소 해석을 실시한 결과, 현 도로교설계기준의 간편법에 의한 단면력은 날개벽 형상에 따라 때로는 안전측이지만 때로는 비안전측인 결과를 나타내고 있어 실제의 단면력을 반영하지 못하는 것으로 분석되었다.

• Wind and Structures
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• 제23권2호
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• pp.127-142
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• 2016

Aerodynamic effects, such as drag force and flow-induced vibration (FIV), on civil engineering structures can be minimized by optimally modifying the structure shape. This work investigates the turbulent wake of a square prism with its faces modified into a sinusoidal wave along the spanwise direction using three-dimensional large eddy simulation (LES) and particle image velocimetry (PIV) techniques at Reynolds number $Re_{Dm}$ = 16,500-22,000, based on the nominal width ($D_m$) of the prism and free-stream velocity ($U_{\infty}$). Two arrangements are considered: (i) the top and bottom faces of the prism are shaped into the sinusoidal waves (termed as WSP-A), and (ii) the front and rear faces are modified into the sinusoidal waves (WSP-B). The sinusoidal waves have a wavelength of $6D_m$ and an amplitude of $0.15D_m$. It has been found that the wavy faces lead to more three-dimensional free shear layers in the near wake than the flat faces (smooth square prism). As a result, the roll-up of shear layers is postponed. Furthermore, the near-wake vortical structures exhibit dominant periodic variations along the spanwise direction; the minimum (i.e., saddle) and maximum (i.e., node) cross-sections of the modified prisms have narrow and wide wakes, respectively. The wake recirculation bubble of the modified prism is wider and longer, compared with its smooth counterpart, thus resulting in a significant drag reduction and fluctuating lift suppression (up to 8.7% and 78.2%, respectively, for the case of WSP-A). Multiple dominant frequencies of vortex shedding, which are distinct from that of the smooth prism, are detected in the near wake of the wavy prisms. The present study may shed light on the understanding of the underlying physical mechanisms of FIV control, in terms of passive modification of the bluff-body shape.

• Computers and Concrete
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• 제21권1호
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• pp.67-74
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• 2018

A differential scheme based micromechanical framework is proposed to obtain the effective properties of the saturated concrete repaired by the electrochemical deposition method (EDM) considering the interfacial transition zone (ITZ) effects. The constituents of the repaired concrete are treated as different phases, consisting of (micro-)cracks, (micro-)voids and (micro-)pores (occupied by water), deposition products, intrinsic concrete made up by the three traditional solid phases (i.e., mortar, coarse aggregates and their interfaces) and the ITZs. By incorporating the composite sphere assemblage (CSA) model and the differential approach, a new multilevel homogenization scheme is utilized to quantitatively estimate the mechanical performance of the repaired concrete with the ITZs. The CSA model is modified to obtain the effective properties of the equivalent particle, which is a three-phase composite made up of the water, deposition products and the ITZs. The differential scheme is employed to reach the equivalent composite of the concrete repaired by EDM considering the ITZ effects. Moreover, modification procedures considering the ITZ effects are presented to attain the properties of the repaired concrete in the dry state. Results in this study are compared with those of the existing models and the experimental data. It is found that the predictions herein agree better with the experimental data than the previous models.

• 한국인터넷방송통신학회논문지
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• 제13권2호
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• pp.239-244
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• 2013

건설현장에서 공사 진행 사항을 실시간으로 취득하여 3차원 공간정보와 센서네트웍을 결합한 유비쿼터스 기반 건설현장 관리시스템을 구현함으로써 건설현장에 가서 공사 진척 현황을 확인해야 하는 수고와 시간을 아낄 수 있고 실시간 정보를 PC, 노트북 또는 스마트 폰 등으로 전송하여 공사 관련 담당자나 담당자가 있는 사무실 등에서 수신할 수 있도록 하였다. 특히, 건설현장의 공사 진행 현황은 물론 공사에 영향을 미칠 수 있는 온도, 습도 등의 환경정보 및 GPS 정보를 모바일 스마트 폰으로 제공함으로써 언제 어느 곳에서든지 필요한 정보를 제공받을 수 있을 뿐만 아니라 공사의 진행과 설계변경 등에 도움을 줄 수 있도록 하여 건설현장 실시간 자동관리가 가능할 수 있도록 연구되었다.

• Bulletin of the Korean Chemical Society
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• 제32권2호
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• pp.613-619
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• 2011

Colloidal silver nanoparticles (AgNPs) have been commercialized as the typically stabilized form via the addition of a variety of surfactants or polymers. Herein, to examine the effects of stabilizing AgNPs in suspension, we modified the surface of bare AgNPs with four type of surfactants (NaDDBS, SDS, TW80, CTAB) and polymers (PVP, PAA, PAH, CMC). The modified AgNPs was applied to compare suspension stability and nanotoxicity test using Escherichia coli (E. coli) as a model organism. Modification of AgNPs surface using chemical stabilizer may be not related with molecular weight, but chemical structure such as ionic state and functional group of stabilizer. In this study, it is noteworthy that AgNPs modified with a cationic stabilizer (CTAB, PAH) were importantly toxic to E. coli, rather than anionic stabilizers (NaDDBS, SDS). Comparing similar anionic stabilizer, i.e., NaDDBS and SDS, the result showed that lipophilicity of chemical structure can affect on E. coli, because NaDDBS, which contains a lipophilic benzene ring, accelerated the cytotoxicity of AgNPs. Interestingly, none of the stabilizers tested, including biocompatible nonionic stabilizers (i.e., TW80 and cellulose) caused a reduction in AgNP toxicity. This showed that toxicity of AgNPs cannot be reduced using stabilizers.

• 한국발생생물학회지:발생과생식
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• 제18권3호
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• pp.153-160
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• 2014

Adaptive development of early stage embryo is well established and recently it is explored that the mammalian embryos also have adaptive ability to the stressful environment. However, the mechanisms are largely unknown. In this study, to evaluate the possible role of aquaporin in early embryo developmental adaptation, the expression of aquaporin (AQP) 5 gene which is detected during early development were examined by the environmental condition. To compare expression patterns between in vivo and in vitro, we conducted quantitative RT-PCR and analyzed localization of the AQP5 by whole mount immunofluorescence. At in vivo condition, Aqp5 expressed in oocyte and in all the stages of preimplantation embryo. It showed peak at 2-cell stage and decreased continuously until morula stage. At in vitro condition, Aqp5 expression pattern was similar with in vivo embryos. It expressed both at embryonic genome activation phase and second mid-preimplantation gene activation phase, but the fold changes were modified between in vivo embryos and in vitro embryos. During in vivo development, AQP5 was mainly localized in apical membrane of blastomeres of 4-cell and 8-cell stage embryos, and then it was localized in cytoplasm. However, the main localization area of AQP5 was dramatically shifted after 8-cell stage from cytoplasm to nucleus by in vitro development. Those results explore the modification of Aqp5 expression levels and location of its final products by in vitro culture. It suggests that expression of Aqp5 and the roles of AQP5 in homeostasis can be modulated by in vitro culture, and that early stage embryos can develop successfully by themselves adapting to their condition through modulation of the specific gene expression and localization.

• Toxicological Research
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• 제24권2호
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• pp.101-107
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• 2008

Studies on hypoxia-signaling pathways have revealed novel Fe(II) and $\alpha$-ketoglutarate-dependent dioxygenases that hydroxylate prolyl or asparaginyl residues of a transactivator, Hypoxia-Inducible $Factor-\alpha(HIF-\alpha)$ protein. The recognition of these unprecedented dioxygenases has led to open a new paradigm that the hydroxylation mediates an instant post-translational modification of a protein in response to the changes in cellular concentrations of oxygen, reducing agents, or $\alpha$-ketoglutarate. Activity of $HIF-\alpha$ is repressed by two hydroxylases. One is $HIF-\alpha$ specific prolyl-hydroxylases, referred as prolyl-hydroxylase domain(PHD). The other is $HIF-\alpha$ specific asparaginyl-hydroxylase, referred as factor-inhibiting HIF-1(FIH-1). The facts (i) that many dioxygenases commonly use molecular oxygen and reducing agents during detoxification of xenobiotics, (ii) that detoxification reaction produces radicals and reactive oxygen species, and (iii) that activities of both PHD and FIH-1 are regulated by the changes in the balance between oxygen species and reducing agents, imply the possibility that the activity of $HIF-\alpha$ can be increased during detoxification process. The importance of $HIF-\alpha$ in cancer and ischemic diseases has been emphasized since its target genes mediate various hypoxic responses including angiogenesis, erythropoiesis, glycolysis, pH balance, metastasis, invasion and cell survival. Therefore, activators of PHDs and FIH-1 can be potential anticancer drugs which could reduce the activity of HIF, whereas inhibitors, for preventing ischemic diseases. This review highlights these novel dioxygenases, PHDs and FIH-1 as specific target against not only cancers but also ischemic diseases.

• Journal of Welding and Joining
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• 제32권3호
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• pp.27-33
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• 2014

This paper presents a brief summary on a relatively new plasma aided electrolytic surface treatment process for light metals. A brief discussion regarding the advantages, principle, process parameters and applications of this process is discussed. The process owes its origin to Sluginov who discovered an arc discharge phenomenon in electrolysis in 1880. A similar process was studied and developed by Markov and coworkers in 1970s who successfully deposited an oxide film on aluminium. Several investigation thereafter lead to the establishment of suitable process parameters for deposition of a crystalline oxide film of more than $100{\mu}m$ thickness on the surface of light metals such as aluminium, titanium and magnesium. This process nowadays goes by several names such as plasma electrolytic oxidation (PEO), micro-arc oxidation (MOA), anodic spark deposition (ASD) etc. Several startups and surface treatment companies have taken up the process and deployed it successfully in a range of products, from military grade rifles to common off road sprockets. However, there are certain limitations to this technology such as the formation of an outer porous oxide layer, especially in case of magnesium which displays a Piling Bedworth ratio of less than one and thus an inherent non protective oxide. This can be treated further but adds to the cost of the process. Overall, it can be said the PEO process offers a better solution than the conventional coating processes. It offers advantages considering the fact that he electrolyte used in PEO process is environmental friendly and the temperature control is not as strict as in case of other surface treatment processes.