• 제목/요약/키워드: environmental induction

검색결과 773건 처리시간 0.019초

Role of CCAAT/ Enhancer Binding Protein ${\beta}$ Activation in the Induction of Glutathione S-Transferase A2 by Toluene

  • Choi, Dal-Woong;Sohn, Jong-Ryeul;Moon, Kyung-Whan;Byeon, Sang-Hoon;Kim, Hi-Chol;Kim, Young-Whan
    • 한국환경보건학회:학술대회논문집
    • /
    • 한국환경보건학회 2005년도 국제학술대회
    • /
    • pp.341-344
    • /
    • 2005
  • The expression of the glutathione S-transferase (GST), whose induction accounts for antioxidant defense system, is regulated by activation of CCAAT/enhancer binding protein ${\beta}$ ($C/EBP{\beta}$), Sick house syndrome (SHS) presents healthy damage owing to the indoor environment of a building. Toluene has been implicated in one of the important causes of SHS. The present study investigated the effects of toluene treatment on the induction of GSTA2 gene and its mechanism. H411E cells treated with toluene, and GSTA2 expression was determined by immunoblot analysis. The translocation of $C/EBP{\beta}$ was assessed by immunocytochemical assays. $C/EBP{\beta}$ DNA binding activity was determined by electrophoretic mobility shift assays. The role of the C/EBP binding site in the induction of the GSTA2 gene was assessed by luciferase reporter-gene activity. Toluene induced GSTA2 protein expression. In toluene-treated cells, $C/EBP{\beta}$ translocated to the nucleus and bound to the consensus sequence of C/EBP (TTGCGCAA). Toluene treatment increased luciferase reporter-gene activity in cells transfected with the C/EBP-containing regulatory region of the GSTA2 gene. Oxidative stress is believed to play an important role in the induction of GSTA2 gene by toluene This study shows that toluene-induced GSTA2 gene expression is dependent upon nuclear translocation and binding of $C/EBP{\beta}$ to the C/EBP response element in the GSTA2 gene promoter.

  • PDF

Researching of the Tesla's Bifilar Coils, as a Sources of Electrical Energy

  • CHERVINSKY, L.;USENKO, S.;SPODOBA, M.
    • 식품보건융합연구
    • /
    • 제5권4호
    • /
    • pp.19-23
    • /
    • 2019
  • In recent years, the Internet was a lot of information on the use of Tesla coils bifilar [1] in conjunction with induction cooker, for "free" electricity during power resistive load, including different incandescent lamps. With the development of scientific and technological progress, the demand for electricity in each year is increasing, and at the same time, the need to increase the capacity of electricity production, which entails large investments and, consequently, increase of prices for consumers. As before today, the search for free electric energy is an up-to-date and still open topic. The purpose of research - simplification of information on the possibility of using bifilar coils as an electric current source in conjunction with induction cooker. Consequently, it can be concluded from the above that the use of Tesla coils in combination with induction cooker has very low k.k.d. and it is not possible to obtain excessive electric energy using the Tesla coil under the connection schemes considered.

Root Induction and Propagation of Sedum takesimense Nakai Using Leaf Cutting Method

  • Cheong, Eun Ju
    • Journal of Forest and Environmental Science
    • /
    • 제34권1호
    • /
    • pp.50-52
    • /
    • 2018
  • The effect of basal nutrients concentrations and exogenous auxin for root induction from leaves of Sedum takesimense were investigated for mass-propagation. Root induction rates were significantly different from the concentrations of basal salts but not influenced by supplemented IBA in the medium. The lowest concentration of MS basal salts (1/10) was most effective to induce roots from leaves followed 1/5 MS, and 1/2 and full strength MS medium. Supplement of IBA $10{\mu}M$ in the medium did not improve the root induction that resulted no differences compare to the hormone free media. Rooted leaves were transplanted in soil and survived in greenhouse.

The Prevention of the Longitudinal Deformation on the Built­Up Beam by using Induction Heating

  • Park, J.U.;Lee, C.H.;Chang, K.H.
    • International Journal of Korean Welding Society
    • /
    • 제3권2호
    • /
    • pp.7-14
    • /
    • 2003
  • During the manufacture of a ship, longitudinal deformation is produced by fillet welding on the Built­Up beam used to improve the longitudinal strength of a ship. This deformation needs a correcting process separate from a manufacture process and decreases productivity and quality. This deformation is caused by welding moment, which is the value multiplied the shrinking force due to welding by the distance from the neutral axis on a cross section of Built­Up beam. This deformation can be offset by generating a moment which is the same magnitude with and is located in an opposite direction to the welding moment on web plate by induction heating. Accordingly, this study clarifies the creation mechanism of the longitudinal deformation on Built­Up beam with FEM analysis and presents the preventative method of this deformation by induction heating basing the mechanism and verifies its validity through analysis and experiments. The induction heating used here is performed by deciding its location and quantity with experiments and simple equations and by applying them to a real structure.

  • PDF

Thermoelectric Properties of n-Type Half-Heusler Compounds Synthesized by the Induction Melting Method

  • Du, Nguyen Van;Lee, Soonil;Seo, Won-Seon;Dat, Nguyen Minh;Meang, Eun-Ji;Lim, Chang-Hyun;Rahman, Jamil Ur;Kim, Myong Ho
    • Transactions on Electrical and Electronic Materials
    • /
    • 제16권6호
    • /
    • pp.342-345
    • /
    • 2015
  • The n -type Hf0.25Zr0.25Ti0.5NiSn0.998Sb0.002 Half-Heusler (HH) alloy composition was prepared by using the induction melting method in addition to the mechanical grinding, annealing, and spark plasma sintering processes. Analysis of X-ray diffraction (XRD) results indicated the formation of a pure phase HH structured compound. The electrical and thermal properties at temperatures ranging from room temperature to 718 K were investigated. The electrical conductivity increased with increasing temperatures and demonstrated nondegenerate semiconducting behavior, and a large reduction in the thermal conductivity to the value of 2.5 W/mK at room temperature was observed. With the power factor and thermal conductivity, the dimensionless figure of merit was increased with temperature and measured at 0.94 at 718 K for the compound synthesized by the induction melting process.

Effects of Intermediate Metabolites on Phenanthrene Biodegradation

  • Cho Hwa-Young;Woo Seung-Han;Park Jong-Moon
    • Journal of Microbiology and Biotechnology
    • /
    • 제16권6호
    • /
    • pp.969-973
    • /
    • 2006
  • Stimulatory effects of three different intermediate metabolites (1-hydroxy-2-naphthoate, salicylate, and catechol) as potential inducers on phenanthrene degradation were investigated using two different bacteria (Pseudomonas putida ATCC 17484 and Burkholderia cepacia PB12). The relative induction capacity was high in the sequence of 1-hydroxy-2-naphthoate, salicylate, and catechol in both strains. The highest of up to 12 times increase of the induction was obtained by the addition of 1-hydroxy-2-naphthoate in the strain PB12, compared with the control where no exogenous inducer was added. The induction capacity of the potential inducers was closely related with the number of oxygenations required per electron equivalents in one mole of the inducer.

CHEMOPREVENTION AGAINST DIETARY MUTAGENS IN HUMANS BY INGESTION OF CRUCIFEROUS VEGETABLES

  • Steinkellner, Hans;Gsur, Andrea;Kundi, Michael;Knasmuller, Siegfried
    • 한국독성학회:학술대회논문집
    • /
    • 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
    • /
    • pp.83-84
    • /
    • 2001
  • Results from laboratory experiments indicate that induction of phase II enzymes by dietary constituents leads to inactivation of genotoxins. In animal studies glutathione S-transferase (GST) induction was paralleled by a reduction of chemically induced tumours. However data on induction of phase II enzymes in humans is scarce. Therefore we carried out intervention studies in which we investigated the effect of cruciferous vegetables on GST induction, and studied the effects of these vegetables on meat derived urinary mutagenicity.(omitted)

  • PDF

Several Human Pharmaceutical Residues in Aquatic Environment may Result in Endocrine Disruption in Japanese Medaka(Oryzias latipes)

  • Kang, Hee-Joo;Kim, Hyun-Soo;Choi, Kyung-Ho;Kim, Kyung-Tae;Kim, Pan-Gyi
    • 한국환경보건학회지
    • /
    • 제31권3호
    • /
    • pp.227-233
    • /
    • 2005
  • This study was conducted to determine the endorcrine disruption effects of the several major pharmaceutical residues in water using adult Japanese medaka (Oryzias latipes). Four frequently used pharmaceuticals including caffeine, ketoconazole, acetaminophen, and diltiazem were investigated for the vitellogenin(Vtg) induction in the medaka using Western blotting and ELISA. $17\beta$,-estradiol was used as a positive control. Vtg was qualified and quantified through Western blot and ELISA. Following SDS gel electrophoresis, the dominant protein band was identified to molecular weight approximately 205 kDa in whole body samples of vitellogenic female. With female medaka exposed to $17\beta,-estradiol$, no significant difference in total protein induction was noted. In contrast, three to five day exposure of male fish to $17\beta,-estradiol$ resulted in $63.07\%o$, increase of total protein comparing to that of control males (p<0.01). Vtg induction in male fish was observed with all the test pharmaceuticals: At concentrations greater than 1ppm of diltiazem, 2 ppm of caffeine, 4 ppm of acetaminophen, and 10 ppm of ketoconazole, Vtg induction was monotonously increased in a dose dependent manner. This study is one of the first reports suggesting potential endocrine disruption mechanism of common human pharmaceutical products in aquatic ecosystem. Although the effect concentrations obtained from this investigation are environmentally unrealistically high, endocrine disruption should be considered as one of the important consequences of pharmaceutical pollution in aquatic environment, and warrants due attention in future researches.

Effects of Environmental Reinforcement Through Motivation on Motor and Cognitive Function in Rats With Focal Ischemic Brain Injury

  • Heo, Myoung
    • 한국전문물리치료학회지
    • /
    • 제16권4호
    • /
    • pp.44-52
    • /
    • 2009
  • It is known that individual factors as cognitive, perception, emotion, and motivation may greatly influence on recovery from neurologic region. This study was to investigate the effects of environmental reinforcement through motivation to perform the tasks voluntarily on motor and cognition function in rats with focal ischemic brain injury. Focal ischemic brain injury was induced in Sprague-Dawley rats (15 rats, $250{\pm}50$ g) through middle cerebral artery occlusion (MCAo). And then, experiment groups were randomly divided into three groups; The control group: MCAo induction ($n_1$=5), the environmental reinforcement (ER) group: the application for ER after MCAo induction ($n_2$=5), the environmental reinforcement through motivation (ERM) group: the application for ERM after MCAo induction ($n_3$=5). The climbing test (CT) and the modified limb placing tests (MLPTs) to measure the motor function and the Morris water maze acquisition test (MWMAT) and the Morris water maze retention test (MWMRT) to measure the cognitive function were performed. For the CT, the ERM group was significantly larger than the ER group. For the MLPTs, the ERM group was significantly decreased compared to other groups. For the MWMAT, the time to find the circular platform in the ERM group significantly decreased compared to other groups. For the MWMRT, the time to dwell on the quadrant circular platform in the ERM group was significantly increased compared to other groups. These results suggested that the ERM could improve the motor and cognitive functions in the rats with focal ischemic brain injury.

  • PDF