• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.6
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• pp.1-8
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• 2005

The quantity of light available for a space can be translated in term of the amount of energy savings through a process of a building energy simulation. To get significant energy savings in general illumination, the electric lighting system must be incorporated with a daylight - activated dimmer control. A prototype configuration of an once interior has been established and the integration between the building envelope and lighting and HVAC systems is evaluated based on computer modeling of a lighting control facility. First of all, an energy-efficient luminaire system is designed and the lighting analysis program, Lumen-Micro 2000 predicts the optimal layout of a conventional fluorescent lighting future to meet the designed lighting level and calculates unit power density, which translates the demanded met of electric lighting energy. A dimming control system integrated with the contribution of daylighting has been applied to the operating of the artificial lighting. Annual cooling load due to lighting and the projecting saving amount of cooling load due to daylighting under overcast diffuse sky m evaluated by computer software ENER-Win. In brief, the results from building energy simulation with measured daylight illumination levels and the performance of lighting control system indicate that daylighting can save over 70 percent of the required energy for general illumination in the perimeter zones through the year A 25[%] of electric energy for cooling and almost all off heating energy may be saved by dimming and turning off the luminaires in the perimeter zones.

• Toxicological Research
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• v.22 no.3
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• pp.283-291
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• 2006

The survival and growth of epithelial cells depends on adhesion to the extracellular matrix. An adhesion signal may regulate the initiation of differentiation, since epidermal keratinocytes differentiate as they leave the basement membrane. A metabolically dead cornified cell envelope is the end point of epidermal differentiation so that this process may be viewed as a specialized form of programmed cell death. In order to investigate the precise cellular signaling events loading to terminal differentiation of keratinocytes, we have utilized HaCaT cells to monitor the biological consequences of $Ca^{2+}$ stimulation and numerous downstream signaling pathways, including activation of the extracellular signal-regulated protein kinase(ERK) pathway and activation of phosphatidylinositol 3-kinase(PI3K). The results presented in this study show that $Ca^{2+}$ function as potent agents for the differentiation of HaCaT keratinocytes, and this differentiation depends or the activation of ERK, Protein kinase B(PKB) and p70 ribosomal protein S6 kinase(p70S6K). Finally, the results show that the expression of Activator protein 1(AP-1; c-Jun and c-Fos) increased following $Ca^{2+}$-mediated differentiation of HaCaT cells, suggesting that ERK-mediated AP-1 expression is critical for initiating the terminal differentiation of keratinocytes.

• Development and Reproduction
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• v.12 no.1
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• pp.41-49
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• 2008

Ultrastructural changes occurring during the course of development and degeneration of oocytes in female Ruditapes philippinarum (Adams & Reeve, 1850) are described for clams collected from Gomso Bay, Korea. During the early stages of oogenesis, desomosome-like gap junctions localized between the early vitellogenic oocyte and the follicle cells. Vitellogenesis occurs through a process of autosynthesis, involving the combined activity of the Golgi complex, mitochondria and rough endoplasmic reticulum, and heterosynthesis in which extraovarian precursors are incorporated into oocytes by endocytotic activity, involving the basal region of the early vitellogenic oocytes prior to the formation of the vitelline envelope. The follicle cells appear to play an integral role in vitellogenesis and oocyte degeneration: phagocytosis and intracellular digestion of products originating from oocyte degeneration. These functions can permit a transfer of yolk precursors necessary to vitellogenesis, and they can accumulate nutrients in the cytoplasm, as glycogen and lipids, which can be employed by the vitellogenic oocyte. During the period of oocyte degeneration, follicle cells may have lysosomal system for breakdown, and resorb various phagosomes in the cytoplasm for nutrient storage. But follicle cells probably are not the major source of yolk precursors in vitellogenesis.

• Journal of Korean Library and Information Science Society
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• v.35 no.3
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• pp.79-94
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• 2004

This research studied the preservation treatment of the papered literature the national treasure 745-9 $\ulcorner$Keumganggyung-samgahae$\lrcorner$, discovered in 1995 from the Four Devas of Borimsa Buddhist Temple at Jangheung County, in the viewpoint of the bibliography. The overall features of the $\ulcorner$Keumganggyung-samgahae$\lrcorner$ were of 25.3cm width, 38.9cm height 1.5cm depth, 58 pages and of high-fine yellow-brown colored reef paper. The book was ruined physically in the shape and color. The covers of the book were deeply stained by the permeated rain and some internal pages were changing into brown color by corrosion. The treatment policies were； maintaining the status quo and capable repeated treatment. And the preservation treatment was done in the sequences of 1) 1st cleaning process, 2) repairing and correcting, 3) 2nd cleaning and preservation 4) cutting, binding the book and making the envelope and wood box. The post-preservation features of $\ulcorner$Keumganggyung-samgahae$\lrcorner$ were； total 64 pages and the size being 25.8 cm width 39.4cm of lenght, and 1.9cm of depth.

• Journal of Environmental Science International
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• v.11 no.10
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• pp.1109-1116
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• 2002

This study analyzed concentrations of volatile organic compounds (VOCs) produced from incineration of papers at $600^{\circ}C$. The papers used in this study included A4 papers (new, printed with ink-jet, printed with carbon), newspapers (printed with bean oil, printed with a general newspaper ink), packaging box, document envelope, single-use paper cup, and cosmetic tissue. Papers were heated from room temperature upto $600^{\circ}C$ providing air inside of the electric furnace and then they were oxidized for 80 minutes at $600^{\circ}C$ maintaining the same air supply. VOCs emitted from the incineration process were sampled using an air sampling pump and bags for 160 minutes and then the components and concentrations of the VOCs were analyzed by a CC-MS. The most prominent chemical structure of the Vous identified from incineration of the papers was furans and then furans were followed by aromatics and aliphatic alkenes. About 40% of the identified VOCs contained double bonds, which have relatively a high ozone (ground level) formation potential, within their molecular structure. Also, some cancer suspecting compounds like benzene, dichlorormethane and chloroform were identified.

• The Korean Journal of Applied Statistics
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• v.26 no.2
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• pp.335-347
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• 2013

There are various types of real world signals. For example, an electrocardiogram(ECG) represents myocardium activities (contraction and relaxation) according to the beating of the heart. ECG can be expressed as the fluctuation of ampere ratings over time. A signal is a composite of various types of signals. An orchestra (which boasts a beautiful melody) consists of a variety of instruments with a unique frequency; subsequently, each sound is combined to form a perfect harmony. Various research on how to to decompose mixed stationary signals have been conducted. In the case of non-stationary signals, there is a limitation to use methodologies for stationary signals. Huang et al. (1998) proposed empirical mode decomposition(EMD) to deal with non-stationarity. EMD provides a data-driven approach to decompose a signal into intrinsic mode functions according to local oscillation through the identification of local extrema. However, due to the repeating process in the construction of envelopes, EMD algorithm is not efficient and not robust to a noise, and its computational complexity tends to increase as the size of a signal grows. In this research, we propose a new method to extract a local oscillation embedded in a signal by utilizing the second derivative.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.6
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• pp.86-93
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• 2023

As the hysteretic behavior of reinforced concrete members under cyclic loading progresses, the energy dissipation ability decreases due to a decrease in stiffness and strength and pinching effects. However, the guideline "Nonlinear Analysis Model for Performance-Based Seismic Design of Reinforced Concrete Building Structures, 2021" requires calculating a single energy dissipation factor for each member and all histeric step, so the decrease in energy dissipation capacity according to histeric step cannot be considered. It is judged that Therefore, in this study, the energy dissipation factor according to the histeric step was examined by comparing the existing experimental results and the nonlinear time history analysis results for a general beam under cyclic loading. The energy dissipation factor was calculated as the ratio of the energy dissipation amount of the actual specimen to the energy dissipation amount of the idealized elastoplastic behavior obtained as a result of nonlinear time history analysis. In the existing experiment results, the energy dissipation factor was derived by calculating one cycle for each histeric step, and the energy dissipation factor was derived based on the nonlinear modeling process in the guidelines. In the existing experimental study, the energy dissipation factor was calculated by setting each histeric step (Y-L-R), and the energy dissipation factor was found to be 0.36 in the Y-L step and 0.28 in the L-R step, and the energy dissipation factor in the guideline was found to be 0.31. This shows that the energy dissipation factor calculation formula in the guidelines does not indicate a decrease in the energy dissipation capacity of reinforced concrete members.

• Journal of the Korean GEO-environmental Society
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• v.20 no.5
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• pp.13-21
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• 2019

There are many cuts or natural rock slopes that remain stable for a long time in the natural environment with steep slopes ($65^{\circ}$ to $85^{\circ}$). In terms of design practice, the rock mass consisting of similar rock condition and geological structures is defined as a good continuum rock slope, and during the process of decision making angle of this rock slope, it will be important to establish the geotechnical properties estimating method of the continuum rock on the process of stability analysis in the early stages of design and construction. In this study, the stability analysis of a good continuum rock slope that can be designed as a steep slope proposed a practical method of estimating the shear strength by induced from the Hoek-Brown failure criterion, and in addition, the design applicability was evaluated through the stability analysis of steep rock slope. The existing method of estimating the shear strength was inadequate for practical use in the design, as the equivalent M-C shear strength corresponding to the H-B envelope changes sensitively, even with small variations in confining stress. To compensate for this problem, it was proposed to estimate equivalent M-C shear strength by iso-angle division method. To verify the design applicability of the iso-angle division method, the results of the safety factor and the displacement according to the change in angle of the cut slope constructed at the existing working design site were reviewed. The safety factor is FS=16~59 on the 1:0.5 slope, FS=12~52 on the 1:0.3 slope, most of which show a 10~12 percent reduction. Displacement is 0.126 to 0.975 mm on the 1:0.5 slope, 0.152 to 1.158 mm on the 1:0.3 slope, and represents an increase of 10 to 15%. This is a slightly change in normal proportion and is in good condition in terms of stability. In terms practical the working design, it was confirmed that applying the shear strength estimated by Iso-angle division method derived from the H-B failure criterion as a universal shear strength for a good continuum rock mass slope was also able to produce stable and economic results. The procedure for stability analysis using LEM (Limit Equilibrium Analysis Method) and FEM (Finite Element Analysis Method) will also be practical in the rock slope where is not distributed fault. The study was conducted by selecting the slope of study area as a good rock condition, establishing a verification for which it can be applied universal to a various rock conditions will be a research subject later on.

• Microbiology and Biotechnology Letters
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• v.37 no.4
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• pp.377-382
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• 2009

Viral safety is an important prerequisite for clinical preparations of all biopharmaceuticals derived from plasma, cell lines, or tissues of human or animal origin. To ensure the safety, implementation of multiple viral clearance (inactivation and/or removal) steps has been highly recommended for manufacturing of biopharmaceuticals. Of the possible viral clearance strategies, Ultraviolet-C (UVC) irradiation has been known as an effective viral inactivating method. However it has been dismissed by biopharmaceutical industry as a result of the potential for protein damage and the difficulty in delivering uniform doses. Recently a continuous flow UVC reactor (UVivatec) was developed to provide highly efficient mixing and maximize virus exposure to the UV light. In order to investigate the effectiveness of UVivatec to inactivate viruses without causing significant protein damage, the feasibility of the UVC irradiation process was studied with a commercial therapeutic protein. Recovery yield in the optimized condition of $3,000\;J/m^2$ irradiation was more than 98%. The efficacy and robustness of the UVC reactor was evaluated with regard to the inactivation of human immunodeficiency virus (HIV), hepatitis A virus (HAV), bovine herpes virus (BHV), bovine viral diarrhea virus (BVDV), porcine parvovirus (PPV), bovine parvovirus (BPV), minute virus of mice (MVM), reovirus type 3 (REO), and bovine parainfluenza virus type 3 (BPIV). Non enveloped viruses (HAV, PPV, BPV, MVM, and REO) were completely inactivated to undetectable levels by $3,000\;J/m^2$ irradiation. Enveloped viruses such as HIV, BVDV, and BPIV were completely inactivated to undetectable levels. However BHV was incompletely inactivated with slight residual infectivity remaining even after $3,000\;J/m^2$ irradiation. The log reduction factors achieved by UVC irradiation were ${\geq}3.89$ for HIV, ${\geq}5.27$ for HAV, 5.29 for BHV, ${\geq}5.96$ for BVDV, ${\geq}4.37$ for PPV, ${\geq}3.55$ for BPV, ${\geq}3.51$ for MVM, ${\geq}4.20$ for REO, and ${\geq}4.15$ for BPIV. These results indicate that UVC irradiation using UVivatec was very effective and robust in inactivating all the viruses tested.

• The Korean Journal of Malacology
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• v.22 no.2
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• pp.157-165
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• 2006

The present study was conducted to confirm that a bivalve Ruditapes philippinarum can be used as a biomarker for the monitoring of the heavy metal pollution in the silt of the marine environment. The clams were collected from the silt of Cheonsu-bay, Buheung-ri, and Tan-island of the West Sea, Korea. To observe the normal structures of the target organs (hepatopancreas and gill), they were dissected out for the immunohistochemical study and the electron microscopy with TEM, SEM, and SEM-EDS. The immunohistochemical study showed that the interdiverticular connective tissues of the hepatopancreas, and the outer epithelium of the gill lamellae was strongly reacted to anti-metallothionein (MT), indicating the presence of MT, a metal-binding protein, involved in metal detoxifying process. According to the examinations under the TEM, the epithelial cells of the hepatopancreas of the clams collected from polluted area (Tan-island) showed certain changes such as swollen rER, swollen nuclear envelope and inclusion bodies in the nulcei. In the SEM-EDS analysis, tissue of the hepatopancreas showed relatively higher concentration of S, Zn, and Cd. These elements are supposed to be concerning with the MT-reaction in the hepatopancreas. Considering that the coastal bivalve R. philippinarum showed immediate subcellular responses to heavy metal pollution in the overall experiments conducted, this species might act as one of efficient biomarkers for the heavy metal contamination in the marine environment.