• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.2
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• pp.235-240
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• 2000

Inhibitory effects of cockle extracts on carcinogen-induced cytotoxicity in C3H/10T1/2 cells were studied. Soup (62$\mu\textrm{g}$/mL), solubility (28$\mu\textrm{g}$/mL) and liposolubility (9 $\mu\textrm{g}$/mL) of the cockle inhibited 3-methyl-cholanthrene(MCA)-induced cytotoxicity in C3H/10T1/2 cells by 53 and 94%, respectively. These results suggest that the extracts cockle might have anticarcinogen-induced cytotoxicity of C3H/10T1/2 cells. The effects of cockle extracts on the immune response related to its antitumor activity in vitro and in vivo were investigated. The cockle extracts showed a direct cytotoxic effect on sarcoma-180 cells, tumor cells in vitro. Soup (0.49 mg/mL), solubility (0.11 mg/mL) and liposolubiliy (0.05 mg/mL) of the cockle markedly decreased the total numbers of sarcoma-180 cells, but not their viability. The phagocytic acitivity of peritoneal macrophage of mice was significantly augmented by these extracts of the cockle compared with that of control in vivo. These extracts also raised the phagocuytic index, indicating that the number of phagocytize dmicrobes per macrophage increased. Thus, cockle extracts might show a antitumor activity by enhancing the phagocytic cell activities.

• Journal of the Korean Society of School Health
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• v.27 no.1
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• pp.39-49
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• 2014

Purpose: The purpose of this study was to investigate the effect of hand washing education programs on knowledge, attitude and performance of hand washing in Undergraduates. Methods: The study used a nonequivalent control group quasi-experimental design. A total of 118 students in K university in Seoul, Korea, participated in this study. 67 students were included in the experimental group and 51 students were in the control group. The experimental group was given a lecture, Educational Hand Washing Program, developed by researchers. Using a structural questionnaire, the students' perception on hand washing was measured before and after the intervention, in terms of knowledge, attitude, and performance at home and school. Results: The experimental group showed significantly higher scores in knowledge (p=.033), attitude (p<.001), and performance at home (p=.001). However, the performance at school didn't show a significant difference between the two groups (p=.063). Conclusion: The results indicate that education is effective in enhancing knowledge, attitude, and performance of hand washing.

• Journal of the Korean Society of School Health
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• v.30 no.3
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• pp.295-305
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• 2017

Purpose: This study was conducted to evaluate the effect of Mindfulness-based Emotion Management Training for adolescents immersed in self-harm behaviors. Methods: The participants were 61 middle school students located in Seoul. Thirty students were assigned to the Mindfulness-based Emotion Management Training (M-EMT) group and the other 31 students were assigned to the waitlist group. The students in the M-EMT group participated in a total of 12 sessions, twice a week, for 6 weeks. The modules of the program comprised of mindfulness for emotion, mindfulness for behavior/impulse, mindfulness for thought, and coping with self-harming behavior. The Distress Tolerance Scale, Deliberate Self-Harm Inventory, Cognitive Emotion Regulation Questionnaire, and Scale Suicidal Ideation were assessed at baseline and post-intervention. Results: Compared to the waitlist group, the intervention group exhibited a statistically significant improvement in distress tolerance and cognitive emotion regulation and a statistically significant reduction in self-harming behaviors and suicidal ideation. Conclusion: These results support the hypothesis that mindfulness-based emotional management training has a positive effect on reducing self-harming behaviors and enhancing distress tolerance and cognitive emotional regulation.

• Journal of Korean Society for Quality Management
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• v.49 no.3
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• pp.393-404
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• 2021

Purpose: The purpose of this study was to examine the corporate responsibility activities and investigate the effects of these activities on financial performance in public institutions. Methods: The collected data using annual performance evaluation for the year 2017-2019 were analyzed using multi-regression analysis. The corporate social responsibility activities for this study were divided into three dimensions such as social value, efficiency, and welfare. Results: The results of this study are as follows; first, public institutions with high evaluation in social value and welfare had a significant positive effect on financial performance factors such as ROA and ROS. Second, we find that there is a significant negative relation between social value activities and debt ratio. This result means that the higher social value activities, the lower debt ratio. It was also found that the activities for enhancing social value made statistically significant positive influence on BIS performance. Conclusion: These results can be interpreted that public institutions trying various social contribution activities does not necessarily bring negative results for financial performance. In conclusion, it means that socially responsible activities and ethical management in the desirable direction can be beneficial to both public institutions and the society to which they belong.

• The Korean Journal of Food And Nutrition
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• v.34 no.5
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• pp.441-448
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• 2021

This study was designed to investigate the intracellular signaling pathways and immunoenhancing effect of macrophage activation by crude polysaccharides (CPP) extracted from citrus peels. CPP did not affect the cytotoxicity of RAW264.7 cells, but showed dose-dependent effects on cell viability. Also, CPP showed high production of chemokine (nitric oxide (NO)) and cytokines (interleukin (IL)-6 and tumor necrosis factor (TNF)-α). CPP increased IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) mRNA expression dose-dependently. CPP also strongly induced the phosphorylation of the ERK, p38, and IκBα pathways in RAW 264.7 cells. In anti-pattern recognition receptors (PRRs) experiments, the effect of CPP on NO production was strongly suppressed by neutralizing toll-like receptor (TLR)2, TLR4, and Dectin1 antibodies, whereas IL-6 and TNF-α production by CPP was mainly suppressed by mannose receptor (MR). Therefore, these results suggest that CPP treatment-induced NO production was regulated by the ERK, p38, and NF-κB pathways through TLR2, TLR4, and Dectin1 receptors, whereas IL-6 and TNF-α production was primarily regulated by the ERK, p38, and NF-κB pathways through MR receptors.

• Korea Journal of Hospital Management
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• v.26 no.2
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• pp.1-16
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• 2021

This study aims to examine the effect of integrated health and welfare(IHW) services on medical use and medical expenses in Korean Veteran Hospitals. Data on the volume of medical use and medical expenses were collected from two patient groups of 5 Veterans' Hospitals: the beneficiary group who has received IHW services and the non-beneficiary group who has not. Each group was composed of 265 patients respectively. The results of the study revealed that the volume of home nursing services, home rehabilitation services, ambulatory services have increased significantly, whereas the average length of stay, number of using emergency services, and average medical expenses have decreased after receiving integrated health services in the beneficiary group. In contrast, the non-beneficiary group showed much more increase both in the volume of inpatient and outpatient services, as well as the average medical expenses, compared to those of the beneficiary group. This results imply that the provision of IHW services have positive impacts on the enhancing the effectiveness of the medical resources utilization for the veteran patients.

• Korean Journal of Childcare and Education
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• v.17 no.2
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• pp.47-68
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• 2021

Objective: This study investigated direct and indirect influences of fathers' parenting involvement on maternal parenting competence by exploring pathways between fathers' parenting involvement, maternal inner strength, and maternal parenting competence. Methods: A total of 329 mothers with 3-year-old children responded to online survey questionnaires, which included questions about fathers' parenting involvement, maternal inner strength, and maternal parenting competence. The data was analyzed by Pearson's correlation coefficients and Structural Equation Modeling. Results: It was observed that maternal inner strength perfectly mediated the association between father's parenting involvement and maternal parenting competence. More concretely, a direct effect of fathers' parenting involvement on maternal parenting competence was not found. It was also found that fathers' parenting involvement effects maternal parenting competence indirectly. The effect of fathers' parenting involvement on maternal inner strength was the greatest among all associations between fathers' parenting involvement, maternal inner strength, and maternal parenting competence. Conclusion/Implications: These findings have insights for research and practice, which emphasize the important considerations that enhancing maternal inner strength and the power of fathers' parenting involvement on maternal inner strength should be emphasized in order to improve maternal parenting competence.

• Journal of Korean Clinical Nursing Research
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• v.25 no.2
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• pp.161-169
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• 2019

Purpose: This study was conducted to examine the effect of a Happiness Self-Coaching program for new graduate nurses working in cancer care units. Methods: A quasi-experimental pretest-posttest, nonequivalent control-group design was applied to conduct the study. Study participants were new graduate nurses employed within 12 months and working as shift employees at G university hospital, located in J city. A total of 21 new graduate nurses participated in the study, 10 in the experimental group, and 11 in the control group. The happiness self-coaching program was conducted weekly for 70 minutes from February 1 to June 6, 2016 for 6 weeks. The experimental group received the Happiness Self-Coaching program through lectures, presentation, group activities, and strength card play. Data were analyzed by using repeated measure ANOVA and paired t-test. Results: The experimental group demonstrated significantly higher happiness (F=6.82, p=.003) and self-efficacy (F=3.38 p=.045) levels compared to the control group. Conclusion: The Happiness Self-Coaching program was effective in enhancing new graduate nurses' happiness and self efficacy. It is recommended that nursing organizations to apply the Happiness Self -Coaching program to facilitate adaption of new graduate nurses in cancer care units.

• Microbiology and Biotechnology Letters
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• v.47 no.2
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• pp.173-182
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• 2019

The use of double lumen catheters as a means of hemodialysis access is commonly accompanied with the use of gentamicin as an antibiotic lock. Other antibiotics and anticoagulants are often added to increase the efficacy of gentamicin in order to reduce catheter-related infection and to prevent biofilm formation. This review aimed to evaluate the following: 1) the use of gentamicin in eliminating catheter-related infection and reducing biofilm formation in hemodialysis catheters, 2) the efficacy of additional antibiotics in combination with gentamicin, and 3) the effect of additional anticoagulants to complement the efficacy of gentamicin as the main prophylactic antibiotic lock. We sorted through data from 242 PubMed and ScienceDirect studies, which were then short-listed to 33 studies. Next, they were grouped, extracted, and analyzed qualitatively to fulfil the objectives of this review. Consequently, the use of a gentamicin-lock solution was shown to reduce the incidence of bacteremia; however, it was not strong enough to inhibit the growth of infectious microbes and formation of biofilms. Several bacteria, such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Klebsiella pneumoniae, have been reported as infectious agents. Combination with other antibiotics also provided no effect in reducing bacterial growth and biofilm formation in catheters. Furthermore, the additional anticoagulants (trisodium citrate and EDTA) were reported to be effective in enhancing the efficacy of gentamicin in avoiding catheter-related infection, bacterial growth, and biofilm formation; thus, the use of gentamicin can be rationalized.

• Korean Journal of Materials Research
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• v.29 no.3
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• pp.189-195
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• 2019

The effect of C, Mn, and Al additions on the tensile and Charpy impact properties of austenitic high-manganese steels for cryogenic applications is investigated in terms of the deformation mechanism dependent on stacking fault energy and austenite stability. The addition of the alloying elements usually increases the stacking fault energy, which is calculated using a modified thermodynamic model. Although the yield strength of austenitic high-manganese steels is increased by the addition of the alloying elements, the tensile strength is significantly affected by the deformation mechanism associated with stacking fault energy because of grain size refinement caused by deformation twinning and mobile dislocations generated during deformation-induced martensite transformation. None of the austenitic high-manganese steels exhibit clear ductile-brittle transition behavior, but their absorbed energy gradually decreases with lowering test temperature, regardless of the alloying elements. However, the combined addition of Mn and Al to the austenitic high-manganese steels suppresses the decrease in absorbed energy with a decreasing temperature by enhancing austenite stability.