• 생약학회지
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• 제46권4호
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• pp.295-302
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• 2015

Cynanchi wilfordii Radix roots have been utilized as traditional medicine for variety of diseases including diabetes mellitus, aging progression and scavenging free radicals, enhancing immunity, reducing high serum cholesterol, and anti-tumor activity. However, the mechanisms underlying this effect remain poorly understood. The principal objective of this study was to determine the effect of cynandione A on osteoclast cells. Thus, we was isolated cynandione A from Cynanchi wilfordii Radix roots and evaluated the effect of cynandione A on receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation. We found that cynandione A significantly inhibited osteoclast differentiation stimulated-RANKL in RAW 264.7 cells. Cynandione A conspicuously inhibited the mRNA and protein expression of matrix metallopeptidase 9 (MMP-9), tartrate-resistant acid phosphatase (TRAP) in cynandione A treated with RANKL. Taken together, our results demonstrated that Cynanchi Wilfordii Radix may be useful treatment option of bone-related disease such as osteoporosis leads to fracture of bone and rheumatoid arthritis.

• 한국치위생학회지
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• 제10권5호
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• pp.797-805
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• 2010

Objectives : This study was application problem-based learning(PBL) of performance oral health manage in dental hygiene education. and evaluate on learning effect - learning attitude, student assessment(good or bed). Methods : For this study, we sampled 31 dental hygiene students composed of PBL group, Dept of Dental Hygiene, A college. The period of this study was 1 semester(from september, 2008 to December, 2008). To identify the effect of PBL on learning attitudes, student assessment, we used a t-test and compared pre & post effects of PBL using a paired t-test and General Linear Model(GLM), McNemar test. Results : The results of this study that problem based learning(PBL) for dental hygiene students education was more effective in learning process and effect of PBL rather than direct instruction. students assessment results that problem based learning improves their medicine knowledge and communication. Conclusions : This study suggest that PBL contribute to enhancing learning attitudes, learning effect and solve the real problems through self-directed learning.

• 보건의료산업학회지
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• 제12권1호
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• pp.149-160
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• 2018

Objectives : The purpose of this study was to examine the mediating effect of professional self-concept on the relationship between professor-student interaction and job-seeking anxiety among nursing students. Methods : A cross-sectional survey was conducted using a convenient sampling method with data collected from a sample of 294 nursing students. The structured questionnaire included items to assess job-seeking anxiety, professional self-concept, and professor-student interaction among nursing students. The data were analyzed with descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and multiple regression using the SPSS 24.0 program. Mediation analysis was performed according to the Sobel test. Results : Analysis of the mediating effect of professional self-concept showed a significant mediating influence of professional self-concept on the relationship between professor-student interaction and job-seeking anxiety. Conclusion : The findings suggest that professional self-concept may play a role in increasing the effect of professor-student interaction on job-seeking anxiety. Therefore, this study underscores the need to consider ways of enhancing professional self-concept during interventions for nursing students.

• 한국보육지원학회지
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• 제14권6호
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• pp.69-88
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• 2018

Objective: The purpose of this study was to examine the relationships between child care teachers' mindfulness, burnout, and sensitivity. Also, the effects of child care teachers' mindfulness on teacher sensitivity, including the mediating effects of burnout, were investigated. Methods: A total of 263 child care teachers who work in Seoul, Gyeonggi and Incheon participated in this study. Data were analyzed by correlations and regressions using SPSS 21.0. Results: First, there were significant correlations between child care teachers' mindfulness, burnout and teacher sensitivity. Second, the relationship between mindfulness and teacher sensitivity was partially mediated by burnout. To be specific, mindfulness not only had a direct effect on teacher sensitivity, but also had an indirect effect on teacher sensitivity through burnout. Among the three dimensions of burnout, the decrease of personal accomplishments had the biggest significant mediation effect on the relationship between mindfulness and teacher sensitivity. Conclusion/Implications: In conclusion, this study highlights the importance of mindfulness in reducing burnout and enhancing teacher sensitivity toward children. Also, this research has implications for future research regarding the mindfulness of child care teachers and offers a foundation for the development of mindfulness training programs for child care teachers.

• 지식경영연구
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• 제20권3호
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• pp.49-71
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• 2019

This study explores the role of knowledge sharing between their social capital and performance in R&D setting. R&D environment is composed of experts from various domains with different backgrounds, such as technologies and experiences. Thus, increasing team social capital and enhancing knowledge sharing are critical for R&D performance. Social capital and Knowledge sharing are classified into two : Social capital and Knowledge sharing within/outside team. A empirical study was conducted at a research institute of large company that leads the advanced research and development of the domestic chemical industry. Data was collected 292 copies out of 500 copies (Response rate 58.4%). The result indicated that both social capital within and outside team had a positive effect on R&D Performance. Social capital within team had a significant impact on knowledge sharing within the team only, and social capital outside team had a significant effect on knowledge sharing outside the team only. Only knowledge sharing outside the team had a positive effect on R&D Performance and the mediating role of knowledge sharing was acquired for social capital outside team and R&D Performance only. From these key findings, this study suggests that, within the team, social capital alone can achieve results, but outside the team, it is necessary that not only social capital but also knowledge sharing are needed in order to achieve results.

• 한국가족관계학회지
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• 제21권3호
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• pp.95-122
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• 2016

Objectives: The purpose of this study was to find out the moderating effect of gender between parenting attitude and anger expression of adolescent. Particularly, to ensure that the anger of emotion is common nature, this study was conducted on the middle class adolescent of stable economic status. Method: The subjects of this study were 357 students, first grade from 3 high schools in Seoul. Data was analyzed by descriptive statistics, t-test, correlation, and hierarchial regression, using the SPSS 18.0 program. Results: The main results were as follows: First, in parenting attitude the perception of monitoring and affection was less important for boys than girls, but more important in over expectation and neglect. Second, in anger expression the level of anger-control appeared higher than anger-in and anger-out, no significant gender difference in subfactors. Third, the effect of gender moderated the relationships between parenting attitude and anger expression of adolescent. Conclusions: The results indicated the need to recognize gender difference in controlling anger of adolescent and to improve dysfunctional parenting attitude in middle class. Furthermore, the implications were discussed in enhancing parent-adolescent communication, developing emotional education programs, and preventing juvenile delinquency.

• 신재생에너지
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• 제17권2호
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• pp.9-23
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• 2021

In Korea, various community investment renewable project models are being implemented to increase community acceptance of renewable energy. An important factor for enhancing local acceptance is that renewable energy projects have a positive effect on revitalizing the local economy such as income increase or job creation for residents and local companies. To maximize the local economic effect of large-scale community investment renewable energy projects, this study developed an evaluation index for local economy activation, whose indicators are the local return on investment, local companies' participation, local job creation, regional cooperation, transparency, and governance. Analysis of existing evaluation indicators and current renewable projects, financial analysis, and expert interviews were used in this research. The pilot evaluation determined that, the local economic effect was high in the following order: a fund investment wind project (Gangwon), benefit-sharing wind project (Jeju), and general wind project. In particular, residents' investment amount, the number of participating residents, and the amount and transparency of the regional cooperation fund were key factors to expand the effect of local economy activation. This evaluation index could be used in public bidding for renewable energy projects such as offshore wind zoning areas of local government.

• 대한본초학회지
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• 제29권1호
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• pp.1-6
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• 2014

Objectives : Many of currently used anti-cancer drugs were developed to target cell death mechanisms and had serious side effects by causing damage to normal cells. Hangambujeongsan or Kangai Fuzheng Powder was a mixture based on the traditional Chinese medicine. It had been used in the local Chinese hospitals to treat cancer patients for decades and had shown a certain level of beneficial effects without major toxic effects. But its mechanism of action had not been elucidated yet. Thus this study aimed to investigate the effects of Kangai Fuzheng Powder in an in vitro experiment. Methods : Cancer lines or RAW264.7 mouse macrophage cells were treated with Kangai Fuzheng Powder. Cell viability was measured by MTT assay, and morphological observation was also performed. Gene expression of cytokines in macrophages was determined by real-time polymerase chain reaction. Phagocytic function assay was also performed in macrophage cells. Results : Kangai Fuzheng Powder had no direct detrimental effect on cancer cells. When macrophages were co-cultured with cancer cells, Kangai Fuzheng Powder had toxic effect on cancer cells. After exposing macrophages to Kangai Fuzheng Powder, macrophages transformed into activated form and the mRNA level of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, interleukin-10 and monocyte chemotactic protein-1 was significantly enhanced. Phagocytic activity of macrophages was dramatically potentiated. Conclusions : We demonstrated that anti-cancer effect of Kangai Fuzheng Powder was related to activation of macrophages including enhanced cytokine production and phagocytic function.

• 한국수소및신에너지학회논문집
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• 제34권6호
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• pp.682-688
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• 2023

In this paper, analyzes the type of failure and its effect on the hydrogen fueling nozzle used in hydrogen station. Failure of hydrogen fueling nozzle was analyzed using a qualitative risk assessment method, failure mode and effect analysis. The failure data of hydrogen fueling nozzles installed in domestic hydrogen stations are collected, and the failure types are classified, checked the main components causing the failure. Criticality analysis was derived based on frequency and severity depending on the failure mode performed. A quality function is developed by a performance test evaluation item of the hydrogen fueling nozzle, and the priority order of design characteristics is selected. Through the analysis results, the elements to improve the main components for enhancing the quality and maintenance of the hydrogen fueling nozzle were confirmed.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권10호
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• pp.2750-2767
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• 2023

Live Commerce is rapidly emerging as a new paradigm for the digital economy and consumption activities in the post-COVID era. Many prior studies have been conducted on Live Commerce, but studies focusing on the characteristics of sources of Live Commerce are insufficient. This study aimed to investigate the human factors of sources that affect consumers' intention to use Live Commerce. For this purpose, based on an expanded TAM (Technology Acceptance Model) through literature research, variables were set, and a survey was conducted targeting Korean consumers who have experienced purchasing products through Live Commerce. Excluding unreliable data, 201 responses were utilized in the analysis of this study. At first, the measurement tools were checked through validity and reliability verification, and correlation analysis was conducted to identify the relationships between variables. Then, the proposed hypotheses were verified through multiple regression analysis. As a result, firstly, the human factors of sources had a positive effect on PU (Perceived Usefulness). Secondly, the PEOU (perceived ease of use) had a positive effect on both PU and CS (Consumer Satisfaction). Thirdly, PU had a positive effect on CS and ITU (Intention to Use). Finally, CS with Live Commerce had a positive effect on the ITU. Through this study, we try to provide an understanding of consumer behavior in the Live Commerce environment and contribute to enhancing the service provider's ability to offer high-quality Live Commerce content.