• The Journal of the Korea Contents Association
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• v.18 no.1
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• pp.132-142
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• 2018

This study attempts to identify the external and internal factors which affect collaboration motives and investigates their respective impacts from the perspective of foreign direct investment(FDI). Although there has been much research on collaboration motives, so far, few studies have associated collaboration motives with FDI. The findings suggest that while price competitiveness and cost structure uncertainty have a positive and significant impact on collaboration motives, the gross added value to property as well as plant and equipment have a significant negative impact. Furthermore, in the case of gross added value to both property and plant and equipment, managers tend to collaborate with others to enhance the value of these factors. For both FDI and non-FDI firms, internal factors such as price competitiveness and investment within three years are significant determinants for the decision to collaborate. The difference between FDI and non-FDI firms is that for the former, the gross added value to property, an internal factor, is a critical factor, while for the latter, the cost structure uncertainty, an external factor, is critical for collaboration. To summarize, this study suggests the following managerial implication: the enhancement of the internal competency of a firm broadens the window of opportunity for collaboration with others, and consequently provides a chance to boost management efficiency.

• Korean Journal of Environment and Ecology
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• v.25 no.4
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• pp.621-630
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• 2011

This research examines the push and pull factors of temple stay in Korean national parks. 152 participants of temple stay in Woljeongsa and Guryongsa in national parks in Gangwon-do area completed a survey to access their reasons for participating in temple stay(push factors) and to evaluate how well the visiting experience performed on a selected set of attributes(push factors). Demographics of respondents were similar to the visitor characteristics of Korean national parks. The result of factor analysis identified 6 push factor domains of 'self actualization', 'health enhancement', 'nature assimilation', 'relationship elevation', 'religious experience', and 'leisure experience'. 6 pull factor domains were 'recuperative quality', 'quality of a temple stay program', 'attributes of a temple', 'user convenience', 'tourism experience' and 'accessibility and transportation'. Satisfaction level of temple stay in a national park was very high of 4.71 in a 5 Likert scale. Gangwon- Do was most preferred with the percentage of 89.2 as a suitable area for temple stay in a national park. Findings of multi-dimensional tourism motivations of temple stay in a national park that encompass nature tourism, cultural tourism and religious tourism is expected to provide useful information for the future development of a more competitive temple stay program and a marketing strategy. However, more defined successive research work is required to generalize findings of wellness oriented push and pull factors of temple stay based on nature in national parks.

• Journal of Nutrition and Health
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• v.47 no.3
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• pp.167-175
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• 2014

Purpose: Previous studies have shown that treatment with Smilax china L. leaf extract (SCLE) produces antidiabetic effects due to ${\alpha}$-glucosidase inhibition. In this study, we examined the mechanism underlying these antidiabetic effects by examining glucose uptake in HepG2 cells cultured with SCLE. Methods: Glucose uptake and glucokinase activity were examined using an assay kit. Expression of glucose transporter (GLUT)-2, GLUT-4, and HNF-$1{\alpha}$ was measured by RT-PCR or western blot. Results: Treatment with SCLE resulted in enhanced glucose uptake in HepG2 cells, and this effect was especially pronounced when cells were cultured in an insulin-free medium. SCLE induced an increase in expression of GLUT-2 but not GLUT-4. The increase in the levels of HNF-$1{\alpha}$, a GLUT-2 transcription factor, in total protein extract and nuclear fraction suggest that the effects of SCLE may occur at the level of GLUT-2 transcription. In addition, by measuring the change in glucokinase activity following SCLE treatment, we confirmed that SCLE stimulates glucose utilization by direct activation of this enzyme. Conclusion: These results demonstrate that the potential antidiabetic activity of SCLE is due at least in part to stimulation of glucose uptake and an increase in glucokinase activity, and that SCLE-stimulated glucose uptake is mediated through enhancement of GLUT-2 expression by inducing expression of its transcription factor, HNF-$1{\alpha}$.

• Korean Journal of Pharmacognosy
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• v.51 no.4
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• pp.244-254
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• 2020

Atractylodes macrocephala is a perennial herb and is a member of the Compositae family. This plant is known to contain various bioactive constituents indicating anti-inflammatory, neuroprotective, anti-oxidant, immunological enhancement, and gastroprotective effects. In this investigation, we isolated four compounds with similar chemical structures from A. macrocephala, and evaluated their anti-inflammatory effects. Among the four compounds, compound 2(atractylenolide II) showed the second-best inhibitory effect on the lipopolysaccharide(LPS)-induced production of nitric oxide in RAW264.7 macrophages and BV2 microglial cells. Compound 2 also inhibited the LPS-induced the production of prostaglandin E2(PGE2), and the expression of inducible nitric oxide synthase(iNOS) and cyclooxygenase(COX)-2 proteins in both cells. In addition, compound 2 suppressed the production of pro-inflammatory cytokines including interleukin(IL)-1β, IL-6, and tumor necrosis factor(TNF)-α. These inhibitory effects were contributed by inactivation of nuclear factor kappa B(NF-κB) and mitogen-activated protein kinases(MAPKs) pathways by treatment with compound 2. This compound did not induce the expression of heme oxygenase(HO)-1 protein indicating that the anti-inflammatory effect of compound 2 was independent with HO-1 protein. Taken together, these results suggested that atractylenolide II can be a candidate material to treat inflammatory diseases.

• The Korea Journal of Herbology
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• v.37 no.3
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• pp.9-19
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• 2022

Objectives : Angelicae Gigantis Radix (AG) is a plant of the Ranunculus family. AG have been reported to have various pharmacological effects on human health which include uterine growth promotion, anti-inflammatory, analgesic, and immune enhancement. However, research on dermatitis disease is insufficient. Therefore, we investigated the effects of AG on tumor necrosis factor-α (TNF-α)/interferon-γ (IFN-γ) stimulated HaCaT cell. Methods : To investigate the effect of AG on HaCaT cell, HaCaT cells were pre-treated with AG for 1 hour and then stimulated with TNF-α/IFN-γ. After 24 hours, media and cells were harvested to analyze the inflammatory mediators. Concentration of human interleukin-1beta (IL-1β), monocyte chemoattractant protein-1 (MCP-1), granulocyte-macrophage colony-stimulating factor (GM-CSF), and TNF-α in the media were assessed by ELISA. mRNA expression of human thymus and activation-regulated chemokine (TARC), IL-6, and IL-8 were analyzed by RT-PCR. Additionally, the mechanisms of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway were investigated by Western blot. Results : The treatment of AG inhibited gene expression levels of IL-6, IL-8, and TARC and protein expression levels of IL-1β, MCP-1, and GM-CSF. Also, AG significantly reduced extracellular signal-regulated kinase (ERK) phosphorylation and NF-κB translocation in TNF-α/IFN-γ stimulated HaCaT cell. Conclusions : Taken together, these results demonstrate that AG can alleviate inflammatory diseases such as atopic dermatitis by regulating the expression of inflammatory cytokines. Also, it suggest that AG may a promising candidate drug for the treatment of inflammatory disease such as atopic dermatitis.

• 한국노년학
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• v.40 no.1
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• pp.73-89
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• 2020

This study validates an abridged version of the age integration scale by Chung et al. (2015), which constitutes sub-dimensions of age flexibility and age heterogeneity-from Riley et al. (1994)-and observes disparities in the perception of age integration among different socio-cultural characteristics. This study analyzed 1,433 people in the "Age Integration and Generation Integration Survey" data, with the support of the Social Science Competency Enhancement Project (SSK) (supported by the Korea Research Foundation). This paper analyzed the data using exploratory factor analysis, confirmatory factor analysis, multiple-group factor analysis, and a compare means test. The results are as follows. First, the scale was abridged to 13 items from 28, of which eight items concern age heterogeneity and five concern age flexibility. Second, the multi-group analysis did not show a significant difference among younger, middle, and older age groups, therefore allowing the scale to be used among all age groups. Third, when sociocultural characteristics were observed, younger adults showed differences in their levels of age integration, age heterogeneity, and age flexibility regarding their residential area. Middle-aged adults showed dif f erences in their levels of age integration, age heterogeneity, and age flexibility regarding their residential area and social status. Older adults showed differences in their level of age integration regarding their residential area, education level, and social status. They also showed differences in the level of age flexibility regarding their residential area and social status and differences in the level of age heterogeneity regarding their residential area and education. Based on the results of the study, political and practical measures to promote perception on age integration in the future were suggested.

• Journal of the Korea institute for structural maintenance and inspection
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• v.28 no.5
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• pp.10-19
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• 2024

In this study, FEM analysis was performed with the goal of optimal design of corrugated CFRP panels reinforcing H-shaped beams with slender plate webs. The buckling reinforcement performance of corrugated CFRP panels according to various specifications was evaluated, and in particular, a new reinforcement method was proposed by analyzing the effect of the ratio of vertical reinforcement according to the net height of the abdomen of the H-type beam on the location of the first elastic buckling mode. To minimize the amount of CFRP used, the attachment angle was set to 45 degrees. Furthermore, parameter analysis was performed according to changes in the specifications of the corrugated CFRP panel, and the buckling reinforcement performance of the corrugated CFRP panel was evaluated through the ductility factor. In addition, we attempted to use the material efficiently by simultaneously considering the maximum load and ductility factor along with the volume of the corrugated CFRP panels. It was confirmed that the model with two or three-layer CFRP laminate have a high ductility factor and efficient use of materials, and that the buckling reinforcement performance is predominantly affected by the length and height of the corrugated CFRP panel rather than the width.

• Journal of Naturopathy
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• v.12 no.2
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• pp.56-66
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• 2023

Background: Self-gravity acupressure (SGA), which complements the limitations of conventional manual therapies, is expected to have a positive effect on mood, closely related to reduction in stress. Purpose: This study aims to evaluate changes in mood states by SGA and to discuss its effects on stress relief and immunity. Methods: For 118 subjects (21 males and 97 females) who experienced the SGA program for 75 minutes, their mood states were assessed before and after the SGA session on 5 scales (0-4 points) using K-POMS consisting a total of 65 items grouped in six factors. For calculating the total mood disturbance score (iTMDs), the scores of the items in the only positive mood factor 'vigor-comfort' were reversed to have iTMDS increase the degree of the positive correlation with negative mood states. Results: The iTMDS decreased by 11.50% from 1.09±0.54 before SGA to 0.63±0.40 after SGA (p<0.001). The average score of the only positive factor 'vigor-comfort' increased by 10.78%, from 1.93±1.17 before SGA to 2.38±1.31 after SGA (p<0.001). On the other hand, the factor 'fatigue-inertia' of the 5 negative factors decreased most significantly in its average score by 16.73%, from 1.19±1.24 before SGA to 0.40±0.58 after SGA (p<0.001). The remaining 4 negative factors (depressed state, anxiety-fear, anger-hostility, and uncertainty-helplessness) decreased by within the range of 7.75% to 11.33% (p<0.001). Conclusions: Changes in K-POMS scores observed in this study indicate that the SGA program improves significantly mood. Since a mood state is closely related to stress and immunity, SGA is expected to have effects on stress relief and immunity enhancement (p<0.001). Continued studies are suggested to further validate the present results and to enhance the clinical utility, which include physiological signal measurements and clinical pathological examinations to test the effetcs of SGA on stress management and immunity enhancement.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.7
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• pp.4697-4703
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• 2015

This study has performed to propose the plan of effective career management systematically for the enhancement of mutual communication with internal and external customers based on the effect of career management activity in hospital organization on the job instability for administrative staff's. Data was collected from 192 hospital administrative staff's located in Busan area where 7 general hospitals and 7 hospitals were involved, and examined the factor analysis, the reliability, the regression analysis and the correlation analysis using SPSS statistical program. The organizational career management activities were classified into direct and indirect activities through the verification of validity and internal consistency, and the job instability was influenced by the direct career management activities. "Consider of countermeasure of necessary training required for the career of staff's" has the strongest relationship with the job instability among the organizational direct career management activities, and "Provide sufficient information service for new job opportunity" and "Develope career management plan participate with the staff's" were also relatively shown the higher relationship. Thus, it was indicated that the organizational effective career management activities for the enhancement of mutual communication with customers were necessary for the strategy establishment of career management activities.

• Radiation Oncology Journal
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• v.9 no.1
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• pp.7-15
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• 1991

Pentoxifylline (PENTO) has been known to improve RBC fluidity, and thus improve the flux of RBC through narrow capillaries. Additionally, PENTO also decreases the $O_2$ affinity of hemoglobin by increasing 2,3-DPG levels, thereby increasing the $O_2$ release from RBC. Nicotinamide (NA) has been reported to decrease the number of acutely hypoxic cells in tumors by temporarily increasing tumor blood flow. Therefore, the purpose of this study was to examine whether the combination of PENTO and NA (PENTO+NA) would reduce the radioresistance of the Fsall murine fibrosarcoma by oxygenating the hypoxic cells. We obsewed a significantly enhanced radiation-induced growth delay of the FSaII tumors by PENTO+NA. Thus the enhancement ratio was between 2.5 and 2.8 in growth delay assay. The $TCD_{50}$ of control tumors was about 57 Gy, but that of PENTO+NA treated tumors was about 32Gy. Thus $TCD_{50}$ was modified by a factor of 1.8. We also observed that PENTO+NA exerted no effect on the radiation-induced skin damage after the legs without bearing tumors were exposed to X-irradiation. In order to clarify radiosensitizing effects of PENTO+ NA, changes in tumor blood flow and intratumor pOf were measured using laser Doppler flowmetry and $O_2$ microelectrode methods. The tumor blood flow significantly increased at 10 min. after injection of PENTO+ NA. Furthermore, we also found that PENTO+ NA significantly increased intratumor $pO_2$ from 8 to 19 mmHg. We concluded that PENTO+MA was far more effective than NA alone or PENTO alone. The increase in the response of tumors in vivo to X-irradiation appeared to be due mainly to an increase in the tumor oxygenation. Further studies using various concentrations of PENTO alone and in combination with NA to obtain better sequencing and maximal radiosensitization are warranted.