• 감성과학
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• 제15권1호
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• pp.37-46
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• 2012

내현적 주의와 재정향이 탐지과제 수행에 미치는 영향을 반응촉진과 회귀억제를 통해 탐색하였다. Posner와 Cohen(1980)의 고전적인 탐지패러다임에서는 단서를 제시하고 일정한 자극제시시차 후 그 단서와 같거나 또는 다른 위치에 나타나는 표적에 대한 탐지수행을 관찰한다. 본 연구에서는 내현적 주의를 유발하기 위해 단서가 표적에 대해 예측력을 가지도록 조작하였고, 단서자극과 표적 사이에 새로운 단서(재정향단서)를 삽입하여 재정향을 유도하였다. 실험 1에서는 재정향단서가 제시되는 시기를 초기, 중기, 후기로 구분하여 실험을 실시하였다. 그 결과 재정향이 제시되는 시기별로 자극제시시차(150ms, 400ms, 850ms)에 따라 다른 양상의 반응촉진 및 회귀억제가 발생하였으나, 해석 가능한 일정 패턴을 확인하기는 어려웠다. 하지만 재정향이 초기에 발생한 실험조건을 재분석한 결과, 반응촉진과 회귀억제가 자극제시시차에 따라 교차하여 나타나는 단순탐지과제의 전형적인 결과를 얻을 수 있었다. 실험 2에서는 실험 1에서 재정향이 초기에 발생하는 조건에 대한 추가 실험을 실시하였다. 실험 결과, 자극제시시차가 짧을 때는 반응촉진이 발생하였으며 자극제시시차가 길때는 회귀억제가 발생하였다. 이 결과는 단서자극이 표적에 대한 예측력을 가질 때 자극제시시차가 긴 조건에서 회귀억제가 사라진다는 기존의 보고(Wright & Richard, 2000)와 반대되는 결과이다. 이 결과는 최초 단서가 제시된 후 회귀억제의 효과가 소멸되기 전에 매우 빠르게 제시되는 재정향단서는 이중 회귀억제를 가져온다는 것을 제안한다. 본 연구는 내현적 주의에 의해 특정한 위치에 주의를 할당할 때에도 반복적으로 빠르게 제시되는 단서자극은 회귀억제를 극대화함으로써 내현적 주의를 상쇄할 수 있음을 시사한다.

• 한국정밀공학회지
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• 제24권10호
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• pp.131-136
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• 2007

In this paper, we estimated the effects of different color stimulation on the cognitive function of human quantitatively. For the stimulations we used color lights with 6 color filters such as red, yellow, green, blue, violet and white. The experiment was performed in a soundproof chamber. 50 young male and female subjects were participated in the experiment. To find the appropriate color cognitive function, the endogenous visuospatial attention task(EVAT) and one back working memory task(OWMT) were performed. The reaction time and accuracy degree were measured. The results showed that the reaction time of EVAT was the fastest and the accuracy degree of attention task was the highest in green environment. The reaction time of OWMT was the fastest in yellow and the accuracy degree of memory task was the highest in blue. For physiological parameters, we measured electrocardiogram(ECG) and HRV spectrum analysis, HF/LF color environment. These results can be used as an indicator in the design of color environment and clinical applications.

• 한국지역사회생활과학회지
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• 제25권1호
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• pp.51-64
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• 2014

With a shift in the rural development process toward a bottom-up approach, the need to enhance the endogenous capacity of communities has become the core of rural development. In this regard, scholars have paid close attention to social capital to identify ways to facilitate endogenous rural development but focused mainly on relationships between social capital and local environment. That is, few studies have investigated the relationships between social capital and its various dimensions in the context of rural development initiatives. This study examines the effects of social capital on the problem-solving ability of community residents'rural development initiatives and assesses the types of social capital associated with such initiatives to propose optimal path for improving this ability. To distinguish between major dimensions of social capital, a questionnaire was developed by considering various stages of the rural development process. The survey considered a sample of 59 employees from public rural development institutions. According to the results, four paths were significant at the 5% level. Among these four paths, three set common goals. The effective channel was the path [common goals${\Rightarrow}$network${\Rightarrow}$cooperation${\Rightarrow}$problem-solving ability]. The key factor in improving problem-solving skills, the endogenous ability of community residents to facilitate rural development initiatives. The results suggest that governments should strengthen education and training programs to help residents set their common goals.

• 생명과학회지
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• 제13권2호
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• pp.236-240
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• 2003

인간의 면역계는 외부의 병원균 등의 침입에 대하여 매우 강력한 방어작용을 수행하고 있다. 하지만, 때로 면역계의 손상으로 인해 비정상적인 면역작용이 유발됨으로써 면역성 질환이 야기되기도 한다. 특히, 자가면역 질환은 그 종류가 매우 다양하며 심각한 위험을 초래하기도 한다 이들 질환에 대한 활발한 병인학적 연구가 진행되고 있으나, 아직 정확한 메커니즘을 밝히지는 못하고 있다. 자가면역성 당뇨병의 원인 유전자로 인간의 게놈에 내생하고 있는 HERV가 거론된 후, 사이토카인의 변화나 외생 레트로바기러스의 감염에 의해 HERV의 발현이 활성화되어 superantigen으로 작용함으로써 비정상적인 면역반응이 유도된다는 새로운 사실이 밝혀져 많은 주목을 끌고 있다. 이는 내생 레트로바이러스 유래의 superantigen과 인간의 질병과의 관련성을 비교적명확하게 제시함으로써, 자가면역 질환의 극복을 위한 향후 연구에 주요한 실마리를 제공하고 있다.

• 유통과학연구
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• 제14권3호
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• pp.39-44
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• 2016

Purpose - The purpose of this research is to investigate whether Korea's economic growth can be explained by the endogenous growth theory. Specifically, we test whether R&D expenditure has a positive and significant effect on the economic growth. Research design, data, and methodology - We hypothesize that R&D expenditure has a positive effect on the economic growth after adding control variables in the growth equation. Korean annual data from 1963 to 2011 from Science and Technology Annual of the Ministry of Education, Science and Technology, the Bank of Korea, etc. are used. We estimate the growth equation by GMM in addition to OLS. Results - We found that R&D expenditure has a positive and significant effect on the economic growth after adding the ratio of investment to GDP, the ratio of FDI to GDP, the ratio of government expenditure to GDP, inflation and the ratio of trade openness to GDP as control variables in the growth equation. Conclusions - Our results show that Korea's rapid economic growth for the past five decades can be explained by the R&D-based endogenous economic growth theory. Our results suggest that the policy attention of the Korean government be paid to R&D promotion.

• 의정연구
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• 제15권1호
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• pp.65-92
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• 2009

정치적 신뢰란 정부가 자신이 기대한 바대로 결과물을 산출하고 있는지에 대한 국민들의 주관적 인식의 결정체라 할 수 있다. 이 연구는 이러한 정치적 신뢰의 내생적(endogenous) 측면과 외생적(exogenous) 측면에 초점을 맞추어 정치적 신뢰가 어떤 요인들에 의해 영향을 받으며 또 어떤 정치적 결과를 만들어 내고 있는지에 대한 이론적 논의를 정리하는 것을 목적으로 한다. 정치적 신뢰의 변화에 영향을 미치는 요인으로 정부정책, 정치인의 비윤리적 행태, 국민들의 참여민주주의적 성향, 정부에 대한 국민들의 왜곡된 이해, 정치문화에 초점을 맞추어 각각의 요인들이 어떻게 정치적 신뢰를 변하게 만드는지 살펴본다. 또한 정부의 통치능력, 선거결과, 정치충원, 정부정책의 방향성의 측면에서 정치적 신뢰가 정치과정에 어떠한 결과를 만들어내는지를 알아본다.

• 한국축산식품학회지
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• 제29권2호
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• pp.278-282
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• 2009

Previous studies indicate that BF-7 enhances learning and memory in normal and elderly individuals. Here, we evaluated whether milk containing BF-7 (BF-7 milk) could improve the brain function, with thirty normal university students $(21{\pm}1.2 years)$. Two versions of the Paced Auditory Serial Addition Test were used under double-blinded conditions to measure the efficacy of BF-7 milk on learning and memory, especially working memory and attention, and on mathematical ability. As a result, BF-7 milk improved the accuracy of the task more than 3-fold. Furthermore, BF-7 milk protected cultured neuronal cells from 3-hydroxykynurenine, a normal endogenous brain stress agent. These results indicate that BF-7 milk enhances memory, attention and mathematical ability in normal persons.

• IMMUNE NETWORK
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• 제11권6호
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• pp.412-415
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• 2011

Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the $H-2K^b$-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.406.2-406.2
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• 2002

Special attention has been paid to human chorionic gonadotropin (hCG) for athlete doping control because it stimulates the endogenous production of testosterone and epitestosterone without increasing the T/E ratio which is a doping indicator for the exogenous administration of testosterone. Even though the IOC banned the use of hCG. a detection method has not been decided upon since there are a variety of immunoassay kits available on the market. We evaluated three kits in terms af their performance characteristics. (omitted)

• Journal of Medicine and Life Science
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• 제18권3호
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• pp.41-48
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• 2021

The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors. Most therapeutic drugs for ADHD have so far targeted biological causes, primarily by regulating catecholaminergic neurotransmitters. However, ADHD drugs that are clinically treated have various problems in their addictiveness and drug stability; thus, it is recommended that efficacy and safety should be secured through simultaneous prescription of multiple drugs rather than a single drug treatment. Accordingly, it is necessary to develop drugs that newly target pathogenic mechanisms of ADHD. In this study, we attempt to confirm the possibility of developing new drugs by reviewing dopamine-related developmental mechanisms of neurons and their correlation with ADHD. Histone deacetylase inhibitors (HDACi) can regulate the concentration of intracellular dopamine in neurons by expressing vesicular monoamine transporter 2 and inducing the exocytosis of neurotransmitters to the synaptic cleft, thereby promoting the development of neurons and signal transmission. This cellular modulation of HDACi is expected to treat ADHD by regulating endogenous catecholamines such as dopamine. Although studies are still in the preclinical stage, HDAC inhibitors clearly have potential as a therapeutic agent with low addictiveness and high efficacy for ADHD treatment.