Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Etiological Relationship between Autoimmune Diseases and HERVs

자가면역 질환과 HERV의 병인학적 관계

  • Published : 2003.04.01
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Abstract

Human immune system acts to protect the host from infectious agents (bacteria, viruses, fungi, parasites) and from other noxious insults. However, immune diseases are sometimes caused by the impairment of immune system leading to abnormal immune response. Especially, autoimmune diseases are very diverse and often bring serious damage Although many active investigations to reveal the etiological mechanisms concerning the autoimmune diseases, it still remains unclear. After proposing a HERV (human endogenous retrovirus) as a candidate autoimmune gene in type I diabetes, it is newly attracting our attention for demonstrating that an endogenous human retroviral superantigen can be transactivated by interferon-$\alpha$ (IFN- $\alpha$) or Epstein-Barr virus (EBV) infection. These might provide us with powerful clues to carry out further studies to overcome autoimmune diseases as the presentation of a relatively clear connection between endogenous superantigens and human diseases.

인간의 면역계는 외부의 병원균 등의 침입에 대하여 매우 강력한 방어작용을 수행하고 있다. 하지만, 때로 면역계의 손상으로 인해 비정상적인 면역작용이 유발됨으로써 면역성 질환이 야기되기도 한다. 특히, 자가면역 질환은 그 종류가 매우 다양하며 심각한 위험을 초래하기도 한다 이들 질환에 대한 활발한 병인학적 연구가 진행되고 있으나, 아직 정확한 메커니즘을 밝히지는 못하고 있다. 자가면역성 당뇨병의 원인 유전자로 인간의 게놈에 내생하고 있는 HERV가 거론된 후, 사이토카인의 변화나 외생 레트로바기러스의 감염에 의해 HERV의 발현이 활성화되어 superantigen으로 작용함으로써 비정상적인 면역반응이 유도된다는 새로운 사실이 밝혀져 많은 주목을 끌고 있다. 이는 내생 레트로바이러스 유래의 superantigen과 인간의 질병과의 관련성을 비교적명확하게 제시함으로써, 자가면역 질환의 극복을 위한 향후 연구에 주요한 실마리를 제공하고 있다.

Keywords

References

  1. Clin. Immunel. Immunopathol. v.56 Human endogenous retroviruses and immune disease Abraham,G.N.;A.S.Khan
  2. Annu. Rev. Immunol. v.13 Superantigens of mouse mammary tumor virus Acha-Crbea,H.;H.R.MacDonald https://doi.org/10.1146/annurev.iy.13.040195.002331
  3. J. Virol. v.75 Envelope gene of the human endogenous retrovirus HERV-W encodes a functional retrovirus envelope An,D.S.;Ym.Xie;I.S.Chen https://doi.org/10.1128/JVI.75.7.3488-3489.2001
  4. J. Autoimmun. v.13 Human retrovirus-5 in rheumatic disease Brand,A.;D.J.Griffiths;C.Herve;E.Mallon;P.J.Venables https://doi.org/10.1006/jaut.1999.0307
  5. J. Exp. Med. v.172 Selective expansion of T cells expressing Vβ2 in toxic shock syndrome Choi,Y.;J.A.Lafferty;J.R.Clements;J.K.Todd;E.W.Gelfand;J.Kappler;P.Marrack;B.L.Kotzin https://doi.org/10.1084/jem.172.3.981
  6. Acta. Neurol. Scand. v.101 Molecular characterization of HERV-H varians associated with multiple sclerosis Christensen,T.;P.Dissing Sorensen;H.Riemann;H.J.Hansen;M.Munch;S.Haahr;A.Moller-Larsen https://doi.org/10.1034/j.1600-0404.2000.09002.x
  7. J. Neuroimmunol. v.99 Immune responses to antigens of human endogenous retroviruses in patients with acute or stable multiple sclerosis Clerici,M.;M.L.Fusi;D.Caputo;F.R.Guerini;D.Trabattoni;A.Salvaggio;C.L.Cazzullo;D.Arienti;M.L.Villa;H.B.Urnovitz;P.Ferrante https://doi.org/10.1016/S0165-5728(99)00123-X
  8. Cell v.90 A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes Conrad,B.;R.N.Weissmahr;J.Boni;R.Arcari;J.Schupbach;B.Mach https://doi.org/10.1016/S0092-8674(00)80338-4
  9. Leukemia v.16 Expression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patients Depil,S.;C.Roche;P.Dussart;L.Prin https://doi.org/10.1038/sj.leu.2402355
  10. Rheumatology v.39 Infrequency of detection of particleassociated MSRV/HERV-W RNA in the synovial fluid of patients with rheumatoid arthritis Gaudin,P.;S.Ijaz;P.W.Tuke;F.Marcel;A.Paraz;J.M.Seigneurin;B.Mandrand;H.Perron;J.A.Garson https://doi.org/10.1093/rheumatology/39.9.950
  11. Immunobiology: the immune system in health and disease(5th eds.) Janeway,Jr.;A.Charles
  12. Proc. Natl. Acad. Sci. USA. v.98 Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia Karlsson,H.;S.Bachmann;J.Schroder;J.McArthur;E.F.Torrey;R.H.Yolken https://doi.org/10.1073/pnas.061021998
  13. FASEB J. v.6 Endogenous retroviruses: potential etiologic agents in autoimmunity Krieg,A.M.;M.F.Gourley;A.Perl
  14. Scand. J. Immunol. v.48 Beneficial role of human endogenous retroviruses: facts and hypotheses Larsson,E.;G.Andersson https://doi.org/10.1046/j.1365-3083.1998.00428.x
  15. Cancer. Res. v.61 Identification of a proviral structure in human breast cancer Liu,B.;Y.Wang;S.M.Melana;I.Pelisson;V.Najfeld;J.F.Holland;B.G.Pogo
  16. Lancet. Infect. Dis. v.2 Superantigens:microbial agents that corrupt immunity Llewelyn,M.;J.Cohen https://doi.org/10.1016/S1473-3099(02)00222-0
  17. J. Gen. Virol. v.82 The full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties Mangeney,M.;N.de Parseval;G.Thomas;T.Heidmann
  18. Virology v.296 Perspectives on the role of endogenous human retroviruses in autoimmune diseases Portis,J.L. https://doi.org/10.1006/viro.2002.1388
  19. Arthritis Rheum. v.35 Antibodies toretroviral proteins in autoimmune connective tissue disease Ranki,A.;P.Kurki;S.Riepponen;E.Stephansson https://doi.org/10.1002/art.1780351212
  20. Acta Neurol. Scand. v.88 Do endogenous retroviruses have etiological implications in inflammatory and degenerative nervous system diseases? Rasmussen,H.B.;H.Perron;J.Clausen https://doi.org/10.1111/j.1600-0404.1993.tb04215.x
  21. Immunity v.15 Interferon-a-induced endogenous superantigen: a model linking environment and autoimmunity Stauffer,Y.;S.Marguerat;F.Meylan;C.Ucla;N.Sutkowski;B.Huber;T.Pelet;B.Conrad https://doi.org/10.1016/S1074-7613(01)00212-6
  22. Cell v.80 Escape from horror autotoxicus: pathogenesis and treatment of autoimmune disease Steinman,L. https://doi.org/10.1016/0092-8674(95)90443-3
  23. Immunity v.15 Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen Sutkowski,N.;B.Conrad;D.A.Thorley-Lawson;B.T.Huber https://doi.org/10.1016/S1074-7613(01)00210-2
  24. Bioessays v.22 Retroviruses and primate evolution Sverdlov,E.D. https://doi.org/10.1002/(SICI)1521-1878(200002)22:2<161::AID-BIES7>3.0.CO;2-X
  25. Ann. Allergy v.69 Evidence for possible retroviral involvement in autoimmune diseases Talal,N.;E.Flescher;H.Dang
  26. Cell v.85 Insulin-dependent diabetes mellitus Tisch,R.;H.McDevitt https://doi.org/10.1016/S0092-8674(00)81106-X
  27. J. Neurovirol. v.2 Augmented type 1 cytokines and human endogenous retroviruses specific immune responses in patients with acute multiple sclerosis Trabattoni,D.;P.Ferrante;M.L.Fusi;M.Saresella;D.Caputo;H.Umovitz;C.L.Cazzullo;M.Clerici
  28. Br. J. Rheumatol. v.31 Retroviruses: potential aetiological agents in autoimmune rheumatic disease Venables,P.;S.Brookes https://doi.org/10.1093/rheumatology/31.12.841
  29. Trends. Immunol. v.23 Immunity and retroviral superantigens in humans Woodland,D.L. https://doi.org/10.1016/S1471-4906(01)02146-9