• Science of Emotion and Sensibility
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• v.15 no.1
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• pp.37-46
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• 2012

We tested the effects of endogenous attention and reorienting on the performance of detection task. In the classic detection paradigm of Posner and Cohen (1980), performance on target detection is measured, where target appears either on the same or difference spatial location of cue stimulus after brief period of SOA (stimulus onset asynchrony). In this study, we induced exogenous attention by manipulating predictability of cue for target, and also induced reorientation by inserting additional (reorienting) cue between initial cue and target. Experiment 1 had three conditions of reorienting speed: Early, middle, and late. Facilitation and IOR (inhibition of return) occurred in different forms depending on SOA and reorienting speed, but we were not able to discover interpretable pattern in the results. However, reanalysis of early reorienting condition revealed that facilitation and IOR occurred in a crossed manner where short SOA found facilitation and long SOA did IOR, the typical results of simple detection task. Experiment 2 collected additional data to replicate the results in early reorienting condition of experiment 1. The results obtained that facilitation occurred with short SOA and IOR with long SOA. These results contrast with those of Wright and Richard (2000) where they reported elimination of IOR when cue had predictability of target locations. These results suggest that additional cue (here, orienting cue), which rapidly appears before extinction of IOR by prior cue, brings about double IOR. The present research demonstrates that even when attention is allocated to certain location via endogenous mechanism, rapidly repeating cues in certain location maximizes IOR that offsets the effects of endogenous attention to the same location.

• Journal of the Korean Society for Precision Engineering
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• v.24 no.10
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• pp.131-136
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• 2007

In this paper, we estimated the effects of different color stimulation on the cognitive function of human quantitatively. For the stimulations we used color lights with 6 color filters such as red, yellow, green, blue, violet and white. The experiment was performed in a soundproof chamber. 50 young male and female subjects were participated in the experiment. To find the appropriate color cognitive function, the endogenous visuospatial attention task(EVAT) and one back working memory task(OWMT) were performed. The reaction time and accuracy degree were measured. The results showed that the reaction time of EVAT was the fastest and the accuracy degree of attention task was the highest in green environment. The reaction time of OWMT was the fastest in yellow and the accuracy degree of memory task was the highest in blue. For physiological parameters, we measured electrocardiogram(ECG) and HRV spectrum analysis, HF/LF color environment. These results can be used as an indicator in the design of color environment and clinical applications.

• The Korean Journal of Community Living Science
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• v.25 no.1
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• pp.51-64
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• 2014

With a shift in the rural development process toward a bottom-up approach, the need to enhance the endogenous capacity of communities has become the core of rural development. In this regard, scholars have paid close attention to social capital to identify ways to facilitate endogenous rural development but focused mainly on relationships between social capital and local environment. That is, few studies have investigated the relationships between social capital and its various dimensions in the context of rural development initiatives. This study examines the effects of social capital on the problem-solving ability of community residents'rural development initiatives and assesses the types of social capital associated with such initiatives to propose optimal path for improving this ability. To distinguish between major dimensions of social capital, a questionnaire was developed by considering various stages of the rural development process. The survey considered a sample of 59 employees from public rural development institutions. According to the results, four paths were significant at the 5% level. Among these four paths, three set common goals. The effective channel was the path [common goals${\Rightarrow}$network${\Rightarrow}$cooperation${\Rightarrow}$problem-solving ability]. The key factor in improving problem-solving skills, the endogenous ability of community residents to facilitate rural development initiatives. The results suggest that governments should strengthen education and training programs to help residents set their common goals.

• Journal of Life Science
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• v.13 no.2
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• pp.236-240
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• 2003

Human immune system acts to protect the host from infectious agents (bacteria, viruses, fungi, parasites) and from other noxious insults. However, immune diseases are sometimes caused by the impairment of immune system leading to abnormal immune response. Especially, autoimmune diseases are very diverse and often bring serious damage Although many active investigations to reveal the etiological mechanisms concerning the autoimmune diseases, it still remains unclear. After proposing a HERV (human endogenous retrovirus) as a candidate autoimmune gene in type I diabetes, it is newly attracting our attention for demonstrating that an endogenous human retroviral superantigen can be transactivated by interferon-$\alpha$ (IFN- $\alpha$) or Epstein-Barr virus (EBV) infection. These might provide us with powerful clues to carry out further studies to overcome autoimmune diseases as the presentation of a relatively clear connection between endogenous superantigens and human diseases.

• Journal of Distribution Science
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• v.14 no.3
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• pp.39-44
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• 2016

Purpose - The purpose of this research is to investigate whether Korea's economic growth can be explained by the endogenous growth theory. Specifically, we test whether R&D expenditure has a positive and significant effect on the economic growth. Research design, data, and methodology - We hypothesize that R&D expenditure has a positive effect on the economic growth after adding control variables in the growth equation. Korean annual data from 1963 to 2011 from Science and Technology Annual of the Ministry of Education, Science and Technology, the Bank of Korea, etc. are used. We estimate the growth equation by GMM in addition to OLS. Results - We found that R&D expenditure has a positive and significant effect on the economic growth after adding the ratio of investment to GDP, the ratio of FDI to GDP, the ratio of government expenditure to GDP, inflation and the ratio of trade openness to GDP as control variables in the growth equation. Conclusions - Our results show that Korea's rapid economic growth for the past five decades can be explained by the R&D-based endogenous economic growth theory. Our results suggest that the policy attention of the Korean government be paid to R&D promotion.

• Korean Journal of Legislative Studies
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• v.15 no.1
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• pp.65-92
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• 2009

Political trust is defined as the degree to which people perceive that government is producing outcomes consistent with their expectations. Political trust as a concept has endogenous as well as exogenous characteristics in that it can cause and be caused by other political factors. The purpose of this study is to introduce and evaluate various theoretical perspectives related to the causes and effects of political trust. With respect to its causes, this study focuses on the following five factors: government policies, unethical behaviors of politicians, citizens' penchant for participatory democracy, the public's misperceptions on government, and political culture. On the other hand, this study discusses the impacts of political trust on each stage of political process by paying attention to the following factors: government's governability, election outcomes, political recruitment, and the directions of government policies.

• Food Science of Animal Resources
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• v.29 no.2
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• pp.278-282
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• 2009

Previous studies indicate that BF-7 enhances learning and memory in normal and elderly individuals. Here, we evaluated whether milk containing BF-7 (BF-7 milk) could improve the brain function, with thirty normal university students $(21{\pm}1.2 years)$. Two versions of the Paced Auditory Serial Addition Test were used under double-blinded conditions to measure the efficacy of BF-7 milk on learning and memory, especially working memory and attention, and on mathematical ability. As a result, BF-7 milk improved the accuracy of the task more than 3-fold. Furthermore, BF-7 milk protected cultured neuronal cells from 3-hydroxykynurenine, a normal endogenous brain stress agent. These results indicate that BF-7 milk enhances memory, attention and mathematical ability in normal persons.

• IMMUNE NETWORK
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• v.11 no.6
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• pp.412-415
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• 2011

Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the $H-2K^b$-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.406.2-406.2
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• 2002

Special attention has been paid to human chorionic gonadotropin (hCG) for athlete doping control because it stimulates the endogenous production of testosterone and epitestosterone without increasing the T/E ratio which is a doping indicator for the exogenous administration of testosterone. Even though the IOC banned the use of hCG. a detection method has not been decided upon since there are a variety of immunoassay kits available on the market. We evaluated three kits in terms af their performance characteristics. (omitted)

• Journal of Medicine and Life Science
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• v.18 no.3
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• pp.41-48
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• 2021

The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors. Most therapeutic drugs for ADHD have so far targeted biological causes, primarily by regulating catecholaminergic neurotransmitters. However, ADHD drugs that are clinically treated have various problems in their addictiveness and drug stability; thus, it is recommended that efficacy and safety should be secured through simultaneous prescription of multiple drugs rather than a single drug treatment. Accordingly, it is necessary to develop drugs that newly target pathogenic mechanisms of ADHD. In this study, we attempt to confirm the possibility of developing new drugs by reviewing dopamine-related developmental mechanisms of neurons and their correlation with ADHD. Histone deacetylase inhibitors (HDACi) can regulate the concentration of intracellular dopamine in neurons by expressing vesicular monoamine transporter 2 and inducing the exocytosis of neurotransmitters to the synaptic cleft, thereby promoting the development of neurons and signal transmission. This cellular modulation of HDACi is expected to treat ADHD by regulating endogenous catecholamines such as dopamine. Although studies are still in the preclinical stage, HDAC inhibitors clearly have potential as a therapeutic agent with low addictiveness and high efficacy for ADHD treatment.