• 가정∙방문간호학회지
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• 제31권1호
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• pp.30-43
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• 2024

Purpose: This study aimed to enhance health management and prevention strategies for precocious puberty by comparing the knowledge, motivation, and behaviors related to reducing exposure to endocrine disrupting chemicals (EDCs) between mothers of children with precocious puberty and those of typically developing children. Methods: Participants were 66 mothers of children with precocious puberty from a hospital and 71 mothers of typically developing children from an elementary school. The research questionnaire assessed knowledge of EDCs, motivation, self-efficacy, and behaviors towards reduced exposure to EDCs, in addition to general characteristics of children with precocious puberty. Data analysis utilized descriptive statistics, chi-square tests, t-tests, ANOVA, and Pearson's correlation. Results: There were statistically significant differences in self-efficacy (p=.015) and behavior (p=.001) regarding reduced exposure to EDCs between the two groups. Behaviors toward reduced exposure to EDCs were positively associated with knowledge of EDCs, motivation, and self-efficacy among mothers of children with precocious puberty. Additionally, these behaviors correlated positively with knowledge of EDCs, motivation, self-efficacy, and the child's birth weight and waist circumference among mothers of typically developing children. Conclusion: The results of this study revealed that mothers of children with precocious puberty exhibited less proactive behavior in reducing exposure to EDCs compared to mothers of typical children. Therefore, it is important to foster interest in the impact of environmental factors, beyond characteristic factors, on behaviors aimed at reducing exposure to EDCs.

• Fisheries and Aquatic Sciences
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• 제16권3호
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• pp.187-194
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• 2013

Microalgae are sensitive indicators of environmental changes, and hence they are widely used in environmental risk assessments and for the development of discharge guidelines. Here we evaluated the toxicity of metals and endocrine-disrupting chemicals (EDCs) to the marine green microalga, Tetraselmis suecica. The toxicants investigated included the metals, Cu, Ni, and Pb; and the EDCs, bisphenol A (BPA), endosulfan (ES), and polychlorinated biphenyl (PCB). The endpoints were variations in cell counts and chlorophyll a levels. T. suecica displayed a varied pattern of sensitivity to the toxicants. Based on the 72-h median effective concentration ($EC_{50}$), ES (0.045 mg/L) was most toxic to T. suecica, followed by PCB (3.96 mg/L) and Pb (9.62 mg/L). Interestingly, T. suecica was relatively tolerant to Cu (43.03 mg/L). The 72-h $EC_{50}$ values of Ni and BPA were approximately 16 mg/L. Our data suggest that this species may be relatively tolerant to most of the chemicals within their permissible limits in the environment.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2001년도 춘계심포지움 및 학술발표회
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• pp.126-126
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• 2001

Over the last few years, an increased awareness of endocrine disrupting chemicals (EDCs) and their potential to affect wildlife and humans has produced a demand for practical screening methods to identify endocrine activity in a wild range of environmental and industrial chemicals. It is clear that in vivo methods will be required to identify adverse effects produced by these chemicals. (omitted)

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2004년도 춘계학술대회
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• pp.61-65
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• 2004

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.283.1-283.1
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• 2002

The adverse health effects on humans and domestic and wildlife species by exposing to environmental contaminants. which interact with the endocrine system. have he en treated as an important issue without hesitation throughout the 1990s. The chemicals with practical and/or potential interfering actions with the endocrine system functions are called endocrine disrupting chemicals (EDCs). (omitted)

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6121-6125
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• 2014

Background: Prostate-specific antigen (PSA) is a potential biomarker for early detection of prostate cancer (PCa) but its level is known to be affected by many background factors and roles of ubiquitous toxicants have not been determined. Endocrine disrupting chemicals (EDCs) are ubiquitous reproductive toxicants used in consumer products, which promote tumor formation in some reproductive model systems by binding to AhR, but human data on its expression in prostate cancer as well as its association with PSA levels are not clear. This study aimed to evaluate the expression levels of AhR and its association with serological levels of PSA and to detect possible effects of background factors and EDC exposure history on PSA levels in PCa cases. Materials and Methods: A cross-sectional study was conducted on the tissue levels of AhR and serum levels of PSA in 53 PCa cases from 2008-2011 and associations between each and background and lifestyle related factors were determined. Results: Although the AhR was overexpressed in PCa and correlated with the age of patients, it did not correlate with PSA levels.Of nutritional factors, increased intake of polysaturated fats and fish in the routine regimen of PCa cases increased the PSA levels significantly. Conclusions: AhR overexpression in PCa pontws to roles of EDCs in PCa but without any direct association with PSA levels. However, PSA levels are affected by exposure to possible toxicants in foods whichneed to be assessed as possible risk factors of PCa in future studies.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2003년도 춘계학술대회
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• pp.149-149
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• 2003

To understand environmental paths of the transport and accumulation of endocrine disrupting chemicals (EDCs), a single cell multimedia fate model has been constructed and evaluated. The EDCs of concern were PAHs, Organochlorine Pesticides (OCPs), PCBs, Alkyl phenols, and phthalates. An evaluation model was designed for the multimedia distribution, including air, water, soil, sediment and vegetation. This model was verified using reported values and via monitoring data. Based on collected data, the distribution trends of EDCs with respect to environmental media were analyzed. Those results have applied to the model for the prediction of the spatial and temporal distribution of EDCs in Seoul. Especially, phenol compound, phthalates, PAHs, PCBs and organochlorine pesticides were estimated and the model was verified. This model was successfully conducted to environmental media, such as air (vapor and suspended particles), soils (forest soil, bare soil, and cement-concrete covered soil), water (dissolved and suspended solids), sediment, trees (deciduous and coniferous). The discrepancies between the model prediction and the measured data are approximately within or near a factor of 10 for the PAHs of three rings through that of six rings, implying that multimedia distribution of the PAHs could be predicted with a factor of 10. Concerning about the air equilibrium may be assumed, a fugacity at steady state is similar in all environmental media. Considering the uncertainties of this model, the use of equilibrium models may be sufficient for assessing chemical fates. In this study, a suggestion was made that modeling and estimation of chemicals in environmental multimedia be rigorously evaluated using the measured flux data. In addition, these data should be obtained, for example, from the precise and standardized inventory of the target chemicals. The model (EDC Seoul) will be refined in an on-going research effort and will be used to support decision-making concerning the management of EDCs.

• Journal of Microbiology and Biotechnology
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• 제33권10호
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• pp.1351-1360
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• 2023

Endocrine-disrupting chemicals (EDCs) are compounds that disturb hormonal homeostasis by binding to receptors. EDCs are metabolized through hepatic enzymes, causing altered transcriptional activities of hormone receptors, and thus necessitating the exploration of the potential endocrine-disrupting activities of EDC-derived metabolites. Accordingly, we have developed an integrative workflow for evaluating the post-metabolic activity of potential hazardous compounds. The system facilitates the identification of metabolites that exert hormonal disruption through the integrative application of an MS/MS similarity network and predictive biotransformation based on known hepatic enzymatic reactions. As proof-of-concept, the transcriptional activities of 13 chemicals were evaluated by applying the in vitro metabolic module (S9 fraction). Identified among the tested chemicals were three thyroid hormone receptor (THR) agonistic compounds that showed increased transcriptional activities after phase I+II reactions (T3, 309.1 ± 17.3%; DITPA, 30.7 ± 1.8%; GC-1, 160.6 ± 8.6% to the corresponding parents). The metabolic profiles of these three compounds showed common biotransformation patterns, particularly in the phase II reactions (glucuronide conjugation, sulfation, GSH conjugation, and amino acid conjugation). Data-dependent exploration based on molecular network analysis of T3 profiles revealed that lipids and lipid-like molecules were the most enriched biotransformants. The subsequent subnetwork analysis proposed 14 additional features, including T4 in addition to 9 metabolized compounds that were annotated by prediction system based on possible hepatic enzymatic reaction. The other 10 THR agonistic negative compounds showed unique biotransformation patterns according to structural commonality, which corresponded to previous in vivo studies. Our evaluation system demonstrated highly predictive and accurate performance in determining the potential thyroid-disrupting activity of EDC-derived metabolites and for proposing novel biotransformants.

• 한국발생생물학회지:발생과생식
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• 제2권2호
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• pp.115-133
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• 1998

지난 반세기 동안내분비 장애물질의 제한없는 생산과 무분별한 소비, 방출, 폐기는 물, 흙, 공기 등 자연을 오염시켜 왔다. 그 결과 생태계의 야생동물이 오염되어, 생식과 발생의 이상이 일어나고, 멸종이 예견되기에 이르렀다. 또한 동물 자신은 물론, 후세대에 내분비계의 교란을 일으켜 정상적인 성생활, 발생과 생식의 기형, 정자수 감소 등의 불임유발, 성행동, 신경계와 면역계의 이상, 암까지 유발하는 것으로 알려지고 있다. 암이 개체의 사멸을 일으키는 반면, 내분비 장애물질은 체내에 잔류되며 대를 이어 전달되고, 사멸하여도 환경의 오염원이 되어 먹이사슬로 축적된다는 의미에서 야생동물은 물론 인간의 미래를 어둡게 만든다고 판단되고 있다. 그러므로 이들이 야생동물의 생식과 발생에 미치는 영향, 먹이사슬내의 이동 및 오염 확산을 개관하고자 하였다. 또한 이에 대처하기 위한 국내외 연구동향을 기술하고, 또 중요한 물질의 생산 현황을 요약하고, 발생과 생식을 전공하는 연구자 제위에게 관심을 유도하고자 하였다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제14권1호
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• pp.44-50
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• 2009

생물체내에 내분비계 기능을 방해하고 생식능력 감소, 암 등을 유발하는 내분비계장애물질이 상수나 폐수, 지표수, 토양 등에서 검출이 증가하는 추세이다. 본 연구에서는 토양 내 내분비계장애물질을 산화공유결합반응을 유도, 토양 유기물화 시켜 제거하기 위하여 망간 산화물인 버네사이트를 촉매로 이용하였다. 수산화 작용기를 갖는 내분비계장애물질인 bisphenol A, 2,4-dichlorophenol 및 17${\beta}$-estradiol을 각각 50, 100, 1.5 mg/L의 농도로 하여 수용액 상에서의 버네사이트 촉매 반응을 관찰한 결과, 모두 60분 이내에 99% 이상 제거되었다. 특히 bisphenol A는 5분 내에 96%이상 제거되는 등 가장 높은 제거효율을 나타냈다. 또한 산화공유결합반응은 버네사이트 표면에서 일어나는 반응으로 버네사이트의 양, 즉 반응 표면적이 넓어질수록 일차반응속도상수가 선형적으로 증가함을 확인하였다. 토양 슬러리 상에서의 각 물질의 반응성을 확인한 결과, 수용액상보다 빠르게 변환되었는데, 이는 버네사이트에 의해 생성된 페녹시 라디칼이 토양유기물과 교차결합하여 더욱 빠르게 제거되었기 ��문으로 판단된다. 이러한 수용액 및 토양에서의 빠른 반응으로 비추어 볼때, 버네사이트를 이용한 유기물화 기술은 수용액 뿐만 아니라 토양 내 내분비계장애물질의 효과적인 처리 방법이 될 것으로 보인다.