• Biotechnology and Bioprocess Engineering:BBE
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• 제9권2호
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• pp.132-136
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• 2004

The LAL (Limulus amebocyte lysate) test for the detection and quantification of endotoxin is based on the gelation reaction between endotoxin and LAL from a blood extract of Limulus polyphemus. The test is labor intensive, requiring dedicated personnel, a relatively long reaction time (approximately 1 h), relatively large volumes of samples and reagents and the detection of the end-point is rather subjective. To solve these problems, a miniaturized LOC (lab-on-a-chip) prototype, 62mm (L) ${\times}$ 18 mm (W), was fabricated using PDMS (polydimethylsiloxane) bonded to glass. Using this prototype, in which 2mm (W) ${\times}$ 44.3mm (L) ${\times}$ 100 $\mu\textrm{m}$ (D) microfluidic channel was constructed, turbidometric and chromogenic assay detection methods were compared, and the chromogenic method was found the most suitable for a small volume assay. In this assay, the kinetic-point method was more accurate than the end-point method. The PDMS chip thickness was found to be minimized to around 2 mm to allow sufficient light transmittance, which necessitated the use of a glass slide bonding for chip rigidity. Due to this miniaturization, the test time was reduced from 1 h to less than 10 min, and the sample volume could be reduced from 100 to ca. 4.4 ${\mu}$L. In summation, this study suggested that the LOC using the LAL test principle could be an alternative as a semi-automated and reliable method for the detection of endotoxin.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 추계학술대회 논문집 Vol.14 No.1
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• pp.181-184
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• 2001

Chemical Mechanical Polishing(CMP) of Shallow Trench Isolation(STD structure in 0.18 m semiconductor device fabrication is studied. CMP process is applied for the STI structure with and without reverse moat pattern and End Point Detection (EPD) method is tested. To optimize the transistor properties related metal 1 parameters. we studied the correlation between CMP thickness of STI using high selectivity slurry. DOE of gate etch recipe, and 1st metal DC values. Remaining thickness of STI CMP is proportional to the thickness of gate-etch process and this can affect to gate profile. As CMP thickness increased. the N-poly foot is deteriorated. and the P-Poly Noth is getting better. If CD (Critical Dimension) value is fixed at some point,, all IDSN/P values are in inverse proportional to CMP thickness by reason of so called Profile Effect. Weve found out this phenomenon in all around DOE conditions of Gate etch process and we also could understand that it would not have any correlation effects between VT and CMP thickness in the range of POE 120 sec conditions. As CMP thickness increased by $100\AA$. 3.2 $u\AA$ of IDSN is getting better in base 1 condition. In POE 50% condition. 1.7 $u\AA$ is improved. and 0.7 $u\AA$ is improved in step 2 condition. Wed like to set the control target of CD (critical dimension) in gate etch process which can affect Idsat, VT property versus STI topology decided by CMP thickness. We also would like to decide optimized thickness target of STI CMP throughout property comparison between conventional STI CMP with reverse moat process and newly introduced STI CMP using high selectivity slurry. And we studied the process conditions to reduce Gate Profile Skew of which source known as STI topology by evaluation of gate etch recipe versus STI CMP thickness.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제13권1호
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• pp.75-80
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• 2010

장중첩증이 재발한 15개월 여아에서 초음파 검사에서 병적 선두로 생각되는 낭성 종괴를 확인하였고 이중벽 징후와 인접한 소장 사이에 Y자 형상의 저반향 경계를 가지고 있어 중복 낭종으로 의심하였다. 이후 절제술을 시행하여 조직병리검사에서 인접한 회장과 근육층을 공유하고 낭종의 바깥쪽으로는 인접한 장 점막상피 조직과 안쪽으로는 이소성 위 점막 조직이 관찰되는 중복 낭종으로 확진되어 문헌 고찰과 함께 보고하는 바이다.

• 한국환경과학회지
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• 제19권6호
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• pp.665-670
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• 2010

Pollutants from urban pavement consists various kinds of substances which are originated from dry deposition, a grind out tire, corrosive action of rain to pavement and facilities and raw materials of the road etc.. These are major pollutants of urban NPS (Non-point source) during rainfall period. However there is not enough information to control such pollutants for appropriate management of natural water quality. In this study of transportation areas, three monitoring stations were set up at trunk road, urban highway and national road in Gyeongnam province. Runoff flow rate was measured at every 15minutes by automatic flow meters installed at the end of storm sewer pipe within the road catchment area for water quality analysis. Data was collected every 15 minutes for initial two hours of rainfall. Additional samples were collected 1-4 hours interval till the end of rainfall. The monitoring parameters were $COD_{Mn}$, SS, T-N & T-P and heavy metals. The average EMCs of TSS and $COD_{Mn}$ were 62.0 mg/L and 24.2 mg/L on the city trunk road, which were higher than those of urban highway and national road, indicating higher pollutant loads due to activities in the city downtown area beside the vehicle. On the other hand, the average EMC of T-N and T-P were in the range of 2.67-3.23 mg/L and 0.19-3.21 mg/L for all the sampling sites. Heavy metals from the roads were mainly Fe, Zn, Cu and Mn, showing variable EMCs by the type of road. From the TSS wash-off analysis in terms of FF(first flush) index, first flush phenomenon was clearly observed in the trunk road(FF : 0.89-1.43). However, such mass delivery behavior was not apparently shown in urban highway(FF : 0.90-1.11) and national road(FF : 0.81-1.41).

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 추계학술대회 논문집
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• pp.181-184
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• 2001

Chemical Mechanical Polishing(CMP) of Shallow Trench Isolation(STI) structure in 0.18 m semiconductor device fabrication is studied. CMP process is applied for the STI structure with and without reverse moat pattern and End Point Detection (EPD) method is tested. To optimize the transistor properties related metal 1 parameters, we studied the correlation between CMP thickness of STI using high selectivity slurry, DOE of gate etch recipe, and 1st metal DC values. Remaining thickness of STI CMP is proportional to the thickness of gate-etch process and this can affect to gate profile. As CMP thickness increased, the N-poly foot is deteriorated, and the P-Poly Noth is getting better. If CD (Critical Dimension) value is fixed at some point, all IDSN/P values are in inverse proportional to CMP thickness by reason of so called Profile Effect. Weve found out this phenomenon in all around DOE conditions of Gate etch process and we also could understand that it would not have any correlation effects between VT and CMP thickness in the range of POE 120 sec conditions. As CMP thickness increased by 100 ${\AA}$, 3.2 u${\AA}$ of IDSN is getting better in base 1 condition. In POE 50% condition, 1.7 u${\AA}$ is improved, and 0.7 u${\AA}$ is improved in step 2 condition. Wed like to set the control target of CD (critical dimension) in gate etch process which can affect Idsat, VT property versus STI topology decided by CMP thickness. We also would like to decide optimized thickness target of STI CMP throughout property comparison between conventional STI CMP with reverse moat process and newly introduced STI CMP using high selectivity slurry. And we studied the process conditions to reduce Gate Profile Skew of which source known as STI topology by evaluation of gate etch recipe versus STI CMP thickness.

• 한국의류학회지
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• 제37권8호
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• pp.1060-1074
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• 2013

This study measured and analyzed pressure at each measurement part of imported compression stockings sold in Korea to provide basic information to establish a pressure standard and grade ranking. This study used 40 medical compression stockings imported from 6 countries. Pressure measurements were taken at 11 points: front side and back side of ankle, end-point of the gastrocnemius muscle, front, inner side, back, and outer side of calf, back side of below knew girth, inner side, and outer side of mid-thigh girth, and inner side of thigh girth. AMI 3037-10 and AMI 3037-2 were used for measurements taken inside an environmental chamber at a temperature of $21^{\circ}C$ and a relative humidity (RH) of 65%. For the measurements, 11 air pack sensors were attached to a wooden model leg (Hohenstein) and three measurements were taken at each measurement point in three minutes. The average of these measurements was used for analysis. The findings of this study were as follows. As for the front side of the ankle, of the 40 products, 14 products (6 USA, 2 Swiss, 3 Italian, and 2 Taiwanese) were within the pressure range indicated on the product label; however, no German products fell within the pressure range. A total of 8 products (5 USA, 1 Swiss, 1 Italian, and 1 German) were gradient compression type; however, no Japanese or Taiwanese product were of this type. The majority of products had the highest pressure at the end-point of the gastrocnemius muscle. Only 3 products, 1 USA (Jobst Opaque 30-40mmHg), 1 Swiss (Sigvaris Cotton 34-46mmHg) and 1 Italian (Jobstocking 25-32mmHg), had measurements that met the indicated standard pressure, were a gradient compression type, and met the overall standard for compression stockings.

• 한국조경학회지
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• 제40권6호
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• pp.60-69
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• 2012

전주시 건지산 UD 숲길은 2008년 한국토지공사 초록사회 만들기 공모사업의 일환으로 전북생명의 숲이 주관하여 설계 및 시공이 추진되었다. 이 연구는 이용자 만족도, 이용자 수 조사의 이용후 평가를 통해 UD 숲길 설계의 적정성을 평가하는데 목적이 있다. 연구결과, 건지산 UD 숲길의 주이용자는 60대 이상의 지역주민이 전체이용자의 37%를 차지하며, 이용목적은 산책과 휴식 51.5%, 운동 및 재활치료 40.6%로 나타났다. UD 숲길 만족도는 5점 리커트 척도에서 3.91로 나타났고, 전체 만족도에 영향을 미치는 주요 요소는 관리, 이용충돌, 폭과 경사에 대한 만족도 순서로 나타났다. 이용자수 조사에서 교통약자는 UD 숲길 45명, 기존 숲길 6명으로 나타났다. 연구결과를 통해 건지산 UD 숲길은 교통약자의 이용을 유도하고, 일반인과 교류할 수 있는 기회를 제공하는 것으로 나타났다. 또한 UD 숲길 주변의 높은 경관만족도는 기존지형과 수목을 가능한 보존하고, 목재 데크를 설치함으로써 기존 자연경관이 잘 유지된 점을 나타냈다. 건지산 UD 숲길의 이용후 평가는 도시숲길 조성시 장애인, 노인, 약자, 임산부, 어린이 등 다양한 신체조건의 이용자들이 안전하고 편리하게 이용할 수 있도록 유니버설 디자인 개념의 도입 필요성을 나타내주고 있다.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.469-480
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• 2018

Objective: Pharmacogenomic-based antidepressant treatment (PGATx) may result in more precise pharmacotherapy of major depressive disorder (MDD) with better drug therapy guidance. Methods: An 8-week, randomized, single-blind clinical trial was conducted to evaluate the effectiveness and tolerability of PGATx in 100 patients with MDD. All recruited patients were randomly allocated either to PGATx (n=52) or treatment as usual (TAU, n=48) groups. The primary endpoint was a change of total score of the Hamilton Depression Rating Scale-17 (HAMD-17) from baseline to end of treatment. Response rate (at least 50% reduction in HAMD-17 score from baseline), remission rate (HAMD-17 score ${\leq}7$ at the end of treatment) as well as the change of total score of Frequency, Intensity, and Burden of Side Effects Ratings (FIBSER) from baseline to end of treatment were also investigated. Results: The mean change of HAMD-17 score was significantly different between two groups favoring PGATx by -4.1 point of difference (p=0.010) at the end of treatment. The mean change in the FIBSER score from baseline was significantly different between two treatment groups favoring PGATx by -2.5 point of difference (p=0.028). The response rate (71.7 % vs. 43.6%, p=0.014) were also significantly higher in PGATx than in TAU at the end of treatment, while the remission rate was numerically higher in PGATx than in TAU groups without statistical difference (45.5% vs. 25.6%, p=0.071). The reason for early drop-out associated with adverse events was also numerically higher in TAU (n=9, 50.0%) than in PGATx (n=4, 30.8%). Conclusion: The present study clearly demonstrate that PGATx may be a better treatment option in the treatment of MDD in terms of effectiveness and tolerability; however, study shortcomings may limit a generalization. Adequately-powered, well-designed, subsequent studies should be mandatory to prove its practicability and clinical utility for routine practice.

• 마이크로전자및패키징학회지
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• 제17권4호
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• pp.73-76
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• 2010

A two-facet approach was used to investigate the parametric performance of functional high-speed DDR3 (Double Data Rate) DRAM (Dynamic Random Access Memory) die placed in different types of BGA (Ball Grid Array) packages: wire-bonded BGA (FBGA, Fine Ball Grid Array), flip-chip (FCBGA) and lead-bonded $microBGA^{(R)}$. In the first section, packaged live DDR3 die were tested using automatic test equipment using high-resolution shmoo plots. It was found that the best timing and voltage margin was obtained using the lead-bonded microBGA, followed by the wire-bonded FBGA with the FCBGA exhibiting the worst performance of the three types tested. In particular the flip-chip packaged devices exhibited reduced operating voltage margin. In the second part of this work a test system was designed and constructed to mimic the electrical environment of the data bus in a PC's CPU-Memory subsystem that used a single DIMM (Dual In Line Memory Module) socket in point-to-point and point-to-two-point configurations. The emulation system was used to examine signal integrity for system-level operation at speeds in excess of 6 Gb/pin/sec in order to assess the frequency extensibility of the signal-carrying path of the microBGA considered for future high-speed DRAM packaging. The analyzed signal path was driven from either end of the data bus by a GaAs laser driver capable of operation beyond 10 GHz. Eye diagrams were measured using a high speed sampling oscilloscope with a pulse generator providing a pseudo-random bit sequence stimulus for the laser drivers. The memory controller was emulated using a circuit implemented on a BGA interposer employing the laser driver while the active DRAM was modeled using the same type of laser driver mounted to the DIMM module. A custom silicon loading die was designed and fabricated and placed into the microBGA packages that were attached to an instrumented DIMM module. It was found that 6.6 Gb/sec/pin operation appears feasible in both point to point and point to two point configurations when the input capacitance is limited to 2pF.

• 한국해양공학회지
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• 제13권3B호
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• pp.38-46
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• 1999

Increasing stringent emissions legislation and requirement of more effective energy used for diesel engine demand the fine control of the fuel injection system. Recently, the electromagnetic fuel injection control system for diesel engine is tried to realize the optimum diesel combustion by the feel back sensing as optical signal of combustion flame. The photo detectors were made for the feed back signal of electromagnetic fuel injection control for small DI diesel engine. Their abilities to detect defining combustion events were examined. By evaluating test results, it was shown that the wider acceptable optical range design of optical probe window face, and selection of installation position and installation method of detector were important point for improving sensing ability. The detector was shown to detect start and end of diffused combustion and maximum point of flame intensity impossible for pressure sensor, and also shown that the maximum point of flame intensity was 75% of accumulated heat release point within the experimental conditions.