• 한국식품과학회지
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• 제47권6호
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• pp.698-703
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• 2015

식물 소재 식품인 우엉을 코팅 및 비코팅 헤미셀룰라아제 효소액으로 침지한 후 시간에 따른 식품의 이화학적 특성 변화를 관찰한 결과, 색도에서는 모든 처리구에서 명도가 감소하는 경향을 나타냈지만, 적색도와 황색도는 감소하는 경향을 나타냈다. 또한 비코팅 효소와 코팅 효소 침지한 우엉 시료에서 공통적으로 본연의 색을 잃어가는 경향을 나타냈다. 경도는 시간에 따라 모든 처리구에서 감소하였고 증류수 침지 처리 시료에 비해 비코팅 효소와 코팅 효소 침지 처리한 시료의 경도 값이 유의적으로 낮았지만 코팅/비코팅 효소 처리한 시료간에는 유의적인 차이를 나타내지 않았다. 효소 활성은 우엉을 침지했던 함침액에 있는 생성물인 포도당의 함량 측정을 통해 진행한 결과 초반에는 비코팅 효소의 활성이 코팅 효소보다 높게 나타났지만 이후 시간의 경과에 따라 코팅 효소의 활성이 증가하며 비코팅 효소액 처리구의 활성보다 높은 함량을 나타냈다. 즉, 코팅막을 이용하여 효소를 포집하면 비코팅 효소에 비해 상대적으로 꾸준하게 효소의 활성을 유지 및 증가시킬 수 있으므로 식품의 연화 효과 및 효소의 활성을 장기간 적용할 수 있었다. 또한 리포좀 코팅은 수용성 및 지용성 성분의 포집이 가능하다. 즉, 본 실험을 통해 코팅된 가수분해효소의 고정화로 음식 재료의 연화 작용을 기대할 수 있으면서 효소 외에 다른 수용성 및 지용성의 영양 성분 및 기능성 성분 등을 함께 포집하여 비파괴 노인식 개발에 응용할 수 있으리라 사료된다.

• 한국컴퓨터정보학회논문지
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• 제9권3호
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• pp.1-6
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• 2004

객체 모델링 기법의 그래픽 표현을 이용하여 자료의 추상화, 캡슐화, 모듈화, 계층화 할 수 있는 새로운 그래픽 정보시스템 개발 기술이 절실히 필요하다. 그래픽 자료의 추상화 방법을 개선하기 위하여 복합객체 기술로 자료의 추상화와 계층화 개념을 기반으로 모델링하였으며, 메쉬, 레이어, 세그먼트, 인스턴스 등과 같은 여러 가지 도형요소의 클래스들을 지원하는 분류화와 다중상속 관계모델을 제안한다. 객체 모델링 기법과 스파이스 참조 모델을 이용하여 간단한 그래픽 정보시스템 개발사례를 통하여 소프트웨어 개발주기와 소프트웨어 유지보수 비용을 줄일 수 있는 요구사항을 지원하는 객체 표현 방법의 데이터 모델링 기법을 비교하고 평가한다.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2009년도 추계학술발표대회
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• pp.38.2-38.2
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• 2009

Regeration of natural tissuesor to create biological substitutes for defective or lost tissues and organs through the use of cells. In addition to cells and their porous, drugs are required to promote tissue regeneration. Therefore, the present studies were prepared using simvastatim loaded porous poly(lactide-co-glycolide) (PLGA) by double emulsion solvent evaporation water-in-oil-in-water technique (W/O/W) as drug delivery system strategies for injuring tissue. The resulting microspheres were evaluated for morphology, particle size, encapsulation efficiency, degradation of PLGA microspheres in vitro drug release and in vitro cell viability. Scanning electronic microscopic (SEM) showed that the porosities of the particles was changed by experimental conditions and cultured cells were attached well on porous microspheres surface. The X-ray diffraction (XRD) and differential scanning calometry (DSC) analysis indicate thatsimvastatim was highly dipersed in the microsphere at amorphousstate.

• 약학회지
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• 제38권2호
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• pp.131-139
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• 1994

Calcein-encapsulated small unilamellar vesicles of various lipid composition were prepared using the sonication technique, and their stabilities at $20^{\circ}C$ were examined by measuring calcein leakage from the liposomes. The fluidity of these liposomal bilayers was also investigated by measuring the fluorescence polarization of DPH labelled into the liposomes. The results showed that liposomes made of PC mixtures with different acyl chain length were very stable, which may be due to the formation of interdigitated bilayer structure. The addition of cholesterol further stabilized these PC liposomes. However, addition of cholesterol reduced the encapsulation efficiences of liposomes. The fluidity of the liposomes was significantly decreased by cholesterol in the liquid crystalline state, but not changed in the gel state. These results suggest that the enhanced stability of PC mixture liposomes may be ascribed to the formation of stable interdigitated bilayer structure. In membrane-mimetic and drug-delivery studies, vesicles made of mixtures of various phospholipids are recommended instead of addition of cholesterol to the phospholipid.

• 한국정보시스템학회지:정보시스템연구
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• 제3권
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• pp.71-82
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• 1994

Knowledge acquisition, maintenance of knowledge base, and validation and verification of knowledge are the addressed bottlenecks of building successful knowledge based systems. Along with the increment of interesting in the knowledge based systems, the organization needs to develop a new one although it has a similar one. This causes several serious problems including knowledge redundancy and maintenance of knowledge base. This paper present three models of the reusable knowledge base which might be the solution to the above problem. Three models are : 1) multiple knowledge bases for a single AI application, 2) multiple knowledge bases for multiple AI applications, 3) a single knowledge base for multiple AI applications. A new approach to build such a reusable knowledge base in a homogeneous environment is presented. Our model combines the essential object-oriented techniques with rules in a consistent manner. Important aspects of applying object-oriented techniques to AI are discussed (inheritance, encapsulation, message passing), and some potential problems in building an AI application (decomposition technique of knowledge, search time, and heterogeneous environment) are pointed out. The models of a reusable knowledge base provide several amenities : 1) reduce the knowledge redundancy, 2) reduce the effort of maintenance of the knowledge base, 3) reuse the resource of the multiple domain knowledge bases, 4) reduce the development time.

• 대한화장품학회지
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• 제20권1호
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• pp.37-51
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• 1994

Glutaraldehyde를 사용하여 화학적인 가교반응에 의해 empty cross-linked chitosan microcapsule을 제조하였다. 또한 chitosan bead는 sodium hydroxide 용액을 이용한 coaervation에 의해 제조하였다. 이들의 제조를 위해 수상/유화제/유기상으로 이루어진 w/o emulsion을 형성시킨 후 에멀젼의 안정성에 영향을 미치는 요소들에 대해 조사하였다. 보조계면활선제로 n-hexanol을 첨가한 결과 유화안정성이 상승적으로 증가하는 경향을 보였다. Chitosan microcapsule은 광택이 나는 형태로 내부가 투명한 반면 chitosan bead는 백탁으로 내부가 불투명하며 매우 porous한 구조를 하고 있었다. Chitosan bead의 유리 아미노기의 분석은 picric acid titration으로 수행하였으며, 아미노산 반응의 종결여부는 ninhydrin color test에 의해 판정하였다. 또한 fluoroscamine에 의한 형광분석으로 chitosan bead의 표면에 많은 반응성 아미노기가 존재하고 있음을 정성적으로 확인할 수 있었으며, 이를 생리활성 펩티드의 커플링 반응에 이용할 수 있었다. 모델 펩티드로서 콜라겐의 receptor 부분에 해당하는 생체내 growth factor로 알려진 Gly-His-Lys를 각 아미노산 유도체를 차례로 커플링하여 chitosan bead 위에서 합성할 수 있으며, 세포 성장인자와 같은 여러 가지 생리 활성 펩티드의 운반체로서 chitosan bead가 쉽게 이용될 수 있는 가능성을 보여 주었다.

• Archives of Pharmacal Research
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• 제26권5호
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• pp.426-431
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• 2003

This study was carried out to investigate the addition of water-soluble isoflavone into milk by means of microencapsulation technique. The yield of microencapsulation, sensory attributes, and capsule stability of water-soluble isoflavone microcapsules in milk were measured. Coating materials used was polyglycerol monostearate (PGMS), and core material was water-soluble isoflavone. The encapsulation yield of water-soluble isoflavone with PGMS was 67.2% when the ratio of coating material to core material was 15 : 1. The rate of water-soluble isoflavone release from capsules was 18, 19, and 25% when stored at 4,20, and $30^{\circ}C$ for 12 days in milk, respectively. In sensory evaluation, beany flavor and color of microencapsuled water-soluble isoflavone added milk were significantly different from uncapsuled water-soluble isoflavone added milk, however, bitterness was not significantly different. In vitro study, micro-capsules of water-soluble isoflavone in simulated gastric fluid with the range of 3 to 6 pHs were released 3.0∼15.0%, however, the capsules in simulated intestinal fluid with pH 7 were released 95.7% for 40 min incubation time. In conclusion, this study provided that PGMS as coating materials was suitable for the microencapsulation of water-soluble isoflavone, and the capsule containing milk was almost not affected with sensory attribute.

• Smart Structures and Systems
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• 제1권4호
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• pp.355-368
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• 2005

Large and complex structures are being built now-a-days and, they are required to be functional even under extreme loading and environmental conditions. In order to meet the safety and maintenance demands, there is a need to build sensors integrated structural system, which can sense and provide necessary information about the structural response to complex loading and environment. Sophisticated tools have been developed for the design and construction of civil engineering structures. However, very little has been accomplished in the area of monitoring and rehabilitation. The employment of appropriate sensor is therefore crucial, and efforts must be directed towards non-destructive testing techniques that remain functional throughout the life of the structure. Fiber optic sensors are emerging as a superior non-destructive tool for evaluating the health of civil engineering structures. Flexibility, small in size and corrosion resistance of optical fibers allow them to be directly embedded in concrete structures. The inherent advantages of fiber optic sensors over conventional sensors include high resolution, ability to work in difficult environment, immunity from electromagnetic interference, large band width of signal, low noise and high sensitivity. This paper brings out the potential and current status of technology of fiber optic sensors for civil engineering applications. The importance of employing fiber optic sensors for health monitoring of civil engineering structures has been highlighted. Details of laboratory studies carried out on fiber optic strain sensors to assess their suitability for civil engineering applications are also covered.

• Bulletin of the Korean Chemical Society
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• 제34권5호
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• pp.1435-1440
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• 2013

To investigate the influence of the carbon matrix on the electrochemical performance of Si/C composites, four types of Si/C composites were prepared using graphite, petroleum coke, pitch and sucrose as carbon precursors. A ball mill was used to prepare Si/C blends from graphite and petroleum coke, whereas a dispersion technique was used to fabricate Si/C composites where Si was embedded in disordered carbon matrix derived from pitch or sucrose. The Si/pitch-based carbon composite showed superior Si utilization (96% in the first cycle) and excellent cycle retention (70% after 40 cycles), which was attributed to the effective encapsulation of Si and the buffering effect of the surrounding carbon matrix on the silicon particles.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 C
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• pp.1412-1413
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• 2006

In this research, an organic thin 13 passivation layer was newly adopted to prefect the organic layer from ambient moisture and oxygen. As the organic thin film passivation layer, poly methyl methacrylate thin films (ppMMA) were deposited using a plasma polymerization technique. In order to their passivation performance for OLEDs, water vapor transmission rate (WVTR) of the ppMMAs were analyzed and luminance-current-voltage (L-I-V)/luminance-time (L-T) characteristics of the OLEDs with and without ppMMA passivation layer were investigated. The OLEDs had a structure of ITO/TPD (HTL)/Alq3(EML&ETL)/Al. The OLED with ppMMA passivation layer showed improved L-T performance than that of without ppMMA passivation layer.