• Clinical and Experimental Pediatrics
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• v.49 no.4
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• pp.368-374
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• 2006

Purpose : The prevalence of obesity in children is increasing rapidly. Epidemiologic studies suggest that obesity induced atherosclerosis may start in childhood. We investigated whether obese children show early abnormalities of the arterial wall and endothelial dysfunction. Methods : Thirty-eight obese children(14-16 years old of age, male, body mass index $29.40{\pm}3.18kg/m^2$) and forty-five age and sex-matched healthy control children(body mass index $18.43{\pm}1.01kg/m^2$) were enrolled. Their carotid artery intima-media thickness(IMT) and brachial artery flowmediated dilation(FMD) response were measured by high-quality ultrasound system, and compliance, distensibility, stiffness index, incremental elastic modulus and wall stress were calculated by equation. In addition, we looked at the relations between these arterial features and metabolic cardiovascular risk factors. Results : The obese children had significantly increased IMT($0.52{\pm}0.09mm$ vs $0.40{\pm}0.07mm$, P< 0.001) and markedly impaired FMD($7.35{\pm}7.78$ percent vs $20.34{\pm}16.81$ percent, P<0.001) than the healthy controls. But the compliance and distensibility were lower, and the stiffness index, incremental elastic modules and wall stress were higher in the obese group than the control group, but not statistically significantly. Body mass index was highly associated with increased IMT(r=0.612, P<0.001) and reduced FMD(r=-0.414, P<0.001). Conclusion : We showed the deleterious effect of child obesity on both early functional and structural atherosclerotic markers. The ultrasonic findings will be used for screening and follow up markers to identify high-risk patients among obese children.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.33 no.5
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• pp.375-384
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• 2011

Purpose: The advent of microsurgical technique and instruments, particularly in the field of perforator flap and supermicrosurgery, which have expanded the scope of microsurgery. However, supermicroanastomosis without any compression, tension, or distortions must be achieved to reach successful outcomes. Small-caliber vessels, such as those with an internal diameter less than 0.2 mm, are susceptible to inadvertent twisting of the anastomosis. In this study, using the superficial inferior epigastric artery (SIEA)-based flap model in Sprague-Dawley (SD) rats, we evaluated the acceptable limits of twisting effects on supermicroanastomotic sites. Methods: A total of 20 supermicroanastomoses were performed using the SIEA-based flap model in 10 male SD rats, 10-weeks-of-age, weighing 300~350 g. Rats were divided into five groups of two with four flaps as follows: 1) sham, 2) control group with end to end SIEA arterial supermicroanastomosis, 3) experimental I (EA1) with $90^{\circ}$ twisting, 4) experimental II (EA2) with $180^{\circ}$ twisting, and 5) experimental III (EA3) with $270^{\circ}$ twisting of the supermicroanastomosis. Each SIEA was anastomosed using six 11-0 $Ethilon^{(R)}$ (Ethicon Inc. Co., NJ, USA) stitches except in the sham group where the SIEA was only clamped with Supermicro vascular $clamps^{(R)}$ (S&T, Neuhausen, Switzerland) for 20 minutes. Results: The anastomosed arterial patency showed no remarkable changes according to doppler waveforms measured with a Smardop 45 Doppler System (Hadeco Inc., Kawasaki, Japan). The pulsatility index (PI) was increased at postoperative day 10 in the EA2 and EA3 groups, and the resistance index (RI) showed no statistically significant difference between preoperative and postoperative values at 10 days. Histologic specimens from the EA3 group showed increased tunica media necrosis, convolution of the internal elastic lamina, densely packed platelets, fibrin, and erythrocytes. Flap viability and anastomosed vessel patency were not significantly affected by the degree of arterial twisting in this study, other than in the EA3 group where minor effects on arterial patency of the microanastomoses were encountered. Conclusion: It appears that minor twisting on small caliber arteries, used in supermicroanastomoses, can be tolerated. However, twisting should be avoided as much as possible, and more than $180^{\circ}$ twisting must be prevented in clinical practice.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.23 no.1
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• pp.1-6
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• 2001

Purpose : This study was undertaken to observe the occurrence of the vessel aneurysms according to several different methods of microvascular anastomosis. Mterials & methods : Forty Sprague-Dawley rats, weighing $180{\sim}200$ grams, were used for this experiment. The rats were divided into 4 groups. Group 1 (10 rats): The adventitia was trimmed off 5mm from the cut edge each and 20 arterial anastomoses were performed using 8 to 10 interrupted 9-0 polypropylene ($Prolene^{TM}$, Ethicon, U.K.) suture. Group 2 (10 rats): The adventitia was trimmed off as in group 1. Twenty arterial anastomoses were performed using continuous 9-0 polypropylene($Prolene^{TM}$, Ethicon, U.K.) suture. Group 3 (10 rats): The adventitia was stripped only 1mm from the cut edge each but not removed,. Twenty arterial anastomoses were performed using 8 to 10 interrupted 9-0 polypropylene($Prolene^{TM}$, Ethicon, U.K.) suture. Group 4 (10 rats): The adventitia was handled as in group 3. Twenty arterial anastomoses were performed using 9-0 polypropylene($Prolene^{TM}$, Ethicon, U.K.) suture. The arteries of the animals in all groups were explored at 28th days. We examined patency, presence of an aneurysm, other vascular abnormalities and microscopically observed the aneurysms with H&E and Van-Gieson stains. Result : 1. Patency rate was 80% in group 1, 95% in group 2, 85% in group 3 and 90% in group 4, respectively. 2. Aneurysm occurred 20% in group 1, 5% in group 2, 5% in group 3 and 5% in group 4, respectively. 3. There was no other vascular abnormalities in each group. 4. Infection rate was 5% in group 1, 0% in group 2, 20% in group 3 and 15% in group 4, respectively. 5. In the histopathological findings, we observed partially necrotic changes, loss and fragmentation of outer elastic lamella of smooth muscle in media and the proliferation of hyperplastic subintima. A lot of inflammatory cells were infiltrated in hyperplastic intima. Conclusions : On the basis of these observation, we could state that there were little differences in the occurrence of aneurysms according to different anastomotic suture methods.

• Molecules and Cells
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• v.38 no.7
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• pp.663-668
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• 2015

hBMSCs are multipotent cells that are useful for tissue regeneration to treat degenerative diseases and others for their differentiation ability into chondrocytes, osteoblasts, adipocytes, hepatocytes and neuronal cells. In this study, biodegradable elastic hydrogels consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(${\varepsilon}$-caprolactone) (PCL) scaffolds were evaluated for tissue engineering because of its biocompatibility and the ability to control the release of bioactive peptides. The primary cultured cells from human bone marrow are confirmed as hBMSC by immunohistochemical analysis. Mesenchymal stem cell markers (collagen type I, fibronectin, CD54, $integrin1{\beta}$, and Hu protein) were shown to be positive, while hematopoietic stem cell markers (CD14 and CD45) were shown to be negative. Three different hydrogel scaffolds with different block compositions (PEG:PCL=6:14 and 14:6 by weight) were fabricated using the salt leaching method. The hBMSCs were expanded, seeded on the scaffolds, and cultured up to 8 days under static conditions in Iscove's Modified Dulbecco's Media (IMDM). The growth of MSCs cultured on the hydrogel with PEG/PCL= 6/14 was faster than that of the others. In addition, the morphology of MSCs seemed to be normal and no cytotoxicity was found. The coating of the vascular endothelial growth factor (VEGF) containing scaffold with Matrigel slowed down the release of VEGF in vitro and promoted the angiogenesis when transplanted into BALB/c nude mice. These results suggest that hBMSCs can be supported by a biode gradable hydrogel scaffold for effective cell growth, and enhance the angiogenesis by Matrigel coating.

• Korean Journal of Mineralogy and Petrology
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• v.33 no.1
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• pp.11-18
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• 2020

High-pressure synchrotron X-ray powder diffraction experiments were performed on natural illite (K_0.65Al₂(Al_0.65Si_3.35)O₁₀(OH)₂) using diamond anvil cell (DAC) under two different pressure transmitting media (PTM), i.e., water and ME41 (methanol:ethanol = 4:1 by volume). When using water as PTM, occasional heating was applied up to about 250℃ while reaching pressure up to 2.7 GPa in order to promote both hydrostatic conditions and intercalation of water molecules into the layer. When using ME41, pressure was reached up to 6.9 GPa at room temperature. Under these conditions, illite did not show any expansion of interlayer distance or phase transitions. Pressure-volume data were used to derive bulk moduli (K₀) of 45(3) GPa under water and 51(3) GPa under ME41 PTM. indicating no difference in compressibility within the analytical error. Linear compressibilities were then calculated to be β^a = 0.0025, β^b = 0.0029, β^c = 0.0144 under ME41 PTM showing the c-axis is ca. six times more compressible than a- and b-axes. These elastic behaviors of illite were compared to muscovite, one of its structural analogues.

• 한국지구물리탐사학회:학술대회논문집
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• 2006.06a
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• pp.201-206
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• 2006

Earth sciences is undergoing a gradual but massive shift from description of the earth and earth systems, toward process modeling, simulation, and process visualization. This shift is very challenging because the underlying physical and chemical processes are often nonlinear and coupled. In addition, we are especially challenged when the processes take place in strongly heterogeneous systems. An example is two-phase fluid flow in rocks, which is a nonlinear, coupled and time-dependent problem and occurs in complex porous media. To understand and simulate these complex processes, the knowledge of underlying pore-scale processes is essential. This paper presents a new attempt to use pore-scale simulations for understanding physical properties of rocks. A rigorous pore-scale simulator requires three important traits: reliability, efficiency, and ability to handle complex microstructures. We use the Lattice-Boltzmann (LB) method for singleand two-phase flow properties, finite-element methods (FEM) for elastic and electrical properties of rocks. These rigorous pore-scale simulators can significantly complement the physical laboratory, with several distinct advantages: (1) rigorous prediction of the physical properties, (2) interrelations among the different rock properties in a given pore geometry, and (3) simulation of dynamic problems, which describe coupled, nonlinear, transient and complex behavior of Earth systems.

• Journal of the Korean Society for Nondestructive Testing
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• v.24 no.3
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• pp.259-267
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• 2004

A finite element method is used to simulate interaction of laser-based ultrasounds with surface breaking tracks in elastic media. The laser line source focused on the surface of semi-infinite medium is modeled as a shear dipole in 2-D plane strain finite elements. The shear dipole-finite clement model is found to give correct directivity patterns for generated longitudinal and shear waves. The interaction of surface waves with surface breaking cracks (2-D machined slot) is considered in two ways. Both the source and receiver are fixed with respect to the cracks in the first case, while the source is moving in another case. It is shown that the crack depth tested in the range of 0.3-5.0mm $({\lambda}_R/d=0.21{\sim}3.45)$ can be measured using the corner reflected waves produced by the fixed laser source. The moving laser source is found to cause a large amplitude change of reflected waves near crack, and the crack whose depth is one order lower than the wavelength ran be detected from this change.

• Journal of the Korean Geotechnical Society
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• v.31 no.6
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• pp.27-44
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• 2015

An analytical solution of dynamic responses for seabed in finite and infinite thicknesses including shallow has been developed under flow and partial standing wave with arbitrary reflection ration coexisting field at a constant water depth condition. In the analytical solution, a field was simply transited to a coexisting field of progressive wave and flow when reflection ratio was 0 and to a coexisting field of fully standing wave and flow when reflection ratio was 1. Based on the Biot's consolidation theory, the seabed was assumed as a porous elastic media with the assumptions that pore fluid is compressible and Darcy law governs the flow. The developed analytical solution was compared with the existing results and was verified. Using the analytical solution the deformation, pore pressure, effective and shear stresses were examined under various given values of reflection ratio, flow velocity, incident wave's period and seabed thickness. From this study, it was confirmed that the dynamic response of seabed was quite different depending on consideration of flow, which causes changing period and length of incident and reflection waves. It was also confirmed that dynamic response significantly depends on the magnitude of reflection ratio.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.27 no.2
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• pp.118-134
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• 2015

An analytical solution of dynamic responses for seabed in shallow, finite and infinite thicknesses has been developed under flow and standing wave coexisting field at a constant water depth condition. To do this, based on the Biot's consolidation theory, the seabed is assumed as a porous elastic media with the assumptions that pore fluid is compressible and Darcy law governs the flow. The developed analytical solution is compared with the previous results and is verified. Using the analytical solution the deformation, pore pressure, effective and shear stresses of seabed are examined under various given values of flow velocity, incident wave period and seabed thickness. From this study, it is confirmed that the seabed response is quite different depending on consideration of flow, which causes changing period and length of incident and reflection waves.

• Geophysics and Geophysical Exploration
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• v.22 no.4
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• pp.177-185
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• 2019

Ground roll is a surface wave which is usually observed in the land seismic data. It is one of the typical coherent noise. During the reflection data processing, ground roll is removed because it is considered as noise. This removal process often causes the loss of reflection signals if the ground roll overlaps reflection signals. In this study, we look over Karhunen-Loeve Transform (KLT) and analyze its effects to suppress the ground roll appropriately while reducing the reflection loss. Numerical tests in homogeneous elastic media show that the ground roll has been properly rejected. However, the field data application reveals that there is no significant suppression of ground roll when compared to band-pass filtering. This can be considered that it is hard to calculate horizontally aligned gathers in the field data because the ground roll contains a wide range of frequency bands. On the contrary, the result of singular value decomposition (SVD) filtering shows that the ground roll has been significantly reduced. It is thought that the SVD filtering performs better in the ground roll suppression than KLT because it is easy to calculate the horizontally aligned gathers in the SVD filtering.