• Korean Journal of Head & Neck Oncology
• /
• v.12 no.2
• /
• pp.206-211
• /
• 1996

On 147 patients with early laryngeal cancer undertaken surgery or radiation therapy at Seoul National University Hospital from January 1987 through December 1994, retrospective analysis with reviewing the medical record was performed. The number of recurred cases was twenty six. The recurrence rate was higher in the cases with radiation therapy than in those with surgical therapy. And the recurrence rate was remarkable in the cases with T2 in supraglottic cancer and in those with T1 in glottic cancer. Of the patients undertaken surgery, recurrence rate was higher in the patients with laser operation than in those with other procedures. It was, however, lower in the patients with laryngofissure with cordectomy than in those with other surgical techniques. The overall three year disease free survival rate was 72 % in early laryngeal carcinoma.

• Korean Journal of Biological Psychiatry
• /
• v.18 no.4
• /
• pp.197-202
• /
• 2011

Subsyndromal anxiety disorder indicates mental states of having anxiety symptoms not fulfilling criteria for anxiety disorders. Despite of the lack of previous objective findings of the subsyndromal anxiety disorder, its clinical importance has increased. It can cause many kinds of clinical anxiety symptoms and functional disabilities. But the early intervention and early treatment make it possible not only to attenuate the anxiety symptoms and functional disabilities but also to prevent disease progression to a full syndromal anxiety disorder. In this article, we will review the previous studies about the subsyndromal anxiety disorder and discuss its clinical characteristics and importance.

• Tuberculosis and Respiratory Diseases
• /
• v.86 no.2
• /
• pp.71-81
• /
• 2023

Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide. COPD is characterized by significant airflow limitation on spirometry. Most patients with COPD are diagnosed in their fifth or sixth decades of life. However, the disease begins much earlier. By the time airflow limitation is detected on spirometry, patients with COPD have lost close to 50% of their small airways. Thus, identification of patients with early COPD, defined as persons with preserved spirometry, who demonstrate pathologic or functional hallmarks of COPD, is essential for disease modification and ultimately disease elimination. This paper provides an up-to-date overview of the current case definition of early COPD, its importance, the novel technologies required for its detection in young adults and future directions in therapeutics for treatment.

• The Korean Journal of Medicine
• /
• v.99 no.1
• /
• pp.32-36
• /
• 2024

Early diagnosis and early treatment of human immunodeficiency virus (HIV) infection are essential for clinical and public health benefits. Diagnostic algorithms for early diagnosis are being emphasized, and rapid tests at the point of care have been expanded to improve voluntary testing rates. Despite advances in laboratory diagnostic tests, early HIV infection can still be missed due to window periods, and it is crucial to recognize the limitations of testing methods and the potential for false negative and false positive results.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.14
• /
• pp.47-51
• /
• 1973

In order to ascertain the effects of fluctuations and range of daily temperatures on the growth of rice, a pot(1/5, 000 are) experiment was conducted in the phytotron, Crop Experiment Station, in 1972. Seven treatment combinations of day-temperatures 25 and $30^{\circ}C$ with night-temperatures 10, 15, 20 and $25^{\circ}C$ were applied in three 10 days periods, in to which the tillering stage was split after rooting of the paddy, namely, early, middle and late. The results may be summarized as follows: 1. The number of tillers were maximum with the treatments of day-temperature $30^{\circ}C$ and night-temperatures 20 as well as $25^{\circ}C$ in the early and middle periods, while the effects were small in the late period. 2. Multiplying plant height and number of panicles resulted in a high figure by combining a day-temperature of $30^{\circ}C$ with night-temperatures 20 as well as $25^{\circ}C$ in the early and middle periods, and no differences in the late period. 3. The treatment in the early period yielded a high RGR(g/g/day), of which the treatment combinations of day-temperature $30^{\circ}C$ with night-temperatures 20 and $25^{\circ}C$ gave the highest figure. 4. High straw weight in ripening stage was obtained with the temperature treatments in the early period rather than those in the late period. 5. Accordingly, it seems that the effect of temperature on the emergence of tillers is the highest at the early stage of tillering.

• Journal of dental hygiene science
• /
• v.18 no.5
• /
• pp.312-318
• /
• 2018

The purpose of this study was to evaluate the relationship between early menopause and periodontal disease in postmenopausal women using data from the 6th Korean National Health and Nutrition Examination Survey (2013~2015). A study was conducted with 2,048 postmenopausal women aged 45 to 74 years. Participants were divided into the early menopause group (menopause occurring at age 45 years or before) and normal menopause group (menopause occurring after age 45 years). A community periodontal index greater than or equal to code 3 was used to define periodontal treatment needs. A chi-square test was used to confirm the bivariate relationship between the variables. Multinomial logistic regression analysis was used to adjust for covariates (age, education, family income, body mass index, alcohol drinking, smoking, visiting dentist in the last year, use of oral care products, frequency of tooth brushing per day). The risk of periodontal disease was higher in the early menopause group after adjusting for potential confounders (odds ratio, 1.59). In particular, the relationship between early menopause and periodontal disease was more evident in women with low education and those who did not use oral care products. The findings of this study suggest that early menopause is a significant factor of periodontal disease in Korean women.

• Clinical and Experimental Pediatrics
• /
• v.54 no.5
• /
• pp.183-191
• /
• 2011

Although antenatal diagnostic technique has considerably improved, precise detection and proper management of the neonate with congenital heart disease (CHD) is always a great concern to pediatricians. Congenital cardiac malformations vary from benign to serious conditions such as complete transposition of the great arteries (TGA), critical pulmonary and aortic valvular stenosis/atresia, hypoplastic left heart syndrome (HLHS), obstructed total anomalous pulmonary venous return (TAPVR), which the baby needs immediate diagnosis and management for survival. Unfortunately, these life threatening heart diseases may not have obvious evidence early after birth, most of the clinical and physical findings are nonspecific and vague, which makes the diagnosis difficult. High index of suspicion and astute acumen are essential to decision making. When patent ductus arteriosus (PDA) is opened Widely, many serious malformations may not be noticed easily in the early life, but would progress as severe acidosis/shock/cyanosis or even death as PDA constricts after few hours to days. Ductus dependent congenital cardiac lesions can be divided into the ductus dependent systemic or pulmonary disease, but physiologically quite different from each other and treatment strategy has to be tailored to the clinical status and cardiac malformations. Inevitably early presentation is often regarded as a medical emergency. Differential diagnosis with inborn error metabolic disorders, neonatal sepsis, persistent pulmonary hypertension of the newborn (PPHN) and other pulmonary conditions are necessary. Urgent identification of the newborn at such high risk requires timely referral to a pediatric cardiologist, and timely intervention is the key in reducing mortality and morbidity. This following review deals with the clinical presentations, investigative modalities and approach to management of congenital cardiac malformations presenting in the early life.

• Journal of Korean Neurosurgical Society
• /
• v.55 no.3
• /
• pp.125-130
• /
• 2014

Objective : This study was conducted to elucidate neuroprotective effect of carnosine in early stage of stroke. Methods : Early stage of rodent stroke model and neuroblastoma chemical hypoxia model was established by middle cerebral artery occlusion and antimycin A. Neuroprotective effect of carnosine was investigated with 100, 250, and 500 mg of carnosine treatment. And antioxidant expression was analyzed by enzyme linked immunosorbent assay (ELISA) and western blot in brain and blood. Results : Intraperitoneal injection of 500 mg carnosine induced significant decrease of infarct volume and expansion of penumbra (p<0.05). The expression of superoxide dismutase (SOD) showed significant increase than in saline group in blood and brain (p<0.05). In the analysis of chemical hypoxia, carnosine induced increase of neuronal cell viability and decrease of reactive oxygen species (ROS) production. Conclusion : Carnosine has neuroprotective property which was related to antioxidant capacity in early stage of stroke. And, the oxidative stress should be considered one of major factor in early ischemic stroke.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.22 no.1
• /
• pp.41-49
• /
• 2019

Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-onset IBD has distinct phenotypic differences compared with adult-onset IBD. In particular, very early-onset IBD (VEO-IBD) differs in many aspects, including the disease type, location of the lesions, disease behavior, and genetically attributable risks. Several genetic defects that disturb intestinal epithelial barrier function or affect immune function have been noted in these patients from the young age groups. In incidence of pediatric IBD in Korea has been increasing since the early 2000s. Neonatal or infantile-onset IBD develops in less than 1% of pediatric patients. Children with "neonatal IBD" or "infantile-onset IBD" have higher rates of affected first-degree relatives, severe disease course, and a high rate of resistance to immunosuppressive treatment. The suspicion of a monogenic cause of VEO-IBD was first confirmed by the discovery of mutations in the genes encoding the interleukin 10 (IL-10) receptors that cause impaired IL-10 signaling. Patients with such mutations typically presented with perianal fistulae, shows a poor response to medical management, and require early surgical interventions in the first year of life. To date, 60 monogenic defects have been identified in children with IBD-like phenotypes. The majority of monogenic defects presents before 6 years of age, and many present before 1 year of age. Next generation sequencing could become an important diagnostic tool in children with suspected genetic defects especially in children with VEO-IBD with severe disease phenotypes. VEO-IBD is a phenotypically and genetically distinct disease entity from adult-onset or older pediatric IBD.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.40 no.4
• /
• pp.335-341
• /
• 2013

Impacted maxillary canines are the most frequently impacted teeth after the third molars. The exact etiology of impacted maxillary canines is unknown, but several complications may result from impacted maxillary canines. An early detection of ectopically erupting teeth can lead to performing interceptive treatment such as early extraction of primary canine and provide the best long-term results. In the absence of prevention, clinicians should consider orthodontic treatment followed by surgical exposure of the canine to bring it into occlusion. However, in cases when the finding ectopically erupting teeth and severe root resorption of adjacent teeth are found late, malposed canine can replace the injured teeth. In these presented cases, early diagnosis and treatment of ectopic eruption and root resorption were not performed. The maxillary incisor replacement with ectopically erupting canine can be the alternative treatment of choice with successful results. The reconstructed canine is planned to be checked periodically for the condition of composite resin restoration. Orthodontic treatment and dental implant are planned. This report shows that when early diagnosis was not done, maxillary incisor replacement with ectopically erupting canine could prevent uncertain prognosis of the adjacent teeth with root resorption and provide esthetic satisfactory with time saved and cost reduced.