• Journal of architectural history
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• v.10 no.2 s.26
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• pp.55-71
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• 2001

This study reviewed the preservation status of the Early Western Style Architecture in Korea based on the on-site research of church buildings which are registered as National Cultural Properties. I have investigated 21 church buildings regarding the frequency, content and concept of restoration. The results are summarized as follows First, the churches have been restored extensively in every 17 years on the average. Second, the main restorations are replacement of bricks, painting, waterproofing, repair of roof and timber. And the main changes are extension of plan, removal of Interior posts, and replacement of floor. Third, the main concept of restorations are historical restoration(62%), critical restoration(23%), stylistic restoration(14%). Forth, the category of restoration have been changed, that is extending of incompletion (1st stage), functional improvement and extension of the span of life(2nd stage), improvement of facilities(3rd stage), restoration to the original state and conservation(4th stage). Fifth, the issues of repairing techniques are revival and replacement of weathered bricks, the removal of painting, and structural reinforcement. This study will be able to be used as the fundamental materials to improve the techniques of restoration of Early Western style masonry buildings.

• Applied Microscopy
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• v.44 no.1
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• pp.1-7
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• 2014

The spermatogenesis of Siamese fighting fish, Betta splendens, belongs to Osphronemidae was investigated by light and electron microscopic observations. In primary spermatocyte stage, the nucleus was comparatively large ellipsoidal, and mitochondria showed a marked development in cytoplasm. In secondary spermatocyte stage, the germ cells were smaller than that of primary spermatocytes. The nucleus was a spherical shape and intercellular space was formed between germ cells. In spermatid stage, the early spermatids were not much different from a secondary spermatocyte. But, the chromatin condensation was occurred from the outside to the inside. The nucleus was more condensed. Intracellular space was larger than early spermatid. The mitochondria were rearranged in a middle piece, and occupied about half of the head part in early sperm. In sperm stage, the head of mature sperm was a spherical shape and had no acrosome. The flagellum was showed the typical 9+2 array of microtubules. Also, the tail of sperm had no lateral fins and outer coarse fibers. These ultrastructural characteristics can be used in classification of species.

• Journal of Arbitration Studies
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• v.14 no.1
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• pp.315-344
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• 2004

Although we try to increase the order of turn key construction for the international competitiveness strengthening, the construction quality advancement and the productivity enhancement of the public sectors, the problems of the domestic turn key systems are causing the hardships of all the participants and many possible disputes. The home turn key constructions have been activated since 1997. A lot of trial and error had been experienced in these days, and the turn key systems have been changed little by little. But the bases are continuously kept because of their reflecting all the participants' opinions. In the inner turn key constructions the problems of uniform types are repeatedly occurred, and, especially, many problems happen up to the stage of early stage owing to the specialties of the turn key construction. So the dispute factors of the Korean turn key constructions were abstracted through the literature searches, the site document examinations, the case studies and the interviews with the experts. When the technicians meeting the interior turn key construction for the first time and working here now are well acquainted with only these factors, many disputes will be prevented.

• Preventive Nutrition and Food Science
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• v.7 no.1
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• pp.1-4
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• 2002

Eleven flavonoids, including rutin, naringin, hesperidin, neohesperidin, quercetin, naringenin, kaempferol, hesperetin, nobiletin, 3,5,6,7,8,3',4'-methoxylated flavone and tangeretin in the peel of late maturing citrus fruit species of Mucott (smith tangerine), Singamha (C. natsudidai), Sambogam (C. sulcata), Hongpalsak (C. hassaku), Seminol (Dancy tangerine) and Jawdung (C. aurantium) harvested during from August to December were analyzed with HPLC. The mobile phase consisted of water and acetonitrile with 0.5% acetic acid. Wavelength in UV detector was determined at 254 nm. Naringin and neohesperidin content in the peel of Jawdung harvested at the early stage of maturation were 34.02 mg/g and 13.68 mg/g, respectively, and it was highest among the tested citrus fruits. Hesperidin content in the peel of Mucott harvested at the earthy stage of maturation was 12.48 mg/g. Rutin content of Sambogam harvested at the early stage of maturation was 5.13 mg/g. Quercetin, naringein, kaempferol, nobiletin, 3,5,6,7,8,3',4'-methoxylated flavone flavonoids were in trace. Flavonoid contents of Singamha, Sambogam and Jawdung were high in the peel of fruits at the early stage of maturation, after which time they decreased rapidly.

• Clinics in Shoulder and Elbow
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• v.26 no.2
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• pp.191-204
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• 2023

Avascular necrosis (AVN) of the humeral head is a rare, yet detrimental complication. Left untreated, humeral head AVN frequently progresses to subchondral fracturing and articular collapse. Cases of late-stage humeral head AVN commonly require invasive procedures including humeral head resurfacing, hemiarthroplasty, and total shoulder arthroplasty (TSA) to improve clinical outcomes. However, in cases of early-stage AVN, core decompression of the humeral head is a viable and efficacious short-term treatment option for patients with pre-collapse AVN of the humeral head to improve clinical outcomes and prevent disease progression. Several techniques have been described, however, a percutaneous, arthroscopic-assisted technique may allow for accurate staging and concomitant treatment of intraarticular pathology during surgery, although further long-term clinical studies are necessary to assess its overall outcomes compared with standard techniques. Biologic adjunctive treatments, including synthetic bone grafting, autologous mesenchymal stem cell/bone marrow grafts, and bone allografts are viable options for reducing the progression of AVN to further collapse in the short term, although long-term follow-up with sufficient study power is lacking in current clinical studies. Further long-term outcome studies are required to determine the longevity of core decompression as a conservative measure for early-stage AVN of the humeral head.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.47 no.6
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• pp.453-458
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• 2002

High temperature sterilization method (30min. at $40^{\circ}C$longrightarrow30 min. at $70^{\circ}C$longrightarrow30 min. cooling at $20^{\circ}C$) was evaluated better than that of chloride, ion water, $O_3$ water, and salt water for the controling of micro-organisms at the early stage of sprout culture. Due to the improved germination rate and effective control of micro-organisms at early stage, the method resulted in much lower in the number of micro-organisms, higher in sprout yield, and 2 days longer in quality keeping at market than sprouts prepared by conventional method. There are two methods related with water temperature; constant temperature method (18.5$\pm$ $0.5^{\circ}C$) which keeps the same water temperature during the culture and 3-stage temperature method which changes the water temperature depending on the days after culture. Three-stage temperature method set the temperature at 21$\pm$ $1^{\circ}C$) in the second and third days after the initial acceleration of germination (about 4 hours), at 18.5$\pm$0.5$^{\circ}C$ in the fourth and fifth days, and at 17.0$\pm$ $0.5^{\circ}C$) in the sixth and seventh days. Three-stage temperature method could enhance the resistance power to diseases at the early growth stage, control the growth to standard goods (8-9cm in length and 2.15-2.30mm in width), and keep good body color at the middle or final stage. This method also increased the sprout yield by 6% compared with the conventional method, constant temperature method.

• Journal of Korea Technology Innovation Society
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• v.15 no.2
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• pp.242-261
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• 2012

Early stages of technology valuation have been often overlooked or under-represented. The early stage technologies are even riskier due to their inadequacy of commercial development and market applicability. More than 95% of patents fail to earn any revenues so that the majority of patents were valueless. Technology transfers from laboratories at universities and research institutes to industrial firms have increased to acquire value from invented technologies. Technology transfer, a process of transferring discoveries and innovations resulted from research to commercial sectors, typically comprises several steps: disclosing the discoveries and innovations, i.e., intellectual property (IP), evaluating the IP's economic prospects, securing a patent, copyright or trademark for the IP, commercializing the technology through licensing, forming a joint venture, or selling. At each of those stages in the research and development of technology, the value of technology would play a very important role of making decision on the movement toward the next step, however, the financial value of technology is not easy to determine due to a great amount of uncertainty in the course of research and development, and commercialization. This paper refers to technology embodied as devices, equipment, software or processes primarily developed at public research institutions such as universities. Sometimes it is also as the result of externally financed projects contracted with industry. Nearly always technology developed at public research entities results in laboratory prototypes. When it is required to define the technology transfer contract terms for the license of the university patrimonial rights to external funding companies or other interested parties, a question arises: what is the monetary value? In this paper, we present a method for technology valuation based on the identification of specific value points related to its development. The final technology value must be within previously defined value limits. This paper consists of the review of issues related to technology transfer and commercialization, the identification of characteristics of technologies in the early stage of technology development, the formulation of framework of methods to value the early stage technologies, and the conclusion and implication of the previous review.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.5
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• pp.610-615
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• 2011

We examined the correlations between lactation curve shape, including persistency and changes in body condition score (BCS) during early-stage (0 to 30 days in milk (DIM)), nadir-stage (31 to 90 DIM), and late-stage (91 to 240 DIM) lactation in 191 first-lactation cows. Data used were first-parity BCS records, scored twice every month after calving, and daily milk yields. Individual lactation curves were depicted by the Wilmink function. Lactation persistency was defined as the difference in estimated milk yields between 240 DIM and 60 DIM. Changes in BCSs in the early and late stages were defined as linear regression coefficients. There were no significant correlations between traits for lactation curve shape and change in BCS in early-stage lactation. Peak yield and total milk yield were negatively correlated with BCSs in nadir- and late-stage lactation and with BCS change in late-stage lactation, suggesting that cows with high lactation yields had low body reserves and health status in mid- to late lactation and had delayed recovery of body reserves. Lactation persistency was positively correlated with change in BCS in late-stage lactation, suggesting that cows with high lactation persistency tended to be healthy and to recover their body reserves well in late lactation.

• Development and Reproduction
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• v.19 no.1
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• pp.53-60
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• 2015

Environmental conditions during early mammalian embryo development are critical and some adaptational phenomena are observed. However, the mechanisms underlying them remain largely masked. Previously, we reported that AQP5 expression is modified by the environmental condition without losing the developmental potency. In this study, AQP11 was examined instead. To compare expression pattern between in vivo and in vitro, we conducted quantitative RT-PCR and analyzed localization of the AQP11 by whole mount immunofluorescence. When the fertilized embryos were developed in the maternal tracts, the level of Aqp11 transcripts was decreased dramatically until 2-cell stage. Its level increased after 2-cell stage and peaked at 4-cell stage, but decreased again dramatically until morula stage. Its transcript level increased again at blastocyst stage. In contrast, the levels of Aqp11 transcript in embryos cultured in vitro were as follows. The patterns of expression were similar but the overall levels were low compared with those of embryos grown in the maternal tracts. AQP11 proteins were localized in submembrane cytoplasm of embryos collected from maternal reproductive tracts. The immune-reactive signals were detected in both trophectoderm and inner cell mass. However, its localization was altered in in vitro culture condition. It was localized mainly in the plasma membrane of the blastocysts contacting with external environment. The present study suggests that early stage embryo can develop successfully by themselves adapting to their environmental condition through modulation of the expression level and localization of specific genes like AQP11.

• Journal of Gastric Cancer
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• v.2 no.2
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• pp.105-114
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• 2002

In this study, the Korean Gastric Cancer Association collected 12,152 gastric cancer patients (5,380 in 1995, 6,772 in 1999) from 29 hospitals. Twelve clinicopathological factorssex, age, operation date, tumor location, size, operation method, gross type of early gastric cancer, Borrmann type, depth of invasion, lymph node metastasis, distant metastasis, stage-were summarized in a database file and analyzed. Chronological change has been evaluated between the patients in 1995 and those in 1999. Proportion of early gastric cancer has been increased from $28.6\%$ in 1995 to $32.8\%$ in 1999. The UICC staging was $25.3\%$ (1995), $29.3\%$ (1999) for stage Ia, $12.7\%,\;13.9\%$, for stage Ib, $15.7\%,\;14.8\%$, for stage II, $15.2\%,\;13.2\%$, for stage IIIa, $8.2\%,\;6.3\%$, for stage IIIb, and $20.1\%,\;18.1\%$, for stage IV. The operation of each year was subtotal gastrectomy ($67.6\%,\;67.3\%$), total gastrectomy ($26.6\%,\;24.1\%$), proximalgastrectomy ($0.3\%,\;3.6\%$), wedge resection ($0.1\%,\;0.5\%$), bypass surgery ($2.3\%,\;1.8\%$), and open biopsy ($3.1\%,\;2.7\%$). In early gastric cancer, type IIc was the most common ($44.5\%$ in 1995, $42.8\%$ in 1999). The incidence of upper one-third cancer was slightly increased in 1999 ($12.5\%$) than 1995 ($11.2\%$), which is reflected in the increased prox-imal gastrectomy in 1999 (207 cases, $3.6\%$). There was no significant difference between either groups regarding the regional differences.