• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8115-8119
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• 2014

Background: Breast cancer continues to be the most common type of cancer afflicting many women worldwide. Presently, educational campaigns and research target only women as if men have no role in the management of this disease. The study examined the willingness of male partners to assist in early female breast cancer detection as well as their awareness and knowledge levels. Materials and Methods: Using a semi-structured questionnaire, data was collected from 500 public servants within the Tamale Metropolis and analyzed in SPSS. Results: The level of awareness of breast cancer was very high (98.8%) but there was a low level of knowledge of breast cancer among the male population. Marital status and religion had no effect on attitude, but increasing educational status significantly increased knowledge and positive attitude towards breast cancer examination (${\chi}^2$=4.255, p=0.0391). The majority (92.0%) agreed that men can assist in early breast cancer detection and 96.2% were willing to be provided with breast examination skills. Conclusions: Although level of awareness on female breast cancers among the men was high, they generally lack knowledge of the disease. Majority of male partners want to assist in early breast cancer detection if provided with the necessary skills.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3541-3547
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• 2013

Background: This cross-sectional observational study was undertaken to establish clinico-pathological characteristics of patients with gynecological malignancies, focusing mainly on symptoms, histological type and stage of the disease at presentation, in a tertiary care setting in Eastern India. Materials and Methods: In the gynecology out-patient clinic of a tertiary care hospital in Kolkata, India, the patients with suggestive symptoms of gynecological malignancies were screened. Their diagnoses were confirmed by histopathology. One hundred thirteen patients with histopathologically confirmed gynecological malignancies were interviewed. Results: The most frequently reported symptoms by the patients with histopathologically confirmed gynecological malignancies were excessive, offensive with or without blood stained vaginal discharge (69.0%), irregular, heavy or prolonged vaginal bleeding (36.3%) and postmenopausal bleeding (31.9%). The majority of the patients (61.0%) had squamous cell carcinoma on histopathological examination, followed by adenocarcinoma (30.1%). Nearly half of the patients (48.7%) were suffering from the Federation Internationale des Gynaecologistes et Obstetristes (FIGO) stage III, followed by stage II (40.7%) malignancy. Conclusions: This study highlights that most of the patients with gynecological malignancies present late at an appropriate health care facility. Ovarian cancer may often have non-specific or misleading symptomatic presentation, whereas cervical cancer often presents with some specific symptoms. These observations point to the need for increasing awareness about gynecological malignancies in the community and providing easily accessible adequate facilities for early detection and treatment of the disease by optimal use of available resources, i.e. strengthening the primary health care system.

• 대한수의학회지
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• 제60권3호
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• pp.117-122
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• 2020

Johne's disease (JD) caused by Mycobacterium avium subspecies paratuberculosis (MAP) is a chronic, wasting infectious disease in ruminants that causes enormous economic losses to the dairy and beef cattle industries. The most effective way to eradicate JD is to detect infected individuals as early as possible and remove them from the herd. However, it is difficult to detect infected individuals early with the currently using diagnostic methods. Two serological diagnostic kits commercially used worldwide and a fecal detection test were compared using 298 serum samples and feces of cattle in this study to present an efficient diagnostic method. Although there was a high correlation between the 2 serological diagnostic kits (R² = 0.7473), kit A showed a higher serological positive rate. However, the correlation between fecal tests and serological diagnosis was very low. MAP was also detected in fecal tests in many serologically negative individuals. In the periodical diagnosis of JD, MAP was detected in the feces of only cows with the higher antibody titer to MAP. These results suggest that for effective eradication of JD, early detection of infected individuals by fecal tests together with the serological tests currently in use and by removal of infected individuals are needed.

• 대한영상의학회지
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• 제83권3호
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• pp.453-472
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• 2022

양전자방출단층촬영(PET)을 이용한 단백질병리의 생체영상기술은 퇴행성 치매의 질병 기전을 이해하는데 필요한 정보를 제공할 뿐 아니라, 질병의 조기 발견과 치료법 개발에서 중요한 역할을 수행하고 있다. 베타아밀로이드와 타우 PET 영상은 인체 뇌병리에 기반한 알츠하이머병 연속체에 대한 진단 바이오마커로 확립되어 조기진단과 감별진단을 용이하게 하고, 질병 예후를 예측하고 있다. 또한, 치매치료제 개발에서 예후 및 대리 바이오마커로의 역할이 커지고 있다. 이 종설에서는 치매를 유발하는 알츠하이머병 및 기타 퇴행성 뇌질환에서 베타아밀로이드와 타우 단백질의 뇌축적을 영상화하는 PET의 최근 임상적 적용과 최근 동향을 살펴보고, 잠재적 유용성을 소개하고자 한다.

• 산업공학
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• 제23권4호
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• pp.365-371
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• 2010

In this study, we propose a novel remote health monitoring system to accurately predict Parkinson's disease severity using a signomial regression method. In order to characterize the Parkinson's disease severity, sixteen biomedical voice measurements associated with symptoms of the Parkinson's disease, are used to develop the telemonitoring model for early detection of the Parkinson's disease. The proposed approach could be utilized for not only prediction purposes, but also interpretation purposes in practice, providing an explicit description of the resulting function in the original input space. Compared to the accuracy performance with the existing methods, the proposed algorithm produces less error rate for predicting Parkinson's disease severity.

• Journal of Chest Surgery
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• 제23권3호
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• pp.537-541
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• 1990

Early esophageal carcinoma is defined as a lesion wherein invasion is confined to the mucosa and submucosa without metastasis to lymph node or other organs. Postoperative 5-year survival rate for early esophageal carcinoma is much superior than advanced carcinoma. Unfortunately, because of the anatomic characteristic of esophagus and absence of specific early symptoms, detection is frequently belated, and advanced disease is present at the time of the initial diagnosis. We experienced 2 cases of early esophageal carcinoma. They complained no specific symptoms. The diagnosis was made by barium esophagogram, esophagofiberscopy with dye staining and endoscopic biopsy. We performed esophagectomy with esophagogastrostomy. All had good postoperative course without any complication. We concluded that the combined use of double contrast radiography, esopagofiberscopy aided by intraluminal staining with Toluidine blue or Lugol`s solution, and endoscopic biopsy is very important in the diagnosis of early esophageal carcinoma in high risk patient group.

• 한국산림과학회지
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• 제100권3호
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• pp.374-381
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• 2011

본 연구에서는 지상형 원격탐사장비인 ADC(Agricultural Digital Camera)를 통해 획득한 영상으로부터 NDVI(Normalized Difference Vegetation Index) 값을 산출하여 소나무 재선충병 감염목의 조기감별에 대한 가능성을 알아보고자 하였다. 재선충에 감염된 임목의 잎은 시들음 현상을 보이게 되고, 이것은 NDVI의 감소를 유발하므로, 정상목과 감염목은 시기에 따라 NDVI 변화양상이 다르게 나타난다. 이러한 현상에 착안하여, 시기에 따라 임목의 NDVI 값의 변화량을 보여주는 DI(Detection Index)를 고안하여 감염목의 판별에 사용하였다. 2007년 5월부터 8월까지의 획득된 영상으로부터 감염목과 정상목의 DI 값을 산출한 후, GLM(General Linear Models)을 이용하여 분석한 결과 6~8월 DI 값이 가장 낮은 유의수준(0.0001)에서 두 집단 간에 차이를 보였다. 6~8월 DI 값으로 감염목과 정상목의 집단 간의 차이를 판별분석(Discriminant Analysis)한 결과, DI 값을 통한 감염목과 정상목의 분류정확도(Hit Ratio)는 71.9%였고, 잭나이프(Jack-knife) 추정방법을 사용했을 때는 73.5%의 정확도를 얻었다. 위의 결과를 통해 DI는 감염목과 정상목을 판별하는데 유용한 지수라고 판단되고, 재선충병에 의한 피해를 방지하는데 도움을 줄 수 있을 것이라 사료된다.

• The Plant Pathology Journal
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• 제39권1호
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• pp.141-148
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• 2023

Black shoot blight disease caused by Erwinia pyrifoliae has serious impacts on quality and yield in pear production in Korea; therefore, rapid and accurate methods for its detection are needed. However, traditional detection methods require a great deal of time and fail to achieve absolute quantification. In the present study, we developed a droplet digital polymerase chain reaction (ddPCR) method for the detection and absolute quantification of E. pyrifoliae using a pair of species-specific primers. The detection range was 10³-10⁷ copies/ml (DNA templates) and cfu/ml (cell culture templates). This new method exhibited good linearity and repeatability and was validated by absolute quantification of E. pyrifoliae DNA copies from samples of artificially inoculated immature pear fruits. Here, we present the first study of ddPCR assay for the detection and quantification of E. pyrifoliae. This method has potential applications in epidemiology and for the early prediction of black shoot blight outbreaks.

• 재활복지공학회논문지
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• 제10권4호
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• pp.259-265
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• 2016

본 논문에서는 폐질환 조기 검출을 위하여 Broncho vascular, Emphysema, Ground Glass Reticular, Ground Glass, Honeycomb, Normal의 6가지 폐조직에 대한 새로운 분류기법을 제안하였다. 단순 베이즈 분류기와 아다부스트 학습 기법을 도입하여 459개의 결합 히스토그램 특징인자로부터 유효한 특징인자를 선별함으로써 폐조직을 분류하였다. 다중 해상도 해석, 체적 LBP 및 CT 휘도를 기반으로 하는 결합 히스토그램 특징인자는 정확도, 민감도, 특이도 결과에서 기존의 3D AMFM보다 우수한 결과를 보였다. 제안한 특징인자와 3D AMFM 특징인자의 정확도는 각각 90.1%과 85.3%로서 제안한 특징인자의 우수한 분류 성능을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2107-2117
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• 2015

Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is autosomal dominantly and gain of function mutations in the RET proto-oncogene are well known to contribute to its development. MTC occurs as hereditary (25%) and sporadic (75%) forms. Hereditary MTC has syndromic (multiple endocrine neoplasia type 2A, B; MEN2A, MEN2B) and non-syndromic (Familial MTC, FMTC) types. Over the last two decades, elucidation of the genetic basis of tumorigenesis has provided useful screening tools for affected families. Advances in genetic screening of the RET have enabled early detection of hereditary MTCs and prophylactic thyroidectomy for relatives who may not show any symptom sof the disease. In this review we emphasize the main RET mutations in syndromic and non syndromic forms of MTC, and focus on the importance of RET genetic screening for early diagnosis and management of MTC patients, based on American Thyroid Association guidelines and genotype-phenotype correlation.