• 대한한방내과학회지
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• 제31권4호
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• pp.846-856
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• 2010

Objective : Allergic disease, a very common chronic illness that affects all ages of patients, has been well characterized as an IgE-dependent immunologic response. Recently, interest has grown about the late inflammatory reaction as well as the early one characterized by IgE and mast cells in allergic disease. The purpose of this study was to find the anti-inflammatory effect of Taeeumjowui-tang (Taiyintiaowei-tang) in allergic reaction. Methods : The experiment was performed using Raw 264.7 cells pretreated with Taeeumjowui-tang contents extracts. The results were measured for different concentrations of Taeeumjowui-tang extracts (100, 200, $300{\mu}g$/ml): the toxicity and proliferation of cells by MTT analysis, LPS-induced NO production using Griess reagent and IL-6/ TNF-${\alpha}$ production, which is a significant criteria for diagnosing allergic reaction. Results : No toxicity of Taeeumjowui-tang (100, 200, $300{\mu}g$/ml) on Raw 264.7 cells was found after 24 hours incubation. LPS-induced NO production was reduced after treatment with Taeeumjowui-tang (100, 200, $300{\mu}g$/ml)(P<0.001). IL-6 decreased only at $100{\mu}g$/ml(P<0.05). TNF-${\alpha}$ production decreased only at $300{\mu}g$/ml, but still statistically insignificant. There was no relationship between any components of Taeeumjowui-tang alone and inhibition of NO production. Conclusions : These data suggest that Taeeumjowui-tang has anti-inflammatory effects in allergic reaction.

• Advances in pediatric surgery
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• 제10권1호
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• pp.17-21
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• 2004

Improvement in prenatal ultrasonography is leading to diagnose choledochal cyst before birth and before onset of classical symptom more frequently. But, there is a controversy about optimal timing for Cyst excision of prenatally diagnosed asymptomatic choledochal cyst. To identify the most appropriate timing for surgery in prenatally diagnosed choledochal Cysts, we analyzed 6 patients who had operation for choledochal cysts within 30days after birth at the division of Pediatric Surgery, Samsung Medical Center and Inha University School of Medicine, from June 1995 to June 2002. Males were four and females 2, the mean age at operation was 11.2 days, and the median age 8.0 days. The range of gestational ages of the antenatal diagnosis of bile duct dilatation was 24 weeks to 32 weeks, mean was 38.3 weeks, and mean birth weight was 3,298.3 g. After birth, abdominal ultrasonography, hepatobiliary scintigraphy, and magnetic resonance cholangiopancratography (MRCP) were performed. Mean age at operation was 11.2 days. All patients had the cyst excision and Rouxen-Y hepaticojejunostomy. Immediate postoperative complication was not found. During the median follow-up period of 41 months, one patient was admitted due to cholangitis, and the other due to variceal bleeding. Early operative treatment of asymptomatic newborn is safe and effective to prevent developing complications later in life.

• Journal of Chest Surgery
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• 제18권1호
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• pp.54-61
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• 1985

One-hundred-and-seven patients were the consecutive cases of double replacement of the mitral and the aortic valves at the same time using the lonescu-Shiley bovine pericardial xenograft valve during the period between May, 1979 and June, 1984. They were 64 males and 43 females, and their ages ranged from 13 to 62 years [mean age, 34.011.9 years]. Eight patients died within 30 days after surgery [operative mortality rate, 7.5%], and 7 others thereafter [late mortality rate, 6.5%; or 4.21%/patient-year]. Ninety-nine early survivors were followed up for a total duration of 166.1 patient-years [mean duration, 20.116.1 months]. Two patients experienced thromboembolic complication with no death [1.20%/patient-year]; five developed prosthetic valve endocarditis [3.01%/patient-year] with one death; and three had a new development of aortic regurgitant murmur and they were, along with a mortality from endocarditis, classified into the cases of tissue valve failure [2.41%/patient-year]. The actuarial survival rate including the operative mortality was 82.24.7% at 6 years after surgery. The probabilities of freedom from thromboembolism and from valve failure were 97.61.7% and 88.67.6% at 6 years respectively. Symptomatic improvement was excellent in most of the cases at the follow-up end, showing the mean of the postoperative NYHA Classes of 1.120.33 from the preoperative one of 2.860.54. These results compares favorably with the ones reported from the major institutions. Clinical results of isolated replacement of the mitral valve and of the aortic valve were previously reported. The clinical results of a total and consecutive patients with replacement of single mitral and single aortic and double mitral and aortic valves on the mortality rate, survival rate, complication frequency, and symptomatic improvement all fully stands for the good therapeutic modalities of the valvular heart diseases with severely damaged lesions.

• Journal of Chest Surgery
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• 제18권2호
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• pp.220-231
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• 1985

In selected patients with occlusive lesions of coronary arteries, aortocoronary bypass grafting has been effective in reducing anginal symptoms and in increasing the patients` longevity. Between May, 1977, and December, 1983, 41 patients with coronary occlusive disease received aortocoronary bypass surgery at Yonsei University Medical Center in Seoul. Thirty-three were male and 8 were female. Their ages ranged from 33 to 70 years [average 531.6 years]. Of the 41 patients, 11 suffered from stable angina, 30 suffered from unstable angina and 4 suffered from a variant type of angina. Eleven patients had 1 diseased vessel, 11 patients had 2 diseased vessels, 19 patients had 3 diseased vessels, and 5 patients had a diseased left main coronary artery. A single graft was placed in 5 patients, a double graft was placed in 17 patients, a triple graft was placed in 11 patients and a quadruple graft was placed in 8 patients. Nineteen patients received a sequential graft [40 sites of 20 vessels]. The average internal diameter of the grafted distal coronary artery was 2.380.15, 1.630.13 mm on the left side and 3.200.20, 1.830.21 mm on the right side. Two operative deaths occurred in the early years of our experience. The mortality rate was 4.87% and there were no late deaths. Of the 39 survivors, 30 [76.9%] were Functional Class I [free of symptoms without medication], 7 [17.9%] were Functional Class II and only 2[5.2%] were Functional Class III during the follow up period [653.75 patient-months]. On the basis of this experience, we conclude that coronary artery occlusive disease is occurring in increasing numbers in Korea. Therefore, a concerted effort is needed to detect this disease and to manage the increasing number of patients suffering from it.

• The Korean Journal of Pain
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• 제18권2호
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• pp.187-191
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• 2005

Background: Discogenic leg pain is a major cause of health problems, often due to herniation of the intervertebral disc, and has traditionally been treated conservatively or with an open surgical discectomy. Conventional open surgery has many complications, such as nerve root injury, discitis and a relatively high mortality rate; failure of conservative treatments is also common. Recently, the $Dekompressor^{(R)}$ Percutaneous Lumbar Discectomy probe was developed. Herein, we present the early results for a percutaneous lumbar discectomy in herniated lumbar disc disease. Methods: Eleven patients, including 8 men and 3 women, with ages ranging from 22 to 78 years, were enrolled in this study. Those patients with a previous history of back surgery were not excluded from the study. All patients were postoperatively evaluated for their clinical outcomes, such as visual analogue scale (VAS) for pain after 1 and 3 months, reduction in analgesics, functional improvement and overall satisfaction. Results: The percutaneous lumbar discectomy was completed in 11 patients (17 levels), with average reductions in pre-VAS of 61.3 and 60.2% at 1 and 3 months, respectively. Also, 72.7% of patients reported functional improvement, with 81.1% expressing overall satisfaction. There were no procedural related complications. Conclusions: We concluded that a percutaneous lumbar discectomy is a safe and effective treatment modality for a herniated lumbar disc.

• 한국지역지리학회지
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• 제17권1호
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• pp.122-139
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• 2011

연변지역은 문화 역사적으로 한국뿐만 아니라 중국에 있어서도 관심 지역이다. 연변지역에 대한 문화 역사적 연구는 많지만 유적 지도화에 대한 연구는 찾아보기 힘들다. 본 연구에서는 구글어스 영상을 이용하여 연변지역의 문화 역사 유적을 지도화하고 공간적 특징을 분석하고자 하였다. 석기시대부터 청나라까지 시기별로 문화 역사 유적 분포도를 제작하였다. 지도화 기호체계는 사기별로 색상기호와 유형별 기호를 제작하였다. 지도화 결과 연변지역에는 다른 시기와 비교해 발해와 요 금나라의 유적이 많은 비중을 차지하였다. 특히 고구려, 발해, 요 금나라의 유적은 시 공간적 누층구조를 보였다. 분포특정은 초기에 분지지역과 하천지역에 위치해 있었고, 역사시기 이후에는 구릉과 산지지역으로 이동하였다. 연구결과는 문화 역사 유적 관련 후속연구에 정보를 제공해 줄 수 있을 것으로 기대된다.

• Applied Microscopy
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• 제23권1호
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• pp.109-124
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• 1993

The prenatal development of thoracic spinal cord was studied by electron microscope in human embryos and fetuses ranging from 9mm to 260mm crown-rump length (5-30 weeks of gestational age). Ependymal cells in all fetal ages had conspicuous junctional complexes close to the lumen of the central canal into which microvilli and cilia projected. The ependymal cells contained numerous longitudinally arranged mitochondria, flattened cisternae of endoplasmic reticulum and Golgi complex. At 20 mm embryo, the floor and roof plates were composed of ependymoglial cells and undifferentiated neuroepithelial cells. The neuroepithelia of the sacral spinal cord were delineated from central medullary cord. By 100 mm fetus few undifferentiated neuroepithelial cells remained in the floor and roof plates. At 150 mm fetus, the whole central canal was formed by ciliated columnar epithelial cells containing cilia with basal bodies. The microvilli became tangled and club-shaped and formed a matted surface. The canal was filled with areas of dark and pale amorphous materials bounded by membrane-like structure. These two types of material were found throughout the whole central canal from 100 mm fetus onwards. By 260 mm fetus, microfibrils were first observed in the ependymal cells. In conclusion, it seems that early development and differentiation of central canal ependyma are simlar to that in other part of the brain ventricular system although ependymoglial cells are more prominent.

• Clinical and Experimental Pediatrics
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• 제45권6호
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• pp.700-711
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• 2002

대 상: 영아의 발달 장애를 조기에 발견하여 치료를 하기 위하여는 발달 장애의 가능성이 있는 영아뿐 아니라 모든 영아의 정기 검진에서 발달 선별 검사를 시행하는 것이 바람직하다. 본 연구에서는 이러한 발달 선별에 사용할 수 있고 결과를 점수화 할 수 있는 새로운 발달 선별 검사를 개발하고자 하였다. 방 법 : 1개월에서 4세의 아동에 사용할 수 있는 이화 영아 발달 선별 검사를 개발하고 이를 베일리 영아 발달 검사를 기본검사로 하여 동시에 104명의 영아에 시행하였다. 104명 중 건강한 아동은 94명, 발달 지연을 주소로 내원한 아동은 10명이였다. 이화 발달 선별 검사의 가상 합격선을 80, 85, 90점으로 하여 각각의 점수에서 민감도와 특이도, 예측가를 계산하였다. 결 과 : 이화 영아 발달 선별 검사의 합격선을 90점으로 하는 경우 민감도 83.3%, 특이도 93.5%, 예측가 62.5%로 비교적 안정된 결과를 나타내었다. 결 론 : 발달 선별 검사의 결과를 점수화 하는 데에는 문제가 있을 수 있지만 발달을 진단하기 위해서가 아니라 선별하기 위해서 사용한다면 이러한 위험을 피할 수 있을 것이며 앞으로 더 많은 수의 아동을 상대로 검사를 시행하여 보완할 필요가 있을 것이다.

• 여성건강간호학회지
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• 제8권1호
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• pp.96-105
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• 2002

The purpose of this study is to identify the relation between functional limitation, functional disability and back pain during pregnancy. Data was collected by interview or self-report from 66 pregnant women between the gestational ages of 17 and 22 weeks who had experienced back pain from February 17 through July 28, 2001. The results of this study are as follows; 1. The prevalent mean week of back pain starting during pregnancy was 12.8. The mean pain intensity scores on the VAS during the past week and now were 5.6 and 3.7. The mean score on the functional limitations was 38.9. The mean score on the functional disability was 19.7. 2. The pain intensity on the past week was correlated with the pain intensity now (r=.339, p<0.01) and the functional limitations (r=.251, p<0.05). The pain intensity now was correlated with the functional limitations (r=.295, p<0.05) and the functional disability (r=.429, p<0.01). The functional limitations was correlated with the functional disability (r=.229, p<0.01). The higher pain intensity was the more functional limitation and functional disability occurred. 3. There was a statistically significant correlation between the pain intensity now and the type of housing (t=-2.051, p=.045), and back pain history before pregnancy (t=-2.429 p=.003). 4. There was a statistically significant correlation between the functional limitation and income (F=2.803, p=.047) and back pain history before pregnancy (t=-3.225, p=.002). There was a statistically significant correlation between the functional disability and back pain history before pregnancy (t=-3.058 p=.003). In conclusion, we found that a history of back pain was an important factor when predicting back pain and functional disability and limitation during pregnancy. The nurse and the prenatal educator should detect risk factors of back pain early in pregnancy and manage continuously though pregnancy.

• 한국제4기학회지
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• 제17권2호
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• pp.117-122
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• 2003

This study is conducted to examine the woods that were excavated at Jangdo Island. The Jangdo site is located in a small island some 180 meters away from the main island of Wando, Jeollanam-do in southern Korea. This site is known as Cheong-Hea Jin fort for the marine King Jang Bogo during the early 9$^{th}$ century. Total of 101 specimens were collected in three groups； small-size piles, log fences (Mok-check) and logs from a well. The species of the group of piles consisted of Quercus spp. (43%), Pinus densiflora (29%), Pinus koraiensis (5%), Alnus japonica (3%), Fraxinus spp. (3%), Styrax obassia (3%), Juglans spp. (2%), Zelkova serrata (2%), Platycarya strobilacea (2%), Celtis spp. (2%), Torreya nucifera (2%), Quercus myrsinaefolia (2%), and Cinnamomum spp. (2%). The species of Mok-check and logs from the well were identified as all Pinus densiflora. The species composition indicated that the climate around A. D. 9th-10th century in southern Korea was similar to the present.. The wooden fences were also examined for tree-ring analysis. The ages of woods were 50∼60 years. We made two site chronologies. The chronologies indicated that southeastern and southwestern fences were repaired frequently. The results could not give the absolute dates due to lack of reference chronologies in this period.