• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3961-3968
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• 2015

Background: Variants of human papillomavirus (HPV) show more oncogenicity than do prototypes. The HPV16 Asian variant (HPV16As) plays a major role in cervical cancer of Asian populations. Some amino acid changes in the E6 protein of HPV16 variants affect E6 functions such as p53 interaction and host immune surveillance. This study aimed to investigate activities of HPV16As E6 protein on modulation of expression of miRNA-21 as well as interferon regulatory factors (IRFs) 1, 3, 7 and c-fos. Materials and Methods: Vectors expressing E6 protein of HPV16As (E6D25E) or HPV16 prototype (E6Pro) were constructed and transfected into C33A cells. HCK1T cells expressing E6D25E or E6Pro were established by transducing retrovirus-containing E6D25E or 16E6Pro. The E6AP-binding activity of E6 and proliferation of the transfected C33A cells were determined. MiR-21 and mRNA of interesting genes were detected in the transfected C33A cells and/or the HCK1T cells, with or without treatment by culture medium from HeLa cells (HeLa-CM). Results: E6D25E showed binding activity with E6AP similar to that of E6Pro. Interestingly, E6D25E showed a higher activity of miR-21 induction than did E6Pro in C33A cells expressing E6 protein. This result was similar to the HCK1T cells expressing E6 protein, with HeLa-CM treatment. The miR-21 up-regulation significantly corresponded to its target expression. Different levels of expression of IRFs were also observed in the HCK1T cells expressing E6 protein. Interestingly, when treated with HeLa-CM, IRFs 1, 3 and 7 as well as c-fos were significantly suppressed in the HCK1T cells expressing E6D25E, whereas those in the HCK1T cells expressing E6Pro were induced. A similar situation was seen for IFN-${\alpha}$ and IFN-${\beta}$. Conclusions: E6D25E of the HPV16As variant differed from the E6 prototype in its activities on epigenetic modulation and immune surveillance and this might be a key factor for the important role of this variant in cervical cancer progression.

• Information and Communications Magazine
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• v.33 no.4
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• pp.17-26
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• 2016

본 논문에서는 차량 내에서 중요성이 증가하고 있는 전기전자 시스템을 효율적으로 설계하기 위해서 진행되고 있는 E/E 아키텍처 설계에 대해서 소개한다. 먼저 차세대 E/E 아키텍처를 설계하기 위한 요소기술로 와이어링 하네스의 설계, 표준회로를 적용한 표준제어기, 소프트웨어 플랫폼 및 E/E 아키텍처 평가기술에 대해서 각각 설명하였다. 다음으로 E/E 아키텍처 설계를 위해서 필요한 차량용 내부 네트워크 기술에 대한 최근의 국제표준화 동향을 살펴보고 세부기술에 대해서 소개하였다. 마지막으로 시스템레벨에서의 최적화를 고려하여 설계한 차세대 E/E 아키텍처의 설계방안에 대해서 기술하였다.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.7 no.4
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• pp.638-645
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• 2003

In existing internet, e-mail protocols including POP3 and IMAP4, provide e-mail services fir exchanging messages with texts, hypertext and images as well. For the e-mail services in wireless mobile network, mobile e-mail service providers have to install a mobile exclusive e-mail server or have to convert e-mail to mobile exclusive e-mail with wireless application format in case of POP3 protocol. In the e-mail service of IMAP4 case known as web-mail, it is difficult to view e-mail directly from server without IMAP4 mobile client because e-mail is stored in mail server side with remote file server. In either case, it also has the problems of viewing the e-mail of hypertext and image information at mobile. This paper provides e-mail extraction engine with image and hypertext conversion facilities that can be applied in wireless mobile internet and it is optimized in mobile communication environments such as a small display, small size of memory with web-mail protocol based on IMAP4 as well as POP3 mail protocol.

• Journal of Radiation Protection and Research
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• v.2 no.1
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• pp.24-30
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• 1977

Les eaux de $g\'{e}n\'{e}rateur$ de vapeur d'un $r\'{e}acteur$ P. W. R peuvent $\^{e}tre$ $contamin\'{e}es$ par des $radio-\'{e}lements$. Ces eaux sont habituellement $condition\'{e}es$ 'phosphate' pour limiter leur $agressivit\'{e}$ et la tendence actuelle est de remplacer les phosphate par un conditionment 'Amoniaques'. La $pr\'{e}sente$ $\'{e}tude$ a pour but de definir la $possibilit\'{e}$ $d'{\'{e}}purer$ des eaux $condition\'{e}es$ $\'{a}$ l'ammoniaque $\'{a}$ l'aide $d'{\'{e}}changeurs$ d'ion organiques. Des Facteurs de $D\'{e}contamination$ (F. D) en Cesium 137 et Strontium 90 et la $dur\'{e}e$ du cycle $d'{\'{e}}puration$ ont $d\^{u}$ $\^{e}tre$ bien meilleurs avec une colonne de 10 ml de $r\'{e}sine$ Carborylique Duolite $CC_4$ mise sous forme acide, suivie d'une colonne de 10 ml de $r\'{e}sine$ cationique Amberlite IR 120 mise sous forme acide et suivie d'une colonne de 10 ml de $r\'{e}sine$ anionique Amberlite IRA 400 mise sous forme hydroxyde.

• Journal of Digital Convergence
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• v.6 no.2
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• pp.135-143
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• 2008

The remarkable growth of the Internet since mid-l990s has expanded the e-learning market and brought the transformation of educational environments and methodology. It can be said that the e-learning has changed the educational paradigm. Korean government is firmly determined to support the diffusion of e-learning because of the benefits of e-learning. People seem to accept the e-learning when its contents have high quality. A lot of research have been conducted on e-learning, however, it was mostly about user's usage intention, satisfaction and educational effect. It can't seem that sufficient research efforts have been put into figuring out the role of e-learning contents quality in the expansion of e-learning. In this paper, we present the empirical study on the influence of e-learning contents quality on user's satisfaction and educational effect. We conducted an questionnaire survey on college students to collect data and found that the quality of e-learning contents has significant influence on the users' satisfaction.

• Journal of Information Technology Applications and Management
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• v.22 no.2
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• pp.219-230
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• 2015

Recently, electronic-book (e-book) market is growing rapidly due to the evolution of information technology and e-book standard EPUB. Users can search e-book on-line and download easily to their e-book readers such as amazon's kindle or smartphones. On the other hand, there is lack of e-book contents for the reading disabled people because of high cost of making e-book accessibility for the reading disabled people. If we can translate EPUB specified e-book contents to the alternative e-book contents suitable for the reading disabled people, then there are many advantages to acquire various types and large volumes of e-book contents for the reading disabled people. This paper suggests a new electronic publishing ecosystem for the reading disabled people using e-book translation method. It also suggests a promotion strategy of e-book market for the reading disabled people.

• Journal of Service Research and Studies
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• v.2 no.2
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• pp.1-21
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• 2012

e-R&D means conducting research and development with network or computer software in cyber space. Given the rapid technology paradigm shift and diversified customer needs, companies face the problem of new product and service innovation. This paper introduces the strategic view for e-R&D status, case examples, and e-R&D service. We state e-R&D adoption stages for strengthening the industry competitiveness and IT service utilization.

• The Journal of Information Systems
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• v.23 no.2
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• pp.25-47
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• 2014

Based on the levels of inter-organizational information flow and the degrees of suppliers' power, this study aims to develop a framework useful for classifying four types of the buyer's e-commerce strategies in manufacturing firms: e-marketplace, e-partnership, e-procurement and supplier's e-marketplace (e-distribution). We adopted a multi-methodological approach by mixing both qualitative and quantitative methods. After developing a framework, through the cases of Cisco, JAL, Toyota Motor, KIST, AMP, and 3M, this paper aims to confirm the actual existence of the four forms of e-commerce. The results from the cases supported the four types of e-commerce strategies in manufacturing firms. With the empirical data, we also demonstrated the configuration of the framework and the four types of e-commerce strategies, and identified the characteristics (i.e., size, age, actual adoption rate of the each type of e-commerce, and supply-chain performance) of the organizations employing each strategy.

• Journal of the Korean Society of Food Science and Nutrition
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• v.19 no.3
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• pp.207-214
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• 1990

Amish 집단(미국 오하이오주 홈스카운터 거주)의 vitamin E 영양상태를 24시간 회상법, 영양보충제의 사용량 조사 colorimetric법에 의한 혈장 vitamin E의 분석으로 평가하였다 평균식이 섭취 vitamin E는 7.4mg a-tocopherol equivalent였으며 평균 181.4 IU는 영양보충제로 섭취했다 전체 vitamin E의 67.7% 는 식이를 통해 섭취했으며 32.4%는 영양보충제를 복용함으로 섭취했다 평균 혈장 vitamin E 농도는 13.4mg/ml였다 혈장 vitamin E와 영양제로 복용한 vitamin E 사이에는 유의적인 상관과계가(r=0.489 p=0.0001)를 보여주었고 혈장 vitamin E와 연령과도 상관관계(r-0.216, p=0.0017)가 있었다 Amish 집단의 vitamin E 영양상태는 충분했으며 이집단 중의 어떤 자들은 고단위의 다량의 vitamin E 영양제를 복용하고 있어 vitamin E에 대한 올바른 정보를 알려주고 효율적인 영양교육을 시킬 필요성이 요청되었다.

• Archives of Pharmacal Research
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• v.9 no.4
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• pp.237-242
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• 1986

The Synthesis of E, E, E-12-fluorofarnesol and E, Z-6-fluorofarnesol which are key intermediates for the study of biosynthesis of some sesquiterpenes, is described. E, E-Farnesyl acetate is treated with selenium dioxide to give E, E, E-12-hydroxy farnesyl acetate, whih is transformed by DAST into E, E, E-12-hydroxy farnesyl acetate, which is transformed by DAST into E, E, E,-12-fluorofarnesylacetate. The latter compound is hydrolyzed to E, E, E,-12-fluorofarnesol. The reformatsky reaction of 6-methyl-5-hepten-2-one with ethyl bromofluoroacetate affords ethyl 2-fluoro-3-hydroxy-3, 7 dimethyl-6-octanoate. This ester is acetylated and eliminated to give ethyl (Z)-2-fluoro-3, 7-dimethylocta-2, 6-dienoate, which is transformed to allyl bromide via allylic alcohol. The allyl bromide is treated with dianion of methyl acetate to give-keto ester. The $\beta$-keto ester is converted to diethyl phosphoryloxy compound. The conjugate addition of lithium dimethylcuprate to the latter compound gives fluoro ester, which is treated with DIBAL to afford E, Z-6-fluorofarnesol.