• Journal of Species Research
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• 제11권4호
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• pp.335-342
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• 2022

Through the 'Discovery of Korean Indigenous Species' project hosted by the National Institute of Biological Resources (NIBR), new or unrecorded species of various protozoans inhabiting the Korean Peninsula have been discovered. Samples were collected from marine, freshwater, and soil habitats in South Korea and all species were identified and reviewed by experts working on the respective taxonomic group. This study includes 17 unrecorded Korean protozoan species discovered through this project, which belong to four phyla: Amoebozoa Lühe, 1913, Cercozoa Cavalier-Smith, 1998, Euglenozoa Cavalier-Smith, 1981, and Ciliophora Doflein, 1901. Among them, three families (Rhogostomidae Dumack et al., 2017, Parauronematidae Small and Lynn, 1985, and Cyclidiidae Ehrenberg, 1838) and three genera (Rhogostoma Belar, 1921, Parauronema Thompson, 1967, and Cyclidium Müller, 1773) were reported for the first time in Korea. Unlike the previous paper of 2017, this study provides a comprehensive taxonomic account of each species (e.g., species name, collection site, synonyms, specimen vouchers, diagnoses, and figures). Additionally, all the species were assigned Korean names.

• 한국IT서비스학회지
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• 제16권3호
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• pp.167-183
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• 2017

The rapid growth of information technology and mobile service platforms, i.e., internet, google, and facebook, etc. has led the abundance of data. Due to this environment, the world is now facing a revolution in the process that data is searched, collected, stored, and shared. Abundance of data gives us several opportunities to knowledge discovery and data mining techniques. In recent years, data mining methods as a solution to discovery and extraction of available knowledge in database has been more popular in e-commerce service fields such as, in particular, movie recommendation. However, most of the classification approaches for predicting the movie popularity have used only several types of information of the movie such as actor, director, rating score, language and countries etc. In this study, we propose a classification-based support vector machine (SVM) model for predicting the movie popularity based on movie's genre data and social network data. Social network analysis (SNA) is used for improving the classification accuracy. This study builds the movies' network (one mode network) based on initial data which is a two mode network as user-to-movie network. For the proposed method we computed degree centrality, betweenness centrality, closeness centrality, and eigenvector centrality as centrality measures in movie's network. Those four centrality values and movies' genre data were used to classify the movie popularity in this study. The logistic regression, neural network, $na{\ddot{i}}ve$ Bayes classifier, and decision tree as benchmarking models for movie popularity classification were also used for comparison with the performance of our proposed model. To assess the classifier's performance accuracy this study used MovieLens data as an open database. Our empirical results indicate that our proposed model with movie's genre and centrality data has by approximately 0% higher accuracy than other classification models with only movie's genre data. The implications of our results show that our proposed model can be used for improving movie popularity classification accuracy.

• Journal of Advanced Marine Engineering and Technology
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• 제38권4호
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• pp.451-455
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• 2014

LTE (Long Term Evolution) 및 LTE-A (Long Term Evolution-Advanced) 망에서는 사용자에 대한 시스템 용량 향상을 위해 펨토셀(femto-cell)을 이용한 계층적(hierarchical) 셀 구조를 고려하며, LTE/LTE-A에서 고려되는 펨토셀은 일반적으로 특정 개인 및 집단에 제한된 접속을 허용하는 배타적 접속(Closed Subscriber Group; CSG) 펨토셀로 구현된다. 하지만 이러한 배타적 접속 펨토셀이 보편화되기 위해서는 배타적 접속 펨토셀로의 진입(inbound) 핸드오버(handover) 지연시간 문제를 해결해야 한다. 특정 단말(User Equipment; UE)에게만 접속이 허용된 배타적 접속 펨토셀은 제한된 지역에만 분포하여 셀 검출 시도의 빈도가 낮을 수 밖에 없으므로 일반적인 매크로셀(macro-cell)에 비해 셀 검출에 보다 많은 시간이 소요되며, 이로 인한 진입 핸드오버 지연이 발생한다. 이러한 배타적 접속 펨토셀에 대한 검출을 고려하지 않은 LTE/LTE-A 단말을 이용하여 접속이 허용된 배타적 접속 펨토셀 검출을 시도할 경우 현재 표준에서 제시하는 셀 검출에 대한 성능 기준을 충족시키지 못할 수 있으며, 따라서 본 논문에서는 현재 LTE/LTE-A 표준에 따른 기본적인 셀 검출 방식을 이용하여 LTE 배타적 접속 펨토셀에 대한 검출 성능평가를 수행하고 문제점을 분석하여, LTE 배타적 접속 펨토셀에 대한 진입 핸드오버 지연 문제를 해결할 수 있는 근거를 제시하고자 한다.

• 한국통신학회논문지
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• 제40권1호
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• pp.32-42
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• 2015

본 논문에서는 LTE (Long Term Evolution)-Advanced 상향링크에서 제한된 자원을 보다 효율적으로 사용하기 위하여 하나의 셀룰러 링크와 다수의 D2D (Device-to-Device) 링크가 자원을 공유하는 시나리오를 고려하였다. 이때, 발생하는 간섭현상을 해결하기 위하여 본 논문에서는 eNB (evolved Node B)에게 영역 정보를 알릴 수 있는 DME (Discovery and Management Entity)라는 보조 장치를 고정위치에 설치한 후, 동일한 자원을 공유하는 CUE (Cellular User Equipment)가 DUE Rx (D2D UE Receiver)에게 주는 간섭을 회피하기 위하여 DME의 영역 정보기반 자원할당 기법을 제안하였고 더 나아가, 앞에서 제기한 영역 정보를 기반으로 자원을 할당한 후, 동일한 자원을 공유하는 D2D 링크들 사이의 간섭을 완화하기 위한 전력제어 기법을 제안하였다. 모의실험을 통하여 비교 및 분석한 결과 D2D 통신의 안정성이 향상되었고 전체시스템 성능도 우수하다는 것을 검증하였다.

• Parasites, Hosts and Diseases
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• 제45권1호
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• pp.1-9
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• 2007

The endosymbionts of 4 strains of Acanthamoeba(KA/E9, KA/E21, KA/E22, and KA/E23) isolated from the infected corneas of Korean patients were characterized via orcein stain, transmission electron microscopic examination, and 16S rDNA sequence analysis. Double membrane-bound, rod-shaped endosymbionts were distributed randomly throughout both the trophozoites and cysts of each of Acanthamoeba isolates. The endosymbionts of KA/E9, KA/E22, and KA/E23 were surrounded by electron-translucent areas. No lacunae-like structures were observed in the endosymbionts of KA/E21, the bacterial cell walls of which were studded with host ribosomes. Comparative analyses of the 16S rDNA sequences showed that the endosymbionts of KA/E9, KA/E22 and KA/E23 were closely related to Caedibacter caryophilus, whereas the KA/E21 endosymbiont was assigned to the Cytophaga-Flavobacterium-Bacteroides(CFB) phylum. In the 4 strains of Acanthamoeba, the hosts of the endosymbionts were identified as belonging to the Acanthamoeba castellanii complex, which corresponds to the T4 genotype. Acanthamoeba KA/E21 evidenced characteristics almost identical to those of KA/E6, with the exception of the existence of endosymbionts. The discovery of these endosymbionts from Acanthamoeba may prove essential to future studies focusing on interactions between the endosymbionts and the amoebic hosts.

• Biomolecules & Therapeutics
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• 제30권6호
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• pp.593-602
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• 2022

The human papillomavirus (HPV)-18 E7 (E7) oncoprotein is a major transforming protein that is thought to be involved in the development of cervical cancer. It is well-known that E7 stimulates tumour development by inactivating pRb. However, this alone cannot explain the various characteristics acquired by HPV infection. Therefore, we examined other molecules that could help explain the acquired cancer properties during E7-induced cancer development. Using the yeast two-hybrid (Y2H) method, we found that the Elk-1 factor, which is crucial for cell proliferation, invasion, cell survival, anti-apoptotic activity, and cancer development, binds to the E7. By determining which part of E7 binds to which domain of Elk-1 using the Y2H method, it was found that CR2 and CR3 of the E7 and parts 1-206, including the ETS-DNA domain of Elk-1, interact with each other. As a result of their interaction, the transcriptional activity of Elk-1 was increased, thereby increasing the expression of target genes EGR-1, c-fos, and E2F. Additionally, the colony forming assay revealed that overexpression of Elk-1 and E7 promotes C33A cell proliferation. We expect that the discovery of a novel E7 function as an Elk-1 activator could help explain whether the E7 has novel oncogenic activities in addition to p53 inactivation. We also expect that it will offer new methods for developing improved strategies for cervical cancer treatment.

• Journal of Information Technology Applications and Management
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• 제15권2호
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• pp.1-14
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• 2008

The distinguished prosperity of information technologies from great progress of e-business during the last decade has unavoidably made software development for active data mining to discovery hidden predictive information regarding business trends and behavior from vary large databases. Therefore this paper develops an active mining object(ADMO) component, which provides real-time predictive information from web databases. The ADMO component is to extended ADO(ActiveX Data Object) component to active data mining component based on COM(Component Object Model) for application program interface(API). ADMO component development made use of window script component(WSC) based on XML(eXtensible Markup Language). For the purpose of investigating the application environments and the practical schemes of the ADMO component, experiments for diverse practical applications were performed in this paper. As a result, ADMO component confirmed that it could effectively extract the analytic information of classification and aggregation from vary large databases for Web services.

• 약학회지
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• 제49권5호
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• pp.386-391
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• 2005

The discovery of drugs for the treatment of mast cell-mediated allergic disease is a very important subject in human health. The Amomum xanthiodes (Zingiberaceae) has been used for centuries as a traditional medicine in Korea and is known to have an anti-inflammatory effect. However, its specific mechanism of action is still unknown. In this report, we investigated the effect of hot water extract from Amomum xanthiodes (EAX) on the mast cell-mediated allergic reaction and studied its possible mechanisms of action. EAX inhibited compound 48/80-induced systemic anaphylaxis and serum his­tamine release in mice. EAX decreased the passive cutaneous anaphylaxis reaction activated by anti-dinitrophenyl (DNP) IgE antibody. EAX dose-dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. EAX increased cAMP and decreased compound 48/80-induced intracellular $Ca^{2+}$ levels. Our findings provide evidence that EAX inhibits mast cell-derived allergic reactions, and also demonstrate the involvement of cAMP and intracellular $Ca^{2+}$ in these effects.

• Natural Product Sciences
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• 제17권3호
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• pp.239-244
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• 2011

Immediate-type hypersensitivity is involved in many allergic diseases such as asthma, allergic rhinitis and anaphylaxis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. Stimulation of mast cells releases inflammatory mediators, such as histamine and pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of the aqueous extract of Schizonepeta tenuifolia (AEST) (Labiatae) on the immediate-type allergic reaction. AEST inhibited compound 48/80-induced systemic allergic reaction. AEST attenuated immunoglobulin E (IgE)-mediated skin allergic reaction and histamine release from human mast cell line (HMC-1) cells. In addition, AEST decreased the gene expression and secretion of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated HMC-1 cells. Our results indicate that AEST inhibits the mast cell-derived allergic reactions and involvement of histamine and pro-inflammatory cytokines in these effects.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2004년도 가을 학술발표논문집 Vol.31 No.2 (3)
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• pp.652-654
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• 2004

e-Business 환경의 핵심기술로 주목을 받고 있는 웹서비스는 기존의 비지니스 로직을 보다 빠르고 효율성있게 구축할 수 있는 방법을 제공하는 바탕이 되어가고 있다. 그러나 아직까지 실제 e-Business 에 적용하기에는 몇 가지 문제점이 존재하는데, 그 중 하나가 비지니스 로직을 자동으로 발견하는 것이다. 이를 위해 웹서비스에 온톨로지를 적용한 시맨틱 웹서비스 기술이 연구되고 있으며, 이를 기반으로 서비스 요구자의 요구사항에 맞는 서비스 발견을 위한 방법들이 선보이고 있다. 그러나 현재의 그러한 연구는 서비스 요구자가 기술하는 질의 온톨로지가 서비스 게시자의 온톨로지와 같다는 전제하에서 연구되고 있다. 본 논문은 이러한 매치 메이킹이 보다 효율적으로 수행되도록 게시자의 온톨로지들을 이용하여 서비스 요구자의 질의를 생성하고, 이를 사용하여 웹서비스를 자동으로 발견하는 방법을 제시한다.