• 대한한방내과학회지
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• 제36권3호
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• pp.361-379
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• 2015

Objectives This study aims to review and summarize existing evidence on moxibustion treatment for cancer patients. Methods Literature published until May 2015 in international journals were searched on PubMed, CAJ (CNKI-Medicine), NDSL (National discovery for science leaders), Sage Journal, ScienceDirect, Taylor&Francis Online (HSS), and Wiley Interscience (including Blackwell); and articles in Korean journals were searched on Korean Studies Information Service System (KISS), DBPIA, E-Article, KSI e-book, New article, Korea Institute of Science and Technology Information (KISTI), and Kyobo scholar. Results We analyzed 65 relevant studies. The number of studies conducted annually has increased and most are conducted in Korea and China. Moxibustion decreases the side effects of palliative treatment, thereby synergizing with anticancer treatment; it also improves the immune system, reduces tumor factors, and relieves symptoms. The mechanism of moxibustion is multi-fold: thermo, chemo, aero and kinetic. Only the kinetic effect is not significant. It also needs a complement to moxibustion because of harmful smoke. Conclusions Thus, the effect and mechanism of moxibustion in cancer patients was reviewed. There is an unmet need to develop a model of moxibustion and test it based on Korean medicine.

• 천문학회보
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• 제38권2호
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• pp.56.1-56.1
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• 2013

Supernovae type Ia (SNe Ia) cosmology is providing the only direct evidence for the presence of dark energy. This result is based on the assumption that the look-back time evolution of SNe Ia luminosity, after light-curve shape correction, would be negligible. However, the most recent compilation of SNe Ia data shows systematic difference in the Hubble residual (HR) between the E and Sd/Irr galaxies, indicating that the light-curve fitters used by the SNe Ia community cannot quite correct for a large portion of the population age effect. In order to investigate this possibility more directly, we have obtained low-resolution spectra for 30 nearby early-type host galaxies. This data set is used to estimate the luminosity-weighted mean ages and metallicities of host galaxies by employing the population synthesis models. We found an interesting trend between the host galaxy age and HR, in the sense that younger galaxies have positive residuals (i.e., light-curve corrected SNe Ia luminosity is fainter). This result is rather independent of the choice of the population synthesis models employed. Taken at face value, this age (evolution) effect can mimic a large fraction of the HR used in the discovery of the dark energy. This result is significant at 1.4 - 3 sigma levels, depending on the light curve fitters adopted, and further observations and analyses are certainly required to confirm the trend reported here.

• 경영정보학연구
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• 제10권2호
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• pp.195-209
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• 2008

고객의 니즈가 시시각각 변화하는 경영환경에서 획일화된 매장관리 방법으로 매장의 수익성을 증대시키기에는 한계가 있다. 따라서 고객의 선호 변화를 예측하여 각 매장에 적절한 상품을 추천할 필요가 있다. 본 연구에서는 판매 데이터 분석을 통해 시간 순서를 고려한 상품 추천 및 매장관리 방법을 제안한다. 즉 자기조직화지도(Self Organizing Map) 알고리즘을 이용하여 매장의 판매 프로파일을 군집화하고, 매장 궤적의 예측을 통해 목표 매장을 관리하는 방법을 제시한다. 본 연구의 방법론을 검증하기 위해 (주)더페이스샵 판매데이터를 적용하여 평가하였으며, 평가결과 제시한 방법론은 화장품처럼 유행에 민감하고 라이프사이클이 짧은 특징을 지닌 상품을 판매하는 매장의 수익성 증대에 기여할 수 있을 것으로 기대된다.

• Advances in Traditional Medicine
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• 제10권4호
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• pp.304-309
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• 2010

Scutellaria pinnatifida A. Hamilt. (Lamiaceae) is an endemic Turkish herb. This plant is also endemic to Iran, and grows abundantly in other central and western Asian countries. Several species of the Scutellaria are known for their traditional uses in the treatment of hypertension, arteriosclerosis, inflammatory diseases, hepatitis, allergy, cancer and diarrhoea. Free-radical-scavenging property, antibacterial activity and brine shrimp toxicity of the n-hexane, dichloromethane (DCM) and methanol (MeOH) extracts of S. pinnatifida were assessed using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the resazurin microtitre plate based assay, and the brine shrimp lethality assay, respectively. The DCM and MeOH extracts exhibited free-radical-scavenging property, with the $RC_{50}$ values of 0.362 and 0.127 mg/ml, respectively. Among the solid-phase extraction fractions of the MeOH extract, the 50% aqueous-MeOH fraction showed the highest level of free-radicalscavenging activity ($RC_{50}$ = 0.039 mg/ml). While the DCM extract showed low level of antibacterial activity against Bacillus subtilis and ampicillin-resistant Escherichia coli, the MeOH extract was active against B. cereus, B. subtilis, E. coli and ampicillin-resistant E. coli. However, the minimum inhibitory concentrations (MIC) of the MeOH extract against these bacterial strains were >10 mg/ml. None of the extracts showed any significant toxicity towards brine shrimps ($LD_{50}$ = > 1.00 mg/ml).

• 한국ITS학회 논문지
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• 제17권1호
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• pp.100-113
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• 2018

네트워크 수요량 향상 방안 중 가장 주목받고 있는 Proximity Service는 주파수 사용의 효율성 증대를 위해 대부분 주파수 재사용 방식을 사용한다. 그 결과 셀 edge에서 셀룰러 사용자의 Proximity Service 사용자의 셀 간 간섭 문제가 발생한다. 본 논문에서는 eNB에 Proximity Function의 기능과 파라미터를 새롭게 정의하고, ProSe 파라미터와 ProSe user equipment에 대한 정보를 X2 인터페이스를 통해 인접 셀과 교환하게 함으로써 셀 간섭 완화 방안을 제안한다. 우선 ProSe 탐색 과정에서 주파수 센싱을 통해 셀 간 간섭 문제를 일으키지 않을 자원을 할당한다. 그리고 ProSe 통신 상황에서는 ProSe application code, ProSe application QoS, ProSe application ID의 validity timer를 기반으로 간섭을 일으키지 않을 적합한 자원을 재 할당함으로써 셀 간 간섭 문제를 해결한다.

• Natural Product Sciences
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• 제12권3호
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• pp.144-149
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• 2006

The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq.(Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor $(TNF)-{\alpha}$ and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.

• 동의생리병리학회지
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• 제31권4호
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• pp.213-219
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• 2017

Atopic dermatitis (AD) is a common skin disease characterized by chronic and relapsing inflammatory dermatitis with immunological disturbances. Spleen deficiency (脾虛) is one of the major causes of AD, so development of animal model is required for AD research that reflects the pattern identification. The groups that we have used in this study included Senna folium extracts (SFE), 2,4-dinitrochlorobenzene (DNCB), and normal mice. Therefore, the present study was developed to atopic dermatitis mouse model with spleen deficiency in 2,4-dinitrochlorobenzene (DNCB) and senna leaves extracts induced AD in NC/Nga mice. The results demonstrated that senna leaves extract treatment significantly increased the dermatitis clinical score and epidermal thickness in AD-like skin lesions. We also proved beyond doubt that there was occurrence of erythema and skin moisture indices in the senna leaves extract groups. Further, we also found that the level of serum immunoglobulin E (IgE) in the senna leaves extract-treated group was increased. The amount of IL-4, IL-13, $TNF-{\alpha}$ and $TGF-{\beta}$ mRNA determined by real-time PCR was increased remarkably when senna leaves extract groups were treated on dorsal skin. Senna leaves extract groups significantly promoted the number of CD11B+/Gr-1 cell in skin, as well as the number of CD4+/CD8+ cell in dorsal skin compared with control. The review summarizes recent process in our understanding of the immunopathophysiology of spleen deficiency AD and the implications for spleen deficiency mouse models of AD on drug discovery from medical plants.

• 한국축산식품학회지
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• 제40권6호
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• pp.924-937
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• 2020

The purpose of this study was to investigate the meat metabolite profiles related to differences in beef quality attributes (i.e., high-marbled and low-marbled groups) using nuclear magnetic resonance (NMR) spectroscopy. The beef of different marbling scores showed significant differences in water content and fat content. High-marbled meat had mainly higher taste compounds than low-marbled meat. Metabolite analysis showed differences between two marbling groups based on partial least square discriminant analysis (PLS-DA). Metabolites identified by PLS-DA, such as N,N-dimethylglycine, creatine, lactate, carnosine, carnitine, sn-glycero-3-phosphocholine, betaine, glycine, glucose, alanine, tryptophan, methionine, taurine, tyrosine, could be directly linked to marbling groups. Metabolites from variable importance in projection plots were identified and estimated high sensitivity as candidate markers for beef quality attributes. These potential markers were involved in beef taste-related pathways including carbohydrate and amino acid metabolism. Among these metabolites, carnosine, creatine, glucose, and lactate had significantly higher in high-marbled meat compared to low-marbled meat (p<0.05). Therefore, these results will provide an important understanding of the roles of taste-related metabolites in beef quality attributes. Our findings suggest that metabolomics analysis of taste compounds and meat quality may be a powerful method for the discovery of novel biomarkers underlying the quality of beef products.

• 한국산업정보학회논문지
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• 제22권6호
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• pp.71-84
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• 2017

Over the past decade, we have witnessed Serious Debates in MISQ and Other Journals Between Two Camps that have Differing Views on the use of Causal Indicators to Measure Constructs. There is the Camp that advocates Causal Indicators (ADVOCATE) and the Camp that opposes Their Usage (OPPONENT). The Debates have been primarily centered on the OPPONENT's Argument that the Meaning of a Latent Variable is determined by its Outcome Variables. However, Little Effort has been made to Validate the ADVOCATE's Dispute (Against the OPPONENT's Arguments) that the Meaning of a Latent Variable is decided by its Causal Indicators if there is no Misspecification. Our Study precisely examines the Integrity of the Argument. For this, we empirically examine how the two Primary Psychometric Properties-Comprehensiveness and Interrelationship-of Causal Indicators Influence Theory Testing between Latent Variables through Three Different Tests (i.e., Comprehensive Test, Interrelationship Test, and Mixed Test). Conducted on Two Different Datasets, Our Analysis Consistently Reveals that Structural Path Coefficients are Hardly Sensitive to the Changes (i.e., Misspecification) in the Properties of Causal Indicators. The Discovery offers Important Evidence that the Sound Theoretical Logic of a Causal Model is not in Sync with the Empirical Mechanism of Parameter Estimation. This Underscores that a Latent Variable Formed by Causal Indicators is empirically an elusive notion that is Difficult to Operationalize. As Our Results have Significant Implications on the Integrity of Numerous IS studies which have conducted Theory or Hypothesis Testing Using Causal Indicators, we strongly advocate Open Discussions among Methodologists regarding Our Findings and Their Implications for Both Published IS Research and Future Practices.

• 천문학회보
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• 제36권2호
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• pp.69.2-69.2
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• 2011

The discovery of dark energy from Type Ia supernovae (SN Ia) is based on the implicit assumption that the look-back time evolution of SN Ia luminosity, after light-curve corrections, would be negligible. A strong support for this assumption was the apparent insensitivity of SN Ia distances across the host galaxy morphologies. However, Hicken et al. 2009 (H09) shows a systematic difference in the Hubble residual (HR) of $0.144{\pm}0.070$ mag between the E-S0 and Scd/Sd/Irr galaxies, after light-curve corrections. If true, this indicates that the light-curve fitters used by the SN Ia community can not correct for the population age (and therefore the evolution) effect. In order to confirm this, we have combined nearby SN Ia samples and the first-year SDSS-II SN Survey. The SNANA package was used for analyzing SN Ia light-curve, both for the MLCS2k2 and SALT2 fitters. We find a systematic difference in the HR of $0.10-0.13{\pm}0.030$ mag between E-S0 and Scd/Sd/Irr galaxies, which is in agreement with the result of H09, but now at the 3-5 ${\sigma}$ level. Considering the significant difference in the mean age of stellar population between these morphological types, the difference in the HR reported here suggests that the evolution effect of SN Ia luminosity should be considered in the cosmological application of SN Ia data.