• 대한한방내과학회지
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• 제36권3호
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• pp.265-275
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• 2015

Objectives: The aim of this study was to investigate the analgesic effect of Yang Eui Gongjin-dan (YEGJD), a traditional Korean medicine, on severe pain or numbness, including acute and chronic non-cancer pain. Methods: Records of patients visiting the Department of Traditional Korean Internal Medicine, Stroke and Neurological Disorders Center, from March 2011 to January 2015, were searched. Their chief complaint was severe numbness or pain (NRS≥7). We compared the NRS of pain pre- and post-YEGJD treatment in 34 patients; and analyzed changes in pain severity pre- and post-YEGJD treatment in 17 chronic non-cancer pain patients. We also investigated other accompanying symptoms, such as insomnia, anorexia, dyspepsia, fatigue, coldness, and excessive sweating, related to the deficiency state (虛症) in traditional Korean medicine. Results: The average pain NRS for the 34 patients significantly decreased from 8.04±1.08 to 3.75±2.54 after YEGJD treatment. The average pain NRS score in chronic non-cancer pain patients also significantly declined from 7.91±0.97 to 3.29±2.29. Conclusions: The traditional Korean medicine Yang Eui Gongjin-dan has an analgesic effect and is useful for treating severe pain or numbness. We recommend a randomized controlled trial using objective assessment scales and a large patient sample to further test the effects of Yang Eui Gongjin-dan.

• 보건교육건강증진학회지
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• 제23권3호
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• pp.121-134
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• 2006

Objectives: This study was conducted to analyze the general properties of beauticians and to analyze correlation between their experiences of indigestion and relevant factors and thus to provide basic data to prevent obstacles to beautician's health. Methods: A self-administered survey on 257 female beauticians in Daegu from March 15 to May 30, 2005 was conducted. Cross-link analysis was used to examine indigestion in relation to the general properties of beauticians, and correlation analysis was used to determine the level of relationship between indigestion and relevant factors, and multiple regression analysis was used to determine the degree of effects of relevant factors on indigestion. Results: The results can be summarized as follows: 1. As for indigestion by general properties and beauty-related properties, there were significant differences in gender(p<0.01), age(p<0.05) and marriage status(p<0.05) among general properties and there were significant differences in the number of holiday(p<0.05), beauty culture career(p<0.01), and the degree of satisfaction on duty(p<0.001) among beauty-related properties. As for indigestion by eating habit and health-related properties, there were significant differences in the degrees of regular eating(p<0.001) and regular living habit(p<0.001), and eating speed(p<0.01). 2. Factors relevant to the eating habit showing significant correlation with indigestion were regular eating habit, taking well-balanced nutrition, and taking salty food. Among them, the regular eating habit was shown to be the most relevant with the correlation coefficient of -0.253(p<0.01). The general and beauty-related factors showing significant correlation with indigestion were beauty culture career, number of holiday, and regular living habit. And regular living habit was shown to be the most relevant with the correlation coefficient of -0.260(p<0.001). 3. Results from the regression analysis showed that relevant factors having significant effects on indigestion were gender, beauty culture career, satisfaction on duty, eating speed, regular eating habit and regular living habit. And satisfaction on duty was found to have the greatest effect on indigestion. Conclusions: The findings of this study could be effectively used to develop a practical management strategy to prevent $beauticia{\acute{n}}s$ indigestion, and to promote $beauticia{\acute{n}}s$ health, and ultimately to improve the $beauticia{\acute{n}}s$ quality of life.

• 대한한방내과학회지
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• 제41권5호
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• pp.838-847
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• 2020

Objectives: The aim of this study was to investigate the clinical characteristics of patients with Burning Mouth Syndrome (BMS) due to hyposalivation (HS). Methods: We reviewed the clinical records of 39 BMS patients who visited the Department of Digestive Diseases of Kyunghee Korean Medicine Hospital from March 1st, 2020 to July 31st, 2020. The subjects were classified according to the presence or absence of hyposalivation and both groups were compared for the proportion of coated tongue, heart rate variability (HRV), Ryodoraku, and the numeral rating scale (NRS) score of tongue pain results. Results: The BMS with Hyposalivation (HS group) and the BMS without Hyposalivation (Non-HS group) showed a significant difference in the proportion of coated tongue and the NRS score for tongue pain. The NRS score was significantly higher in the Non-HS group and the proportion of coated tongue was lower. However, no significant differences were noted in several HRV parameters between the two groups. The most frequent accompanying symptoms were xerostomia and dyspepsia. Conclusions: The results of this study suggest that hyposalivation might be one of the main causes of tongue pain, the key complaint in BMS patients. Sympathetic/parasympathetic imbalance might not be a main contribution of hyposalivation in BMS. Instead, factors such as the number of medications taken seem to correlate with hyposalivation in BMS. This results could be useful in the management of BMS patients with hyposalivation in clinical practice.

• 대한한방내과학회지
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• 제25권2호
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• pp.329-334
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• 2004

There are different kinds of the pseudo-mass of the gallbladder(GB) such as GB stones, GB polyps, GB sludge, and these can be differentiated by simple-ultrasonogram(USG). The most common symptoms of GB polyps are abdominal pain(RUQ), dyspepsia, jaundice, but usually there are no symptoms. GB polyps are commonly treated with a cholecystectomy if 10 mm or more in diameter. Pseudo-mass of the GB is regarded as products of stagnation of the Liver Ki in Oriental Medicine. The patient suffered from mild fever. abdominal pain(RUQ), and jaundice. He was diagnosed with a GB polyp(10 mm), liver cyst(12 mm) by simple USG. We treated him with Acupuncture, Herbal Medicine(Hoinsamgum-tang). After three days of treatment, the symptoms improved, and after one month the GB polyp was removed on the follow up of USG.

• 정신신체의학
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• 제8권2호
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• pp.172-180
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• 2000

연구목적 : 상부 위장관의 소화 장애를 가진 환자들이 스트레스를 지각하였을 때 나타내는 반응 및 소화장애 증상의 여러 변인들과의 관계를 알아봄으로써 특정 정신신체질환군에서의 스트레스에 대한 반응특성과 해당 질환과의 연관성을 알아보고자 한다. 방법 : 소화장애 증상으로 인천기독병원 소화기내과를 방문하여 위내시경 소견 상 병변이 확인된 84명의 환자와 94명의 정상 대조군을 대상으로 국내에서 개발된 스트레스반응 지각척도를 사용하여 스트레스를 인지하였을 때 나타내는 반응을 비교분석하였다. 또한 환자군에서 현재 호소하는 소화장애 증상의 기간, 소화장애의 과거력, 증상의 심각도, 심리적 고통의 존재 여부에 따라 스트레스에 대한 지각반응이 어떻게 나타나는지 평가하였다. 결과 : 스트레스반응 지각척도는 8개의 하위척도로 구성되어 있으며 연구 대상자 178명에서 8개 하위척도와 척도전체의 내적 일치도는 .65~.95로써 통계적으로 유의하게 높았다. 환자군이 대조군에 비해서 척도의 전체총점과 일반적 신체증상척도, 특정신체증상척도의 접수가 통계적으로 유의하게 더 높았다. 소화장애 증상과 스트레스반응 지각척도와의 관련성은 소화장애의 기간, 소화장애의 과거력, 증상의 심각도는 특정신체증상을, 심리적 고통의 존재는 인지기능의 저하와 일반적 부정적 사고를 잘 예측해 주는 것으로 나타났다. 결론 : 실제 상부위장관에 병변을 가진 소화장애 환자들은 정상인에 비해서 강한 스트레스 반응 지각을 나타내었으며 특히 스트레스를 경험하고 인지하였을 때 감정, 인지, 행동 영역의 반응보다는 자율신경계 및 특정신체부위와 연관된 신체증상을 주로 경험하고 있음을 알 수 있다. 또한 이들은 소화장애의 기간이 길고, 과거력이 있을수록, 그리고 증상이 심할수록 스트레스에 대해 소화기 증상을 주로 한 특정신체증상으로 반응하며 심리적 고통을 주는 스트레스의 존재는 인지기능을 저하시키고 부정적인 사고반응을 일으킴을 알 수 있다.

• 대한한방소아과학회지
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• 제15권2호
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• pp.75-83
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• 2001

Background and method : The Cervi cornu parvum for children patients have been widely used nowadays: however, there have been no reports about the children patients' conditions and the parents' responses. To investigate these things, the questionnaires were used for the children patients(the ages between 0 and 15) who took the herbal medication combined with Cervix cornu parvum and their parents from January 1, 2000 to June 31 at the Dong-seo oriental Hospital. The chief complaints such as common cold, dyspepsia of using Cervi cornu parvum were divided into five categories and the changes were observed, scoring each stages. Besides, the quantity of taking herbal medication combined with Cervix cornu parvum, the expectancy, the satisfaction, the continual favor were included in the questionnaires. The result : 1. The trackable sample was 53: male infants 34(64.2%), female infants 19(35.8%). There is no differences between genders in the treating results. The treating results were increased after taking herbal medication combined with Cervi cornu parvum 2. When age is grouped by three categories(0-1, 2-6, 7-14 ages), the statistics shows that the treating results have no differences between each group(P>0.05) Regardless of the ages, the treats have correlated.(P<0.05) 3. When each symptoms made treated one case are analyzed, there have been correlations between the taking herbal medication combined with Cervi cornu parvum and recovery.(P<0.05) 4. The treating result have not affected by the expectancy.(P>0.05) Each group(good, moderate, poor) showed the recovery after the treatment.(P<0.05) 5. When the satisfaction divided into three groups(good, moderate, poor) there existed differences between groups.(P<0.05) Especially, the group with high expectancy increased the treatment. 6. About the recognition of herbal medication combined with Cervi cornu parvum is like this: the health refreshment, ordinary taking whenever turning-point of seasons comes, treatment, disbelieving the overdose of herbal medication combined with Cervi cornu parvum, disbelief about the security of the medicine such as fake medicine, mad cow diseases, the imported medicine, ignorance about the way of taking the medicine.

• 대한한방소아과학회지
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• 제16권2호
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• pp.69-81
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• 2002

The Purpose of this study was to collect statistics of pediatric problems, and so to investigate the new effective oriental medicine treatments in pediatric disease and its clinical applicability. The Study was composed of 698 new patient who had been treated at the pediatric unit in th Dong Sea Oriental Medical Hospital for 1 year, from 1 September 2001 to 31 October 2002, and aged between 0 and 18 years. The Chief complaints and their care-givers. Result: 1. In the study, male children are 403 and female children are 295. So the sex ratio between male and female is 1.37 : 1. 2. In age distribution, 0-3 years : 317(45.4%), 4-6 years : 148(21.2%). 7-9 years 98(14.0%), 10-12 years: 66(9.5%), 13-15 years : 40(5.7%), 16-18 years 29(4.2%). 3. The chief complaint according to systemic division was Respiratory diseases covers 30.1%, Digestive diseases covers 20.8%, Physique diseases covers 10.6%. 4. The Respiratory diseases tended to increase in autumn and appeared mostly in the age group between 0 and 9 years. The Digestive diseases increase in summer and appeared mostly in the age group between 10 and 12 years. The physique diseases increase in winter and appeared mostly in he age group between 13 and 18 years. 5. Most of patient came to the hospital from diseases such as common cold, weakness, dyspepsia, atopic dermatitis, rhinitis, take a easy cold, short stature, sweating, Bell's palsy, abdominal pain, etc. Conclusion : 1. The chief complaint In pediatric diseases that needed an oriental medical treatment was mainly the disease that tends to take long time and the weakness, and appeared frequency in respiratory and digestive disease. 2. The oriental medical treatment was still preferred as a way to improve the weakness by patients, rather than a way to overcome their disease. in particular, the study shows that the oriental medical treatment should be emphasized in terms of preventing the disease. 3. The new disease, which were developed with change of human life and environment, should be investigated as a new fie of oriental medical treatment.

• Journal of Gastric Cancer
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• 제8권2호
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• pp.104-109
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• 2008

목적: 국내 위 점막하 종양의 임상병리학적 양상과 치료방법에 대해 파악하고자 전국조사를 실시하였다. 대상 및 방법: 국내 47개 병원에서 2005년부터 2006년까지 위 점막하 종양으로 수술 받은 환자 878명의 자료를 수집하여, 진단명, 증상, 위치, 수술법, 사망률, 종양의 크기, 악성도 등을 조사하였다. 결과: 위 점막하 종양의 수술 후 진단으로는 위장관 간질 종양(Gastrointestinal stromal tumor, GIST)이 586명(66.8%)으로 가장 많았고, 평활근종(Leiomyoma) 97명(11.1%), 신경초종(schwannoma) 70명(8.0%), 이소성 췌장(Ectopic pancreas) 68명(7.8%), 유암종(carcinoid) 16명(1.8%) 순이었다. 환자의 평균 나이는 56.0세, 남녀 비는 1:1.18이었으며, 50.9%의 환자가 증상 없이 발견되었다. 위 상부 1/3에 위치한 위 점막하 종양이 가장 흔했으며(n=449, 52.0%), GIST의 55.4% (n=319), 평활근종의 84.5% (n=82)가 위 상부 1/3에 위치하였다. 복강경적 접근이 전체 환자의 44.2% (n=388)에서 시행되었으며, 수술방법으로는 쐐기 절제술(n=726, 82.8%)이 가장 빈번히 시행되었다. 전체 환자 중 1명(0.1%)만이 수술 후 30일 이내에 사망하였다. GIST 환자 중 115명(21.1%, 115/544)이 고위험도의 악성도를 가졌고, 41명(8.3%, 45/495)에서 수술 후 imatinib mesylate 항암 치료를 하였다. 결론: 조사된 국내 점막하 종양의 약 2/3가 GIST였으며, 약 1/2에서 복강경하 절제술이 이루어졌다. 향후 이 보고가 위점막하 종양의 진료 및 연구의 참고자료로 활용되기를 기대한다.

• 생명과학회지
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• 제28권1호
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• pp.43-49
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• 2018

Chrysoeriol은 alfalfa에서 주로 발견되는, 식물계에 많이 분포하고 있는 flavone으로 전통의학에서 소화불량, 천식, 비뇨기계 이상의 치료에 사용되어 왔다. 최근의 연구에서는 항염증 효과가 있는 것으로 밝혀졌으나 항산화 효과에 대한 분석은 없었다. 본 연구에서는 chrysoeriol의 항산화 효과와 그 분자적 기전을 RAW 264.7 cell에서 세포생존율, reactive oxygen species (ROS)와 Western blot분석을 통해 알아보고자 하였다. Chrysoeriol은 lipopolysaccharide(LPS)에 의해 발생한 ROS를 세포독성없이 농도의존적으로 제거하였다. 그리고 항산화효과를 보이는 2상 효소 중 하나인 heme oxygenase (HO)-1의 발현을 강하게 유도하였고, 그와 동시에 전사인자인 Nrf2의 핵내 이동도 촉진하는 것으로 밝혀졌다. 특히, 산화스트레스에 대한 세포내 산화환원항상성 유지에 중요한 역할을 하고 있는 것으로 알려진 mitogen activated protein kinase (MAPK)와 phosphoinositide 3-kinase (PI3K)의 분석결과, chrysoeriol은 extracellular signal regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK)와 p38의 인산화를 통해 HO-1의 발현을 유도하는 것으로 나타났다. HO-1에 의한 항산화 효과를 확인하기 위하여 chrysoeriol을 전처리한 후 t-BHP에 의한 산화 스트레스에 세포를 노출시킨 결과, chrysoeriol 처리에 의해 세포사멸이 줄어드는 것을 확인하였고, HO-1의 유도제와 억제제의 처리에 따라 세포생존율 또한 조절되는 것을 확인할 수 있었다. 따라서, chrysoeriol은 HO-1의 발현을 유도하여 항산화 효과를 높이고 이것은 Nrf2/MAPK 신호전달 체계에 의한다는 것을 알 수 있었다.

• 치위생과학회지
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• 제17권4호
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• pp.352-357
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• 2017

액상소화제의 법랑질 부식능을 알아보기 위하여 마트에서 쉽게 구입할 수 있는 2종의 액상소화제와 약국에서 판매하는 1종의 액상소화제 그리고 대조군으로 생수를 선정하였다. 음료의 pH와 적정산도를 측정하고, 시편을 제작하여 음료에 1, 3, 5, 10, 15, 30분을 침지한 후 나타나는 양상을 표면 미세 경도계로 측정하여 다음과 같은 결론을 얻었다. 대조군인 생수를 제외한 모든 액상소화제의 pH가 4.0 이하로 나타났으며 위청수에서 $2.93{\pm}0.00$으로 가장 낮았다. pH 5.5로 변환하는 데 필요한 적정산도 또한 위청수에서 1.27 ml로 가장 높게 나타났다. 모든 액상소화제에서 침지시간이 증가함에 따라 표면경도가 감소하였으며 음료 30분 처리 후 표면 경도값은 위청수에서 $207.80{\pm}15.52$ VHN으로 가장 낮았고, 까스활명수 $216.86{\pm}4.01$, 생록천 $223.28{\pm}9.56$ 순이었다. 실험에 사용된 모든 액상소화제는 치아 법랑질에 부식을 유발하였으며, 음료처리 후에 pH가 가장 낮고 적정산도가 가장 높은 위청수에서 가장 낮은 표면 경도 값을 보여 실험에 사용된 액상소화제 중 가장 많은 법랑질 부식을 유발하였다. 따라서 액상소화제의 섭취는 법랑질표면경도를 감소시켜 치아 부식을 유발할 수 있으므로 이에 대한 대처방안이 마련되어야 할 것이다.