• Journal of Periodontal and Implant Science
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• v.53 no.1
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• pp.20-37
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• 2023

Purpose: Our pilot study showed that a 3-dimensional dual drug delivery scaffold (DDDS) loaded with Chinese herbs significantly increased the regenerated bone volume fraction. This study aimed to confirm the synergistic anti-inflammatory and osteogenic preclinical effects of this system. Methods: The targets and pathways of parthenolide and naringin were predicted. Three cell models were used to assess the anti-inflammatory effects of parthenolide and the osteogenic effects of naringin. First, the distance between the cementoenamel junction and alveolar bone crest (CEJ-ABC) and the bone mineral density (BMD) of surgical defects were measured in a rat model of periodontitis with periodontal fenestration defects. Additionally, the mRNA expression levels of matrix metallopeptidase 9 (MMP9) and alkaline phosphatase (ALP) were measured. Furthermore, the number of inflammatory cells and osteoclasts, as well as the protein expression levels of tumor necrosis factor-alpha (TNF-α) and levels of ALP were determined. Results: Target prediction suggested prostaglandin peroxidase synthase (PTGS2) as a potential target of parthenolide, while cytochrome P450 family 19 subfamily A1 (CYP19A1) and taste 2 receptor member 31 (TAS2R31) were potential targets of naringin. Parthenolide mainly targeted inflammation-related pathways, while naringin participated in steroid hormone synthesis and taste transduction. In vitro experiments revealed significant antiinflammatory effects of parthenolide on RAW264.7 cells, and significant osteogenic effects of naringin on bone marrow mesenchymal stem cells and MC3T3-E1 cells. DDDS loaded with parthenolide and naringin decreased the CEJ-ABC distance and increased BMD and ALP levels in a time-dependent manner. Inflammation was significantly alleviated after 14 days of DDDS treatment. Additionally, after 56 days, the DDDS group exhibited the highest BMD and ALP levels. Conclusions: DDDS loaded with parthenolide and naringin in a rat model achieved significant synergistic anti-inflammatory and osteogenic effects, providing powerful preclinical evidence.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.6
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• pp.167-173
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• 2016

Compressed Sensing(CS) is the theory that can recover signals which are sampled below the Nyquist sampling rate to original analog signals. In this paper, we propose the estimation algorithm of ultrasonic attenuation coefficients in the frequency domain using CS. While most estimation algorithms transform the time-domain signals into the frequency-domain using the Fourier transform, the proposed method directly utilize the spectral information in the recovery process by the basis matrix without the completely recovered signals in the time domain. We apply three transform bases for sparsifying and estimate the attenuation coefficients using the Centroid Downshift method with Dual-reference diffraction compensation technique. The estimation accuracy and execution time are compared for each basis matrix. Computer simulation results show that the DCT basis matrix exhibits less than 0.35% estimation error for the compressive ratio of 50% and about 6% average error for the compressive ratio of 70%. The proposed method which directly extracts frequency information from the CS signals can be extended to estimating for other ultrasonic parameters in the Quantitative Ultrasound (QUS) Analysis.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.49 no.8
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• pp.27-34
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• 2012

In this paper, the implementation of high throughput two-dimensional (2-D) $8{\times}8$ forward and inverse integer DCT transform for H.264 is presented. The forward and inverse transforms are represented using simple shift and addition operations. Matrix decomposition and matrix operation such as the Kronecker product and direct sum are used to reduce the computation complexity. The proposed design uses integer computations and does not use transpose memory and hence, the resource consumption is also reduced. The maximum operating frequency of the proposed pipelined architecture is 1.184 GHz, which achieves 25.27 Gpixels/sec throughput rate with the hardware cost of 44864 gates. High throughput and low hardware makes the proposed design useful for real time H.264/AVC high definition processing.

• Journal of Digital Convergence
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• v.13 no.12
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• pp.381-390
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• 2015

One of the fundamental requirements of entertainment applications is interactivity with users. The mobile device such as the smartphone, however, does not guarantee it due to the limit of the application processor's computing power, memory size and available electric power of the battery. This paper proposes a methodology to boost responsiveness of interactive applications by taking advantage of the parallel architecture of mobile devices which, for instance, have dual-core, quad-core or octa-core. To harness the multi-core architecture, it exploits the POSIX thread, a platform-independent thread library to be able to be used in various mobile platforms such as Android, iOS, etc. As a useful application example of the methodology, a heavy matrix calculation function was transformed to a parallelized version which showed around 2.5 ~ 3 times faster than the original version in a real-world usage environment.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2701-2705
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• 2015

Chondrosarcoma, the second most common type of bone malignancy, is characterized by distant metastasis and local invasion. Previous studies have shown that treatment by pulsed electromagnetic field (PEMF) has beneficial effects on various cancer cells. In this study, we investigated the effects of PEMF applied for 3 and 7 days on the matrix metalloproteinase (MMP) levels in chondrosarcoma SW1353 cells stimulated with two different doses of $IL-1{\beta}$. SW1353 cells were treated with (0.5 and 5 ng/ml) $IL-1{\beta}$ and PEMF exposure was applied either 3 or 7 days. MMP-9 and TIMP-1 levels were measured in conditioned media by enzyme-linked immunosorbent assay. The results were relative to protein levels. Statistical analyses were performed using one-way analysis of variance (ANOVA). P<0.05 was considered significant. PEMF treatment significantly decreased MMP-9 protein levels in human chondrosarcoma cells stimulated with 0.5 ng/ml $IL-1{\beta}$ at day 7, whereas it did not show any effect on cells stimulated with 5 ng/ml $IL-1{\beta}$. There was no significant change in TIMP-1 protein levels either by $IL-1{\beta}$ stimulation or by PEMF treatment. The results of this study showed that PEMF treatment suppressed $IL-1{\beta}$-mediated upregulation of MMP-9 protein levels in a dual effect manner. This finding may offer new perspectives in the therapy of bone cancer.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.10
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• pp.118-128
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• 2015

Compressive sensing (CS) has to face with two challenges of computational complexity reconstruction and low coding efficiency. As a solution, this paper presents a novel spatially scalable Kronecker two layer compressive sensing framework which facilitates reconstruction up to three spatial resolutions as well as much improved CS coding performance. We propose a dual-resolution sensing matrix based on the quincunx sampling grid which is applied to the base layer. This sensing matrix can provide a fast-preview of low resolution image at encoder side which is utilized for predictive coding. The enhancement layer is encoded as the residual measurement between the acquired measurement and predicted measurement data. The low resolution reconstruction is obtained from the base layer only while the high resolution image is jointly reconstructed using both two layers. Experimental results validate that the proposed scheme outperforms both conventional single layer and previous multi-resolution schemes especially at high bitrate like 2.0 bpp by 5.75dB and 5.05dB PSNR gain on average, respectively.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.1
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• pp.56-62
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• 2019

To investigate the effect of Bombycis Corpus on male osteoporosis, we performed Dual Energy X-Ray Absorptiometry(DEXA) and histochemical methods. The animals were used ICR-based male mice of 8 weeks and 50 weeks, respectively. ICR male mice at 8 weeks were used in the control group, and ICR male mice at 50 weeks were used in aging group and Bombycis Corpus group(BC group). In the aging group, 0.5 ml of distilled water was administered once a day for 6 months. In BC group, Bombycis Corpus(0.78g/kg) was dissolved in distilled water for 6 months once a day. As a result, Bombycis Corpus decreased bone loss, increased bone density by reducing the loss of bone matrix in the femur due to aging, and increased osteoblast - induced osteopontin(OPN) and osteocalcin(OPC) positivite reaction. In addition, administration of Bombycis Corpus decreased Reaction of activation of nuclear factor kappa B ligand(RANKL) positive reaction, increased osteoprotegerin(OPG) positive reaction, and decreased matrix metalloproteinase-3(MMP-3) and 8-hydroxy-2'-deoxyguanosine(8-OHdG) positivite reaction. Taken together, Bombycis Corpus increases the activity of osteoblasts, inhibits osteoclast function, promotes osteoblast function, inhibits bone tissue degradation, and inhibits bone loss due to oxidative stress. It was observed that Bombycis Corpus reduced bone loss and increased bone density caused by aging to improve male osteoporosis. Therefore, Bombycis Corpus may be used as a preventive and therapeutic agent for male osteoporosis.

• Journal of the Korean Vacuum Society
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• v.10 no.2
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• pp.241-246
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• 2001

Single or dual ion implantations were performed onto the transparent polyethylene terephthalate(PET) sheet, and the surface hardness and the light transmittance in the visual-UV range were examined. Nanoindentation showed that the surface hardness was the highest at about 50 nm depth from the surface and was increased by about 3 times when nitrogen ions were implanted with energy and dose of 90 keV and $1\times10^{15}\textrm{/cm}^2$ respectively. When dual ions such as He+N and N+C ions were implanted into PET, the hardness was increased even more than the case only N ions were implanted. Especially, when PET were implanted with N+C dual ions, the surface hardness of PET increased 5 times more as compared to when implanted with N ions alone. The light at the 550 nm wavelength(visual range) transmitted more than 85%, which is close to that of as-received PET, and at the wavelength below 300 nm(UV range) the rays were absorbed more than 95% as traveling through the sheet. implying that there are processing parameters which the ion implanted PET maintains the transparency and absorbs the UV rays. It can be considered that the increase in the hardness of polymeric materials is attributed to not only cross linking but also forming hard inclusions such as hard C-N compounds, as evidenced by the formation of the highest hardness when both N and C ions are implanted onto PET.

• Food Science and Biotechnology
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• v.14 no.4
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• pp.456-460
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• 2005

To enforce the maximum residue limit for residual hexane (0.005 g/kg) in commercially available Korean vegetable oil, convenient and accurate quantification methods were investigated. Using dual surrogate standards, pentane and heptane were dissolved in ethanol, and then added to hexane-tree sunflower oil for setting up the calibration curve. Gas Chromatograph-Flame Ionization Detector with a porous layer open tubular column, indicated good chromatographic separation of hexane from other inhibiting matrix components. The lowest calibration level was $0.5\;{\mu}g/g$, not exceeding a relative standard deviation of 10% (RSD%), and 1.0\;{\mu}g/g$ not exceeding a deviation of 22% RSD% using heptane as an internal standard for the Static headspace analysis by using a headspace auto-sampler and manual injection, respectively. The residual hexane was detected in nine of the samples among 87 vegetable oil samples purchased on the local market.

• Journal of Institute of Control, Robotics and Systems
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• v.6 no.2
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• pp.190-196
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• 2000

A hybrid position/force control scheme to regulate the force and position by dual arms is proposed where two arms are treated as one rm in a kinematic viewpoint. The force error calculated from the information of two force/torque sensors attached to the end of each arm is transferred to minimum configuration space coordinates and then is distributed to total system joint coordinates, The position adjustment at the total con-figuration coordinates is computed based on the effective compliance matrix with respect to total joint coordinates which is obtained by coordinate transformation between the task coordinates and the total joint coordinates. The proposed scheme is applied to sawing task. When the trajectory of the saw is planned to follow a line in a horizontal plane 2 position parameters are to be controlled(i.e., two translational positions) Also a certain level of contact force has to be controlled along the vertical direction(i.e. minus z-direction) not to loose the contact with the object to be sawn. We experimentally show that the performance of the velocity and force response are satisfactory. The proposed hybrid control scheme can be applied to arbitrary two cooperating arm system regardless of their kinematic structure and the number of actuated joints.