• Title/Summary/Keyword: drug use behavior

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Biomarkers for Combat-Related Stress and Fatigue-Mitigating Drugs Discovery (전투 스트레스 및 피로 완화 약물 탐색을 위한 생체지표)

  • Koo, Hyojin;Kim, Chang Yul;Kim, Yeonkyung;Sin, So Jung;Cheon, Kicheol;Kim, Dongsoo
    • Journal of the Korea Institute of Military Science and Technology
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    • v.21 no.2
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    • pp.246-254
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    • 2018
  • Psychological stress and physical fatigue, such as anxiety, fear, sleep disturbance, etc., caused by exposure to the war, can lead to post-traumatic stress syndrome(PTSD) or war syndrome. The military has also prepared for drug use to minimize war syndrome and preserve combat strength. However, efforts to prevent war syndrome are still lacking. This study was conducted to identify biomarkers that can track psychophysiological changes. Psychophysiological changes associated with PTSD can be divided into four main categories. The four categories are behavioral changes, changes in brain cognition, neuroimmunological changes, and changes in innate immunity. This study suggest that biomarker profile can be made by the distance moved and the anxiety-like behavior in the open field for behavior category, brain BDNF levels in the brain cognition category, serum corticosterone in the neuroimmunology category, and inflammatory cytokine levels in the innate immunity category.

Factors influencing high-caffeine drink intake in adolescents: using data from the 13th(2017) Korea Youth Risk Behavior Online Survey (청소년의 고카페인 음료섭취 영향요인 : 제13차(2017년) 청소년건강행태 온라인조사 통계를 이용하여)

  • Kim, Dong-Ok;Lee, Haejin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.8
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    • pp.111-121
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    • 2019
  • This study investigated the status of drinking highly caffeinated beverages by Korean adolescents, and we identified the factors influencing this behavior by Korean adolescents by using statistics from the 13th (2017) Survey on Youth Health Behavior Online Survey. The data was collected from 62,276 middle and high school students and the variables of this study included demographic factors, health behavioral factors, mental health factors and the availability of highly caffeinated beverages. The methods of data analysis included descriptive statistics, Chi-square tests and logistic regression analysis. This study found that the intake rate of highly caffeinated beverages was 1.9% for men and 1.5% for women, and these percentages increased with age (p<0.001). Current smoking and drinking, current drug usage and active people also had high intake of caffeinated beverages (p<0.001). A high level of stress, a low level of subjective sleep satisfaction and a feeling of happiness increased the rate of consuming highly caffeinated beverages. The factors of drinking highly caffeinated beverages were gender, age, smoking, physical activity, drug use, stress level, depression and suicidal ideation. Therefore, continuous discussion is needed to improve both the health behavior and mental health by managing the stress felt by Korean adolescents.

Factors related to Suicidal Planning among Adolescents who had Suicidal Ideation (자살생각을 해 본 청소년의 자살계획 관련요인)

  • Yi, Jee-Seon;Park, Chang-Seung
    • Journal of the Korean Society of School Health
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    • v.35 no.2
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    • pp.57-64
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    • 2022
  • Purpose: Adolescent suicide is an important issue worldwide. Although literature on preventing suicide among adolescents tends to focus on suicidal ideation, suicidal planning is also an important issue as a stage leading to suicidal behavior. This study aims to identify suicidal planning-related factors, including generalized anxiety disorder, among adolescents who had suicidal ideation. Methods: This secondary study used data generated from the 16th(2020) Korea Youth Risk Behavior Web-based Survey, which included 5,979 students who had suicidal ideation. Factors related to suicidal planning were identified by performing a logistic regression analysis of the participants. All analyses were performed using SPSS 27.0. Results: Among adolescents who had suicidal ideation, 23.8% had suicide plans. The suicidal plans were significantly related to school level (middle, OR=1.38, 95% CI=1.22~1.55), whether they were living with family (no, OR=1.36, 95% CI=1.06~1.75), perceived body image (normal, OR=1.23, 95% CI=1.05~1.44; Obese, OR=1.33, 95% CI=1.14~1.54), depression (yes, OR=1.47, 95% CI=1.25~1.72), tobacco use (yes, OR=1.31, 95% CI=1.12~1.54), alcohol use (yes, OR=1.21, 95% CI=1.06~1.38), drug use (yes, OR=1.96, 95% CI=1.44~2.66), and/or generalized anxiety disorder (severe, OR=1.76, 95% CI=1.44~2.14). Conclusion: The findings of the study suggest that in addition to the commonly recognized factors for adolescent suicide, generalized anxiety disorder should also be considered when establishing strategies to prevent suicide planning in adolescents who had suicidal ideation.

A Study on Self-medication Beharior of Four Cautious Drugs. (특정의약품의 자가투약행위에 관한 연구)

  • 황미숙
    • Korean Journal of Health Education and Promotion
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    • v.4 no.2
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    • pp.46-70
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    • 1987
  • The survey with questionnaire were conducted to grasp the actual condition of four cautious drugs-antibiotics, sedative hypnctics, mincr tranquilizer, analeptics-self -medication behavior through drugstore use and to analyze the primary factors connected with it. The following six objectives were established. 1) To catch the reason why the man who medicate himself buy four cautious drugs at a drugstore, and to know the choice motive of each drug purchased. 2) To grasp the distribution of four cautious drug taken by the man who medicate himself and to analyse the reason of taking the drug. 3) To find out whether the buyer has taken the same drug past and to know the duration and the frequency. 4) To grasp the degree of recognition about four cautious drugs and the attitude toward continuous taking them. 5) To analyze the degree of recognition about the influence on human body and the attitude of medication behavior. 6) To know "the experience of side-effects" and to grasp the kind of the side-effects. The data were collected from 15 drugstores with 677 respondents in seoul from August 17 to september 21, 1987. The following results were obtained. 1) The reasons for drugstore use were first, "for easy access and convenience" (53.7%) second, "for the slightness of illness" (19.9%) third "for the cheap price" (13.2%). According to that result, the factor of "the easy access of drugstore" was most influential. In case of the poor, the factor "for the cheap price "was revealed second (37.3%). And "for the slightness of illness" was second reason in the medically insured (22. 9%), "for the cheap price" was second reason in the others (29%). 2) The kind of drugs purchased were antibiotics (62.8%), analeptics(17.2%), minor tranquilizer(13.3%) and sedative hypnotics (6.7%) on the whole. In teenagers, besides antibiotics the percentage of taking analepits came second (42.4%) and it was revealed that the percentage of sedative hypnotics, minor tranquilizer increase with age. But in proportion to the increase of age, the taking of analeptis decreased. 3) The choice motives of each drug purchased were all different. In case of antibiotics "recommendation of pharmacist" was 39.6%, sedative hypnotics "recommendation of pharmacist" and "my own judgement", 28.9%, respectively, minor tranquilizer "my own judgement", 35.2%. and in case of analeptics "my oun judgement" was most common with 53.5%. 4) The reasons for taking drugs were as follows. antibiotics was taken for the inflammation mitigation of a wound and a swelling (38.5%), sedative hypnotics for the removal of insomnia (97.5%), minor tranquilizer because of restlessness and qloominess(39.3%), and analeptics for the shortening of sleeping hours (35.1%). 5) Those experienced in taking four cautious drugs were 78.2% on the average. It was revealed that antibiotics use duration was "from one week to one month" (38.9%), the frequency was "rarely" (62.1%), sedative hypnotics and minor tranquilizer; "More than three years", (35.7%, 30.4%), respectively, "Somtimes", (43.8%, 35%), respectively. analeptics ; "from one year to three years", (27.6%), "Sometimes", (42.7%). 6) In regard to the source of information in taking drugs, 35.3 percent of male were relied on "recommendation of pharmacist", 32.6 percent of female "my own judgement", There was a difference between below the middle school graduates and over the high school graduates Thease were relied on "recommendation of pharmacist" first, those "my own judgement" first. And "my own judgement" was the first source of specialist(40%), labours(41.4%), salesman(43.5%), and jobless men(36.8%), "recommendation of ralatives on friends" was the first source of students (30.4%), "recommendation of pharmacist" was the first soure of teachers, administrative office workers (39%) and housewives (40.7%). 7) The degree of recognition about four cautious drugs was as follows. "know a little" was (43.0%), "don't know" (30.2%), "know" (26.8%), respectively. In regard to the attitude toward continuous taking them, it was revealed that "I will take it according to circumstamces" was first (56.2%), " I will not take it as possible" was first(56.2%), "I dont know well" (12.9%), "I will take it continuously" (8.3%). 8) About the influence on human body, "if proper, it is effect" was common attitude toward antibiotics (43.6%), "Probably bad influence on the health" was first toward the other drugs (46.2%), In terms of the degree of observance to taking-time and dose of drugs, "suitably" was first (37.3%), "relatively correctly" second (27%), "correctly" (17%). 9) The percentage of four cautious drugs side-effects was 27.5 on the average. The kind of side-effects were eruption and urticaria (28.5%), heart acceleration and so forth. (25.4%), headache and Giddiness, dyspepsia (23%), respectively.

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Pattern of Pharmacist Consultation among the Health Counseling Services via Internet Portal Sites: A Pilot Study (국내 포털사이트에서의 지식검색서비스를 이용한 약사와의 상담 패턴에 대한 시험적 연구)

  • Kim, Heejin;Park, Jun Ha;Ji, Eunhee
    • Korean Journal of Clinical Pharmacy
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    • v.26 no.4
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    • pp.324-329
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    • 2016
  • Background: With the development of information and communication technology, there is a growing number of people looking for health information on the internet. This pilot study was performed to analyze the pattern of pharmacist consultation on the internet portal site. Methods: Questions and answers posted on the portal site "Naver Jisik-iN" from March 1st to 31th in 2016 were collected. Medications asked were categorized into prescription drugs, nonprescription drugs, sanitary aids, emergency drugs, functional health foods, and others. Medications were subcategorized into 14 according to the anatomical therapeutic chemical classification system. Questions were divided into 10 categories based on Hepler's drug-related problems. Results: Of the 955 cases, females accounted for 59.5% and inquirers from 11 to 40 years old, 89.4%. The number of prescription drugs, nonprescription drugs, sanitary aids, emergency drugs, functional health foods, and others were 428 (44.8%), 328 (34.3%), 31 (3.3%), 2 (0.2%), 122 (12.8%), and 44 (4.6%), respectively. Questions for drugs acting on alimentary tract and metabolism took up 27.4% followed by those on nervous system, 13.6% and anti-infectives for systemic use, 12.2%. Pharmacist consultation regarding drug information, drug interaction, and adverse reaction occupied 47.9%, 15.2%, and 12.3%, respectively. Conclusion: Health counseling through online is predicted to increase steadily, so pharmacists should broaden their boundaries beyond off-line pharmacies to meet social needs.

Preparation of Thermo-Responsive and Injectable Hydrogels Based on Hyaluronic Acid and Poly(N-isopropylacrylamide) and Their Drug Release Behaviors

  • Ha Dong In;Lee Sang Bong;Chong Moo Sang;Lee Young Moo;Kim So Yeon;Park Young Hoon
    • Macromolecular Research
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    • v.14 no.1
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    • pp.87-93
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    • 2006
  • Copolymers composed of hyaluronic acid (HA) and poly(N-isopropylacrylamide) (PNIPAAm) were prepared to create temperature-sensitive injectable gels for use in controlled drug delivery applications. Semi-telechelic PNIPAAm, with amino groups at the end of each main chain, was synthesized by radical polymerization using 2-aminoethanethiol hydrochloride (AESH) as the chain transfer agent, and was then grafted onto the carboxyl groups of HA using carbodiimide chemistry. The result of the thermo-optical analysis revealed that the phase transition of the PNIPAAm-grafted HA solution occurred at around 30$\∼$33$^{circ}C$. As the graft yield of PNIPAAm onto the HA backbone increased, the HA-g-PNIPAAm copolymer solution exhibited sharper phase transition. The short chain PNIPAAm-grafted HA ($M_{w}$=6,100) showed a narrower temperature range for optical turbidity changes than the long chain PNIPAAm-grafted HA ($M_{w}$=13,100). PNIPAAm-grafted HA exhibited an increase in viscosity above 35$^{circ}C$, thus allowing the gels to maintain their shape for 24 h after in vivo administration. From the in vitro riboflavin release study, the HA-g-PNIPAAm gel showed a more sustained release behavior when the grafting yield of PNIPAAm onto the HA backbone was increased. In addition, BSA released from the PNIPAAm-g-HA gels showed a maximum concentration in the blood 12 h after being injected into the dorsal surface of a rabbit, followed by a sustained release profile after 60 h.

Comparative Study of Health Risk Behaviors, Mental Health and Subjective Health Status of Adolescents in Multicultural and Monocultural Families (다문화 가정과 한국문화 가정 청소년의 건강위험행위, 정신건강 및 건강인식 비교)

  • Jang, Insun
    • Journal of the Korean Society of School Health
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    • v.33 no.2
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    • pp.115-124
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    • 2020
  • Purpose: The purpose of this study was to compare the health risk behaviors, mental health and subjective health status of adolescents in multicultural families and monocultural (Korean) families. This study was conducted to prepare basic data for education and policy proposals related to health promotion of adolescents in multicultural families. Methods: The study was a secondary analysis using the raw data of the 15th Youth Risk Behavior Web-based Survey (2019). A complex sample multiple logistic regression analysis was conducted to understand the influence of growing up in a multicultural family on health risk behaviors, mental health and subjective health status by comparing the variables to those of monocultural adolescents. Results: Adolescents from multicultural families had a 3.3 times higher rate of drug use experience, 1.89 times higher rate of sexual experience, and 1.24 times higher rate of not wearing seat belts. In addition, the rate of not washing hands and the rate of suicide attempts were 1.34-1.50 times and 1.62 times higher, respectively, compared to adolescents from monocultural families. Conclusion: This study showed that it is necessary to develop appropriate health promotion programs to solve the problems of drug use, sexual intercourse, not wearing seat belts, not washing hands, and attempting suicides, which are more prevalent among adolescents from multicultural families than from monocultural families. It will serve a basic policy for the long-term development and growth of Korea at this critical time when multicultural adolescents are increasing.

pH-Sensitive Dynamic Swelling Behavior of Glucose-containing Anionic Hydrogels (글루코스를 함유한 음이온 하이드로젤의 pH 감응성 동적 팽윤거동)

  • Kim, Bumsang
    • Korean Chemical Engineering Research
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    • v.43 no.2
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    • pp.299-304
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    • 2005
  • There have been many efforts to use anionic hydrogels as oral protein delivery carriers due to their pH-responsive swelling behavior. The dynamic swelling behavior of poly(methacrylic acid-co-methacryloxyethyl glucoside) [P(MAA-co-MEG)] hydrogels was investigated to determine the mechanism of water transport through these anionic hydrogels. The exponential relation $M_t/M_{\infty}=kt^n$ was used to calculate the exponent, n, describing the Fickian or non-Fickian behavior of swelling polymer networks. The mechanism of water transport through these gels was significantly affected by the pH of the swelling medium. The mechanism of water transport became more relaxation-controlled in the swelling medium of pH 7.0 that was higher than the $pK_a$ of the gels. Experimental results of time-dependent swelling behavior of the gels were analyzed with several mathematical models. Using ATR-FTIR spectroscopy, the effect of ionization of the carboxylic acid groups in the polymer networks on the water transport mechanism was investigated.

The Nonlinear Association Between Internet Using Time for Non-Educational Purposes and Adolescent Health

  • Kim, Jong-Yeon
    • Journal of Preventive Medicine and Public Health
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    • v.45 no.1
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    • pp.37-46
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    • 2012
  • Objectives: This study was performed to consider the association between Internet using time for non-educational purposes and adolescent health, and to examine how health status differs between Internet users and non-users. Methods: We analyzed 2009 data from the Korea Adolescent Risk Behavior Web-Based Survey, conducted on a nationally representative sample of students in grades 7 to 12. A total of 75 066 adolescents were categorized into four groups according to their Internet using time excluding using for educational purposes: non-Internet users (NIUs), occasional Internet users (OIUs) (<1 h/d), moderate Internet users (MIUs) (${\geq}1$ and <2 h/d), and heavy Internet users (HIUs) (${\geq}2$ h/d). Health factors included eight health risk behavior indices, four mental health indices and six physical health indices. Results: The distribution of Internet use was as follows: NIUs 17.4%, OIUs 68.1%, MIUs 12.7%, and HIUs 1.7%. In multivariate analysis, using OIUs as a reference, U- or J-shaped associations were observed for five health risk behavior indices (current smoking, current drinking, drug abuse, sexual intercourse, sedentary behavior on weekdays) and four mental health indices (stressed, depressed, suicidal ideation, attempted suicide) in both genders. After removing confounding effects, including age, region, school type, subjective school record, subjective economic status, presence of parents, living with family, and sedentary behavior, these associations were still observed. Conclusions: Health professionals should consider both Internet non-users (for non-educational purposes) and heavy users to be high-risk groups in terms of health status. Also, more well-designed studies are needed to clarify what factors are working in these nonlinear associations.

The Influencing Factors on Suicide Attempt among Adolescents in South Korea (청소년의 자살시도에 영향을 주는 요인)

  • Park, Eun-Ok
    • Journal of Korean Academy of Nursing
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    • v.38 no.3
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    • pp.465-473
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    • 2008
  • Purpose: Suicide has been considered a large public health concern in recent years because suicide mortality has been increasing rapidly. This study was done to investigate the prevalence and risk factors of a suicide attempt among adolescents in South Korea. Methods: The data of the 2006 Youth Health Risk Behavior web-based Survey collected by the Korean Center for Disease Control was analyzed using logistic regression for this study. Results: The prevalence of a suicide attempt was 5.2% in South Korea. The risk factors of a suicide attempt were suicidal ideation (odds 31.83), depression (odds 7.98), drug use (odds 4.67), currently smoking (odds 3.19), feeling unhappiness (odds 2.77), stress (odds 2.60), currently drinking alcohol (odds 2.39), sexual activity (odds 2.33), living with neither parent (odds 2.24), initial alcohol drinking by age 9 (odds 1.80), health status (odds 2.15), skipped breakfast (odds 1.75), disease (odds 1.65), and school records (odds 1.22). Conclusion: Suicide screening and prevention programs should be developed, considering these risk factors. Suicide prevention programs should be applied to the at risk population prior to a suicide attempt.