• Journal of Biomedical Engineering Research
• /
• v.40 no.1
• /
• pp.7-14
• /
• 2019

The microencapsulation of nifedipine (NF) with 4 wt% of poly(${\varepsilon}-caprolactone$) (PCL)/polyvinylpyrollidone (PVP) or PCL/polyethylene glycol (PEG) was carried out by solvent evaporation method in oil in water emulsion system to investigate the effect of PVP and PEG addition on drug release behavior of the microcapsules. The PVA (emulsifier) concentration of 1.0 wt% was chosen for the formation of PCL capsule having an average size of $154{\pm}25{\mu}m$ due to nearly spherical shape with a narrow size distribution. As PCL/PVP and PCL/PEG ratios were raised from 10/0 to 6/4, the capsule size increased gradually from $154{\pm}25{\mu}m$ to $236{\pm}32{\mu}m$ and $248{\pm}56{\mu}m$, respectively. The drug release rate of PCL/PVP and PCL/PEG capsules increased dramatically from 0 to 4 h at the beginning and then reached the plateau region from 20 h. As the concentration of PVP or PEG increased, the amount of drug release increased, suggesting that the larger capsule size was attributed to the higher drug content. However, the drug release behavior remained almost constant. The PCL capsules exhibited no evidence of causing cell lysis or toxicity regardless of NF loading, implying that the microcapsules are clinically suitable for use as drug delivery systems.

• Health Communication
• /
• v.13 no.2
• /
• pp.185-193
• /
• 2018

Background: Nursing college students are exposed to information about diseases or drugs, and are likely to have a distorted perception of drug knowledge or behavior. The study aimed to identify knowledge and attitude about drugs and current status of self-medication among nursing students. Methods: The subjects were 172 nursing students from a university in Busan. Data were collected with structured questionnaires and analyzed using descriptive analysis, t-test, and one-way ANOVA using SPSS 23.0. Results: Nursing students had a high level of knowledge about drugs, but attitudes toward drugs were relatively low. 83.7% of patients had experience of self-medication. The methods to acquire information for self-administration were 29.9% by smart phone and 27.1% by internet. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) among self-medication drugs was the highest. The most common reason for self-medication was 'I thought it to be a mild disease', and the pharmacists were the most affected by choice of self-medication. The knowledge about drugs was statistically significant according to grade, school life satisfaction and subjective health status. The attitudes about medication were statistically significant according to grade and self-medication experience. Conclusion: Nursing college students need drug safety education to improve awareness and practice of correct drug use.

• Journal of the Korean Applied Science and Technology
• /
• v.39 no.2
• /
• pp.193-204
• /
• 2022

This study was to identify factors related to the experience of violence damage, focusing on health risk behavior of multi-cultural and general adolescents in Korea. Data from the 15th online survey of youth health behavior (2019) was used to analyze 35,574 adolescents. The data were analyzed using complex sample analysis by using SPSS/Win 22.0. The multi-cultural adolescents had significantly higher experience of smoking and habitual drug use and violence damage than those ordinary adolescents. In both multi-cultural and general adolescents, the more they did not live with their family, the more they had smoking experience and habitual drug use experience, the higher they experienced violence. The experience of violence victimization of general youth was significantly related to gender, school, economic status, and drinking experience. To prevent the violence victimization of adolescents, social support for adolescents who do not live with their families is required, and careful attention is needed to adolescents who have smoking and drug use experience. In addition, since multi-cultural youth are more vulnerable to health risk behaviors and violence damage than general youth, educational programs are needed to induce multi-cultural youth to practice correct health behaviors and prevent experiences of violence.

• Journal of Korean Academy of Fundamentals of Nursing
• /
• v.14 no.2
• /
• pp.230-238
• /
• 2007

Purpose: The Transtheoretical Model (TTM) is a theoretical construct explaining stages of health behavior change. The purpose of this study was to describe and analyze the stages of health behavior change and health related quality of life (HRQL), Method: A descriptive survey design was utilized, and, using a questionnaire, which included a series of 5 questions designed to assess stages of health behavior change and HRQL instrument, data were collected from 292 adults. Means, standard deviation, t-test, ANOVA, and SNK test were used to analyze the collected data. Results: Health risk behaviors were lack of stress management(44%), alcohol use (42.5%), poor nutrition (37%), smoking (36.3%), a lack of spirituality (28.8%), poor communication skills (21.9%), Lack of safety(21.6%), lack of fittness (20.1%), violent behavior(12.3%), and drug use(6.8%). There was a significant difference in HRQL according to stage of health behavior change (P=0.001). Conclusion: The results of the study identified the need for individualized nursing interventions that based on the stage of health behavior change. Nursing interventions that focus on the stage of health behavior change would be effective for health promotion for Koreans.

• Biomolecules & Therapeutics
• /
• v.14 no.1
• /
• pp.1-10
• /
• 2006

Drug dependence deals a heavy socioeconomic burden to the society. For adolescents, the damage from drug dependence is greater than adults considering their higher susceptibility to drug effect and increasing chance for violence leading to criminal punishment process. Habitual drug use depends on genetic and environmental factors and the complex interactions between the two. Mammalian model systems have been useful in understanding the neurochemical and cellular impacts of abused drugs on specific regions of the brain, and in identifying the molecular targets of drugs. More elucidation is required whether biological effects of drugs actually cause the habitual dependence at the cellular level. Although there is much insight available on the nature of drug abuse problems, none of the systems designed to help drug dependent individuals is efficient in screening functional ingredients of the drug, and thus resulting in the failure of helping drug dependent individuals recover from drug dependence. Alternative model systems draw the attention of researchers, such as the invertebrate model systems of nematodes (Caenorhabditis elegans) and fruit flies (Drosophila melanogaster). These models should provide new insight into the mechanisms leading to the behavior of drug users (even functional studies analyzing molecular mechanism), and screening useful components to help remove drug dependence among drug users. The relatively simple anatomy and gene expression of the invertebrate model systems should enable researchers to coordinate current knowledge on drug abuse. Furthermore, the invertebrate model systems should facilitate advance in experiments on the susceptibility of specific genetic backgrounds and the interaction between genetic factors to drug dependence.

• Journal of Dental Anesthesia and Pain Medicine
• /
• v.21 no.4
• /
• pp.369-376
• /
• 2021

In adult patients with dental phobia, dental treatment may be difficult, or may not be possible. Depending on the level of fear or anxiety, non-pharmacological or pharmacological behavior management techniques are used in the dental treatment of such patients. Among the pharmacological behavior management techniques, minimal sedation, that is, the lowest depth of sedation, can be easily obtained in adult patients using oral sedatives, does not require special equipment or tools, and does not affect ventilatory and cardiovascular function. Diazepam is an anxiolytic drug belonging to the benzodiazepine family that, in addition to relieving anxiety, produces muscle relaxation, and is a representative drug used in adult patients with fear of dental treatment. Herein, we report the case of a 50-year-old woman with severe dental fear who successfully underwent long-term dental treatment in approximately 20 visits with minimal sedation using oral diazepam. In addition, we reviewed the considerations for the use of benzodiazepines for minimal sedation.

• Journal of the Korean Society of Visualization
• /
• v.10 no.2
• /
• pp.32-38
• /
• 2012

In recent years a unique drug delivery system named as the transdermal drug delivery system has been developed which can deliver drug particles to the human skin without using any external needle. The solid drug particles are accelerated by means of high speed gas flow through a shock tube imparting enough momentum so that particles can penetrate through the outer layer of the skin. Different systems have been tried and tested in order to make it more convenient for clinical use. One of them is the contoured shock tube system (CST). The contoured shock tube consists of a classical shock tube connected with a correctly expanded supersonic nozzle. A set of bursting membrane are placed upstream of the nozzle section which retains the drug particle as well as initiates the gas flow (act as a diaphragm in a shock tube). The key feature of the CST system is it can deliver particles with a controllable velocity and spatial distribution. The flow dynamics of the contoured shock tube is analyzed numerically using computational fluid dynamics (CFD). To validate the numerical approach pressure histories in different sections on the CST are compared with the experimental results. The key features of the flow field have been studied and analyzed in details. To investigate the performance of the CST system flow behavior through the shock tube under different operating conditions are also observed.

• Research in Community and Public Health Nursing
• /
• v.26 no.3
• /
• pp.190-198
• /
• 2015

Purpose: This study aimed to compare health risk behaviors among adolescents according to whether or not the parents were born in South Korea. Methods: From the database of the ninth Korea Youth Risk Behavior Web-based Survey (KYRBS), the researchers classify adolescents into four groups: those whose parents were both native Korean, those whose mother only was a native Korean, those whose father only was a native Korean, and those whose parents were both foreign-born. Data were analyzed using ${\chi}^2$-test and multiple logistic regression with the SPSS/WIN 18.0 program. Results: The adolescents with a foreign-born mother were less likely to smoke and drink alcohol than those with native Korean parents, but for other health risk behaviors the two groups were similar to each other. The adolescents with a foreign-born father were at a greater risk of drug use, intercourse, depression and violence at school than those with native Korean parents. The adolescents whose parents were born abroad were at a greater risk of smoking, drug use, intercourse, depression, suicidal ideation and violence at school than those with native Korean parents. Conclusion: Health promotion approaches differentiated by the type of multi-cultural family are needed in order to improve multi-cultural adolescents' health.

• Journal of the Korean Society of School Health
• /
• v.28 no.2
• /
• pp.89-98
• /
• 2015

Purpose: The purpose of this study was to determine the factors that influence suicidal ideation and suicidal attempts of adolescents who had been bullied. Methods: This study used data extracted from Korea Youth Risk Behavior Web-Based Survey of 2014. The data of 1,926 adolescents, in total, who had experienced violence were included in the analysis, The analysis was done using SPSS/WIN. Results: The adolescents with an experience of being bullied were more likely to engage in suicidal ideation and suicidal attempts than the average teenagers in Korea. In addition, suicidal thoughts were affected by gender, experience of habitual drug use, subjective happiness, as well as sadness and despair. Suicidal attempts were influenced by gender, grade, smoking experience, experience of habitual drug use, size of the city of residence, subjective happiness, sadness and hopelessness, existence of people to get counseling, and habit of walking for 10 minutes every day. Conclusion: More attention should be given to the suicidal risk of adolescents having experienced violence. Further studies are required to develop an intervention program for suicide prevention targeting adolescents who have experienced violence and assess the program's effectiveness.

• Korean Journal of Health Education and Promotion
• /
• v.28 no.5
• /
• pp.61-71
• /
• 2011

Objectives: This study aims to identify differences in problem gambling among Korean university students by gender and to analyze the relationship between problem gambling and health risk behaviors. Methods: With a sample of 2,026 4-year university students, a questionnaire included CPGI (Canadian Problem Gambling Index) scale and health risk behavior items was administered. Descriptive statistics, t-test, and ANOVA were performed on the data. Results: The prevalence of gambling addiction of male students(14.6%) was two times higher than that of female students(6.6%). The severity of problem gambling was higher in: smokers, those with drug use experience, heavy drinkers, and those with frequently recurring suicidal thoughts, respectively. Conclusions: This study suggests that the problem gambling of university students is a complicated and comprehensive public health problem that is related with health risk behaviors such as alcohol drinking, smoking, drug use, and suicidal thoughts. Prevention strategies and policies are suggested based on the study results.