• Journal of Powder Materials
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• v.30 no.6
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• pp.493-501
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• 2023

This study aimed to develop a solid self-nanoemulsifying drug delivery system (solid-SNEDDS) to enhance the formulation of ketoconazole (KTZ), a BCS Class II drug with poor solubility. Ketoconazole, which is insoluble above pH 3, requires solubilization for effective delivery. This SNEDDS comprises oil, surfactant, and co-surfactant, which spontaneously emulsify in the gastrointestinal tract environment to form nanoemulsions with droplet sizes less than 100 nm. The optimal SNE-vehicle composition of oleic acid, TPGS, and PEG 400 at a 10:80:10 weight ratio was determined based on the smallest droplet size achieved. This composition was used to prepare liquid SNEDDS containing ketoconazole. The droplet size and polydispersity index (PDI) of the resulting liquid SNEDDS were analyzed. Subsequently, solid-SNEDDS was fabricated using a spray-drying method with solidifying carriers such as silicon dioxide, crospovidone, and magnesium alumetasilicate. The physicochemical properties of the solid-SNEDDS were characterized by scanning electron microscopy and powder X-ray diffraction, and its solubility, droplet size, and PDI were evaluated. In particular, the solid-SNEDDS containing ketoconazole and crospovidone in a 2:1 weight ratio exhibited significantly enhanced solubility, highlighting its potential for improved medication adherence and dissolution rates.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.666-669
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• 2008

Droplet in miniaturized microfluidic systems have received much focused attention recently. In this work, electrical charging phenomenon of a conducting water droplet on the electrode under the dc electric field is studied and using this phenomenon droplet actuation method for microreactor applications is experimentally demonstrated. To find effects of key factors, the effects of electric field, medium viscosity, and droplet size are investigated. A scaling law of charging for the conducting droplet is derived from the experimental results. Unlike the case of a perfect conductor, the estimated amount of electrical charge ($Q_{est}$) of a water droplet is proportional to the 1.59 power of the droplet radius (R) and the 1.33 power of the electric field strength (E). (For a spherical perfect conductor, Q is proportional to R2 and E.) It is thought that the differences are mainly due to incomplete charging of a water droplet resulted from the combined effect of electrochemical reaction at electrode and the relatively low conductivity of water. Using this phenomenon, we demonstrate the transport of the charged droplet and fusion of two oppositely-charged droplets. When electric field is subjected sequentially on the electrode, the charged droplet is transported on the electrode. For the visualization of fusion of charged droplets, the precipitation reaction is used. When subjected to a DC voltage, two droplets charged are moving and merging toward each other due to the Coulombic force and chemical reaction is simultaneously occurred by coalescence of droplets. It may be due to the interchange effect of charge. It is shown that the droplet can be used for microreactor where transporting, merging etc. of reagents constitute unit operation.

• International Journal of Aeronautical and Space Sciences
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• v.15 no.4
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• pp.444-453
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• 2014

A throttleable rocket engine enables operational possibilities such as the docking of spacecraft, maneuvering in a certain orbit and landing on a planet's surface, altitude control, and entrance to atmosphere-less planets. Thus, throttling methods have long been researched. However, dual-manifold injectors, which represent one throttling method, have been investigated less than others. In this study, dual-manifold and single-manifold injectors were compared to determine the characteristics of dual-manifold injectors. Also, the effects of gas injection were investigated with various F/O ratios. To investigate the characteristics, mass flow rate, spray pattern, spray angle, and droplet size were measured. The spray angle and droplet size were captured by indirect photography. About 30 images were taken to assess the spray patterns and spray angle. Also, 700 images were analyzed to understand the droplet distribution and targeting area, moving to the right from the centerline with 1.11-cm intervals. The droplet size was obtained from an image processing procedure. From the results, the spray angle showed two transition regions, due to swirl momentum in the swirl chamber regardless of the F/O ratio. The droplet size showed similar trends in both dual-manifold and single-manifold injectors except in the low mass flow rate region. In the case of the dual- manifold injector, the spray cone was not fully developed in the low mass flow rate region due to low angular momentum in the swirl chamber.

• Journal of the Korean Society of Visualization
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• v.19 no.3
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• pp.39-45
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• 2021

An experiment to visualize fine dust captured by FOG droplet is conducted. Coal dust with 23.56 MMD (Mean Median Diameter) and water with 17.02 MMD is used as fine dust and FOG droplet. Long distance microscope and high-speed camera are used to capture the images of micro-scale particles sprinkled by acrylic duct. After measuring and comparing the size of the coal dust and FOG droplet to MMD, process to seize the coal dust with FOG droplet is recorded in 2 conditions: Fixed and Floated coal dust in the floated FOG droplet flow. In both conditions, a coal dust particle is collided and captured by a FOG droplet particle. A FOG droplet particle attached at the surface of the coal dust particle does not break and remains spherical shape due to surface tension. Combined particles are rotated by momentum of the particle and fallen.

• Journal of the Korean Society of Combustion
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• v.4 no.1
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• pp.17-26
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• 1999

Vaporization, ignition and combustion of fuel droplets in tandem array are theoretically investigated to understand the droplet interactions in combustors. Including the effects of density variation in gas-phase, internal circulation and transient liquid heating, a numerical studies are performed by changing parameters such as initial droplet temperatures, initial droplet spacings, initial Reynolds numbers, surrounding gas temperatures, and activation energies of fuel vapors. Combustion regime maps classify the droplet combustion phenomena according to the configuration and location of the flame with respect to injection Reynolds numbers and surrounding gas temperatures. In addition, it is shown that the dynamic histories of droplets and ignition delay times are dependent on droplet size ratios and initial spacings of tandem droplets.

• Journal of Mechanical Science and Technology
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• v.17 no.1
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• pp.114-121
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• 2003

Water droplet erosion is one of major concerns in the design of modern large fossil steam turbines because it causes serious operational problems such as performance degradation and reduction of service life. A new erosion model has been developed in the present study for the prediction of water droplet erosion of rotor blades operated in wet steam conditions. The major four erosion parameter : impact velocity, impacting droplet flow rate, droplet size and hardness of target are involved in the model so that it can also be used for engineering purpose at the design stage of rotor blades. Comparison of the predicted erosion rate with the measured data obtained from the practical steam turbine operated for more than 90,000 hours shows good agreement.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.1897-1902
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• 2004

Numerical analysis of the heat transfer associated with droplet impact on a hot solid surface is performed by solving the mass, momentum and energy equations for the liquid-gas region. The deformed droplet shape is tracked by a level set method which is modified to achieve volume conservation during the whole calculation procedure and to include the effect of contact angle at the wall. The numerical method is validated through test calculations for the cases reported in the literature. Based on the numerical results, the effects of advancing/receding contact angle, impact velocity and droplet size on the heat transfer during droplet impact are quantified.

• Fire Science and Engineering
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• v.15 no.4
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• pp.41-48
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• 2001

Halogen-based fire suppressing agents have been the most effective fire suppressants and widely used for flammable liquid and electric fire. However they have environmental problems causing stratospheric ozone depletion and globe warming. As a substitution of halon, fire suppression system using fine water mist is one of an effective fire suppressant. Suffocating and cooling effects of water mist are increased by the evaporation characteristics because it has droplet size less than 1,000 $\mu{m}$ and very large surface area. In this study, the extinguishing characteristics of fire was measured with changing of water mist droplet size, flow density; discharge pressure, and fire size. As a result, the extinguishing time of pool fire was shortened with the increase of flow density and in case of low flow density less than 0.5$\pm$0.05 ml/$\textrm{cm}^2$ . min, the extinguishing time was shortened with the increase of droplet size. The cycling discharge was effective for $\eta$-heptane pool fire, and total amount of water mist required to extinguish fire was reduced to a quarter compare with continuous discharge.

• Korean Journal of Materials Research
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• v.23 no.2
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• pp.81-88
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• 2013

In this study, using a tin chloride solution as the raw material, a nano-sized tin oxide powder with an average particle size below 50 nm is generated by a spray pyrolysis process. The properties of the tin oxide powder according to the nozzle tip size are examined. Along with an increase in the nozzle tip size from 1 mm to 5 mm, the generated particles that appear in the shape of droplets maintain an average particle size of 30 nm. When the nozzle tip size increases from 1 mm to 2 mm, the average size of the generated particles is around 80-100 nm, and the ratio of the independent particles with a compact surface structure increases significantly. When the nozzle tip size is at 3 mm, the majority of the generated particles maintain the droplet shape, the average size of the droplet-shaped particles increases remarkably compared to the cases of other nozzle tip sizes, and the particle size distribution also becomes extremely irregular. When the nozzle tip size is at 5 mm, the ratio of droplet-shaped particles decreases significantly and most of the generated particles are independent ones with incompact surface structures. Along with an increase in the nozzle tip size from 1 mm to 3 mm, the XRD peak intensity increases, whereas the specific surface area decreases greatly. When the nozzle tip size increases up to 5 mm, the XRD peak intensity decreases significantly, while the specific surface area increases remarkably.

• Polymer(Korea)
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• v.39 no.3
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• pp.475-479
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• 2015

Droplet distribution of LCP(Vectra 950) and PET blend by repeated extrusion was examined through morphology analysis. Repeated extrusion was respectively proceeded twice and three times with blending condition and droplet distribution of only once extrusion sample showed uniform shape. However, droplet size of twice and three times extrusion samples increased and it was confirmed that droplets were concentrated on the center of specimens. It is thought that this phenomena were due to the compatibility and viscoelastic behavior of LCP/PET blend. Finally, it is thought that fiber manufacturing of different diameter is possible from spinning of repeated extrusion LCP/PET blended chip under same spinning condition.