• 한방안이비인후피부과학회지
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• 제34권2호
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• pp.80-85
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• 2021

Objectives : The purpose of this study is to report on the treatment of wound dressing in patients with diabetic foot ulcers in the dermatology clinic of Korean medicine. Methods : First, sufficient marginal resection of the ulcer and necrotic tissue on the foot of a patient with diabetic peripheral neuropathy was performed. Inflammation was treated with Anti-inflammatory pharmacopuncture solution, and dressings were applied for one month using Cornu Cervi Parvum pharmacopuncture solution, and Haeboo ointment for granulation tissue formation and skin regeneration. Results : After 10 days of the treatment, the formation of new granulation tissue was observed in the necrotic tissue area, and the extent of the lesion decreased sharply from the 14th day. On the 40th day, epithelialization progressed so that the treatment was terminated, and complete keratinization of the site was observed at follow-up 3 weeks after the end of the treatment. Conclusions : In the treatment of wound dressings in diabetic foot ulcer patients, marginal resection treatment with the application of pharmacopuncture solution and herbal ointment showed good effect.

• 대한화상학회지
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• 제16권2호
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• pp.99-103
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• 2013

Purpose: The biggest problem of wound healing is a possible occurrence of lesion. Especially, in the case of patients who have a skin injury around exposed body parts, if their treatment period drag on for long time, they can suffer from aftereffects and the costs can be passed on to a society. Therefore, in this research, we investigated the need to develop the effective medicine and appliances for the patients by examining which therapy methods are being applying to the skin damage and what is the advantage and limit by evaluating the patient's satisfaction level. Methods: We carried out an online and offline survey targeting medical teams in order to analyze device for wound care. A total of 125 medical teams applied to the research, and investigate the level of customer satisfaction. Results: The moist dressings are the most used method for wound healing. When it comes to the level of customer satisfaction, biological dressing product also has a high satisfaction level. However its high cost tends to limit the use. Conclusion: This research reached a conclusion that it is need to develop a low cost and high efficiency wound care product considering the fact that its high cost and low efficiency induced economic problems. Generally, it is needed to develop a product for skin regeneration based on biological technologies, not a product just for damage cure.

• KSBB Journal
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• 제23권1호
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• pp.8-17
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• 2008

There are many different approaches to healing of acute and chronic ulcer and large skin defect, such as burn. Currently available wound covers fall into two categories. Permanent covering, such as autografts, and temporary ones, such as allograft including de-epidermized cadaver skin, bioartificial skin, xenografts, and synthetic dressings. Autologous skin grafting in the form of split- or full-thickness skin is still the good standard. Following on from developments in the 1980s involving the use of cultured keratinocyte grafts in wound healing, the last decade has been great progress in the fabrication of composite bioartificial skin grafts. However, two bottleneck on producing cultured bioartificial skin, whether of the simple epithelial cell sheet type, or the more complex composite type, continue to be the generation of sufficient keratinocytes cheaply and quickly and develop biocompatible dermal scaffolds. This article covers the development, clinical application, and current research directions associated with bioartificial skin.

• Archives of Plastic Surgery
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• 제40권5호
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• pp.630-632
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• 2013

Vacuum-assisted wound healing has been proven to be more efficacious than conventional dressings. Vacuum dressing has been frequently modified given the restrictions in resources available. Here we present a modified method of vacuum dressing by using surgical or gynaecological gloves for lower and upper limb wounds. Vacuum dressing was applied with parts of a surgical or gynaecological glove and Opsite with T-tailing of the suction outlet. Vacuum-assisted wound healing using the surgical gloves showed relatively good wound healing in the amputation stump, finger, arm, and leg in the cases studied.

• Journal of Applied Biological Chemistry
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• 제61권4호
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• pp.351-355
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• 2018

Treatment towards wound healing, a complex and dynamic process, has been given a great deal of efforts in the last few decades. Focus has been imposed on developing wound dressings that meet the requirements for proper wound healing. In this study, hydrogel made from blends of poly (vinyl alcohol) and ${\beta}$-1,6-branched-${\beta}$-1,3-glucan (beta-glucan) were synthesized by modified solvent casting method for wound dressing application. Optimization of hydrogel composition and analysis of wound dressing parameters such as stability and fluid uptake capacity (in the presence of water, saline and different pH solutions) has been studied. The result indicated that the PVA/beta-glucan hydrogel hold its structural integrity even at alkaline pH (pH~9) and upholds fluids four times of its original weight. Thus, the developed hydrogel is expected to be a promising candidate as wound dressing.

• International Journal of Industrial Entomology and Biomaterials
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• 제48권1호
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• pp.1-12
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• 2024

Silk sericin, a natural protein from silkworm cocoons, is emerging as a multifunctional biomaterial in biomedicine, particularly in tissue engineering and wound healing. Recent studies have highlighted its biocompatibility, biodegradability, and potential for chemical modification, which allows it to be incorporated into various scaffold architectures. This review article synthesizes current research, including the development of sericin-based hydrogel scaffolds for tissue engineering and sericin's role in enhancing wound healing. Key findings demonstrate sericin's ability to refine scaffold porosity and mechanical strength, expedite tissue healing, and reduce bacterial load in wounds. The integration of sericin into novel bioactive dressings and its use in peripheral nerve injury repair are also discussed, showcasing its adaptability and efficacy. The convergence of these studies illustrates the broad applications of sericin, from scaffold design to clinical interventions, making it a promising material in regenerative medicine and tissue engineering, with the potential to improve patient outcomes significantly.

• Journal of Periodontal and Implant Science
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• 제29권3호
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• pp.693-703
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• 1999

Since they were introduced by Ward in 1923, periodontal dressing have been routinely used following the periodontal surgery to avoid pain, infection, desensitizing teeth, inhibiting food impaction of the surgical areas, and immobilizing injured areas. Recently, however, the value of periodontal dressings and their effects on periodontal wound healing have been questioned, several authors have been reported that the use of dressing has little influence on healing following periodontal surgical procedures. In addition, there is evidence that when good flap adaptation is achieved, the use of a periodontal dressing does not add to patient comfort nor promote healing. The purpose of this study was to evaluate patient postoperative pain experience and discomfort with and without the use of periodontal dressing following periodontal surgery. Twenty-eight patients, 11 male and 17 female. were selected for this study; The age range was 31 to 56, with an average of 40.2years. Patient selection was based on existence of two bilateral sites presenting similar periodontal involvement, as determined by clinical and radiographic assessment, and requiring comparable bilateral surgical procedures. Using a splitmouth dressing. one site received a periodontal dressing while the other site did not. Pain assessment was made according to a horizontal, rating scale(0-10). After at least a two-week period, the second surgical precedure was performed using the alternate postoperative treatment. At the conclusion of the trial, a self-administered questionnaire on postoperative experience was administered, and were asked of their preference of either, dressed or undressed. The results were as follows: 1. A similar trend for mean pain and discomfort scores as assessed by patients both dressed and salinetreated procedures was evident during 7-day postsurgical period. 2. Statistical analysis of differences between the dressed side and salinetreated side with respect to pain, discomfort and patient's experiences revealed that both treatment sides behaved similarly at any postoperative day(P>0.05). 3. Considering the patient's preference, on the basis of pain and discomfort experienced, 43% preferred the saline-mouthwash and 32% preferred the dressing, 25% showing no preference for either the dressing or the saline-mouthwash. There is evidence to support the use of a periodontal dressing in retention of an apically positioned flap by preventing coronal displacement, or its use to provide additional support to stabilize a free gingival graft. However, there will always be a use for periodontal dressing although routine use of dressings may decrease because of better surgical techniques and the use of antibacterial mouth rinses.

• 한국식품영양과학회지
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• 제44권2호
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• pp.250-259
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• 2015

본 연구에서는 현대인의 건강에 대한 관심과 머루의 영양성과 이용성 증대의 일환으로 머루 분말을 1%, 2%, 3% 및 5% 첨가한 샐러드드레싱을 제조하고 저장 중의 품질 특성, 항산화 특성 및 관능검사를 실시하였다. 점도는 머루 분말 첨가량이 증가할수록 유의적으로 낮아졌으며(P<0.05), 저장기간 중의 점도 측정 결과에서 3주차까지는 실험군들 모두 점도가 증가하는 경향을 나타내었다. pH는 머루 분말 첨가량이 증가할수록 유의적으로 낮아졌으며(P<0.05), 저장 기간이 증가함에 따라 pH가 증가하는 경향을 나타내었다. 수분 함량은 머루 분말 첨가량이 증가할수록 유의적으로 낮아졌으며(P<0.05), 수분활성도는 대조군이 0.924로 유의적으로 가장 높았고 저장 4주차에는 머루 분말 첨가군들 0.902~0.912로 대조군에 비해 대체적으로 낮은 결과를 나타내었다. 명도와 황색도는 머루 분말 첨가량이 증가할수록 낮아졌고 적색도는 유의적으로 증가하였으며(P<0.05), 명도와 적색도는 저장기간이 증가할수록 낮아지는 경향을 나타내었다. 총 폴리페놀 함량, DPPH, ABTS 라디칼 소거활성은 머루 분말 첨가량이 증가할수록 유의적으로 높아졌으며 저장기간이 증가할수록 감소하는 경향을 나타내었다. 기호도 검사 결과 색은 대조군이 가장 높았으며 향미는 2% 첨가군이 5.58로 유의적으로 가장 높았다(P<0.05). 전체적인 기호도는 1% 첨가군과 2% 첨가군이 각각 5.71, 5.49로 유의적으로 가장 높게 나타났다(P<0.05). 따라서 샐러드드레싱의 품질 특성, 관능검사 및 항산화 효과를 고려할 때 머루 분말 2% 첨가한 샐러드드레싱이 최적의 배합비로 사료되었다. 또한 머루를 이용한 가공식품으로서의 활용 가능성을 높이고 샐러드드레싱 제품 개발의 기초 자료로 이용될 수 있을 것이라 생각된다.

• Archives of Plastic Surgery
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• 제37권3호
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• pp.220-226
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• 2010

Purpose: Many topical agents had been used for burn or wound treatment. An awareness of topical agents on various aspects of wound healing permits the clinician to choose the most appropriate material to advantageously control the wound process and final results. Although polydeoxyribonucleotide (PDRN) was used as a tissue repair stimulating agent in a number of human diseases, such as ulcers and burns, its wound healing effects were largely unreported. We aimed to compare the woundhealing effects of PDRN and common dressing materials on full-thickness skin defect in the mouse. Methods: Full-thickness skin defects were made on the back of mice (N=60). The mice were divided into the following 4 groups according to the dressing used for the wounds: group O (Polydeoxyribonucleotide cream), group I (Polydeoxyribonucleotide solution), group M (Medifoam$^{(R)}$), and group G (dry gauze, control group). We analyzed the gross findings, wound sizes and histological findings for the groups. Results: The rate of wound size was decreased in order of group I, group O, group M and group G. The histological findings revealed that the I group showed more reepithelialization and granulation tissue formation and less inflammatory cell infiltration than the other materials. The grade score of wound healing was increased in order of group I, group O, group M and group G. Conclusion: PDRN applicated wound dressings can be used for treating a full-thickness skin defect wounds. Considering its superior efficacy in comparison to the efficacies of other wound dressings, PDRN soaked gauze dressing should be preferentially used for the treatment of fullthickness skin wounds.

• 한국조리학회지
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• 제18권4호
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• pp.255-265
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• 2012

본 연구는 블루베리즙을 요구르트 드레싱에 첨가하여 이화학적 및 관능적 특성을 평가하였다. 블루베리즙 첨가 요구르트 드레싱의 유기산 분석 결과 citric acid, malic acid와 succinic acid는 블루베리즙 첨가량이 증가할수록 높았다(p<0.001). 반면 tartaric acid, lactic acid와 acetic acid는 대조군이 블루베리즙 첨가군보다 높게 나타나 시료간의 유의적인 차이가 있었다. 요구르트 드레싱의 pH 측정 결과 대조군이(3.75) 블루베리 첨가군(3.68~3.48)보다 더 높게 나타났다(p<0.001). 요구르트 드레싱의 당도는 대조군이 15.86 brix%로 가장 높았고 블루베리즙 첨가량이 증가할수록 당도가 감소하였다(p<0.001). 블루베리즙 첨가 요구르트 드레싱의 DPPH radical 소거활성은 대조군이 26.44%였으며 블루베리 첨가군이 63.16~87.46%로 높게 나타났다(p<0.001). 색도 측정 결과 블루베리즙을 첨가할수록 명도 L값과 황색도 b값은 감소하고 적색도 a값은 증가하는 경향을 보였다. 드레싱의 점도는 대조군이 2386.67 cP였으며 블루베리 첨가군은 8348.00~10523.00 cP로 대조군보다 약 3.5배~4.4배 정도 더 높게 나타났다(p<0.001). 관능검사 결과 블루베리즙 20% 첨가군이 6.60으로 가장 높았고 대조군보다 블루베리즙 첨가 요구르트 드레싱의 기호도가 더 좋게 평가되었다(p<0.001). 이상으로 블루베리즙 첨가 요구르트 드레싱 제조 시 블루베리즙 첨가량은 20%가 가장 적합하리라 사료된다.