• Title/Summary/Keyword: downstream processing

Search Result 102, Processing Time 0.02 seconds

DeNERT: Named Entity Recognition Model using DQN and BERT

  • Yang, Sung-Min;Jeong, Ok-Ran
    • Journal of the Korea Society of Computer and Information
    • /
    • v.25 no.4
    • /
    • pp.29-35
    • /
    • 2020
  • In this paper, we propose a new structured entity recognition DeNERT model. Recently, the field of natural language processing has been actively researched using pre-trained language representation models with a large amount of corpus. In particular, the named entity recognition, which is one of the fields of natural language processing, uses a supervised learning method, which requires a large amount of training dataset and computation. Reinforcement learning is a method that learns through trial and error experience without initial data and is closer to the process of human learning than other machine learning methodologies and is not much applied to the field of natural language processing yet. It is often used in simulation environments such as Atari games and AlphaGo. BERT is a general-purpose language model developed by Google that is pre-trained on large corpus and computational quantities. Recently, it is a language model that shows high performance in the field of natural language processing research and shows high accuracy in many downstream tasks of natural language processing. In this paper, we propose a new named entity recognition DeNERT model using two deep learning models, DQN and BERT. The proposed model is trained by creating a learning environment of reinforcement learning model based on language expression which is the advantage of the general language model. The DeNERT model trained in this way is a faster inference time and higher performance model with a small amount of training dataset. Also, we validate the performance of our model's named entity recognition performance through experiments.

RNase P-dependent Cleavage of Polycistronic mRNAs within Their Downstream Coding Regions in Escherichia coli

  • Lee, Jung-Min;Kim, Yool;Hong, Soon-Kang;Lee, Young-Hoon
    • Bulletin of the Korean Chemical Society
    • /
    • v.29 no.6
    • /
    • pp.1137-1140
    • /
    • 2008
  • M1 RNA, the catalytic subunit of Escherichia coli RNase P, is an essential ribozyme that processes the 5' leader sequence of tRNA precursors (ptRNAs). Using KS2003, an E. coli strain generating only low levels of M1 RNA, which showed growth defects, we examined whether M1 RNA is involved in polycistronic mRNA processing or degradation. Microarray analysis of total RNA from KS2003 revealed six polycistronic operon mRNAs (acpP-fabF, cysDNC, flgAMN, lepAB, phoPQ, and puuCBE) showing large differences in expression between the adjacent genes in the same mRNA transcript compared with the KS2001 wild type strain. Model substrates spanning an adjacent pair of genes for each polycistronic mRNA were tested for RNase P cleavage in vitro. Five model RNAs (cysNC, flgMN, lepAB, phoPQ, and puuBE) were cleaved by RNase P holoenzyme but not by M1 RNA alone. However, the cleavages occurred at non-ptRNA-like cleavage sites, with much less efficiency than the cleavage of ptRNA. Since cleavage products generated by RNase P from a polycistronic mRNA can have different in vivo stabilities, our results suggest that RNase P cleavage may lead to differential expression of each cistron.

Computer Simulation of Coating Behavior Including Air for Various Coater Geometries and Operational Conditions (코팅 공정에서 공기를 고려한 코터형상 및 운전조건에 따른 코팅현상 해석)

  • Kim, H.Y.;Lyu, M.Y.;Choi, J.G.
    • Transactions of Materials Processing
    • /
    • v.18 no.2
    • /
    • pp.156-159
    • /
    • 2009
  • Slot coating has been wide spread in photo-resist coating on the glass for liquid crystal display. Die in slot coater consists of manifold and land. Material comes in inlet of the die and flow into the manifold and then flow out through the land. The coating thickness variations along the die length depend upon inside of die design such as manifold and die land. However the coating thickness variations along the moving direction(coating direction) of the coater depend upon the operational conditions of coater as well as die lip design. The coating behaviors including atmospheric air have been investigated in this study. Die geometries considered in this study were nozzle gap and length of the die lip. Coating gap and coating speed were the variables fur coating operational conditions. When the nozzle gap and length of die lip increased climbing effect of PR on the downstream die lip was reduced. Subsequently uniformity of coating thickness improved. Uniformity of coating thickness also enhanced as coating gap and coater speed increased. The uniformity of coating gap was related to the velocity vector distributions on the coating surface.

Velocity Profile and Wall Shear Stress Distributions of Developing Turbulent Oscillatory Flows in an Oscillator Connected to Straight Duct Located in Exit Region of a Curved Duct (가진 펌프에 연결된 곡관 출구의 직관에서 난류진동유동의 속도분포와 전단응력분포)

  • 손현철;이행남;박길문
    • Transactions of the Korean Society of Mechanical Engineers B
    • /
    • v.26 no.10
    • /
    • pp.1378-1386
    • /
    • 2002
  • In the present study, velocity profile and wall shear stress distributions of developing turbulent oscillatory flows in an oscillator connected to straight duct located in exit region of a curved duct was investigated experimentally. The experimental study for air flows was conducted to measure axial velocity profiles, shear stress distributions by using the Laser Doppler Velocimetry(LDV) system with the data acquisition and processing system of Rotating Machinery Resolver(R.M.R) and PHASE software. The results obtained from experimental studies are summarized as follows. The critical Reynolds number for a change from transitional oscillatory flow to turbulent flow was about 7500, in the 60region of dimensionless axial position which was considered as a fully developed flow region. The turbulent oscillatory flow, velocity profiles of the inflow period in the entrance region were gradually developed, but those of the outflow period were not changed nearly. Velocity profiles of inflow and outflow were shown as a symmetric form in a fully developed flow region. The wall shear stress distributions of turbulent oscillatory flow increase rapidly as the flow proceeds to downstream and flow was in good agreement with the theoretically.

Acetone-Butanol-Ethanol (ABE) Production in Fermentation of Enzymatically Hydrolyzed Cassava Flour by Clostridium beijerinckii BA101 and Solvent Separation

  • Lepiz-Aguilar, Leonardo;Rodriguez-Rodriguez, Carlos E.;Arias, Maria Laura;Lutz, Giselle
    • Journal of Microbiology and Biotechnology
    • /
    • v.23 no.8
    • /
    • pp.1092-1098
    • /
    • 2013
  • Cassava constitutes an abundant substrate in tropical regions. The production of butanol in ABE fermentation by Clostridium beijerinckii BA101 using cassava flour (CF) was scaled-up to bioreactor level (5 L). Optimized fermentation conditions were applied; that is, $40^{\circ}C$, 60 g/l CF, and enzymatic pretreatment of the substrate. The batch fermentation profile presented an acidogenic phase for the first 24 h and a solventogenic phase afterwards. An average of 37.01 g/l ABE was produced after 83 h, with a productivity of 0.446 g/l/h. Butanol production was 25.71 g/l with a productivity of 0.310 g/l/h, high or similar to analogous batch processes described for other substrates. Solvent separation by different combinations of fractioned and azeotropic distillation and liquid-liquid separation were assessed to evaluate energetic and economic costs in downstream processing. Results suggest that the use of cassava as a substrate in ABE fermentation could be a cost-effective way of producing butanol in tropical regions.

Improving Protein Production on the Level of Regulation of both Expression and Secretion Pathways in Bacillus subtilis

  • Song, Yafeng;Nikoloff, Jonas M.;Zhan, Dawei
    • Journal of Microbiology and Biotechnology
    • /
    • v.25 no.7
    • /
    • pp.963-977
    • /
    • 2015
  • The well-characterized gram-positive bacterium Bacillus subtilis is an outstanding industrial candidate for protein expression owing to its single membrane and high capacity of secretion, simplifying the downstream processing of secretory proteins. During the last few years, there has been continuous progress in the illustration of secretion mechanisms and application of this robust host in various fields of life science, such as enzyme production, feed additives, and food and pharmaceutical industries. Here, we review the developments of Bacillus subtilis as a highly promising expression system illuminating strong chemical- and temperatureinducible and other types of promoters, strategies for ribosome-binding-site utilization, and the novel approach of signal peptide selection. Furthermore, we outline the main steps of the Sec pathway and the relevant elements as well as their interactions. In addition, we introduce the latest discoveries of Tat-related complex structures and functions and the countless applications of this full-folded protein secretion pathway. This review also lists some of the current understandings of ATP-binding cassette transporters. According to the extensive knowledge on the genetic modification strategies and molecular biology of Bacillus subtilis, we propose some suggestions and strategies for improving the yield of intended productions. We expect this to promote striking future developments in the optimization and application of this bacterium.

Phytoremediation of Contaminated Soils (오염 토양의 phytoremediation)

  • Young-Gyun Cho;Sung-Keun Rhee;Sung-Taik Lee
    • Journal of Korea Soil Environment Society
    • /
    • v.2 no.1
    • /
    • pp.3-12
    • /
    • 1997
  • Phytoremediation, using plants to remediate toxic organic and inorganic pollutants in contaminated soils, is an emerging technology for environmental cleanup. Three strategies of this technology are applicable to the remediation of toxic heavy metals, radionuclides, and toxic organic pollutants: They are (1) phytoextraction, in which plants anumulate the contaminants and are harvested for the downstream processing; (2) phytodegradation, in which plant-released enzymes or plant-associated microorganisms convert toxic pollutants into non-toxic materials; and (3) phytostabilization, in which toxic pollutants are precipitated from solution or absorbed in either the plant tissue or the soil matrix. Phytoremediation is more effective and less expensive than other current treatment technologies.

  • PDF

Flood Hindcast in the Tidal Reaches of the Han River (한강감조구간(漢江感潮區間)의 홍수추정(洪水推定))

  • Choi, Byung Ho;Suh, Kyung Suck
    • KSCE Journal of Civil and Environmental Engineering Research
    • /
    • v.7 no.3
    • /
    • pp.133-139
    • /
    • 1987
  • Three disastrous floods experienced over the tidal reaches of the Han River are investigated numerically with the use of one-dimensional finite-difference tidal flow model. The hindcast scheme involves processing flood hydrograph at Indogyo to provide the necessary discharge variation at upstream boundary and predicting tidal elevations at downstream boundary that computes the response in terms of flood levels and discharges within the tidal reaches. Computed results of 1925, 1972 and 1984 floods are presented and discussed.

  • PDF

Development of a System for Selecting High-Quality Mold Manufacturing NC Data Using Evaluating the NC Data (NC 데이터 정량화를 통한 고품질 사출금형 NC 가공데이터 선정 방안)

  • Heo Eun-Young;Kim Bo-Hyun;Kim Dong-Won
    • Journal of the Korean Society for Precision Engineering
    • /
    • v.23 no.4 s.181
    • /
    • pp.99-108
    • /
    • 2006
  • Since mold industries are regarded as belonging to three types of bad business, capable young people are reluctant to work in this field. The industries are hard to employ skilled workers who have much experience and knowledge On the mold manufacturing. Thus, effective CAM systems are required for unskilled workers to create process plans and NC data for the manufacturing, and process plans play important roles in the downstream manufacturing processes, such as NC machining, polishing, and final assembly. This study proposes a decision support system that facilitates unskilled workers to easily select high quality NC-data, as well as to increase productivity. The proposed system is assumed to follow a CAM operation scenario that consists of next three steps: 1) identifying several process plans and enumerating feasible unit machining operations (UMOs) from material and part surface information, 2) creating all feasible NC-data based on UMOs using a commercial CAM system, 3) selecting the best NC data among the feasible NC data using four screening criteria, such as machining accuracy, machining allowance, cutting load, and processing time. A case study on the machining of a camera core mold is provided to demonstrate the proposed system.

Tomographic Interpretations of Visible Emissions from the Axisymmetric Partially Premixed Flames (단층진단법을 이용한 축대칭 부분예혼합 화염의 자발광 스펙트럼 해석에 관한 연구)

  • Ha, Kwang-Soon;Choi, Sang-Min
    • Transactions of the Korean Society of Mechanical Engineers B
    • /
    • v.24 no.6
    • /
    • pp.769-776
    • /
    • 2000
  • Visible spectral characteristics of cross-sectional emissions from a partially premixed methane/air and propane/air flames have been investigated. An optical train with a two-axis scanning mirror system was used to record line-of-sight emission spectra from 354nm to 618nm, and inversion technique was adapted to obtain cross-sectional emission spectra. By analyzing the reconstructed emission spectra, cross-sectional intensities of CH and $C_2$ radicals were separated from the background emissions. The blue flame edge and yellow flame edge were also obtained by image processing technique for edge detection with color photograph of flame. These edges were compared with radial distributions of CH, $C_2$ radicals and background emissions. The CH radicals were observed at blue flame edge. The background emissions were generated by soot precursor at upstream of flame and by soot at downstream of flame. The $C_2$ radicals in propane/air flame were observed more than those in methane/air flame.