• 한국해안해양공학회지
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• 제4권4호
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• pp.219-224
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• 1992

이차원 비선형 정상파의 파낭포텐셜과 수면 파형곡선을 임의 계수를 갖는 Fourier 급수로 대치하고 그 계수를 지배방정식 및 경계조건으로부터 비롯되는 비선형 연립방정식의 Newton 해법에 의하여 결정하는 방법을 제시하였다. 해석결과의 유효성을 검증하기 위하여 본 교치분석을 재내의 4차 미소치 섭동기법과 비교하였으며, 또한 파형과 파염을 관측하기 위한 수리실험을 실시하여 그 결과를 수치해석결과와 비교ㆍ검토하였다. 검토 결과, 본 해석 기법은 수심조건에 관계없이 비교적 큰 파형 경사에서도 정확한 해를 주는 것으로 나타났으며 또한 비선형성이 강한 정상파에서 파염곡선의 파봉부분에 일반적으로 나타나는 이중 돌출부를 잘 예측함으로써 그 타당성을 입증하였다.

• Preventive Nutrition and Food Science
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• 제19권4호
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• pp.367-372
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• 2014

Caffeine is widely consumed and well known for stimulating the central nervous system. When developing new foods and beverages that contain caffeine, it is important to explore the potential synergistic effects of consuming amino acids and other food ingredients with caffeine on humans. Given the physiological pathways affected by the amino acid ornithine, consumption of ornithine with caffeine may have synergistic effects. The purpose of the present study was to examine the effect of consuming caffeine with ornithine in humans. The study used a randomized, placebo-controlled, double-blinded crossover design. The subjects were all healthy office workers who ingested the placebo, 100 mg caffeine, or 100 mg caffeine plus 200 mg ornithine in the morning and completed questionnaires about their mood. Office workers who consumed the combination of caffeine and ornithine had higher mood ratings 8 h after consumption than office workers who consumed caffeine alone. The results of the present study suggest that there is a unique synergistic effect between caffeine and ornithine on the mood of healthy office workers and that ornithine may potentiate the effects of caffeine.

• 한국산학기술학회논문지
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• 제15권2호
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• pp.638-645
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• 2014

컨테이너 물동량 증대에 따라 항만 내 타부두 간 환적 물동량 수요가 크게 증대되었으나, 기존 YT 방식의 타부두 환적은 이를 효율적으로 뒷받침하지 못하고 있다. 본 논문은 컨테이너항만의 경쟁력 향상을 위한 컨테이너 대용량 이송장치 개발방안을 제시하였다. 시스템 대안의 장단점 분석과 국내 터미널 운영형태를 고려하여 2단적재 다중 편성시스템(DMTS)을 최종 대안으로 선정하였다. DMTS 회전반경은 13.5m로, 국내 기존 항만의 layout에서 즉시 운용 가능할 것으로 판단된다. 특허분석을 통하여 DMTS 핵심기술 항목으로서 현가 조향장치 최적설계, 동력 및 동력전달 장치, 주행제어 및 안전감시장치, 그리고 트레일러 간 연결기 등을 도출하였다. DMTS는 국내 수출입 항만에 적용하는데 문제가 없으며 단위 수송용량이 높아 운영 효율성 개선에 기여할 것으로 판단된다.

• Carbon letters
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• 제28권
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• pp.87-95
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• 2018

This study examined the influence of operating parameters on the electrosorptive recovery system of lithium ions from aqueous solutions using a spinel-type lithium manganese oxide adsorbent electrode and investigated the electrosorption kinetics and isotherms. The results revealed that the electrosorption data of lithium ions from the lithium containing aqueous solution were well-fitted to the Langmuir isotherm at electrical potentials lower than -0.4 V and to the Freundlich isotherm at electrical potentials higher than -0.4 V. This result may due to the formation of a thicker electrical double layer on the surface of the electrode at higher electrical potentials. The results showed that the electrosorption reached equilibrium within 200 min under an electrical potential of -1.0 V, and the pseudo-second-order kinetic model was correlated with the experimental data. Moreover, the adsorption of lithium ions was dependent on pH and temperature, and the results indicate that higher pH values and lower temperatures are more suitable for the electrosorptive adsorption of lithium ions from aqueous solutions. Thermodynamic results showed that the calculated activation energy of $22.61kJ\;mol^{-1}$ during the electrosorption of lithium ions onto the adsorbent electrode was primarily controlled by a physical adsorption process. The recovery of adsorbed lithium ions from the adsorbent electrode reached the desorption equilibrium within 200 min under reverse electrical potential of 3.5 V.

• KSBB Journal
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• 제22권4호
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• pp.218-221
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• 2007

본 연구에서는 초음파 파쇄기를 이용하여 폴리엔 항진균 활성을 갖는 방선균 배양액으로부터 pellet을 회수하여 미생물농약으로 사용이 용이한 포자를 확보하기 위한 최적화 연구를 수행하였다. 그 결과, Streptomyces sp. MMBL001, MMBL003 그리고 Pseudonocardia autotrophica는 각각 12%, 18%, 12% 출력 (100%, 700 W)에서 최적의 포자 전환율을 보임을 확인하였다. 이렇게 확보한 포자를 10% skim milk 보호제를 사용하여 동결건조한 후 각각의 생균수를 측정한 결과, MMBL003이 MMBL001과 P. autotrophica에 비해 3배 이상의 생균수가 유지됨이 측정되었다. C. albicans를 대상으로 항진균 효과를 확인한 결과, 동결건조된 3종의 방선균주 모두 우수한 항진균 활성을 유지함으로써 신규 폴리엔 생산 방선균을 이용한 미생물농약으로서의 활용 가능성을 제시하였다.

• 한국산림과학회지
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• 제105권2호
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• pp.238-246
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• 2016

본 연구는 Post-2020을 대비하는 일본의 REDD+의 국가전략과 각 기관별 추진현황을 파악하고, JCM(Joint Credit Mechanism) REDD+ 가이드라인의 문제점에 대한 우리나라 REDD+의 대응 방안 및 시사점을 제시하는 것을 목적으로 한다. JCM-REDD+ 가이드라인의 기술적 한계를 보면, REDD+ 사업의 대상이 되는 산림의 적합성은 세이프가드 간섭이 적은 곳을 선점하는 문제가 있으며, 참조배출기준선의 설정은 기준연도에 따라서 추세선이 변화하기 때문에 배출량 차이가 발생할 수 있다. 또한, REDD+의 배출이동(누출)은 누출지역이 발생하였을 때, 누출면적과 관계없이 일정계수를 곱하여 산출하기 때문에 불확실성을 포함하고 있으며, 모니터링 실시방침은 국가 및 준국가 단위의 방법만을 제시하고 있어 프로젝트 단위의 방법론이 필요하다. 마지막으로 세이프가드에 대한 방침은 세부사항 없이 목록으로만 제시하고 있어 국제통용의 항목 규정이 필요하다. 이와 같은 문제점들은 크레딧의 분배와 계층적접근(Nested Approach) 등의 더블카운팅(Double Counting) 문제와도 관련이 있으며, 앞으로 우리나라는 이를 고려하여 REDD+ 사업을 시행해야 할 것이다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제43회 하계 정기 학술대회 초록집
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• pp.174-175
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• 2012

(In, Ga) N-based III-nitride semiconductor materials have been viewed as the most promising materials for the applications of blue and green light emitting devices such as light-emitting diodes (LEDs) and laser diodes. Although the InGaN alloy can have wide range of visible wavelength by changing the In composition, it is very hard to grow high quality epilayers of In-rich InGaN because of the thermal instability as well as the large lattice and thermal mismatches. In order to avoid phase separation of InGaN, various kinds of structures of InGaN have been studied. If high-quality In-rich InGaN/GaN multiple quantum well (MQW) structures are available, it is expected to achieve highly efficient phosphor-free white LEDs. In this study, we proposed a novel InGaN double hetero-structure grown on GaN nano-pyramids to generate broad-band red-color emission with high quantum efficiency. In this work, we systematically studied the optical properties of the InGaN pyramid structures. The nano-sized hexagonal pyramid structures were grown on the n-type GaN template by metalorganic chemical vapor deposition. SiNx mask was formed on the n-type GaN template with uniformly patterned circle pattern by laser holography. GaN pyramid structures were selectively grown on the opening area of mask by lateral over-growth followed by growth of InGaN/GaN double hetero-structure. The bird's eye-view scanning electron microscope (SEM) image shows that uniform hexagonal pyramid structures are well arranged. We showed that the pyramid structures have high crystal quality and the thickness of InGaN is varied along the height of pyramids via transmission electron microscope. Because the InGaN/GaN double hetero-structure was grown on the nano-pyramid GaN and on the planar GaN, simultaneously, we investigated the comparative study of the optical properties. Photoluminescence (PL) spectra of nano-pyramid sample and planar sample measured at 10 K. Although the growth condition were exactly the same for two samples, the nano-pyramid sample have much lower energy emission centered at 615 nm, compared to 438 nm for planar sample. Moreover, nano-pyramid sample shows broad-band spectrum, which is originate from structural properties of nano-pyramid structure. To study thermal activation energy and potential fluctuation, we measured PL with changing temperature from 10 K to 300 K. We also measured PL with changing the excitation power from 48 ${\mu}W$ to 48 mW. We can discriminate the origin of the broad-band spectra from the defect-related yellow luminescence of GaN by carrying out PL excitation experiments. The nano-pyramid structure provided highly efficient broad-band red-color emission for the future applications of phosphor-free white LEDs.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.2043-2049
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• 2015

Background: Serum Golgi protein 73 (GP73) as a novel and potential marker for diagnosing hepatocellular carcinoma (HCC) have been found to be elevated in HCC patients and associated with clinical variables representing tumor growth and invasiveness. The aim of this study was to prepare a pair of monoclonal antibodys (mAbs) against GP73 and develop a newly designed double-antibody sandwich enzyme-linked immunosorbent assay (s-ELISA), which would be used in the detection of serum GP73 (sGP73) as well as in the diagnosis of HCC. Materials and Methods: Produced by prokaryotic expression, the purified recombinant GP73 (rGP73), produced by prokaryotic expression, was used to immunize the Balb/c mice. Two hybridoma cell lines against GP73 were obtained by fusing mouse Sp2/0 myeloma cells with spleen cells from the immunized mice. The titers of anti-GP73 mAb reached 1:243,000. Western blotting analysis and Immunohistochemistry staining revealed that anti-GP73 mAb could recognize GP73 protein. The double-antibody s-ELISA was successfully established and validated by 119 HCC and 103 normal serum samples. Results: showed that the detection limit of this method could reach 1.56 ng/ml, and sGP73 levels in HCC group (mean=190.6 ng/ml) were much higher than those of in healthy controls (mean=70.92 ng/ml). Conclusions: Results of our study not only showed that sGP73 levels of HCC patients were significantly higher than those of healthy controls, but also indicated that the laboratory homemade anti-GP73 mAbs could be the optimal tool used in evaluating sGP73 levels, which would provide a solid foundation for subsequent clinical applications.

• 의료법학
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• 제9권2호
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• pp.181-207
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• 2008

With recent emphasis on evidence based medicine, clinical practice guidelines are seen as a potential mechanism by which unify various managerial and professional approaches to improving the quality of care. The development process of guidelines has been the subject of much research. and it is need translating the medical evidence of research into a clinical practice guidelines. the gathered evidence needs to be interpreted into a clinical, public health, policy, or payment context. The term 'clinical practice guidelines' can evoke a diverse range of responses from healthcare personnel. Clinical practice guidelines are increasingly used in patient management but some clinicians are not familiar with their origin or appropriate applications. Understanding the limitations as well as benefits of CPG could enable clinicians to have clearer view of the place of guidelines in every practice. In the context of increasing complaints and litigation in healthcare, the legal implications of clinical practice guidelines are of increasing importance. Clinical practice guidelines could, in theory, influence the manner in which the courts establish negligence by suggesting the doctor breached the duty of care by failing to provide the required standard of medical care. In several studies, the CPGs were relevent to and played a pivotal role in the proof of negligence. Much depends on the quality of guidelines and the tools developed and the authoritativeness of a guideline. Recently, there are several opinions the court also should review the validity and reliability of expert testimony including medical evidence. and widespread use of guidelines in malpractice lawsuit could lead the physicians to greater compliance with guidelines in the long term. In conclusion, Health care reformers, physicians as well as guidelines developers should understand that guidelines have both medical and legal aspects as a double-edges sword. so clinicians, legal representatives and decision-makers should not defer unduly to guidelines.

• International Journal of Oral Biology
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• 제34권2호
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• pp.105-113
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• 2009

Dentin, a major component of teeth, is formed by odontoblasts which produce the dentin matrix beneath the dental epithelium and induce the mineralization of dentin. To date, the biochemical properties of dentin matrix proteins have been well characterized, but upstream regulators of these proteins are not yet well known. Recently in this regard, several transcription factors have been identified as potential regulators of matrix proteins. Most transcription factors are generally involved in diverse biological processes and it is essential to identify those that are odontoblast-specific transactivators to further understand the process of dentin formation. We thus analyzed the expression pattern of dentin matrix proteins and the activities of established transactivators containing a Cre-locus. Expression analyses using in situ hybridization showed that dentin matrix proteins are sequentially expressed in differentiating odontoblasts, including type-I collagen, Dmp-1 and Dspp. The activities of the transactivators were evaluated using ${\beta}$-galactosidase following the generation of double transgenic mice with each transactivator and the ROSA26R reporter line. The ${\beta}$-galactosidase activity of each transactivator paralled the expression of the matrix proteins. These results thus showed that these transactivators could be utilized for odontoblastspecific conditional gene targeting. In addition, time- and tissue-specific conditional gene targeting might also be achieved using a combination of these transactivators. Odontoblast-specific conditional gene targeting with these transactivators will likely also provide new insights into the molecular mechanisms underlying dentin formation.