• Journal of Chest Surgery
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• v.20 no.2
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• pp.281-288
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• 1987

A total and consecutive 163 patients underwent cardiac valve replacement using the Hancock porcine xenograft cardiac valves from 1 976 to 1984. Of 198 substitute valves, 177 were the Hancock valves. One hundred twenty-nine patients[79.1%] had single valve replacement: MVR 118, AVR 8 and TVR 3; 33[20.3%] had double valve replacement: MVR+AVR 27 and MVR+TVR 6; and a single case had triple valve replacement. Other surgical procedures were added in 34 patients. The operative mortality rate within 30 days of surgery was 6.1%, and it was, however, 4.2%, with single MVR. Late mortality rate was 6.7% or 1.95%/patient-year of a linealized mortality rate. Early survivors of 153 patients were followed up for a total of 565.1 patient-years [a mean of 44.3*27.1 months]. The linealized annual complication rates were: 1.95% emboli/patient-year, 0.89% bleeding/patient-year 1.24% endocarditis/patient-year, and 4.25% overall failure/patient-year. Primary tissue failure occurred at a rate of 1.59%/patient-year. The actuarial survival rates including operative mortality were 87.0*4.1% and 77.3*6.6% at 5 and 11 years after surgery respectively. The probability of freedom from thromboembolic complication of 89.2*3.4% at 5 years after surgery lasted unchanged upto 11 years. The probability of freedom from overall valve failure was 81.3*4.5% at postoperative 5 years, and it dropped down to 26.2*19.4% at 11 years, although the latter was statistically insignificant because of a small number of patients entering into the years approaching the follow-up end. However, the probability of freedom from the primary tissue failure was 81.3*10.6% at postoperative 9 years, which coincides closely with the speculated rate of tissue degeneration of about 20% in 10 years. These clinical results confirm the low thrombogenicity of the Hancock porcine valve and the reasonable failure rate of tissue degeneration.

• Journal of the Korean Chemical Society
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• v.40 no.1
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• pp.65-71
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• 1996

The chemical behaviour of the Eu(Ⅲ) complexes with organic ligands(tris[3-(trifluoromethylhydroxymethylene-camphorato)]) and tris[3-heptafluoropropylhydroxymethylene-camphorato)] has been investigated by the UV/vis-spectrophotometric, magnetic, and electrochemcial methods. The two or three energy absorption bands are observed by the spectra of these complexes. The magnitude of crystal field splitting energy, the spin pair energy and strength were obtained from the spectra of the complexes. These complexes are found to be delocalization, low-spin state, and strong bonding strenth of electron configuration. The magnetic dipolemoment are found to be diamagnetic. The redox reaction processes of complexes were investigated by cyclic voltammetry in aprotic solvent. The redox reaction processes of complexes are turned out to be single or double reaction with respect to one electron diffusion current.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.9
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• pp.961-966
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• 2009

In this paper, a novel voltage-controlled oscillator(VCO) using the metamaterial broadside coupled spiral resonators(BC-DSRs) is presented for reducing the phase noise. For reducing of the phase noise, the series spiral structures have been applied for the signal plane and ground plane at each in order to have the large coupling. Compared with the conventional VCO, the proposed VCO has the larger coupling coefficient constant, which makes a higher Q-factor and has reduced the phase noise of the VCO. The proposed VCO has the phase noise of $-121{\sim}-117.16\;dBc$/Hz at 100 kHz in the tuning range, $5.749{\sim}5.853\;GHz$. The figure of merit(FOM) of this VCO is $-198.45{\sim}-194.77\;dBc$/Hz at 100 Hz in the same tuning range, respectively.

• Tuberculosis and Respiratory Diseases
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• v.80 no.3
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• pp.265-269
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• 2017

Background: The first line of anti-tuberculosis (TB) drugs are the most effective standard of drugs for TB. However, the use of these drugs is associated with hepatotoxicity. Silymarin has protective effects against hepatotoxicity of anti-TB drugs in animal models. This study aims to investigate the protective effect of silymarin on hepatotoxicity caused by anti-TB drugs. Methods: This is a prospective, randomized, double-blind and placebo-controlled study. Patients were eligible if they were 20 years of age or order and started the first-line anti-tuberculosis drugs. Eligible patients were randomized for receiving silymarin or a placebo for the first 4 weeks. The primary outcome was the proportion of patients who showed elevated serum liver enzymes more than 3 times the upper normal limit (UNL) or total bilirubin (TBil) > $2{\times}UNL$ within the first 8 weeks of anti-TB treatment. Results: We enrolled a total of 121 patients who silymarin or a placebo to start their anti-TB treatment, for the first 8 weeks. The proportions of elevated serum liver enzymes more than 3 times of UNL at week 2, week 4, and week 8 did not show any significant difference between the silymarin and placebo groups, at 0% versus 3.6% (p>0.999); 4.4% versus 3.6% (p>0.999); and 8.7% versus 10.8% (p=0.630), respectively. However, patients with TBil >$2{\times}UNL$ at week 8 were significantly low in the silymarin group (0% versus 8.7%, p=0.043). Conclusion: Our findings did not show silymarin had any significant preventive effect on the hepatotoxicity of anti-TB drugs.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.6 no.2
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• pp.315-322
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• 2002

A thin film oxide semiconductor micro gas sensor array which shows only 60㎽ of power consumption at an operating temperature of 30$0^{\circ}C$ has been fabricated using microfabrication and rnicrornachining techniques. Excellent thermal insulation of the membrane is achieved by the use of a double la! or structure of 0.1${\mu}{\textrm}{m}$ thick Si$_3$N$_4$ and 1${\mu}{\textrm}{m}$ thick phosphosilicate glass(PSG) prepared by low pressure chemical vapor deposition(LPCVD) and atmospheric－pressure chemical-vapor deposition(APCVD), respectively. The sensor way consists of such thin film oxide semiconductor sensing materials as 1wt.％ Pd-doped SnO$_2$, 6wt.% AI$_2$O$_3$-doped ZnO, WO$_3$ and ZnO. The thin film oxide semiconductor micro gas sensor array exhibited resistance changes usable for subsequent data processing upon exposure to various gases and the sensitivity strongly depended on the sensing layer materials. Heater Part of the sensor structure has been modified in order to improve the process yield of the sensor, and as a result of modified heater structure improved process yield has been achieved.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.4
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• pp.629-635
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• 2009

The FSK duplex remote controlling wireless transmission units with a common local oscillator circuit for transmitter and receiver are designed and implemented in this paper. In the FSK full-duplex the channel frequency for Tx/Rx is allocated, a common switching oscillator circuit for Tx/Rx is designed in the FSK half-duplex scheme. Both of FSK units get functions of automatic channel detection for busy channels and channel configuration for an idle channel in order to reduce the RF channel interference and are designed as a remote controller with small-sized low power of 10mW and the 400MHz-colpitz type PLL configuration of 50kHz channel separation. The full-duplex Tx/Rx link frequency gets frequency difference of 42.8MHz, which is double of 21.4MHz IF frequency.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.48 no.8
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• pp.45-52
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• 2011

Flash memory is becoming widely prevalent in various area due to high performance, non-volatile features, low power, and robust durability. As price-per-bit is decreased, NAND flash based SSDs (Solid State Disk) have been attracting attention as the next generation storage device, which can replace HDDs (Hard Disk Drive) which have mechanical properties. Especially for the single package SSD, if channel number or FIFO buffer size per channel increases to improve performance, the size of a controller and I/O pin count will increase linearly with channel numbers and form factor will be affected. We propose a novel technique which can minimize form factor by optimizing the number of NAND flash channels and the size of interface FIFO buffer in the SSD. For SSD with 10 channel and double buffer, the experimental results show that buffer block size can be reduced about 73% without performance degradation and total size of a controller can be reduced about 40% because control block per channel and I/O pin count decrease according to decrease channel number.

• Journal of the Microelectronics and Packaging Society
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• v.16 no.4
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• pp.23-28
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• 2009

We investigated the wafer-level MEMS capping process for which cavity formation in Si wafer was not required. Ni caps were formed by electrodeposition on 4" Si wafer and Ni rims of the Ni caps were bonded to the Cu rims of bottom Si wafer by using epoxy. Then, top Si wafer was debonded from the Ni cap structures by using SnBi layer of low melting temperature. As-evaporated SnBi layer was composed of double layers of Bi and Sn due to the large difference in vapor pressures of Bi and Sn. With keeping the as-evaporated SnBi layer at $150^{\circ}C$ for more than 15 sec, SnBi alloy composed of eutectic phase and Bi-rich $\beta$ phase was formed by interdiffusion of Sn and Bi. Debonding between top Si wafer and Ni cap structures was accomplished by melting of the SnBi layer at $150^{\circ}C$.

• Journal of Environmental Science International
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• v.20 no.6
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• pp.711-719
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• 2011

This study was conducted to estimate the distribution characteristics and budget of organic matter in the Lake Hapcheon. In the dry season, the concentration ranges of organic carbons were similar, but in the rainfall season, it showed about double concentrations. Changes of vertical water quality in the lake, there were no big differences with the concentration by the depth. However, it tends to be relatively high on the surface, a little low on the mid-depth and high in the lake bottom. DOC rate at TOC, it was lower than POC rate at inflow and DOC rate was higher than POC rate in the lake and discharging water. R-DOC accounted for more 80% of DOC rate in all investigated areas, therefore we judge that this R-DOC is to increase the organic carbon pollution gradually. As the result of the calculated organic carbon budget in the Lake Hapcheon, the amount of allochthonous, autochthonous and release were 3,552, 3,288, 228 tonC/year, respectively. the amount of discharge, decomposition and sedimentation were 504, 1,344, 5,520 tonC/year, respectively. According to this investigation, the changed amount of organic matter in the Lake Hapcheon recorded -300 tonC/year with the increase of 7,068 tonC/year and the decrease of 7,368 tonC/year.

• Journal of the Korean earth science society
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• v.41 no.1
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• pp.1-18
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• 2020

This study presented the effects of the assumed mass-size relationship for snow on the simulated surface precipitation by using cloud microphysics parameterizations in Weather Research and Forecasting (WRF) model. The selected cloud microphysics parameterizations are WRF Double-Moment 6-class (WDM6) and WRF Single-Moment 6-class (WSM6) in the WRF model. We replaced the mass-size relationship for snow in WDM6 and WSM6 with Thompson's mass-size relationship retrieved from measurement data. The sensitivity of the modified WDM6 and WSM6 was tested for the idealized 2-dimensional squall line and winter precipitation system over the Korean peninsula, respectively. The modified WDM6 and WSM6 resulted in the increase of graupel/rain mixing ratios and the decrease of snow mixing ratio in the low atmosphere. The changes of hydrometeor mixing ratio and surface precipitation could be due to the collision-coalescence process between raindrops and snow and the graupel melting process.