• Journal of Genetic Medicine
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• v.13 no.1
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• pp.1-13
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• 2016

Although some mutations are beneficial and are the driving force behind evolution, it is important to maintain DNA integrity and stability because it contains genetic information. However, in the oxygen-rich environment we live in, the DNA molecule is under constant threat from endogenous or exogenous insults. DNA damage could trigger the DNA damage response (DDR), which involves DNA repair, the regulation of cell cycle checkpoints, and the induction of programmed cell death or senescence. Dysregulation of these physiological responses to DNA damage causes developmental defects, neurological defects, premature aging, infertility, immune system defects, and tumors in humans. Some human syndromes are characterized by unique neurological phenotypes including microcephaly, mental retardation, ataxia, neurodegeneration, and neuropathy, suggesting a direct link between genomic instability resulting from defective DDR and neuropathology. In this review, rare human genetic disorders related to abnormal DDR and damage repair with neural defects will be discussed.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.55 no.12
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• pp.561-569
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• 2006

Because of the trend of deregulation, power industry is going through an unprecedented transformation in North America and Europe, and there are a host of acquisitions and mergers by the private sector to position themselves to take advantage of new business opportunities. Deregulation has accelerated the development of smaller generators and fuel cells will gradually become more attractive to mainstream electricity users as they improve in capability and decrease in cost. Fuel Cell technology is surveyed and the potential of using fuel cell as a distributed generation source is presented. This paper recommends the fuel cell power plants as alternative energy sources for distributed generation in Jeju Island, Korea. This will help in increasing fuel efficiency, at least double the current thermal plants', increasing the reliability of power supply, reducing the dependency on the HVDC link, providing quality power to the growing infrastructure, and maintaining clean air in meeting the free-trade international island.

• Journal of the Semiconductor & Display Technology
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• v.15 no.4
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• pp.61-66
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• 2016

This paper presents the implementation for a network structure of railway cars using a point to point communication. Most of network's representative specifications for a train are the FIP (Field Bus), MVB (Multifunction Vehicle Bus), CAN and WTB (Wire Train Bus) which is used by ALSOM, SIEMENS and BOMBADIER as major in this field. These networks in a physical layer use a multi-drop method, connected from $1^{st}$ car to $n^{th}$ car of a train through a cable without any extra services such as an electric part, amplifier. However waveforms which is passed through a long cable in the multi-drop are distorted by a capacitance or resistance of the cable or environments. Also since using a cable connected directly from $1^{st}$ car to $n^{th}$ car, if over two trains make double head, it isn't easy to distinguish ID for each railway cars. So by using the point to point network per each car, it is able to reduce a distortion. Also since reducing distortion, this communication speed can be been higher and transmit and receive any packets more stably. Using proposed token in a packet, this can make ID per each railway car automatically. Finally experimental results show the good performance and effectiveness of the proposed method.

• Earthquakes and Structures
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• v.16 no.6
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• pp.641-654
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• 2019

This paper investigates the seismic response of a typical non-navigable continuous girder bridge isolated with friction sliding bearings of the Hong Kong-Zhuhai-Macao link projects in China. The effectiveness of the friction pendulum system (FPS) and accuracy of the numerical model were evaluated by a 1/20 scaled bridge model using shaking table tests. Based on the hysteretic properties of friction pendulum system (FPS), double concave friction pendulum (DCFP), and triple friction pendulum system (TFPS), seismic response analyses of isolated bridges with the three sliding-type bearings are systematically carried out considering soil-pile interaction under offshore soft clay conditions. The fast nonlinear analysis (FNA) method and response spectrum are employed to investigate the seismic response of isolated offshore bridge structures. The numerical results show that the implementation of the three sliding-type bearings effectively reduce the base shear and bending moment of the reinforced concrete pier, at the cost of increasing the absolute displacement of the bridge superstructure. Furthermore, the TFPS and DCFP bearings show better isolation effect than FPS bearing for the example continuous girder bridge.

• The Transactions of the Korean Institute of Power Electronics
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• v.25 no.6
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• pp.459-468
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• 2020

The pole interaction of the line-commutated converter high-voltage direct current (HVDC) is analyzed, and a practical solution that uses a surge arrester is proposed. Jeju HVDC No. 2 is a double-monopole HVDC link that has a rated power capacity of 2 × 200 MW and was commissioned in 2012. During normal operation, Jeju HVDC No. 2 is operated in the bipolar mode to minimize the loss caused by the dedicated metallic return. However, when one pole of the inverter valve is bypassed, a commutation failure can occur in the other pole. This phenomenon is called pole interaction in this work. This pole interaction interrupts the HVDC power transfer for almost 2 s and may affect the stability of the power system. This research proposes the installation of a surge arrester at the inverter neutral, which can be an effective and practical solution for pole interaction. The HVDC system is analyzed, and the residual voltage of the surge arrester is determined. Detailed simulation using PSCAD/EMTDC demonstrates that the proposed method eliminates the pole interaction of the bipolar-operated HVDC.

• International Journal of Computer Science & Network Security
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• v.22 no.4
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• pp.1-12
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• 2022

In order to overcome the power fluctuation issues in photovoltaic (PV) smart grid-connected systems and the inverter nonlinearity model problem, an adaptive backstepping command-filter and a double second order generalized Integrators (DSOGI) controller are designed in order to tune the AC current and the DC-link voltage from the DC side. Firstly, we propose to present the filter mathematical model throughout the PV system, at that juncture the backstepping control law is applied in order to control it, Moreover the command filter is bounded to the controller aiming to exclude the backstepping controller differential increase. Additionally, The adaptive law uses Lyapunov stability criterion. Its task is to estimate the uncertain parameters in the smart grid-connected inverter. A DSOGI is added to stabilize the grid currents and eliminate undesirable harmonics meanwhile feeding maximum power generated from PV to the point of common coupling (PCC). Then, guaranteeing a dynamic effective response even under very unbalanced loads and/or intermittent climate changes. Finally, the simulation results will be established using MATLAB/SIMULINK proving that the presented approach can control surely the smart grid-connected system.

• The Plant Pathology Journal
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• v.39 no.6
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• pp.566-574
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• 2023

The aim of this study was to investigate the regulation of lantipeptide production in Streptomyces globisporus SP6C4, which produces the novel antifungal lantipeptides conprimycin and grisin, and to identify the role of cytochrome P450 (P450) in tis regulation. To investigate the regulation of lantipeptide production, we created gene deletion mutants, including ΔP450, ΔtsrD, ΔlanM, ΔP450ΔtsrD, and ΔP450ΔlanM. These mutants were characterized in terms of their morphology, sporulation, attachment, and antifungal activity against Fusarium oxysporum. The gene deletion mutants showed distinct characteristics compared to the wild-type strain. Among them, the ΔP450ΔlanM double mutant exhibited a recovery of antifungal activity against F. oxysporum, indicating that P450 plays a significant role in regulating lantipeptide production in S. globisporus SP6C4. Our findings highlight the significant role of P450 in the regulation of lantipeptide production and morphological processes in S. globisporus. The results suggest a potential link between P450-mediated metabolic pathways and the regulation of growth and secondary metabolism in SP6C4, thereby highlighting P450 as a putative target for the development of new antifungal agents.

• Journal of Microbiology and Biotechnology
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• v.25 no.1
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• pp.98-108
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• 2015

Staphylococcus aureus is an important foodborne pathogen that causes diverse diseases ranging from minor infections to life-threatening conditions in humans and animals. To further understand its pathogenesis, the genome of the strain S. aureus FORC_001 was isolated from a contaminated food. Its genome consists of 2,886,017 bp double-stranded DNA with a GC content of 32.8%. It is predicted to contain 2,728 open reading frames, 57 tRNAs, and 6 rRNA operons, including 1 additional 5S rRNA gene. Comparative phylogenetic tree analysis of 40 complete S. aureus genome sequences using average nucleotide identity (ANI) revealed that strain FORC_001 belonged to Group I. The closest phylogenetic match was S. aureus MRSA252, according to a whole-genome ANI (99.87%), suggesting that they might share a common ancestor. Comparative genome analysis of FORC_001 and MRSA252 revealed two non-homologous regions: Regions I and II. The presence of various antibiotic resistance genes, including the SCCmec cluster in Region I of MRSA252, suggests that this strain might have acquired the SCCmec cluster to adapt to specific environments containing methicillin. Region II of both genomes contains prophage regions but their DNA sequence identity is very low, suggesting that the prophages might differ. This is the first report of the complete genome sequence of S. aureus isolated from a real foodborne outbreak in South Korea. This report would be helpful to extend our understanding about the genome, general characteristics, and virulence factors of S. aureus for further studies of pathogenesis, rapid detection, and epidemiological investigation in foodborne outbreak.

• KIPS Transactions on Computer and Communication Systems
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• v.12 no.9
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• pp.263-272
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• 2023

Industrial Internet of Things (IIoT) is an important factor in increasing production efficiency in industrial sectors, along with data collection, exchange and analysis through large-scale connectivity. However, as traffic increases explosively due to the recent spread of IIoT, an allocation method that can efficiently process traffic is required. In this thesis, I propose a two-stage task offloading decision method to increase successful task throughput in an IIoT environment. In addition, I consider a hybrid offloading system that can offload compute-intensive tasks to a mobile edge computing server via a cellular link or to a nearby IIoT device via a Device to Device (D2D) link. The first stage is to design an incentive mechanism to prevent devices participating in task offloading from acting selfishly and giving difficulties in improving task throughput. Among the mechanism design, McAfee's mechanism is used to control the selfish behavior of the devices that process the task and to increase the overall system throughput. After that, in stage 2, I propose a multi-armed bandit (MAB)-based task offloading decision method in a non-stationary environment by considering the irregular movement of the IIoT device. Experimental results show that the proposed method can obtain better performance in terms of overall system throughput, communication failure rate and regret compared to other existing methods.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.11A
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• pp.867-875
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• 2003

Current end-to-end congestion control depends only on the information of end points (using three duplicate ACK packets) and generally responds slowly to the network congestion. This mechanism can't avoid TCP global synchronization in which TCP congestion window size is fluctuated during congestion period. Furthermore, if RTT(Round Trip Time) is increased, three duplicate ACK packets are not correct congestion signals because congestion might already disappear and the host may send more packets until it receives three duplicate ACK packets. Recently there are increasing interests in solving end-to-end congestion control using AQM(Active Queue Management) to improve the performance of TCP protocols. AQM is a variation of RED-based congestion control. In this paper, we first evaluate the effectiveness of the current AQM schemes such as RED, CHOKe, ARED, FRED and SRED, over traffic with different rates and over traffic with mixed responsive and non-responsive flows, respectively. In particular, CHOKe mechanism shows greater unfairness, especially when more unresponsive flows exist in a shared link. We then propose a new AQM scheme using CHOKe mechanism, called DQC(Double Queue CHOKe), which uses two FIFO queues before applying CHOKe mechanism to adaptive congestion control. Simulation shows that it works well in protecting congestion-sensitive flows from congestion-causing flows and exhibits better performances than other AQM schemes. Also we use partial state information, proposed in LRURED, to improve our mechanism.